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The map label for this gene is argH

Identifier: 116516947

GI number: 116516947

Start: 110545

End: 111936

Strand: Direct

Name: argH

Synonym: SPD_0111

Alternate gene names: 116516947

Gene position: 110545-111936 (Clockwise)

Preceding gene: 116515666

Following gene: 116516334

Centisome position: 5.4

GC content: 40.95

Gene sequence:

>1392_bases
ATGGCTAAGAATACAAAATTATGGGGTGGTCGCTTTGAAGGTACTGTCGAAGACTGGGTAGAGCGCTTTGGTGCGAGTAT
ATCTTTTGACCAGAAATTAGCTAAATTTGATGTGATTGGTTCTTTAGCCCACGTTCAGATGTTGGGTCAGACGGGCATTT
TGAGTTTGGAGGAGTCAGAAAAGATTCAAGTAGGCTTGAAAGAGCTTTTAGAAGAGCTAGAGGCAGGTCAACTTGACTTT
GATATCGCAAACGAAGATATTCATATGAATATGGAAGTGTTGCTGACAGAAAAAATTGGTCCCCTTGCAGGGAAGTTACA
TACGGCTCGTTCTCGAAATGACCAAGTTGCGACAGATATGCACTTGTATCTCAAGGAACAACTAGGCTATGTCCTAGATA
AACTGGCTCATCTTAAGGGTGTTTTATTAGACTTGGCGGAAAATCATGTGGCGACGATCATGCCGGGCTATACCCATCTG
CAACATGCCCAGCCTATTAGTTTTGCCTACCACCTGATGGCTTACTACAATATGTTTCAAAGAGACAGTGAACGTTTTGA
ATTTAACCAGAAGCATACAGACCTATGCCCTTTAGGTGCGGCAGCTTTGGCAGGAACGACTTTCCCCATTGATCGCCAAT
TGTCTAGCGATTTGCTGGAGTTTAAGCAACCTTATACAAATTCTTTGGATGCTGTTAGTGACCGCGATTTTATCTTAGAA
TTTCTATCAAATGCCAGCATACTCATGATGCATATGAGTCGTTTTTGCGAAGAAATGATTAATTGGTGTAGTTTTGAGTA
CCAATTCATTACCTTGTCAGATACGTTTACAATAGGTTCCTCTATTATGCCCCAAAAGAAAAATCCAGATATGGCTGAGT
TGATTCGAGGAAAGACTGGCAGAGTTTATGGGCATTTGTTTGGACTGTTGACAGTCATGAAGTCCTTGCCTTTAGCTTAT
AATAAGGATTTGCAAGAAGATAAGGAAGGAATGTTTGATACGGTCGAAACGATTTTAAATTCCCTCGATGTGTTGGCAGG
TATGTTATCTAGTTTGCAGGTAAACAAGGAAAAAATGCAAGAATCAACAGAGAAGGACTTTTCAAATGCAACTGAGTTGG
CAGATTATTTGGCAGGGAAAGGCTTGCCATTTAGAGAAGCTCATGAGGTTGTGGGAAGATTAGTGCTAGACTCTATCAAG
TCTGCTAAAAATCTTCAAGATTGGACTTTGGAGGAATTACAAACCTATCATTCTCTCATTACCGAGGATATCTATGTCTA
CTTGCAACCTAAAACTGCTGTTCAAAGACGAAATTCCTTGGGAGGCACAGGGTTTGACCAAGTCGAATACCAGATTGCAG
TCGCTAAGAAAGCGAATGAAGCTAAAAAGTGA

Upstream 100 bases:

>100_bases
GCTGTTGGCTTTATTAAGTTATGGGGACTTCCAACCAAGGTTCATTCTGAGGTTCAAAAAAGCGCCAAATAGGACGATTG
GATAGAGAGGTGGATGTGAT

Downstream 100 bases:

>100_bases
TGGAGTGATGGGTTCAGAATAAGAGGTTGGTCGATTGGCAGCCTCTTTCTTGTCGTTGAAAAAGTGAGATATATTGACTT
TTGAAAAAAATGTCATAATT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MAKNTKLWGGRFEGTVEDWVERFGASISFDQKLAKFDVIGSLAHVQMLGQTGILSLEESEKIQVGLKELLEELEAGQLDF
DIANEDIHMNMEVLLTEKIGPLAGKLHTARSRNDQVATDMHLYLKEQLGYVLDKLAHLKGVLLDLAENHVATIMPGYTHL
QHAQPISFAYHLMAYYNMFQRDSERFEFNQKHTDLCPLGAAALAGTTFPIDRQLSSDLLEFKQPYTNSLDAVSDRDFILE
FLSNASILMMHMSRFCEEMINWCSFEYQFITLSDTFTIGSSIMPQKKNPDMAELIRGKTGRVYGHLFGLLTVMKSLPLAY
NKDLQEDKEGMFDTVETILNSLDVLAGMLSSLQVNKEKMQESTEKDFSNATELADYLAGKGLPFREAHEVVGRLVLDSIK
SAKNLQDWTLEELQTYHSLITEDIYVYLQPKTAVQRRNSLGGTGFDQVEYQIAVAKKANEAKK

Sequences:

>Translated_463_residues
MAKNTKLWGGRFEGTVEDWVERFGASISFDQKLAKFDVIGSLAHVQMLGQTGILSLEESEKIQVGLKELLEELEAGQLDF
DIANEDIHMNMEVLLTEKIGPLAGKLHTARSRNDQVATDMHLYLKEQLGYVLDKLAHLKGVLLDLAENHVATIMPGYTHL
QHAQPISFAYHLMAYYNMFQRDSERFEFNQKHTDLCPLGAAALAGTTFPIDRQLSSDLLEFKQPYTNSLDAVSDRDFILE
FLSNASILMMHMSRFCEEMINWCSFEYQFITLSDTFTIGSSIMPQKKNPDMAELIRGKTGRVYGHLFGLLTVMKSLPLAY
NKDLQEDKEGMFDTVETILNSLDVLAGMLSSLQVNKEKMQESTEKDFSNATELADYLAGKGLPFREAHEVVGRLVLDSIK
SAKNLQDWTLEELQTYHSLITEDIYVYLQPKTAVQRRNSLGGTGFDQVEYQIAVAKKANEAKK
>Mature_462_residues
AKNTKLWGGRFEGTVEDWVERFGASISFDQKLAKFDVIGSLAHVQMLGQTGILSLEESEKIQVGLKELLEELEAGQLDFD
IANEDIHMNMEVLLTEKIGPLAGKLHTARSRNDQVATDMHLYLKEQLGYVLDKLAHLKGVLLDLAENHVATIMPGYTHLQ
HAQPISFAYHLMAYYNMFQRDSERFEFNQKHTDLCPLGAAALAGTTFPIDRQLSSDLLEFKQPYTNSLDAVSDRDFILEF
LSNASILMMHMSRFCEEMINWCSFEYQFITLSDTFTIGSSIMPQKKNPDMAELIRGKTGRVYGHLFGLLTVMKSLPLAYN
KDLQEDKEGMFDTVETILNSLDVLAGMLSSLQVNKEKMQESTEKDFSNATELADYLAGKGLPFREAHEVVGRLVLDSIKS
AKNLQDWTLEELQTYHSLITEDIYVYLQPKTAVQRRNSLGGTGFDQVEYQIAVAKKANEAKK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=451, Percent_Identity=42.7937915742794, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI68303542, Length=451, Percent_Identity=42.7937915742794, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI68303549, Length=451, Percent_Identity=40.7982261640798, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI68303547, Length=451, Percent_Identity=40.1330376940133, Blast_Score=335, Evalue=6e-92,
Organism=Escherichia coli, GI1790398, Length=451, Percent_Identity=46.3414634146341, Blast_Score=414, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6321806, Length=452, Percent_Identity=42.0353982300885, Blast_Score=341, Evalue=1e-94,
Organism=Drosophila melanogaster, GI221473854, Length=453, Percent_Identity=36.4238410596026, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI78706858, Length=453, Percent_Identity=36.4238410596026, Blast_Score=309, Evalue=3e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_STRP2 (Q04MW6)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_815610.1
- ProteinModelPortal:   Q04MW6
- SMR:   Q04MW6
- STRING:   Q04MW6
- EnsemblBacteria:   EBSTRT00000019696
- GeneID:   4442024
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_0111
- eggNOG:   COG0165
- GeneTree:   EBGT00050000027083
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 52324; Mature: 52193

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKNTKLWGGRFEGTVEDWVERFGASISFDQKLAKFDVIGSLAHVQMLGQTGILSLEESE
CCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCH
KIQVGLKELLEELEAGQLDFDIANEDIHMNMEVLLTEKIGPLAGKLHTARSRNDQVATDM
HHHHHHHHHHHHHHCCCCCEEECCCCEECCHHEEEEHHCCHHHHHHHHHCCCCCCHHHHH
HLYLKEQLGYVLDKLAHLKGVLLDLAENHVATIMPGYTHLQHAQPISFAYHLMAYYNMFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCHHHHHHHHHHHHHHHH
RDSERFEFNQKHTDLCPLGAAALAGTTFPIDRQLSSDLLEFKQPYTNSLDAVSDRDFILE
CCCHHHCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
FLSNASILMMHMSRFCEEMINWCSFEYQFITLSDTFTIGSSIMPQKKNPDMAELIRGKTG
HHCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCHHCCCCCCCCCCCCCHHHHHCCCCC
RVYGHLFGLLTVMKSLPLAYNKDLQEDKEGMFDTVETILNSLDVLAGMLSSLQVNKEKMQ
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ESTEKDFSNATELADYLAGKGLPFREAHEVVGRLVLDSIKSAKNLQDWTLEELQTYHSLI
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TEDIYVYLQPKTAVQRRNSLGGTGFDQVEYQIAVAKKANEAKK
HHCEEEEECCHHHHHHHHCCCCCCCHHHHEEEEEHHHHCCCCC
>Mature Secondary Structure 
AKNTKLWGGRFEGTVEDWVERFGASISFDQKLAKFDVIGSLAHVQMLGQTGILSLEESE
CCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCH
KIQVGLKELLEELEAGQLDFDIANEDIHMNMEVLLTEKIGPLAGKLHTARSRNDQVATDM
HHHHHHHHHHHHHHCCCCCEEECCCCEECCHHEEEEHHCCHHHHHHHHHCCCCCCHHHHH
HLYLKEQLGYVLDKLAHLKGVLLDLAENHVATIMPGYTHLQHAQPISFAYHLMAYYNMFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCHHHHHHHHHHHHHHHH
RDSERFEFNQKHTDLCPLGAAALAGTTFPIDRQLSSDLLEFKQPYTNSLDAVSDRDFILE
CCCHHHCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
FLSNASILMMHMSRFCEEMINWCSFEYQFITLSDTFTIGSSIMPQKKNPDMAELIRGKTG
HHCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCHHCCCCCCCCCCCCCHHHHHCCCCC
RVYGHLFGLLTVMKSLPLAYNKDLQEDKEGMFDTVETILNSLDVLAGMLSSLQVNKEKMQ
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ESTEKDFSNATELADYLAGKGLPFREAHEVVGRLVLDSIKSAKNLQDWTLEELQTYHSLI
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TEDIYVYLQPKTAVQRRNSLGGTGFDQVEYQIAVAKKANEAKK
HHCEEEEECCHHHHHHHHCCCCCCCHHHHEEEEEHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA