Click here to switch to the map view.

The map label for this gene is pyrDa

Identifier: 116516687

GI number: 116516687

Start: 685393

End: 686328

Strand: Direct

Name: pyrDa

Synonym: SPD_0665

Alternate gene names: 116516687

Gene position: 685393-686328 (Clockwise)

Preceding gene: 116515567

Following gene: 116515334

Centisome position: 33.5

GC content: 42.74

Gene sequence:

>936_bases
ATGGTATCAACGAAAACACAAATTGCTGGTTTTGAGTTTGACAATTGCTTGATGAATGCAGCAGGTGTGGCTTGTATGAC
GATAGAGGAGTTAGAAGAGGTCAAAAACTCAGCGGCAGGAACCTTTGTTACTAAGACAGCGACCTTGGACTTCCGTCAGG
GGAATCCTGAGCCACGCTACCAAGATGTTCCACTTGGTTCCATCAACTCTATGGGCTTGCCAAATAATGGCTTAGACTAT
TATTTGGATTATCTTTTGGATTTGCAGGAAAAAGAGTCGAACCGAACTTTCTTCTTATCTCTGGTCGGCATGTCTCCAGA
GGAAACCCATACTATTTTGAAAAAAGTCCAAGAGAGTGATTTTCGTGGTCTGACTGAGCTAAATCTTTCCTGTCCAAATG
TTCCAGGTAAACCTCAGATTGCCTATGATTTTGAGACAACAGACCGGATTTTGGCAGAAGTGTTTGCTTACTTCACCAAA
CCTCTTGGAATTAAATTGCCACCTTATTTTGATATTGTTCACTTTGATCAAGCGGCAGCTATTTTCAACAAATATCCGCT
CAAGTTTGTCAACTGCGTTAACTCTATCGGAAACGGCCTCTATATAGAAGACGAATCTGTCGTTATTCGGCCTAAGAATG
GTTTTGGTGGAATTGGTGGAGAATACATCAAACCGACTGCTCTAGCCAATGTTCACGCCTTTTATCAACGTTTAAATCCT
CAAATCCAAATTATCGGAACAGGTGGCGTTCTGACTGGTCGAGATGCCTTTGAACACATCCTCTGTGGAGCAAGTATGGT
GCAGGTGGGAACGACCCTTCACAAAGAAGGCGTCAGTGCTTTTGACCGCATTACCAATGAACTGAAAGCAATCATGGTGG
AAAAAGGCTACGAGAGCTTAGAAGATTTCCGTGGGAAATTGCGCTATATTGACTAA

Upstream 100 bases:

>100_bases
TCTTTTCCGAATAAATAGATAGAACCACAGAATCTAGTAAACCTAGAATTAAAATTATGGTATAATATTAGCAATAAAAG
AAATCTGGAGGATTAGAATC

Downstream 100 bases:

>100_bases
ATTAAATCGAAAAATCTGAAGAAAGGAGAGACGATGCTAGCCATTGAAGAAAGTCAGAAGTTGACTTTATCAAATTTACC
GAGCCTGAGCCTATTTACAG

Product: dihydroorotate dehydrogenase 1A

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MVSTKTQIAGFEFDNCLMNAAGVACMTIEELEEVKNSAAGTFVTKTATLDFRQGNPEPRYQDVPLGSINSMGLPNNGLDY
YLDYLLDLQEKESNRTFFLSLVGMSPEETHTILKKVQESDFRGLTELNLSCPNVPGKPQIAYDFETTDRILAEVFAYFTK
PLGIKLPPYFDIVHFDQAAAIFNKYPLKFVNCVNSIGNGLYIEDESVVIRPKNGFGGIGGEYIKPTALANVHAFYQRLNP
QIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKEGVSAFDRITNELKAIMVEKGYESLEDFRGKLRYID

Sequences:

>Translated_311_residues
MVSTKTQIAGFEFDNCLMNAAGVACMTIEELEEVKNSAAGTFVTKTATLDFRQGNPEPRYQDVPLGSINSMGLPNNGLDY
YLDYLLDLQEKESNRTFFLSLVGMSPEETHTILKKVQESDFRGLTELNLSCPNVPGKPQIAYDFETTDRILAEVFAYFTK
PLGIKLPPYFDIVHFDQAAAIFNKYPLKFVNCVNSIGNGLYIEDESVVIRPKNGFGGIGGEYIKPTALANVHAFYQRLNP
QIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKEGVSAFDRITNELKAIMVEKGYESLEDFRGKLRYID
>Mature_311_residues
MVSTKTQIAGFEFDNCLMNAAGVACMTIEELEEVKNSAAGTFVTKTATLDFRQGNPEPRYQDVPLGSINSMGLPNNGLDY
YLDYLLDLQEKESNRTFFLSLVGMSPEETHTILKKVQESDFRGLTELNLSCPNVPGKPQIAYDFETTDRILAEVFAYFTK
PLGIKLPPYFDIVHFDQAAAIFNKYPLKFVNCVNSIGNGLYIEDESVVIRPKNGFGGIGGEYIKPTALANVHAFYQRLNP
QIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKEGVSAFDRITNELKAIMVEKGYESLEDFRGKLRYID

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=325, Percent_Identity=23.6923076923077, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI87082059, Length=249, Percent_Identity=24.4979919678715, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322633, Length=312, Percent_Identity=61.8589743589744, Blast_Score=409, Evalue=1e-115,
Organism=Drosophila melanogaster, GI281361352, Length=323, Percent_Identity=24.4582043343653, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137316, Length=323, Percent_Identity=24.4582043343653, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_STRPN (Q9X9S0)

Other databases:

- EMBL:   AJ131985
- EMBL:   AE005672
- PIR:   E95088
- RefSeq:   NP_345262.1
- ProteinModelPortal:   Q9X9S0
- SMR:   Q9X9S0
- IntAct:   Q9X9S0
- EnsemblBacteria:   EBSTRT00000026841
- GeneID:   930714
- GenomeReviews:   AE005672_GR
- KEGG:   spn:SP_0764
- TIGR:   SP_0764
- GeneTree:   EBGT00050000027667
- HOGENOM:   HBG472415
- OMA:   KPLGVKL
- ProtClustDB:   PRK02506
- BioCyc:   SPNE170187-1:SP_0764-MONOMER
- BRENDA:   1.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00224_B
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 34528; Mature: 34528

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2; PS00013 PROKAR_LIPOPROTEIN

Important sites: ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSTKTQIAGFEFDNCLMNAAGVACMTIEELEEVKNSAAGTFVTKTATLDFRQGNPEPRY
CCCCCCEECCCCHHHHHHHHCCCCEEEHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCC
QDVPLGSINSMGLPNNGLDYYLDYLLDLQEKESNRTFFLSLVGMSPEETHTILKKVQESD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHH
FRGLTELNLSCPNVPGKPQIAYDFETTDRILAEVFAYFTKPLGIKLPPYFDIVHFDQAAA
CCCCEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHH
IFNKYPLKFVNCVNSIGNGLYIEDESVVIRPKNGFGGIGGEYIKPTALANVHAFYQRLNP
HHHHCCHHHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCC
QIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKEGVSAFDRITNELKAIMVEKGYESL
EEEEEECCCEEECHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
EDFRGKLRYID
HHHHHHCCCCC
>Mature Secondary Structure
MVSTKTQIAGFEFDNCLMNAAGVACMTIEELEEVKNSAAGTFVTKTATLDFRQGNPEPRY
CCCCCCEECCCCHHHHHHHHCCCCEEEHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCC
QDVPLGSINSMGLPNNGLDYYLDYLLDLQEKESNRTFFLSLVGMSPEETHTILKKVQESD
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHH
FRGLTELNLSCPNVPGKPQIAYDFETTDRILAEVFAYFTKPLGIKLPPYFDIVHFDQAAA
CCCCEEECCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHH
IFNKYPLKFVNCVNSIGNGLYIEDESVVIRPKNGFGGIGGEYIKPTALANVHAFYQRLNP
HHHHCCHHHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCC
QIQIIGTGGVLTGRDAFEHILCGASMVQVGTTLHKEGVSAFDRITNELKAIMVEKGYESL
EEEEEECCCEEECHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
EDFRGKLRYID
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10432287; 11463916