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The map label for this gene is holA [H]

Identifier: 116515334

GI number: 116515334

Start: 686362

End: 687399

Strand: Direct

Name: holA [H]

Synonym: SPD_0666

Alternate gene names: 116515334

Gene position: 686362-687399 (Clockwise)

Preceding gene: 116516687

Following gene: 116515547

Centisome position: 33.54

GC content: 38.82

Gene sequence:

>1038_bases
ATGCTAGCCATTGAAGAAAGTCAGAAGTTGACTTTATCAAATTTACCGAGCCTGAGCCTATTTACAGGGACAGATCAGGG
TCAGTTTGAAGTGATGAAGAGTCAAGTGTTGAAACAGATTGGGTATGATTCTGCTGACCTCAACTTTGCCTACTTTGATA
TGAAAGAAGTAGTTTACAAGGATGTGGAACTGGAGTTGGTCAGTCTTCCTTTCTTTGCGGATGAGAAAATCGTGATATTA
GATTATTTTATGGATATCACGACTGCTAAGAAACGCTTTTTGACAGATGATGAGCTTAAGTCATTTGAGGAATACCTTGA
CAATTCTTCTCCAACAACCAAGTTGATAATCTTTGCAGAAGGAAAGCTGGATAGCAAAAGACGGTTAGTCAAATTACTTA
AGCGTGATGCCAAGGTCTTCGATGCAGTAGAAGTAAAAGAACAAGAATTGCGCCAGTATTTCCAAAAGTGGAGTCAGAAA
CAAGGTCTGCAGTTTACCAATCATTCTTTTGAAAATCTCCTCATCAAGTCGGGGTTTCAATTTAGCGAAATCCAGAAAAA
TCTTCTCTTTTTACAGTCCTATAAGGCGAATTCTGTTATTGAGGAAGAGGATATTGTTAACGCAATTCCCAAGACCTTGC
AGGACAATATTTTTGATTTAACTCAGTTTATTCTGACTAAAAAGATGGATCAGGCGCGCGATTTGGTGAGAGACTTGACC
TTGCAAGGGGAAGATGAAATCAAACTGATTGCAGTCATGCTGGGACAATTTCGGACTTTTACTCAGGTGAAGATTTTGGC
GGAGTCTGGCCAAACAGAATCGCAGATTGCAAGTAGTTTAGGTAGTTATCTGGGACGTAACCCAAATCCTTATCAAATCA
AGTTTGCATTAAGAGATTCGAGAGGACTTTCTTTGAGCTTTTTGAAGCAAGCTATTTCCTATTTGATTGAGACAGACTAT
CAGATTAAGACAGGTCTTTATGAAAAAGGTTTCCTTTTTGAAAAGGCACTCTTACAGATTGCTAGTCAGGTCAATTGA

Upstream 100 bases:

>100_bases
AATCATGGTGGAAAAAGGCTACGAGAGCTTAGAAGATTTCCGTGGGAAATTGCGCTATATTGACTAAATTAAATCGAAAA
ATCTGAAGAAAGGAGAGACG

Downstream 100 bases:

>100_bases
CATTTGTTGAAACTACAACCCGCGTCAGGACTATCTTGTCGTGGGTTTCTTGCTGATTTGCTTATTTTATTAGAAAGTAT
GTCAGTGATTTCCTTATCTA

Product: DNA polymerase III subunit delta

Products: diphosphate; DNAn+1

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MLAIEESQKLTLSNLPSLSLFTGTDQGQFEVMKSQVLKQIGYDSADLNFAYFDMKEVVYKDVELELVSLPFFADEKIVIL
DYFMDITTAKKRFLTDDELKSFEEYLDNSSPTTKLIIFAEGKLDSKRRLVKLLKRDAKVFDAVEVKEQELRQYFQKWSQK
QGLQFTNHSFENLLIKSGFQFSEIQKNLLFLQSYKANSVIEEEDIVNAIPKTLQDNIFDLTQFILTKKMDQARDLVRDLT
LQGEDEIKLIAVMLGQFRTFTQVKILAESGQTESQIASSLGSYLGRNPNPYQIKFALRDSRGLSLSFLKQAISYLIETDY
QIKTGLYEKGFLFEKALLQIASQVN

Sequences:

>Translated_345_residues
MLAIEESQKLTLSNLPSLSLFTGTDQGQFEVMKSQVLKQIGYDSADLNFAYFDMKEVVYKDVELELVSLPFFADEKIVIL
DYFMDITTAKKRFLTDDELKSFEEYLDNSSPTTKLIIFAEGKLDSKRRLVKLLKRDAKVFDAVEVKEQELRQYFQKWSQK
QGLQFTNHSFENLLIKSGFQFSEIQKNLLFLQSYKANSVIEEEDIVNAIPKTLQDNIFDLTQFILTKKMDQARDLVRDLT
LQGEDEIKLIAVMLGQFRTFTQVKILAESGQTESQIASSLGSYLGRNPNPYQIKFALRDSRGLSLSFLKQAISYLIETDY
QIKTGLYEKGFLFEKALLQIASQVN
>Mature_345_residues
MLAIEESQKLTLSNLPSLSLFTGTDQGQFEVMKSQVLKQIGYDSADLNFAYFDMKEVVYKDVELELVSLPFFADEKIVIL
DYFMDITTAKKRFLTDDELKSFEEYLDNSSPTTKLIIFAEGKLDSKRRLVKLLKRDAKVFDAVEVKEQELRQYFQKWSQK
QGLQFTNHSFENLLIKSGFQFSEIQKNLLFLQSYKANSVIEEEDIVNAIPKTLQDNIFDLTQFILTKKMDQARDLVRDLT
LQGEDEIKLIAVMLGQFRTFTQVKILAESGQTESQIASSLGSYLGRNPNPYQIKFALRDSRGLSLSFLKQAISYLIETDY
QIKTGLYEKGFLFEKALLQIASQVN

Specific function: Unknown

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: 2.7.7.7

Molecular weight: Translated: 39729; Mature: 39729

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAIEESQKLTLSNLPSLSLFTGTDQGQFEVMKSQVLKQIGYDSADLNFAYFDMKEVVYK
CCCCCCCCCEEHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHH
DVELELVSLPFFADEKIVILDYFMDITTAKKRFLTDDELKSFEEYLDNSSPTTKLIIFAE
CCCEEEEECCCCCCCCEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEEC
GKLDSKRRLVKLLKRDAKVFDAVEVKEQELRQYFQKWSQKQGLQFTNHSFENLLIKSGFQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCC
FSEIQKNLLFLQSYKANSVIEEEDIVNAIPKTLQDNIFDLTQFILTKKMDQARDLVRDLT
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LQGEDEIKLIAVMLGQFRTFTQVKILAESGQTESQIASSLGSYLGRNPNPYQIKFALRDS
CCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECC
RGLSLSFLKQAISYLIETDYQIKTGLYEKGFLFEKALLQIASQVN
CCCCHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLAIEESQKLTLSNLPSLSLFTGTDQGQFEVMKSQVLKQIGYDSADLNFAYFDMKEVVYK
CCCCCCCCCEEHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHH
DVELELVSLPFFADEKIVILDYFMDITTAKKRFLTDDELKSFEEYLDNSSPTTKLIIFAE
CCCEEEEECCCCCCCCEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEEC
GKLDSKRRLVKLLKRDAKVFDAVEVKEQELRQYFQKWSQKQGLQFTNHSFENLLIKSGFQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCC
FSEIQKNLLFLQSYKANSVIEEEDIVNAIPKTLQDNIFDLTQFILTKKMDQARDLVRDLT
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LQGEDEIKLIAVMLGQFRTFTQVKILAESGQTESQIASSLGSYLGRNPNPYQIKFALRDS
CCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECC
RGLSLSFLKQAISYLIETDYQIKTGLYEKGFLFEKALLQIASQVN
CCCCHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxynucleoside triphosphate; DNAn

Specific reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]