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The map label for this gene is cobD [H]

Identifier: 119356939

GI number: 119356939

Start: 1266050

End: 1267003

Strand: Direct

Name: cobD [H]

Synonym: Cpha266_1119

Alternate gene names: 119356939

Gene position: 1266050-1267003 (Clockwise)

Preceding gene: 119356938

Following gene: 119356940

Centisome position: 40.4

GC content: 54.4

Gene sequence:

>954_bases
ATGACAGCTCCCGAATATTTGTTTGCGGCAGCCTTTGTGCTTGACCTGATGCTCGGCGATCCTCGCTGGATGCCTCATCC
GGTAAAGGGAATCGGCTGGCTTGCATTACGCACAGAATCGCTGATGCGTCGGACAGCTCTTCCGCTTCGTCTTGCCGGAA
TTGCGGCGGTACTCTGTATTGTTGGAGGATCTGCCGTTTTGGCCTGGTTGCTGGTAACCGGAGCCACTCTTCTGCATCCT
GCAATCGGCGCGGCGGCAGGCATCTATCTGTCTTACAGCGCCTTTGCGACAAGGGATCTTGGAGATCATGCCCGTGCGGT
TCTTCGCGCTCTTCAGTCAGGAGATACTGCACTTGCCCGTCAAAAGGTATCCTTTATGGTCGGTCGGGATACGGCAGCCA
TGACGTTGGAGGATGTCGCACAGGCGGCAACGGAAAGCGTTGCCGAAAATACAGTTGACGGCGTTACGGCGCCCCTGTTC
TATGCGCTGCTCTTTGGCCCGGTCGGAGCTATTGCCTACAAGGCGGTCAACACTCTTGATTCCACCTTCGGGTACAAGAA
CGAACGCTATCTTGAGTTTGGCTGGGCTGCGGCTAAACTCGATGATTTAGCCAACTATCTGCCGGCAAGGTTGACGGTTC
TCGTTATAGCGCTGGCGGCGGCTATCAGAAAACTTCGGTTTATTGATATTTTTCGTTCTGTTCGAGAGGGTGCCCGGCTG
CATGCAAGTCCCAATGCAGGATACCCCGAAGCTGCATTTGCAGGCGCTCTCGGGGTTACTTTCGGCGGGAGGCGCAGTTA
TGGCGGCAGTATCGAAGATGCCCCGCTGCTTGGAGTTAAAAACGAGCCATGCCGCCCGGAAACGCTTCAGGAGAGTATCA
TCCTGATGCAGCTTACGTCAGCGACGTTTGCCGTAACAGGAATTGTTTTGTGTCTCATTCTTGGGTATTTTTAA

Upstream 100 bases:

>100_bases
AGAACTATTTTCGATTTGCCATAAGAACTCCCGAAGAGAATACTCGCCTGCTCGACGTTTTTCAGCACCTGACAGAGCAA
TCAGTCGATTTATCTGTTTC

Downstream 100 bases:

>100_bases
TGAACAGCCTCATCAACGAAACGACAGAGCGGATGAAACCTCGAAGGATTCTTCTTTTTACAGGAAACGGCAAAGGAAAA
AGCACAGCGGCGTTTGGCAT

Product: cobalamin biosynthesis protein

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MTAPEYLFAAAFVLDLMLGDPRWMPHPVKGIGWLALRTESLMRRTALPLRLAGIAAVLCIVGGSAVLAWLLVTGATLLHP
AIGAAAGIYLSYSAFATRDLGDHARAVLRALQSGDTALARQKVSFMVGRDTAAMTLEDVAQAATESVAENTVDGVTAPLF
YALLFGPVGAIAYKAVNTLDSTFGYKNERYLEFGWAAAKLDDLANYLPARLTVLVIALAAAIRKLRFIDIFRSVREGARL
HASPNAGYPEAAFAGALGVTFGGRRSYGGSIEDAPLLGVKNEPCRPETLQESIILMQLTSATFAVTGIVLCLILGYF

Sequences:

>Translated_317_residues
MTAPEYLFAAAFVLDLMLGDPRWMPHPVKGIGWLALRTESLMRRTALPLRLAGIAAVLCIVGGSAVLAWLLVTGATLLHP
AIGAAAGIYLSYSAFATRDLGDHARAVLRALQSGDTALARQKVSFMVGRDTAAMTLEDVAQAATESVAENTVDGVTAPLF
YALLFGPVGAIAYKAVNTLDSTFGYKNERYLEFGWAAAKLDDLANYLPARLTVLVIALAAAIRKLRFIDIFRSVREGARL
HASPNAGYPEAAFAGALGVTFGGRRSYGGSIEDAPLLGVKNEPCRPETLQESIILMQLTSATFAVTGIVLCLILGYF
>Mature_316_residues
TAPEYLFAAAFVLDLMLGDPRWMPHPVKGIGWLALRTESLMRRTALPLRLAGIAAVLCIVGGSAVLAWLLVTGATLLHPA
IGAAAGIYLSYSAFATRDLGDHARAVLRALQSGDTALARQKVSFMVGRDTAAMTLEDVAQAATESVAENTVDGVTAPLFY
ALLFGPVGAIAYKAVNTLDSTFGYKNERYLEFGWAAAKLDDLANYLPARLTVLVIALAAAIRKLRFIDIFRSVREGARLH
ASPNAGYPEAAFAGALGVTFGGRRSYGGSIEDAPLLGVKNEPCRPETLQESIILMQLTSATFAVTGIVLCLILGYF

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 33739; Mature: 33607

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPEYLFAAAFVLDLMLGDPRWMPHPVKGIGWLALRTESLMRRTALPLRLAGIAAVLCI
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VGGSAVLAWLLVTGATLLHPAIGAAAGIYLSYSAFATRDLGDHARAVLRALQSGDTALAR
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHH
QKVSFMVGRDTAAMTLEDVAQAATESVAENTVDGVTAPLFYALLFGPVGAIAYKAVNTLD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STFGYKNERYLEFGWAAAKLDDLANYLPARLTVLVIALAAAIRKLRFIDIFRSVREGARL
HHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
HASPNAGYPEAAFAGALGVTFGGRRSYGGSIEDAPLLGVKNEPCRPETLQESIILMQLTS
ECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHH
ATFAVTGIVLCLILGYF
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAPEYLFAAAFVLDLMLGDPRWMPHPVKGIGWLALRTESLMRRTALPLRLAGIAAVLCI
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VGGSAVLAWLLVTGATLLHPAIGAAAGIYLSYSAFATRDLGDHARAVLRALQSGDTALAR
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHH
QKVSFMVGRDTAAMTLEDVAQAATESVAENTVDGVTAPLFYALLFGPVGAIAYKAVNTLD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STFGYKNERYLEFGWAAAKLDDLANYLPARLTVLVIALAAAIRKLRFIDIFRSVREGARL
HHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
HASPNAGYPEAAFAGALGVTFGGRRSYGGSIEDAPLLGVKNEPCRPETLQESIILMQLTS
ECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHH
ATFAVTGIVLCLILGYF
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]