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The map label for this gene is cobD [H]

Identifier: 119356938

GI number: 119356938

Start: 1264953

End: 1266053

Strand: Direct

Name: cobD [H]

Synonym: Cpha266_1118

Alternate gene names: 119356938

Gene position: 1264953-1266053 (Clockwise)

Preceding gene: 119356937

Following gene: 119356939

Centisome position: 40.36

GC content: 51.32

Gene sequence:

>1101_bases
TTGACCATGAAGAGTATCTATTATCATGAGCACGGAGGCACTCCCGAACGCCGATTTGCTGTGAATCCCGAAGAGCTTCT
GGATTTCAGTGTCAATATCAGTCCGTTGTTTCCGCCTCTCGAAAACCGATTACTTGACACCTATGCGCTTGATCGGTACC
CCTCGGTTGATGGGAGGGGAATCATTGATTTTTATGCCGGAAGGTTTCAGTTGCATCGCTCGACCATTCTTGCGCTTAAC
GGGGCCACAGAGGGGATCTATCTGCTTCCACGTGCACTCGGGTTTCGACGCATGATGGTGCTCTCCCCCACGTTTTATGA
GTATGAGCGAGCAGGGCGTCTTGCCGGTGCGGCAATCGGGTTCATTCGACTTACTCCCGATAACGGAGGTTTTCTTCTCC
CTCGGCTTGAAGAACTTGCCGCAATGCTTGAGGATGCCGATGCTTTTTTTGCAGCCAATCCCAACAACCCTACGGGAACC
GTTGTTCCGCCGGAAATCATCCTTGCGCTGGCGAGTCGCTTTCCCGACAAATGGTTTCTGGTGGACGAAGCTTTTCTGCA
GTATTCGACCAACTATCACGACACTACGTTGATGAACATGGTTACTGCCATGAAAAATATTGTCGTAATTCAATCGTTAA
CCAAGTTTTATGCTCTTCCGGGTCTGCGTCTCGGAGCACTCATAGCTCACCCGGAGGTGATTACGCGGTTACTGGAATAC
AAGGAGCCCTGGTCGGTCAACACCATTGCCGAAACAGTTGCCCGTGAACTGCTTGCATGTCGGGCCTATGAAACGGCCGT
GTGTGATCTTGTTCTGTCTGAACGGGGGCGGATCACCCAGGCTCTCTCTGATAACCGGGCGATAAAGCTGGCAGGCGGAG
CGGCAAATTTTTTTCTCGCCCGCTGGCAGGGGAGCGCCAATCTTGATGATCTCCTGAACGCACTTCTGCAGCAGGGAATC
TATGTCAGAGACTGCCGGAATTTTGCCGGGCTTGAGGAGAACTATTTTCGATTTGCCATAAGAACTCCCGAAGAGAATAC
TCGCCTGCTCGACGTTTTTCAGCACCTGACAGAGCAATCAGTCGATTTATCTGTTTCATGA

Upstream 100 bases:

>100_bases
GTGGGCGGCAAGAGAGTTATGATTTGCTTGCCGACCATTTTTCAGGGTATCTCGATATTCCGAAACTCTATGAGATCATA
CAGCGACCATGTCCGAACCC

Downstream 100 bases:

>100_bases
CAGCTCCCGAATATTTGTTTGCGGCAGCCTTTGTGCTTGACCTGATGCTCGGCGATCCTCGCTGGATGCCTCATCCGGTA
AAGGGAATCGGCTGGCTTGC

Product: L-threonine O-3-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MTMKSIYYHEHGGTPERRFAVNPEELLDFSVNISPLFPPLENRLLDTYALDRYPSVDGRGIIDFYAGRFQLHRSTILALN
GATEGIYLLPRALGFRRMMVLSPTFYEYERAGRLAGAAIGFIRLTPDNGGFLLPRLEELAAMLEDADAFFAANPNNPTGT
VVPPEIILALASRFPDKWFLVDEAFLQYSTNYHDTTLMNMVTAMKNIVVIQSLTKFYALPGLRLGALIAHPEVITRLLEY
KEPWSVNTIAETVARELLACRAYETAVCDLVLSERGRITQALSDNRAIKLAGGAANFFLARWQGSANLDDLLNALLQQGI
YVRDCRNFAGLEENYFRFAIRTPEENTRLLDVFQHLTEQSVDLSVS

Sequences:

>Translated_366_residues
MTMKSIYYHEHGGTPERRFAVNPEELLDFSVNISPLFPPLENRLLDTYALDRYPSVDGRGIIDFYAGRFQLHRSTILALN
GATEGIYLLPRALGFRRMMVLSPTFYEYERAGRLAGAAIGFIRLTPDNGGFLLPRLEELAAMLEDADAFFAANPNNPTGT
VVPPEIILALASRFPDKWFLVDEAFLQYSTNYHDTTLMNMVTAMKNIVVIQSLTKFYALPGLRLGALIAHPEVITRLLEY
KEPWSVNTIAETVARELLACRAYETAVCDLVLSERGRITQALSDNRAIKLAGGAANFFLARWQGSANLDDLLNALLQQGI
YVRDCRNFAGLEENYFRFAIRTPEENTRLLDVFQHLTEQSVDLSVS
>Mature_365_residues
TMKSIYYHEHGGTPERRFAVNPEELLDFSVNISPLFPPLENRLLDTYALDRYPSVDGRGIIDFYAGRFQLHRSTILALNG
ATEGIYLLPRALGFRRMMVLSPTFYEYERAGRLAGAAIGFIRLTPDNGGFLLPRLEELAAMLEDADAFFAANPNNPTGTV
VPPEIILALASRFPDKWFLVDEAFLQYSTNYHDTTLMNMVTAMKNIVVIQSLTKFYALPGLRLGALIAHPEVITRLLEYK
EPWSVNTIAETVARELLACRAYETAVCDLVLSERGRITQALSDNRAIKLAGGAANFFLARWQGSANLDDLLNALLQQGIY
VRDCRNFAGLEENYFRFAIRTPEENTRLLDVFQHLTEQSVDLSVS

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=318, Percent_Identity=26.1006289308176, Blast_Score=96, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322075, Length=291, Percent_Identity=26.4604810996564, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 41171; Mature: 41039

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMKSIYYHEHGGTPERRFAVNPEELLDFSVNISPLFPPLENRLLDTYALDRYPSVDGRG
CCCCEEEEECCCCCCCCEECCCHHHHHEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCE
IIDFYAGRFQLHRSTILALNGATEGIYLLPRALGFRRMMVLSPTFYEYERAGRLAGAAIG
EHEECCCEEEEECEEEEEEECCCCCEEEHHHHHCHHHHHHCCCCHHHHHHHCCHHHEEEE
FIRLTPDNGGFLLPRLEELAAMLEDADAFFAANPNNPTGTVVPPEIILALASRFPDKWFL
EEEEECCCCCEECCCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEE
VDEAFLQYSTNYHDTTLMNMVTAMKNIVVIQSLTKFYALPGLRLGALIAHPEVITRLLEY
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHC
KEPWSVNTIAETVARELLACRAYETAVCDLVLSERGRITQALSDNRAIKLAGGAANFFLA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCEEEEE
RWQGSANLDDLLNALLQQGIYVRDCRNFAGLEENYFRFAIRTPEENTRLLDVFQHLTEQS
EECCCCCHHHHHHHHHHCCCEEEHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCC
VDLSVS
CCEECC
>Mature Secondary Structure 
TMKSIYYHEHGGTPERRFAVNPEELLDFSVNISPLFPPLENRLLDTYALDRYPSVDGRG
CCCEEEEECCCCCCCCEECCCHHHHHEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCE
IIDFYAGRFQLHRSTILALNGATEGIYLLPRALGFRRMMVLSPTFYEYERAGRLAGAAIG
EHEECCCEEEEECEEEEEEECCCCCEEEHHHHHCHHHHHHCCCCHHHHHHHCCHHHEEEE
FIRLTPDNGGFLLPRLEELAAMLEDADAFFAANPNNPTGTVVPPEIILALASRFPDKWFL
EEEEECCCCCEECCCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEE
VDEAFLQYSTNYHDTTLMNMVTAMKNIVVIQSLTKFYALPGLRLGALIAHPEVITRLLEY
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHC
KEPWSVNTIAETVARELLACRAYETAVCDLVLSERGRITQALSDNRAIKLAGGAANFFLA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCEEEEE
RWQGSANLDDLLNALLQQGIYVRDCRNFAGLEENYFRFAIRTPEENTRLLDVFQHLTEQS
EECCCCCHHHHHHHHHHCCCEEEHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCC
VDLSVS
CCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]