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The map label for this gene is hemB [H]

Identifier: 118578883

GI number: 118578883

Start: 464035

End: 465012

Strand: Direct

Name: hemB [H]

Synonym: Ppro_0442

Alternate gene names: 118578883

Gene position: 464035-465012 (Clockwise)

Preceding gene: 118578881

Following gene: 118578890

Centisome position: 11.58

GC content: 60.94

Gene sequence:

>978_bases
ATGAGGGAGTCGTACTTCAGGGCGCGCAGGATTAGGGGAAATGAAACCATGCGGCGGATGGTCCGCGAGACCAGCCTGTC
GGTCGATGATCTGGTTTACCCGCTGTTTTCAGCCTTCGGCAGCGGCATCATGAAGGAGATCTCCTCCATGCCGGGCATCT
ACCAGCAGTCCATCGAGCATCTGGTGGAGGAGTGCAGGGAGGTGCAGGGACTGGGTATCCCGGCCGTGCTGTTGTTCGGT
ATTCCAGAGAGTAAGGATGGGGTGGGGAGCGACGCCTATTCGGACAGCGGCATCATCCAGGAAACGATTCGCGCCATCAA
GCGTGAAGTGCCTGGTCTGACGGTCATCACCGATGTCTGTCTCTGCGAATACACCGATCACGGTCATTGCGGCGTGATCG
AGGATGGCGACGTGGACAATGACGCGACCCTGGAACTGCTGGCGAAGGAGGCGCTCTCCCATGTCAGGGCCGGGGCCGAC
ATGGTGGCGCCGTCGGACATGATGGACGGCCGTGTGGCGGCAATACGCGAAGCACTGGACAATAGCGGCTTTAGCTCGGT
TCCGGTCATGAGCTATGCGGTCAAATATGCCTCCGGGTACTACGGACCCTTCCGCGAGGCTGCCGAGTCAACACCCCAGT
TCGGCGACCGCCGCAGCTACCAGATGGATCCTGCCAACCGCAGGGAGGCTTTGCGCGAGGCTTCCGCCGACATCGACGAG
GGAGCCGACATCATCATGGTCAAGCCCGGACTCCCCTATCTGGATATCCTGCGCGACCTACGCAACAGCTGCAACCTGCC
GCTGGCGGTCTACAACGTGTCGGGCGAATACAGCATGGTCAAGGCCGCTGCGGCAAACGGATGGATCGACGAGGAGCGGG
TTGTGCTGGAGACCATGCTCGGCTTCAAGCGCGCCGGCGCCGATATCATCATCACCTATCATGCCAAGGATGTGGCTCGC
TGGCTTGGGCGGAACTAG

Upstream 100 bases:

>100_bases
GTGACAGTGCTATGGCTCGCCATGAAAGCTTGCCTTTTGGCATTTGTTTGCAGTACTGTTTTCGCCAGTGACGAACATGG
CTGGAATGGAGGGGTAAGTG

Downstream 100 bases:

>100_bases
GCGGCCTATTCCCCCAGGCGTTCCGCCATTTCCTTCTTGTGCTGCCTGATCGCCCCGCCGCCGCCCGTTGACGGCACCAG
GCTTTCTGGTGATTTCTCCG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MRESYFRARRIRGNETMRRMVRETSLSVDDLVYPLFSAFGSGIMKEISSMPGIYQQSIEHLVEECREVQGLGIPAVLLFG
IPESKDGVGSDAYSDSGIIQETIRAIKREVPGLTVITDVCLCEYTDHGHCGVIEDGDVDNDATLELLAKEALSHVRAGAD
MVAPSDMMDGRVAAIREALDNSGFSSVPVMSYAVKYASGYYGPFREAAESTPQFGDRRSYQMDPANRREALREASADIDE
GADIIMVKPGLPYLDILRDLRNSCNLPLAVYNVSGEYSMVKAAAANGWIDEERVVLETMLGFKRAGADIIITYHAKDVAR
WLGRN

Sequences:

>Translated_325_residues
MRESYFRARRIRGNETMRRMVRETSLSVDDLVYPLFSAFGSGIMKEISSMPGIYQQSIEHLVEECREVQGLGIPAVLLFG
IPESKDGVGSDAYSDSGIIQETIRAIKREVPGLTVITDVCLCEYTDHGHCGVIEDGDVDNDATLELLAKEALSHVRAGAD
MVAPSDMMDGRVAAIREALDNSGFSSVPVMSYAVKYASGYYGPFREAAESTPQFGDRRSYQMDPANRREALREASADIDE
GADIIMVKPGLPYLDILRDLRNSCNLPLAVYNVSGEYSMVKAAAANGWIDEERVVLETMLGFKRAGADIIITYHAKDVAR
WLGRN
>Mature_325_residues
MRESYFRARRIRGNETMRRMVRETSLSVDDLVYPLFSAFGSGIMKEISSMPGIYQQSIEHLVEECREVQGLGIPAVLLFG
IPESKDGVGSDAYSDSGIIQETIRAIKREVPGLTVITDVCLCEYTDHGHCGVIEDGDVDNDATLELLAKEALSHVRAGAD
MVAPSDMMDGRVAAIREALDNSGFSSVPVMSYAVKYASGYYGPFREAAESTPQFGDRRSYQMDPANRREALREASADIDE
GADIIMVKPGLPYLDILRDLRNSCNLPLAVYNVSGEYSMVKAAAANGWIDEERVVLETMLGFKRAGADIIITYHAKDVAR
WLGRN

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=304, Percent_Identity=47.0394736842105, Blast_Score=275, Evalue=3e-74,
Organism=Escherichia coli, GI87081728, Length=313, Percent_Identity=50.4792332268371, Blast_Score=310, Evalue=8e-86,
Organism=Saccharomyces cerevisiae, GI6321398, Length=312, Percent_Identity=42.6282051282051, Blast_Score=246, Evalue=4e-66,
Organism=Drosophila melanogaster, GI21358291, Length=315, Percent_Identity=40.9523809523809, Blast_Score=253, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 35824; Mature: 35824

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRESYFRARRIRGNETMRRMVRETSLSVDDLVYPLFSAFGSGIMKEISSMPGIYQQSIEH
CCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LVEECREVQGLGIPAVLLFGIPESKDGVGSDAYSDSGIIQETIRAIKREVPGLTVITDVC
HHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
LCEYTDHGHCGVIEDGDVDNDATLELLAKEALSHVRAGADMVAPSDMMDGRVAAIREALD
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHH
NSGFSSVPVMSYAVKYASGYYGPFREAAESTPQFGDRRSYQMDPANRREALREASADIDE
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
GADIIMVKPGLPYLDILRDLRNSCNLPLAVYNVSGEYSMVKAAAANGWIDEERVVLETML
CCCEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHH
GFKRAGADIIITYHAKDVARWLGRN
HHHHCCCCEEEEECHHHHHHHHCCC
>Mature Secondary Structure
MRESYFRARRIRGNETMRRMVRETSLSVDDLVYPLFSAFGSGIMKEISSMPGIYQQSIEH
CCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LVEECREVQGLGIPAVLLFGIPESKDGVGSDAYSDSGIIQETIRAIKREVPGLTVITDVC
HHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
LCEYTDHGHCGVIEDGDVDNDATLELLAKEALSHVRAGADMVAPSDMMDGRVAAIREALD
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHH
NSGFSSVPVMSYAVKYASGYYGPFREAAESTPQFGDRRSYQMDPANRREALREASADIDE
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
GADIIMVKPGLPYLDILRDLRNSCNLPLAVYNVSGEYSMVKAAAANGWIDEERVVLETML
CCCEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHH
GFKRAGADIIITYHAKDVARWLGRN
HHHHCCCCEEEEECHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]