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The map label for this gene is cobH [H]

Identifier: 119717117

GI number: 119717117

Start: 3077313

End: 3077975

Strand: Reverse

Name: cobH [H]

Synonym: Noca_2893

Alternate gene names: 119717117

Gene position: 3077975-3077313 (Counterclockwise)

Preceding gene: 119717118

Following gene: 119717116

Centisome position: 61.73

GC content: 67.72

Gene sequence:

>663_bases
ATGACCCTGTCCCGCCCACCTTGCCGCTACGAGTACGTCGACAATGGCCCGGCCATCTACGTCGACTCCTTTGCCACCAT
CCGCCGAGAGGCCGACCTGTCGGCGATCCCGGTCGACGCCGAGAAGCTGGCGGTGCGGATGATCCACGGAAGCGGGCAGG
TCGATCTTGCTGCCGACCTCGTCGTGCATCCGCGGATGGTGTCCGCAGCGCGCACCGCCTTGGAGGCGGGCGCGTCCGTG
CTGTGTGACGCGACGATGGTGGCGACCGGCGTTACCCGCAGCCGTCTGCCGAAGGACAACGACGTGTTGTGCTTCCTCAA
CGATCCCCGGGTCCCGGCTCTCGCGAAGCAGTGGGAAACCACCCGCACCGCCGCTGCGGTCTCGCTGTGGCCGCCCTACC
TGGACGGTGCGGTGGTCGCGATCGGCAACGCGCCGACCGCCTTGTTCCATCTGCTCGAGCTCATCCTCGACGGCGGTCCC
CGGCCCGCTGCGATCGTCGGCTGTCCGGTCGGTTTCATCGGTGCCGCGGAGTCCAAGCAGGCACTGGTCGACTTCCACGA
CCAGCATGGGATCGACATCCCCTTCGTCACCGTCCGCGGTCGCCGTGGCGGTTCGGCGATGACCTCCTCCGCACTCAACG
CACTCGCCCAGGAGATCGAATGA

Upstream 100 bases:

>100_bases
AGGGGCTGCTCGACCGTGCCTTGGTCGACTCGCTCACCTCTATCTCAGAGTTCCTGGTCGTCACGCCCTGGCGCGGCGTC
CTCGTCCCGGGGGAGCCCCG

Downstream 100 bases:

>100_bases
ACGGCACGTTCACGGTCGTGGGAATCGGCCCGGGCGATCCGGAGCTGATGACCCTCAAGGCCGTTCGCCTCATCGGCGAC
GCGCAGGTCGTCGCCTTCCA

Product: precorrin-8X methylmutase

Products: NA

Alternate protein names: HBA synthase; Precorrin isomerase [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MTLSRPPCRYEYVDNGPAIYVDSFATIRREADLSAIPVDAEKLAVRMIHGSGQVDLAADLVVHPRMVSAARTALEAGASV
LCDATMVATGVTRSRLPKDNDVLCFLNDPRVPALAKQWETTRTAAAVSLWPPYLDGAVVAIGNAPTALFHLLELILDGGP
RPAAIVGCPVGFIGAAESKQALVDFHDQHGIDIPFVTVRGRRGGSAMTSSALNALAQEIE

Sequences:

>Translated_220_residues
MTLSRPPCRYEYVDNGPAIYVDSFATIRREADLSAIPVDAEKLAVRMIHGSGQVDLAADLVVHPRMVSAARTALEAGASV
LCDATMVATGVTRSRLPKDNDVLCFLNDPRVPALAKQWETTRTAAAVSLWPPYLDGAVVAIGNAPTALFHLLELILDGGP
RPAAIVGCPVGFIGAAESKQALVDFHDQHGIDIPFVTVRGRRGGSAMTSSALNALAQEIE
>Mature_219_residues
TLSRPPCRYEYVDNGPAIYVDSFATIRREADLSAIPVDAEKLAVRMIHGSGQVDLAADLVVHPRMVSAARTALEAGASVL
CDATMVATGVTRSRLPKDNDVLCFLNDPRVPALAKQWETTRTAAAVSLWPPYLDGAVVAIGNAPTALFHLLELILDGGPR
PAAIVGCPVGFIGAAESKQALVDFHDQHGIDIPFVTVRGRRGGSAMTSSALNALAQEIE

Specific function: Catalyzes the conversion of precorrin-8X to hydrogenobyrinic acid; a methyl migration reaction during the transformation of precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: =5.4.1.2 [H]

Molecular weight: Translated: 23312; Mature: 23181

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSRPPCRYEYVDNGPAIYVDSFATIRREADLSAIPVDAEKLAVRMIHGSGQVDLAADL
CCCCCCCCCEEEECCCCEEEEECHHHHHHCCCCCCCCCCHHHEEEEEEECCCCEEEEEHE
VVHPRMVSAARTALEAGASVLCDATMVATGVTRSRLPKDNDVLCFLNDPRVPALAKQWET
EECCHHHHHHHHHHHCCCHHHCCHHHHHHCCHHHHCCCCCCEEEEECCCCCCHHHHHHHH
TRTAAAVSLWPPYLDGAVVAIGNAPTALFHLLELILDGGPRPAAIVGCPVGFIGAAESKQ
HHHHEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCEECCCCCCH
ALVDFHDQHGIDIPFVTVRGRRGGSAMTSSALNALAQEIE
HHEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLSRPPCRYEYVDNGPAIYVDSFATIRREADLSAIPVDAEKLAVRMIHGSGQVDLAADL
CCCCCCCCEEEECCCCEEEEECHHHHHHCCCCCCCCCCHHHEEEEEEECCCCEEEEEHE
VVHPRMVSAARTALEAGASVLCDATMVATGVTRSRLPKDNDVLCFLNDPRVPALAKQWET
EECCHHHHHHHHHHHCCCHHHCCHHHHHHCCHHHHCCCCCCEEEEECCCCCCHHHHHHHH
TRTAAAVSLWPPYLDGAVVAIGNAPTALFHLLELILDGGPRPAAIVGCPVGFIGAAESKQ
HHHHEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCEECCCCCCH
ALVDFHDQHGIDIPFVTVRGRRGGSAMTSSALNALAQEIE
HHEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211521; 1732194 [H]