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The map label for this gene is pepA2 [H]

Identifier: 119773932

GI number: 119773932

Start: 979556

End: 981064

Strand: Reverse

Name: pepA2 [H]

Synonym: Sama_0795

Alternate gene names: 119773932

Gene position: 981064-979556 (Counterclockwise)

Preceding gene: 119773935

Following gene: 119773929

Centisome position: 22.78

GC content: 56.99

Gene sequence:

>1509_bases
ATGGAGTTTAGCGTAAAGAGCGGCAGCCCGGAAAAACAACGCTCAGCGTGCATTGTTGTGGGTGTATACGAACCCCGCCG
TTTGTCCGGCATCGCAGAGCAACTGGACAAAATCAGCGAAGGTTATATCAGCAATCTGTTGCGTCGTGGTGATCTGGAAG
GCAAGCCAGGCCAGATGCTGCTTCTGCACCACGTCCCCAACGTGCTCAGTGAGCGTGTTCTCTTGGTTGGTTGTGGTAAA
GAGCGCGAGCTGGACGAGCGTCAATACAAGCAAATCATCGCCAAGACCATCAACACCCTTAACGAAACTGGTTCCATGGA
AGCCGTGTGTTTTCTGACCGAGCTGCACGTTAAAGGTCGCGATACCTATTGGAAAGTGCGTCAGGCCGTAGAAACCACGC
AAAACAGCCTCTACAGCTTCGATACCCTGAAAAGCCGTAAAGGCGAGACCCGTCGTCCACTTCGCAAACTGGTGTTCAAC
GTGCCTACACGCCGTGAACTGACCGTTGGCGAGCGCGCCATCGAGCACGGTGTTGCCGTAGCCTCGGGTATGCACCTGTG
CCGCGACGTGGCCAACATGCCGCCTAACATCTGTAATCCGGCTTACCTCGCCTCTCAGGCCCGTCAGCTGGCCGAAGTAC
ACGAAAACCTGCAGGTATCTACTGTGGGTGAAGAGCAAATGGCCAAACTGGGCATGAACTCTTACCTCGCCGTGGGCCGC
GGCAGTGCCAATGAGTCCATCATGACTGTGATGGAGTACAAGGGCGCCGTGGACAGCACCGCCAAGCCAATCGTGCTGGT
AGGTAAAGGCCTGACTTTCGATTCCGGCGGTATCTCTCTCAAGCCAGGCGAAGCCATGGACGAGATGAAGTACGACATGG
GCGGCGCCGCTGGCGTTATCGGTACCATGAAGGCTATCTGCGAAATGAAGCTGCCGCTGAACGTAGTGGGTATTCTGGCT
GGCTGTGAAAACATGCCTTCCGGCAATGCATACCGTCCAGGCGACATCCTCACTACCATGAGCGGTCAAACCGTGGAAGT
GCTGAACACTGACGCCGAAGGCCGTCTGGTTCTGTGCGATGTGCTGACCTACGTTGAGCGTTTCGACCCTGAACTGGTGG
TCGATACCGCCACCCTGACCGGTGCCTGTGTGATCGCGCTTGGTAAGCATGCCTCTGGCCTCTTCTCTTCCCACAATCCG
CTGGCACACGAGCTGCTGAGCGCCGGTGAGCAAAGTGGTGACCGCGCCTGGCGCATGCCACTGTGGGATGAGTATCAGGA
CATGCTGGACAGTCCGTTTGCCGACATGACCAACCTCGGTGGCCGTCCGGCGGGCTCCATCACCGCCGCCTGTTTCCTGT
CGCGCTTTGCCAAGAAATACAACTGGGCACACCTTGACGTAGCAGGTACTGCCTGGAACAGCGGTGCCAACAAGGGCTCT
ACCGGTCGTCCGGTTCCTCTGTTGACTCAGTTCCTGATAAACCGCGCCGGTGTAGAACAGGGCGAATAA

Upstream 100 bases:

>100_bases
AGTAACAGGCCTTGGCGCAGAAACTTAGGCCCGATTTCGGGCACAAGCAGGCATTATCCAATAAATATAAAAATTTGTCT
TTAAGAATCTAGGAGTGCTC

Downstream 100 bases:

>100_bases
GCCAAACAGCTGTGTTAAGCACATAAAAAAAGCGAAGCCCCGGGTTCGCTTTTTTGTTGCCCGTAATCCGTTATTTTCAG
GACGCCTTGTCGATTCTCAG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase 2; LAP 2; Leucyl aminopeptidase 2 [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQMLLLHHVPNVLSERVLLVGCGK
ERELDERQYKQIIAKTINTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVETTQNSLYSFDTLKSRKGETRRPLRKLVFN
VPTRRELTVGERAIEHGVAVASGMHLCRDVANMPPNICNPAYLASQARQLAEVHENLQVSTVGEEQMAKLGMNSYLAVGR
GSANESIMTVMEYKGAVDSTAKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVIGTMKAICEMKLPLNVVGILA
GCENMPSGNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFDPELVVDTATLTGACVIALGKHASGLFSSHNP
LAHELLSAGEQSGDRAWRMPLWDEYQDMLDSPFADMTNLGGRPAGSITAACFLSRFAKKYNWAHLDVAGTAWNSGANKGS
TGRPVPLLTQFLINRAGVEQGE

Sequences:

>Translated_502_residues
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQMLLLHHVPNVLSERVLLVGCGK
ERELDERQYKQIIAKTINTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVETTQNSLYSFDTLKSRKGETRRPLRKLVFN
VPTRRELTVGERAIEHGVAVASGMHLCRDVANMPPNICNPAYLASQARQLAEVHENLQVSTVGEEQMAKLGMNSYLAVGR
GSANESIMTVMEYKGAVDSTAKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVIGTMKAICEMKLPLNVVGILA
GCENMPSGNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFDPELVVDTATLTGACVIALGKHASGLFSSHNP
LAHELLSAGEQSGDRAWRMPLWDEYQDMLDSPFADMTNLGGRPAGSITAACFLSRFAKKYNWAHLDVAGTAWNSGANKGS
TGRPVPLLTQFLINRAGVEQGE
>Mature_502_residues
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQMLLLHHVPNVLSERVLLVGCGK
ERELDERQYKQIIAKTINTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVETTQNSLYSFDTLKSRKGETRRPLRKLVFN
VPTRRELTVGERAIEHGVAVASGMHLCRDVANMPPNICNPAYLASQARQLAEVHENLQVSTVGEEQMAKLGMNSYLAVGR
GSANESIMTVMEYKGAVDSTAKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVIGTMKAICEMKLPLNVVGILA
GCENMPSGNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFDPELVVDTATLTGACVIALGKHASGLFSSHNP
LAHELLSAGEQSGDRAWRMPLWDEYQDMLDSPFADMTNLGGRPAGSITAACFLSRFAKKYNWAHLDVAGTAWNSGANKGS
TGRPVPLLTQFLINRAGVEQGE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=490, Percent_Identity=33.8775510204082, Blast_Score=265, Evalue=6e-71,
Organism=Homo sapiens, GI47155554, Length=362, Percent_Identity=29.2817679558011, Blast_Score=123, Evalue=4e-28,
Organism=Escherichia coli, GI1790710, Length=498, Percent_Identity=76.9076305220884, Blast_Score=813, Evalue=0.0,
Organism=Escherichia coli, GI87082123, Length=311, Percent_Identity=39.871382636656, Blast_Score=190, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17556903, Length=290, Percent_Identity=32.7586206896552, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17565172, Length=385, Percent_Identity=27.7922077922078, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20129969, Length=523, Percent_Identity=30.2103250478011, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI161077148, Length=501, Percent_Identity=29.5409181636727, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI20130057, Length=501, Percent_Identity=29.5409181636727, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI21355725, Length=324, Percent_Identity=33.9506172839506, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24662227, Length=508, Percent_Identity=29.9212598425197, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24661038, Length=324, Percent_Identity=34.2592592592593, Blast_Score=194, Evalue=9e-50,
Organism=Drosophila melanogaster, GI21355645, Length=507, Percent_Identity=29.9802761341223, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24662223, Length=507, Percent_Identity=29.9802761341223, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI20129963, Length=507, Percent_Identity=28.9940828402367, Blast_Score=188, Evalue=7e-48,
Organism=Drosophila melanogaster, GI19922386, Length=498, Percent_Identity=29.1164658634538, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI21357381, Length=290, Percent_Identity=32.7586206896552, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI221379063, Length=290, Percent_Identity=32.7586206896552, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI221379062, Length=290, Percent_Identity=32.7586206896552, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24646701, Length=263, Percent_Identity=27.3764258555133, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24646703, Length=263, Percent_Identity=27.3764258555133, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21358201, Length=263, Percent_Identity=27.3764258555133, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54571; Mature: 54571

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQML
CCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
LLHHVPNVLSERVLLVGCGKERELDERQYKQIIAKTINTLNETGSMEAVCFLTELHVKGR
HHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCC
DTYWKVRQAVETTQNSLYSFDTLKSRKGETRRPLRKLVFNVPTRRELTVGERAIEHGVAV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
ASGMHLCRDVANMPPNICNPAYLASQARQLAEVHENLQVSTVGEEQMAKLGMNSYLAVGR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHCCCCEEEECC
GSANESIMTVMEYKGAVDSTAKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVI
CCCCHHHHHHHHHCCCCCCCCCCEEEEECCCEECCCCCEECCCCHHHHHHHHCCCHHHHH
GTMKAICEMKLPLNVVGILAGCENMPSGNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCD
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEHHH
VLTYVERFDPELVVDTATLTGACVIALGKHASGLFSSHNPLAHELLSAGEQSGDRAWRMP
HHHHHHHCCCCEEEECHHHHCEEHEEECCCHHCCCCCCCHHHHHHHHCCCCCCCCEECCC
LWDEYQDMLDSPFADMTNLGGRPAGSITAACFLSRFAKKYNWAHLDVAGTAWNSGANKGS
CHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
TGRPVPLLTQFLINRAGVEQGE
CCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEFSVKSGSPEKQRSACIVVGVYEPRRLSGIAEQLDKISEGYISNLLRRGDLEGKPGQML
CCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
LLHHVPNVLSERVLLVGCGKERELDERQYKQIIAKTINTLNETGSMEAVCFLTELHVKGR
HHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCC
DTYWKVRQAVETTQNSLYSFDTLKSRKGETRRPLRKLVFNVPTRRELTVGERAIEHGVAV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
ASGMHLCRDVANMPPNICNPAYLASQARQLAEVHENLQVSTVGEEQMAKLGMNSYLAVGR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHCCCCEEEECC
GSANESIMTVMEYKGAVDSTAKPIVLVGKGLTFDSGGISLKPGEAMDEMKYDMGGAAGVI
CCCCHHHHHHHHHCCCCCCCCCCEEEEECCCEECCCCCEECCCCHHHHHHHHCCCHHHHH
GTMKAICEMKLPLNVVGILAGCENMPSGNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCD
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEHHH
VLTYVERFDPELVVDTATLTGACVIALGKHASGLFSSHNPLAHELLSAGEQSGDRAWRMP
HHHHHHHCCCCEEEECHHHHCEEHEEECCCHHCCCCCCCHHHHHHHHCCCCCCCCEECCC
LWDEYQDMLDSPFADMTNLGGRPAGSITAACFLSRFAKKYNWAHLDVAGTAWNSGANKGS
CHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
TGRPVPLLTQFLINRAGVEQGE
CCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]