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The map label for this gene is hemG [H]

Identifier: 116872286

GI number: 116872286

Start: 900531

End: 901919

Strand: Direct

Name: hemG [H]

Synonym: lwe0866

Alternate gene names: 116872286

Gene position: 900531-901919 (Clockwise)

Preceding gene: 116872285

Following gene: 116872287

Centisome position: 32.0

GC content: 38.88

Gene sequence:

>1389_bases
GTGAAACATATAGTTATTATCGGAGGCGGCTTATCAGGGCTTGCAGCAGCGTATGAACTACAAAAAACACATCCGAATTA
TACGTGGGAATTAGTAGAAAAAGACGAGAAATTAGGCGGGAAATTTGAAACTGTTAAACGAGATGGATTTTTAATTGAAA
AAGGTCCAGATTCCTTTTTAGCTAGAAAACCTGCTGGTGTGGGTCTTGTGAAGGATTTAGGATTAGATGATAAATTGATT
GCGAATGCCACTGGAAGATCCTATATTTATCATGAAAAAGCACTCCACCCAATTCCAGAAGGTTCTGTGATGGGGATTCC
GACAAACAAACAAGCGCTTCTAGCAACGACGCTAGTTTCGGAAATAGGAAAAGCGCGCGCACTTCAAGAACCAACCATTC
AACCAAATAATAAAGAAACGGATCAAGCACTTGGGGATTTTTTTGAGGCTAGATTTGGAAAAGAATTAGTAAAAACAATT
ATCGAACCGCTGTTATCAGGTATTTATGCAGGTGATATTTATAAAATGAGCTTGCGTGCTACATTTCCACAATTTGAACA
GACTGTCAAAAAATATGGAAATCTAATGGATGGACTGAAAGAAAGCAATATGCAAACTACTGGTACTAAAGCGACAATTG
GTGCTTTTAGAACATTAGAAGGCGGACTTGATACTTTGCCAAAAGCAATTGCAGATGCACTACCAGCAGAAAACTTGTAT
ACAAAAAAACAAGCAACGAACATCGTGAAAAAGAATGGCACGTATGAAATTTCTTTTGCAGATGGAGATAAAAAGGAAGC
AGATGGCATTATTATTGCAGCCACACATGATGCGCTCATTCATTTATTAAAGGAAACAACGACAGAACCTTTTGCAGGAC
AGCCTTTGACAACACTTGCGACGGTTTCGTTAGCATACAATGAAGTAGATGTACCCGTTTTACCAGATGGGACAGGTTAT
TTAGTTGCAAGGACAGCCCCATATAAAACAACTGCTTGTACTTGGGTGCAAAAAAAATGGCCGCATATGGTTCCAGAAAA
TAAAATGTTATTACGTGGTTTTGTGGGGAAAGCAGGAGAATCTTGGTTAGAAGAGGCAAGTGATGAAGCTATCGTTACTG
CTGTTTTAAAAGATTATGCGGAAATTATGGATCTTCATGCTGCGCCACTTTTTTATGAAGTGAGTCGAATGAAGTCCGCC
ATGCCGCAATATTTAACGGGTCATCAAAACCGTTTAAATCAATTAAAAAAGAATATGAAAGCAGATTATCCAGGGGTTTA
TTTTGCAGGTATGAGTTATGAAGGCGTCGGTATTCCCGATTGTATTGCTGGAGCGCAAACTGCGGTTACTGAGCTCACAG
ATATTTTAGAAGAGGTGTCAAATGATTAA

Upstream 100 bases:

>100_bases
TTAAGAAGCGGGTGTTCTTTTATTTTTTGTTCAATTAAGCAGAAATCTGGTAAAATAGATAGAATAAACAAAGCATAAGC
TAGAGAGGATTGGTTAAGTA

Downstream 100 bases:

>100_bases
AGGAATTGGACTAGATATGATTGACTTAGAGCGTGTAAAACAAGTACTAGAAAAAAATCCGCGTTTTATTGAAAGAGTCC
TTACTGAAAAAGAAATTAAG

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MKHIVIIGGGLSGLAAAYELQKTHPNYTWELVEKDEKLGGKFETVKRDGFLIEKGPDSFLARKPAGVGLVKDLGLDDKLI
ANATGRSYIYHEKALHPIPEGSVMGIPTNKQALLATTLVSEIGKARALQEPTIQPNNKETDQALGDFFEARFGKELVKTI
IEPLLSGIYAGDIYKMSLRATFPQFEQTVKKYGNLMDGLKESNMQTTGTKATIGAFRTLEGGLDTLPKAIADALPAENLY
TKKQATNIVKKNGTYEISFADGDKKEADGIIIAATHDALIHLLKETTTEPFAGQPLTTLATVSLAYNEVDVPVLPDGTGY
LVARTAPYKTTACTWVQKKWPHMVPENKMLLRGFVGKAGESWLEEASDEAIVTAVLKDYAEIMDLHAAPLFYEVSRMKSA
MPQYLTGHQNRLNQLKKNMKADYPGVYFAGMSYEGVGIPDCIAGAQTAVTELTDILEEVSND

Sequences:

>Translated_462_residues
MKHIVIIGGGLSGLAAAYELQKTHPNYTWELVEKDEKLGGKFETVKRDGFLIEKGPDSFLARKPAGVGLVKDLGLDDKLI
ANATGRSYIYHEKALHPIPEGSVMGIPTNKQALLATTLVSEIGKARALQEPTIQPNNKETDQALGDFFEARFGKELVKTI
IEPLLSGIYAGDIYKMSLRATFPQFEQTVKKYGNLMDGLKESNMQTTGTKATIGAFRTLEGGLDTLPKAIADALPAENLY
TKKQATNIVKKNGTYEISFADGDKKEADGIIIAATHDALIHLLKETTTEPFAGQPLTTLATVSLAYNEVDVPVLPDGTGY
LVARTAPYKTTACTWVQKKWPHMVPENKMLLRGFVGKAGESWLEEASDEAIVTAVLKDYAEIMDLHAAPLFYEVSRMKSA
MPQYLTGHQNRLNQLKKNMKADYPGVYFAGMSYEGVGIPDCIAGAQTAVTELTDILEEVSND
>Mature_462_residues
MKHIVIIGGGLSGLAAAYELQKTHPNYTWELVEKDEKLGGKFETVKRDGFLIEKGPDSFLARKPAGVGLVKDLGLDDKLI
ANATGRSYIYHEKALHPIPEGSVMGIPTNKQALLATTLVSEIGKARALQEPTIQPNNKETDQALGDFFEARFGKELVKTI
IEPLLSGIYAGDIYKMSLRATFPQFEQTVKKYGNLMDGLKESNMQTTGTKATIGAFRTLEGGLDTLPKAIADALPAENLY
TKKQATNIVKKNGTYEISFADGDKKEADGIIIAATHDALIHLLKETTTEPFAGQPLTTLATVSLAYNEVDVPVLPDGTGY
LVARTAPYKTTACTWVQKKWPHMVPENKMLLRGFVGKAGESWLEEASDEAIVTAVLKDYAEIMDLHAAPLFYEVSRMKSA
MPQYLTGHQNRLNQLKKNMKADYPGVYFAGMSYEGVGIPDCIAGAQTAVTELTDILEEVSND

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=498, Percent_Identity=27.5100401606426, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4506001, Length=498, Percent_Identity=27.5100401606426, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24649745, Length=461, Percent_Identity=23.8611713665944, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 50451; Mature: 50451

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00778 HIS_ACID_PHOSPHAT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHIVIIGGGLSGLAAAYELQKTHPNYTWELVEKDEKLGGKFETVKRDGFLIEKGPDSFL
CCEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCHHHCCCCEEEEECCCEEEECCCCHHH
ARKPAGVGLVKDLGLDDKLIANATGRSYIYHEKALHPIPEGSVMGIPTNKQALLATTLVS
HCCCCCCCHHHHCCCCCHHEECCCCCCEEEEHHHCCCCCCCCEEECCCCCHHHHHHHHHH
EIGKARALQEPTIQPNNKETDQALGDFFEARFGKELVKTIIEPLLSGIYAGDIYKMSLRA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHH
TFPQFEQTVKKYGNLMDGLKESNMQTTGTKATIGAFRTLEGGLDTLPKAIADALPAENLY
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHH
TKKQATNIVKKNGTYEISFADGDKKEADGIIIAATHDALIHLLKETTTEPFAGQPLTTLA
HHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCCCCHHHHH
TVSLAYNEVDVPVLPDGTGYLVARTAPYKTTACTWVQKKWPHMVPENKMLLRGFVGKAGE
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCHH
SWLEEASDEAIVTAVLKDYAEIMDLHAAPLFYEVSRMKSAMPQYLTGHQNRLNQLKKNMK
HHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
ADYPGVYFAGMSYEGVGIPDCIAGAQTAVTELTDILEEVSND
CCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKHIVIIGGGLSGLAAAYELQKTHPNYTWELVEKDEKLGGKFETVKRDGFLIEKGPDSFL
CCEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCHHHCCCCEEEEECCCEEEECCCCHHH
ARKPAGVGLVKDLGLDDKLIANATGRSYIYHEKALHPIPEGSVMGIPTNKQALLATTLVS
HCCCCCCCHHHHCCCCCHHEECCCCCCEEEEHHHCCCCCCCCEEECCCCCHHHHHHHHHH
EIGKARALQEPTIQPNNKETDQALGDFFEARFGKELVKTIIEPLLSGIYAGDIYKMSLRA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHH
TFPQFEQTVKKYGNLMDGLKESNMQTTGTKATIGAFRTLEGGLDTLPKAIADALPAENLY
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHH
TKKQATNIVKKNGTYEISFADGDKKEADGIIIAATHDALIHLLKETTTEPFAGQPLTTLA
HHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCCCCHHHHH
TVSLAYNEVDVPVLPDGTGYLVARTAPYKTTACTWVQKKWPHMVPENKMLLRGFVGKAGE
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCHH
SWLEEASDEAIVTAVLKDYAEIMDLHAAPLFYEVSRMKSAMPQYLTGHQNRLNQLKKNMK
HHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
ADYPGVYFAGMSYEGVGIPDCIAGAQTAVTELTDILEEVSND
CCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]