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The map label for this gene is pgi

Identifier: 119356916

GI number: 119356916

Start: 1239049

End: 1240728

Strand: Direct

Name: pgi

Synonym: Cpha266_1095

Alternate gene names: 119356916

Gene position: 1239049-1240728 (Clockwise)

Preceding gene: 119356915

Following gene: 119356934

Centisome position: 39.54

GC content: 48.15

Gene sequence:

>1680_bases
ATGGAATTATCCCGAAGCGCAGCCTGGAGCGCCCTGGTTTTTCACAAGCATGAGGTTGACAAAAAAACAATGCGCGACAT
GTTTGCCGGTGATAGCGACCGGTTTGTCAAGTTTTCATTGAGCTGGAAAGAGATGCTGCTCGATTACTCGAAAAACAGGA
TAACCTCTCGTACGATGGAGCTTCTCCTTGAGCTTGCGCACTCTGCGGGTGTGGATGAAAAACGTCAGCAGATGTTTCAG
GGGGCACCGATCAACTTTACTGAAAACCGTTCGGTTCTTCATACGGCACTTCGCAGGCCTCCGGGGTATGTTCTTGAGGT
TGACGGTCTGAATATTGGCGATGAAATTGCCGGGGTGCTGTTTCAGATGAAAAACTTCTGCGAAAAGGTTATATCGGGAA
AATGGAAAGGGTATACAGGCAAGTCGATCACTGACGTTGTCAATATCGGCATCGGGGGTTCAGACCTTGGCCCGTATATG
GTTACTGAAGCGCTTAAGCCTTTTGCGCATGGCGGGCTGGATGTTCATTTTGTGTCGAATATCGATGGTACCCACATCAG
GGAGACCCTCAAAAGACTCGATCCTGAAACAACGCTGTTCATTATTGCTTCAAAAACCTTTACGACACAGGAAACCCTGA
CCAATGCGATGAGTGCCCGAGAGTGGTTTTTAGCTCGGGCAGTTGAAGAAGAGTACATTAAAAAACATTTCGCCGCTGTT
TCAACGAATCAGGAAAAGGTGGTGGAGTTCGGCATTGATGATGCGAACATGTTCCGTTTCTGGGACTGGGTTGGTGGCAG
GTACTCGCTCTGGTCTTCAATCGGACTTTCGATCGCTCTCTATCTCGGATTTAACAGGTTCGAAGAGCTGCTGGCAGGAG
CTCATGCAATGGACGAGCATTTTCTTAATGAGCCGTTCAATCGAAATATACCGGTTATTCTTGCTCTTCTCGGCATCTGG
TATCGGAACTTTTTTGATGCAGCATCCCATGCCGTCATACCCTATGATCAGTATCTTCACCGTTTCCCGGCCTATTTACA
GCAGCTTGATATGGAAAGTAACGGCAAAAGGGTTGATGAGAACGGCCATACCGTCACGCATGCTACCGGACCGGTTATCT
GGGGCGAACCGGGCACTAATGCACAGCATGCCTTTTTTCAGTTGCTTCATCAGGGTCCTGATTTAATTCCGGCAGACTTT
ATTGTTCCACTTAAAAGTCAGAATCCCTCAGGTGAACATCACGATATGCTGCTTGCCAACTGTTTTGCTCAGACTGAAGC
GTTGATGAAGGGCAAGACCGAACAAGAGGTTCGAGCTGAACTTTCCGATGCCGGATATGATGAAGCCGATATTCAAAAGC
TGTTTCAACACAAGGTGTTTTCGGGAAATCGTCCGACCAATACCATTCTTGTTCATGAGCTGAATCCCTTCATGCTCGGC
AGTCTTATTGCCATGTATGAGCACAAGGTTTTCGTGCAGGGCGTTATCTGGCGCATCAACTCATTTGATCAGTGGGGTGT
CGAGCTCGGCAAGCAGCTCGCCAGAACGATTCTGCCGGAGATCCAGTCGGCAGAGGCCGTTACCGCTCACGATGCGTCAA
CAAATGCGCTGATCAATATGGCACGAACATTCAGAGAGGAAAATATTCGAAAGGAATCTGCACAGCTATCGTTTTTTTAG

Upstream 100 bases:

>100_bases
GTTGGAGTTGAAGTGTCCGATGGAAGATCAACGCTCAAGCTTCGCTATACCCCGTACTGAACTGCGATTTTTTAGTAACG
CTTAGAATTTATTATCAATT

Downstream 100 bases:

>100_bases
GGATTTTGTCAATCATGCAATCAGACAGCCAAACAGATTAAGAGCGTCGACTGCGATTTGTTTGGCGTTTCCCCAACCAG
CAGGGACAAGAGGACGTTAC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MELSRSAAWSALVFHKHEVDKKTMRDMFAGDSDRFVKFSLSWKEMLLDYSKNRITSRTMELLLELAHSAGVDEKRQQMFQ
GAPINFTENRSVLHTALRRPPGYVLEVDGLNIGDEIAGVLFQMKNFCEKVISGKWKGYTGKSITDVVNIGIGGSDLGPYM
VTEALKPFAHGGLDVHFVSNIDGTHIRETLKRLDPETTLFIIASKTFTTQETLTNAMSAREWFLARAVEEEYIKKHFAAV
STNQEKVVEFGIDDANMFRFWDWVGGRYSLWSSIGLSIALYLGFNRFEELLAGAHAMDEHFLNEPFNRNIPVILALLGIW
YRNFFDAASHAVIPYDQYLHRFPAYLQQLDMESNGKRVDENGHTVTHATGPVIWGEPGTNAQHAFFQLLHQGPDLIPADF
IVPLKSQNPSGEHHDMLLANCFAQTEALMKGKTEQEVRAELSDAGYDEADIQKLFQHKVFSGNRPTNTILVHELNPFMLG
SLIAMYEHKVFVQGVIWRINSFDQWGVELGKQLARTILPEIQSAEAVTAHDASTNALINMARTFREENIRKESAQLSFF

Sequences:

>Translated_559_residues
MELSRSAAWSALVFHKHEVDKKTMRDMFAGDSDRFVKFSLSWKEMLLDYSKNRITSRTMELLLELAHSAGVDEKRQQMFQ
GAPINFTENRSVLHTALRRPPGYVLEVDGLNIGDEIAGVLFQMKNFCEKVISGKWKGYTGKSITDVVNIGIGGSDLGPYM
VTEALKPFAHGGLDVHFVSNIDGTHIRETLKRLDPETTLFIIASKTFTTQETLTNAMSAREWFLARAVEEEYIKKHFAAV
STNQEKVVEFGIDDANMFRFWDWVGGRYSLWSSIGLSIALYLGFNRFEELLAGAHAMDEHFLNEPFNRNIPVILALLGIW
YRNFFDAASHAVIPYDQYLHRFPAYLQQLDMESNGKRVDENGHTVTHATGPVIWGEPGTNAQHAFFQLLHQGPDLIPADF
IVPLKSQNPSGEHHDMLLANCFAQTEALMKGKTEQEVRAELSDAGYDEADIQKLFQHKVFSGNRPTNTILVHELNPFMLG
SLIAMYEHKVFVQGVIWRINSFDQWGVELGKQLARTILPEIQSAEAVTAHDASTNALINMARTFREENIRKESAQLSFF
>Mature_559_residues
MELSRSAAWSALVFHKHEVDKKTMRDMFAGDSDRFVKFSLSWKEMLLDYSKNRITSRTMELLLELAHSAGVDEKRQQMFQ
GAPINFTENRSVLHTALRRPPGYVLEVDGLNIGDEIAGVLFQMKNFCEKVISGKWKGYTGKSITDVVNIGIGGSDLGPYM
VTEALKPFAHGGLDVHFVSNIDGTHIRETLKRLDPETTLFIIASKTFTTQETLTNAMSAREWFLARAVEEEYIKKHFAAV
STNQEKVVEFGIDDANMFRFWDWVGGRYSLWSSIGLSIALYLGFNRFEELLAGAHAMDEHFLNEPFNRNIPVILALLGIW
YRNFFDAASHAVIPYDQYLHRFPAYLQQLDMESNGKRVDENGHTVTHATGPVIWGEPGTNAQHAFFQLLHQGPDLIPADF
IVPLKSQNPSGEHHDMLLANCFAQTEALMKGKTEQEVRAELSDAGYDEADIQKLFQHKVFSGNRPTNTILVHELNPFMLG
SLIAMYEHKVFVQGVIWRINSFDQWGVELGKQLARTILPEIQSAEAVTAHDASTNALINMARTFREENIRKESAQLSFF

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=542, Percent_Identity=59.5940959409594, Blast_Score=686, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=542, Percent_Identity=55.3505535055351, Blast_Score=622, Evalue=1e-178,
Organism=Escherichia coli, GI1790457, Length=543, Percent_Identity=59.6685082872928, Blast_Score=681, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=545, Percent_Identity=58.5321100917431, Blast_Score=659, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=545, Percent_Identity=58.5321100917431, Blast_Score=659, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=542, Percent_Identity=55.719557195572, Blast_Score=594, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24651916, Length=526, Percent_Identity=61.2167300380228, Blast_Score=661, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=526, Percent_Identity=61.2167300380228, Blast_Score=661, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=526, Percent_Identity=61.2167300380228, Blast_Score=661, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_CHLPD (A1BFF9)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911560.1
- ProteinModelPortal:   A1BFF9
- SMR:   A1BFF9
- STRING:   A1BFF9
- GeneID:   4570039
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_1095
- NMPDR:   fig|290317.7.peg.1161
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- ProtClustDB:   PRK00179
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 63300; Mature: 63300

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 352-352 ACT_SITE 383-383 ACT_SITE 511-511

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELSRSAAWSALVFHKHEVDKKTMRDMFAGDSDRFVKFSLSWKEMLLDYSKNRITSRTME
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
LLLELAHSAGVDEKRQQMFQGAPINFTENRSVLHTALRRPPGYVLEVDGLNIGDEIAGVL
HHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHH
FQMKNFCEKVISGKWKGYTGKSITDVVNIGIGGSDLGPYMVTEALKPFAHGGLDVHFVSN
HHHHHHHHHHHCCCCCCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECC
IDGTHIRETLKRLDPETTLFIIASKTFTTQETLTNAMSAREWFLARAVEEEYIKKHFAAV
CCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STNQEKVVEFGIDDANMFRFWDWVGGRYSLWSSIGLSIALYLGFNRFEELLAGAHAMDEH
CCCHHHHHEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
FLNEPFNRNIPVILALLGIWYRNFFDAASHAVIPYDQYLHRFPAYLQQLDMESNGKRVDE
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECC
NGHTVTHATGPVIWGEPGTNAQHAFFQLLHQGPDLIPADFIVPLKSQNPSGEHHDMLLAN
CCCEEEECCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHH
CFAQTEALMKGKTEQEVRAELSDAGYDEADIQKLFQHKVFSGNRPTNTILVHELNPFMLG
HHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHH
SLIAMYEHKVFVQGVIWRINSFDQWGVELGKQLARTILPEIQSAEAVTAHDASTNALINM
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHH
ARTFREENIRKESAQLSFF
HHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MELSRSAAWSALVFHKHEVDKKTMRDMFAGDSDRFVKFSLSWKEMLLDYSKNRITSRTME
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
LLLELAHSAGVDEKRQQMFQGAPINFTENRSVLHTALRRPPGYVLEVDGLNIGDEIAGVL
HHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHH
FQMKNFCEKVISGKWKGYTGKSITDVVNIGIGGSDLGPYMVTEALKPFAHGGLDVHFVSN
HHHHHHHHHHHCCCCCCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECC
IDGTHIRETLKRLDPETTLFIIASKTFTTQETLTNAMSAREWFLARAVEEEYIKKHFAAV
CCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STNQEKVVEFGIDDANMFRFWDWVGGRYSLWSSIGLSIALYLGFNRFEELLAGAHAMDEH
CCCHHHHHEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
FLNEPFNRNIPVILALLGIWYRNFFDAASHAVIPYDQYLHRFPAYLQQLDMESNGKRVDE
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECC
NGHTVTHATGPVIWGEPGTNAQHAFFQLLHQGPDLIPADFIVPLKSQNPSGEHHDMLLAN
CCCEEEECCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHH
CFAQTEALMKGKTEQEVRAELSDAGYDEADIQKLFQHKVFSGNRPTNTILVHELNPFMLG
HHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHH
SLIAMYEHKVFVQGVIWRINSFDQWGVELGKQLARTILPEIQSAEAVTAHDASTNALINM
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHH
ARTFREENIRKESAQLSFF
HHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA