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The map label for this gene is prs [H]

Identifier: 119386530

GI number: 119386530

Start: 961636

End: 962655

Strand: Direct

Name: prs [H]

Synonym: Pden_3823

Alternate gene names: 119386530

Gene position: 961636-962655 (Clockwise)

Preceding gene: 119386527

Following gene: 119386535

Centisome position: 55.58

GC content: 64.8

Gene sequence:

>1020_bases
ATGCCGGCCATGACCGAACCGAAGCTTATCGCGGGGAATGCGAACCGGCCTCTGGCCAATGCCATCGCCCGGCGCATGTC
GATGCATCGCGGGATGAACGTCGCCCCCATCGAGGCGCGGGTCGAGCGCTTCAACGATCAGGAAATCTTCGTCGAAGTCT
ATGAGAACGTCCGCGGCGAGGACATGTTCATCATCCAGCCGACCTCGAACCCGGCCAATGACAACCTGATGGAACTGCTG
ATCATGACGGATGCGCTGAAGCGCTCGTCGGCGGCGCGCATCACGGCGGTGATCCCCTATTTCGGCTATGCCCGGCAGGA
CCGCCGCGCCAAGGCCCGCACGCCGATCAGCGCCAAGCTGGTGGCGAACCTGTTGACCGAGGCGGGCGTGGACCGCGTGC
TGACGCTGGACCTGCATGCCGCGCAGATCCAGGGCTTTTTCGACATTCCGGTGGACAACCTCTATGCCGCGCCGGTCTTT
GCGCTGGACATCAAGCATCATTTCCGCGAGCGGCTCTCGGACCTGATGGTGATCTCGCCCGACGTGGGCGGCGTGGCGCG
GGCGCGCGAACTGGCGCAGCGCATCGGCGCACCGCTGGCCATCGTGGACAAGCGCCGCGAGAAGCCGGGCGAGGTGGCCG
AGATGACCGTGATCGGCGACGTGACCGGCAAGACCTGCATCATCGTCGACGACATCTGCGACACGGCCGGCACGCTGTGC
AAGGCGGCGCAGGTCCTGACCGAGCACGGCGCGACCGAGGTTCACGCCTATATCACCCATGGCGTCCTGTCCGGCCCGGC
GGTCGAGCGGGTGCAGGGCTCGGTGATGAAATCGCTGGTCATCACCGATTCCATCGAGCCGACCGAAAAGGTGAAATCGG
CCTCGAACATCCGCATCGTGCCGACCGCGCCGATGTTTGCGCAGGCGATCCTGAACATCTGGAACGGCACTTCGGTCAGC
TCGCTGTTCGAGGTGGACACGCTGGGTCCGATCTACGAAGGGCTCTATTCGGGCGTCTGA

Upstream 100 bases:

>100_bases
AATAGTCGATATGCGCCATCAGTGTGCCTCCGGGGTTTGCGGGCAAGCTAGCCCGGTGCTAAGCGGGGTGCAATCGCACG
AATCCAGACAGGGAAAGCCC

Downstream 100 bases:

>100_bases
TCGCCCTTGCCGCAAAAAGGCCCCGGTCCGAATGGAACCGGGGCCTTTTTCATGCGGCTTTCGCAGCTCAAAGAAAGCGC
GGGAACTCGATCTTCGGGCA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MPAMTEPKLIAGNANRPLANAIARRMSMHRGMNVAPIEARVERFNDQEIFVEVYENVRGEDMFIIQPTSNPANDNLMELL
IMTDALKRSSAARITAVIPYFGYARQDRRAKARTPISAKLVANLLTEAGVDRVLTLDLHAAQIQGFFDIPVDNLYAAPVF
ALDIKHHFRERLSDLMVISPDVGGVARARELAQRIGAPLAIVDKRREKPGEVAEMTVIGDVTGKTCIIVDDICDTAGTLC
KAAQVLTEHGATEVHAYITHGVLSGPAVERVQGSVMKSLVITDSIEPTEKVKSASNIRIVPTAPMFAQAILNIWNGTSVS
SLFEVDTLGPIYEGLYSGV

Sequences:

>Translated_339_residues
MPAMTEPKLIAGNANRPLANAIARRMSMHRGMNVAPIEARVERFNDQEIFVEVYENVRGEDMFIIQPTSNPANDNLMELL
IMTDALKRSSAARITAVIPYFGYARQDRRAKARTPISAKLVANLLTEAGVDRVLTLDLHAAQIQGFFDIPVDNLYAAPVF
ALDIKHHFRERLSDLMVISPDVGGVARARELAQRIGAPLAIVDKRREKPGEVAEMTVIGDVTGKTCIIVDDICDTAGTLC
KAAQVLTEHGATEVHAYITHGVLSGPAVERVQGSVMKSLVITDSIEPTEKVKSASNIRIVPTAPMFAQAILNIWNGTSVS
SLFEVDTLGPIYEGLYSGV
>Mature_338_residues
PAMTEPKLIAGNANRPLANAIARRMSMHRGMNVAPIEARVERFNDQEIFVEVYENVRGEDMFIIQPTSNPANDNLMELLI
MTDALKRSSAARITAVIPYFGYARQDRRAKARTPISAKLVANLLTEAGVDRVLTLDLHAAQIQGFFDIPVDNLYAAPVFA
LDIKHHFRERLSDLMVISPDVGGVARARELAQRIGAPLAIVDKRREKPGEVAEMTVIGDVTGKTCIIVDDICDTAGTLCK
AAQVLTEHGATEVHAYITHGVLSGPAVERVQGSVMKSLVITDSIEPTEKVKSASNIRIVPTAPMFAQAILNIWNGTSVSS
LFEVDTLGPIYEGLYSGV

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=320, Percent_Identity=45.625, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI4506129, Length=315, Percent_Identity=45.3968253968254, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI28557709, Length=320, Percent_Identity=45, Blast_Score=288, Evalue=4e-78,
Organism=Homo sapiens, GI84875539, Length=318, Percent_Identity=44.9685534591195, Blast_Score=287, Evalue=8e-78,
Organism=Homo sapiens, GI4506133, Length=352, Percent_Identity=34.0909090909091, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI194018537, Length=337, Percent_Identity=34.4213649851632, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI310128524, Length=150, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI310115209, Length=150, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI310118259, Length=150, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI310119946, Length=150, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1787458, Length=323, Percent_Identity=50.7739938080495, Blast_Score=319, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17554704, Length=317, Percent_Identity=44.4794952681388, Blast_Score=284, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI25149168, Length=320, Percent_Identity=44.375, Blast_Score=283, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI17554702, Length=320, Percent_Identity=44.375, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI71989924, Length=320, Percent_Identity=44.375, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17570245, Length=347, Percent_Identity=31.4121037463977, Blast_Score=173, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6321776, Length=318, Percent_Identity=45.2830188679245, Blast_Score=272, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6319403, Length=326, Percent_Identity=44.7852760736196, Blast_Score=266, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6320946, Length=321, Percent_Identity=43.3021806853583, Blast_Score=257, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6322667, Length=207, Percent_Identity=38.6473429951691, Blast_Score=149, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6324511, Length=115, Percent_Identity=39.1304347826087, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355239, Length=320, Percent_Identity=45.9375, Blast_Score=287, Evalue=9e-78,
Organism=Drosophila melanogaster, GI45551540, Length=343, Percent_Identity=42.8571428571429, Blast_Score=274, Evalue=6e-74,
Organism=Drosophila melanogaster, GI24651458, Length=366, Percent_Identity=32.7868852459016, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24651456, Length=366, Percent_Identity=32.7868852459016, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI281362873, Length=366, Percent_Identity=32.7868852459016, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24651454, Length=366, Percent_Identity=32.7868852459016, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24651462, Length=385, Percent_Identity=31.6883116883117, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24651464, Length=385, Percent_Identity=31.6883116883117, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI45552010, Length=385, Percent_Identity=31.6883116883117, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 36917; Mature: 36786

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAMTEPKLIAGNANRPLANAIARRMSMHRGMNVAPIEARVERFNDQEIFVEVYENVRGE
CCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCC
DMFIIQPTSNPANDNLMELLIMTDALKRSSAARITAVIPYFGYARQDRRAKARTPISAKL
EEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHCHHHHCCCHHHHH
VANLLTEAGVDRVLTLDLHAAQIQGFFDIPVDNLYAAPVFALDIKHHFRERLSDLMVISP
HHHHHHHCCCCEEEEEEEEHHHHCCEEECCCCCEECCCEEEEHHHHHHHHHHHCEEEECC
DVGGVARARELAQRIGAPLAIVDKRREKPGEVAEMTVIGDVTGKTCIIVDDICDTAGTLC
CCCHHHHHHHHHHHHCCCEEEEHHCCCCCCCEEEEEEEEECCCCEEEEEHHHHHHHHHHH
KAAQVLTEHGATEVHAYITHGVLSGPAVERVQGSVMKSLVITDSIEPTEKVKSASNIRIV
HHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEE
PTAPMFAQAILNIWNGTSVSSLFEVDTLGPIYEGLYSGV
ECCHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHCCC
>Mature Secondary Structure 
PAMTEPKLIAGNANRPLANAIARRMSMHRGMNVAPIEARVERFNDQEIFVEVYENVRGE
CCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCC
DMFIIQPTSNPANDNLMELLIMTDALKRSSAARITAVIPYFGYARQDRRAKARTPISAKL
EEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHCHHHHCCCHHHHH
VANLLTEAGVDRVLTLDLHAAQIQGFFDIPVDNLYAAPVFALDIKHHFRERLSDLMVISP
HHHHHHHCCCCEEEEEEEEHHHHCCEEECCCCCEECCCEEEEHHHHHHHHHHHCEEEECC
DVGGVARARELAQRIGAPLAIVDKRREKPGEVAEMTVIGDVTGKTCIIVDDICDTAGTLC
CCCHHHHHHHHHHHHCCCEEEEHHCCCCCCCEEEEEEEEECCCCEEEEEHHHHHHHHHHH
KAAQVLTEHGATEVHAYITHGVLSGPAVERVQGSVMKSLVITDSIEPTEKVKSASNIRIV
HHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEE
PTAPMFAQAILNIWNGTSVSSLFEVDTLGPIYEGLYSGV
ECCHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA