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The map label for this gene is cueR [H]

Identifier: 117919290

GI number: 117919290

Start: 970946

End: 971383

Strand: Reverse

Name: cueR [H]

Synonym: Shewana3_0838

Alternate gene names: 117919290

Gene position: 971383-970946 (Counterclockwise)

Preceding gene: 117919291

Following gene: 117919289

Centisome position: 19.54

GC content: 48.63

Gene sequence:

>438_bases
ATGAATATTGGTGAATTATCCCAAAAGACCGGACTTGCGGCGTCGCGGATCCGATTCTACGAACGCATTGGTTTACTCAA
AGCGGTGAAACGTAAAGCGAATGGTTATCGCAGTTATCCGCCTGAGGCAGTGATGGCGCTGGAGATGATCACTACGGGGC
AACAGGCGGGATTTAGCCTCGATGAACTGCGGTTATTACTGCCAGCCGATCTGGCCAACTGGGATCATCAGCATTTACTC
AATACGCTGCGGCAAAAGGTCAACGATCTCGAAGAAATCGAGCGAAAAATCGCACTCAACAAAGCCAAGTTATTGGAGGT
CTTAACCGAAATTGAAGCTAAACCCCAAGATATGGACTGCCAAACCAATGCGCAGCGGGTGATGTCTCAATTCGGTTGGG
ATATTTTACCCGCCCAATCGCAGCCAAAGTCCAAATAA

Upstream 100 bases:

>100_bases
CGCCGTACCTATAGTCGGCTCATTGAAATGAGCCAGCAAAGAGTAGAATGAGGCGTCCCGCAATGGGCACGATTAACATC
AGCAAGAAAGTGATATCAAG

Downstream 100 bases:

>100_bases
CCCCATCATCGAAGGGCCTCATTTCGAAGACAATAACGGCCCCCTCTTTTTGCCACCACTTTGCTGGCAGTGGATTTAGC
CTAAATGAGTCACCATATTC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MNIGELSQKTGLAASRIRFYERIGLLKAVKRKANGYRSYPPEAVMALEMITTGQQAGFSLDELRLLLPADLANWDHQHLL
NTLRQKVNDLEEIERKIALNKAKLLEVLTEIEAKPQDMDCQTNAQRVMSQFGWDILPAQSQPKSK

Sequences:

>Translated_145_residues
MNIGELSQKTGLAASRIRFYERIGLLKAVKRKANGYRSYPPEAVMALEMITTGQQAGFSLDELRLLLPADLANWDHQHLL
NTLRQKVNDLEEIERKIALNKAKLLEVLTEIEAKPQDMDCQTNAQRVMSQFGWDILPAQSQPKSK
>Mature_145_residues
MNIGELSQKTGLAASRIRFYERIGLLKAVKRKANGYRSYPPEAVMALEMITTGQQAGFSLDELRLLLPADLANWDHQHLL
NTLRQKVNDLEEIERKIALNKAKLLEVLTEIEAKPQDMDCQTNAQRVMSQFGWDILPAQSQPKSK

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=122, Percent_Identity=33.6065573770492, Blast_Score=64, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 16462; Mature: 16462

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGELSQKTGLAASRIRFYERIGLLKAVKRKANGYRSYPPEAVMALEMITTGQQAGFSL
CCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHCCCH
DELRLLLPADLANWDHQHLLNTLRQKVNDLEEIERKIALNKAKLLEVLTEIEAKPQDMDC
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
QTNAQRVMSQFGWDILPAQSQPKSK
HHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MNIGELSQKTGLAASRIRFYERIGLLKAVKRKANGYRSYPPEAVMALEMITTGQQAGFSL
CCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHCCCH
DELRLLLPADLANWDHQHLLNTLRQKVNDLEEIERKIALNKAKLLEVLTEIEAKPQDMDC
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
QTNAQRVMSQFGWDILPAQSQPKSK
HHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]