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The map label for this gene is hisB

Identifier: 119717267

GI number: 119717267

Start: 3240298

End: 3240906

Strand: Reverse

Name: hisB

Synonym: Noca_3043

Alternate gene names: 119717267

Gene position: 3240906-3240298 (Counterclockwise)

Preceding gene: 119717268

Following gene: 119717266

Centisome position: 65.0

GC content: 71.59

Gene sequence:

>609_bases
ATGACGAGGACGGCACGCATCGAGCGGCAGACCAGCGAGTCCAAGGTGCTCGTCGAGGTCGACCTCGACGGCACCGGGCG
CCACGACGTCTCGACCGGCGTGGGCTTCTACGACCACATGCTGACCGCGTTCGCCCGCCACGCGCTGGTCGACCTGACCG
TGCAGACCGACGGCGACACCCACATCGACGCCCACCACACCGTCGAGGACACCGCGATCGCGCTCGGCCAGGCGCTGCGC
CAGGCGCTCGGTGACAAGCGGGGCATCCGCCGGTTCGGCGACGCGACCGTGCCGCTGGACGAGGCGCTCGTGCAGGCCGT
GGTCGATGTCTCCGGCCGGCCCTACTGCGTGCACACCGGCGAGCCCGAGGGGCAGCAGTACGTCCAGCTGGGTGGCACCA
CGCCGGCGTACCTGGGCTCGCTGACCCAGCACGTCTTCGAGTCGATCGCGTTCCACGGCCACTTCGCCCTCCACGTCCGG
GTGCTGGCCGGCCGCGAGCCGCACCACATCGTGGAGACCCAGTTCAAGGCGGTCGCCCGGGCCTTCCGCGACGCCGTCGC
GCTCGACCCGCGCGAGACCGGGATCCCCAGCACCAAGGGCGCTTTGTGA

Upstream 100 bases:

>100_bases
GGGAGACCGGCCCGGACGGCTGGCTGCGGGTCTCGATCGGCACCGCCGAGGAGATGCAGGCATTCAAGGACGCACTGACC
CAGGTCAGGAAGGAAATGTG

Downstream 100 bases:

>100_bases
CCCGTCCGAACGTGGTGGTCCTCGACTACGGCTCGGGGAACCTCCGCTCCGCCGTGCGCGCGGTCGAACGCGCCGGCGCC
GAGGTCACGCTGACCGCCGA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MTRTARIERQTSESKVLVEVDLDGTGRHDVSTGVGFYDHMLTAFARHALVDLTVQTDGDTHIDAHHTVEDTAIALGQALR
QALGDKRGIRRFGDATVPLDEALVQAVVDVSGRPYCVHTGEPEGQQYVQLGGTTPAYLGSLTQHVFESIAFHGHFALHVR
VLAGREPHHIVETQFKAVARAFRDAVALDPRETGIPSTKGAL

Sequences:

>Translated_202_residues
MTRTARIERQTSESKVLVEVDLDGTGRHDVSTGVGFYDHMLTAFARHALVDLTVQTDGDTHIDAHHTVEDTAIALGQALR
QALGDKRGIRRFGDATVPLDEALVQAVVDVSGRPYCVHTGEPEGQQYVQLGGTTPAYLGSLTQHVFESIAFHGHFALHVR
VLAGREPHHIVETQFKAVARAFRDAVALDPRETGIPSTKGAL
>Mature_201_residues
TRTARIERQTSESKVLVEVDLDGTGRHDVSTGVGFYDHMLTAFARHALVDLTVQTDGDTHIDAHHTVEDTAIALGQALRQ
ALGDKRGIRRFGDATVPLDEALVQAVVDVSGRPYCVHTGEPEGQQYVQLGGTTPAYLGSLTQHVFESIAFHGHFALHVRV
LAGREPHHIVETQFKAVARAFRDAVALDPRETGIPSTKGAL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=200, Percent_Identity=40.5, Blast_Score=144, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6324776, Length=175, Percent_Identity=46.8571428571429, Blast_Score=142, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_NOCSJ (A1SL60)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_924232.1
- ProteinModelPortal:   A1SL60
- SMR:   A1SL60
- STRING:   A1SL60
- GeneID:   4600160
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_3043
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   RQAVEYD
- ProtClustDB:   CLSK2783647
- BioCyc:   NSP35761:NOCA_3043-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21936; Mature: 21805

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRTARIERQTSESKVLVEVDLDGTGRHDVSTGVGFYDHMLTAFARHALVDLTVQTDGDT
CCCCCHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCC
HIDAHHTVEDTAIALGQALRQALGDKRGIRRFGDATVPLDEALVQAVVDVSGRPYCVHTG
CCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECC
EPEGQQYVQLGGTTPAYLGSLTQHVFESIAFHGHFALHVRVLAGREPHHIVETQFKAVAR
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHHHH
AFRDAVALDPRETGIPSTKGAL
HHHHHHCCCCHHCCCCCCCCCC
>Mature Secondary Structure 
TRTARIERQTSESKVLVEVDLDGTGRHDVSTGVGFYDHMLTAFARHALVDLTVQTDGDT
CCCCHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCC
HIDAHHTVEDTAIALGQALRQALGDKRGIRRFGDATVPLDEALVQAVVDVSGRPYCVHTG
CCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECC
EPEGQQYVQLGGTTPAYLGSLTQHVFESIAFHGHFALHVRVLAGREPHHIVETQFKAVAR
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHHHH
AFRDAVALDPRETGIPSTKGAL
HHHHHHCCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA