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The map label for this gene is trpC

Identifier: 116516838

GI number: 116516838

Start: 1614629

End: 1615396

Strand: Reverse

Name: trpC

Synonym: SPD_1599

Alternate gene names: 116516838

Gene position: 1615396-1614629 (Counterclockwise)

Preceding gene: 116516280

Following gene: 116515967

Centisome position: 78.95

GC content: 46.61

Gene sequence:

>768_bases
ATGAGTCAGGAATTTTTAGCACGAATCTTAGAGCAGAAGGCGCGTGAGGTGGAGCAGATGAAGCTGGAGCAAATCCAGCC
TCTGCGCCAGACCTATCGCTTGGCAGAATTTTTGAAGAATCATCAGGACTGCTTGCAGGTAATCGCTGAGGTCAAGAAAG
CTAGCCCTAGTTTGGGAGATATCAATCTCGATGTGGATATTGTGCAACAGGCCCAGACTTATGAAGAAAACGGAGCAGTG
ATGATTTCGGTGTTGACAGATGAGGTTTTCTTTAAAGGGCATTTGGATTATCTACGGGAAATTTCCAGTCAGGTAGAGAT
TCCGACGCTCAACAAAGACTTTATCATAGATGAAAAGCAAATCATCCGCGCTCGCAATGCAGGTGCGACAGTTATCTTGC
TCATTGTGGCAGCCTTGTCCGAAGAACGCCTCAAGGAACTGTATGACTACGCGACAGAGCTTGGTCTGGAAGTCTTGGTG
GAGACTCACAATCTAGCTGAACTAGAGGTAGCCCACAGACTTGGTGCTGAGATTATCGGGGTCAACAACCGCAACTTGAC
TACCTTTGAGGTCGACTTGCAGACCAGTGTAGATTTAGCCCCTTACTTTGAGGAAGGTCGCTATTACATTTCTGAATCTG
CCATTTTCACAGGGCAGGATGCGGAACGACTAGCCCCATACTTTAATGGAATTTTGGTAGGGACAGCTCTTATGCAGGCA
GAAAATGTGGTCCAGAGAATCAAGGAGTTGCAGATTGACAAAGGTTAA

Upstream 100 bases:

>100_bases
GTAAGATTGATAGCATCAAGGAAGGAGTTGCCTTGGCCCGTCAAGTGATTGCTAGAGGCAAGGCCCTTGAAAAACTCAGA
CTGTTACAGGAGTACCAAAA

Downstream 100 bases:

>100_bases
AATTTGTGGACTATCGACCAAAGAAGCGGTGGAAACAGCCGTTTCAGCAGGAGCCGACTATATCGGTTTTGTCTTTGCAC
CTAGTAAAAGACAGGTGACT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MSQEFLARILEQKAREVEQMKLEQIQPLRQTYRLAEFLKNHQDCLQVIAEVKKASPSLGDINLDVDIVQQAQTYEENGAV
MISVLTDEVFFKGHLDYLREISSQVEIPTLNKDFIIDEKQIIRARNAGATVILLIVAALSEERLKELYDYATELGLEVLV
ETHNLAELEVAHRLGAEIIGVNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQA
ENVVQRIKELQIDKG

Sequences:

>Translated_255_residues
MSQEFLARILEQKAREVEQMKLEQIQPLRQTYRLAEFLKNHQDCLQVIAEVKKASPSLGDINLDVDIVQQAQTYEENGAV
MISVLTDEVFFKGHLDYLREISSQVEIPTLNKDFIIDEKQIIRARNAGATVILLIVAALSEERLKELYDYATELGLEVLV
ETHNLAELEVAHRLGAEIIGVNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQA
ENVVQRIKELQIDKG
>Mature_254_residues
SQEFLARILEQKAREVEQMKLEQIQPLRQTYRLAEFLKNHQDCLQVIAEVKKASPSLGDINLDVDIVQQAQTYEENGAVM
ISVLTDEVFFKGHLDYLREISSQVEIPTLNKDFIIDEKQIIRARNAGATVILLIVAALSEERLKELYDYATELGLEVLVE
THNLAELEVAHRLGAEIIGVNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQAE
NVVQRIKELQIDKG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=254, Percent_Identity=37.7952755905512, Blast_Score=132, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322638, Length=213, Percent_Identity=42.7230046948357, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_STRP2 (Q04IY7)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_817051.1
- ProteinModelPortal:   Q04IY7
- SMR:   Q04IY7
- STRING:   Q04IY7
- EnsemblBacteria:   EBSTRT00000020466
- GeneID:   4442158
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_1599
- eggNOG:   COG0134
- GeneTree:   EBGT00050000029214
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- ProtClustDB:   PRK00278
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28915; Mature: 28784

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQEFLARILEQKAREVEQMKLEQIQPLRQTYRLAEFLKNHQDCLQVIAEVKKASPSLGD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCC
INLDVDIVQQAQTYEENGAVMISVLTDEVFFKGHLDYLREISSQVEIPTLNKDFIIDEKQ
CCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHH
IIRARNAGATVILLIVAALSEERLKELYDYATELGLEVLVETHNLAELEVAHRLGAEIIG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEE
VNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQA
CCCCCEEEEEEEECCCCCCCHHHHCCCEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHH
ENVVQRIKELQIDKG
HHHHHHHHHHCCCCC
>Mature Secondary Structure 
SQEFLARILEQKAREVEQMKLEQIQPLRQTYRLAEFLKNHQDCLQVIAEVKKASPSLGD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCC
INLDVDIVQQAQTYEENGAVMISVLTDEVFFKGHLDYLREISSQVEIPTLNKDFIIDEKQ
CCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHH
IIRARNAGATVILLIVAALSEERLKELYDYATELGLEVLVETHNLAELEVAHRLGAEIIG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEE
VNNRNLTTFEVDLQTSVDLAPYFEEGRYYISESAIFTGQDAERLAPYFNGILVGTALMQA
CCCCCEEEEEEEECCCCCCCHHHHCCCEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHH
ENVVQRIKELQIDKG
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA