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The map label for this gene is ispA [H]

Identifier: 116516004

GI number: 116516004

Start: 1090438

End: 1091313

Strand: Reverse

Name: ispA [H]

Synonym: SPD_1065

Alternate gene names: 116516004

Gene position: 1091313-1090438 (Counterclockwise)

Preceding gene: 116516524

Following gene: 116516842

Centisome position: 53.34

GC content: 44.75

Gene sequence:

>876_bases
ATGAAAAAGCAAGAAAAATTAGCTCTTGTCGAGTCGGCTTTGGAAGATTTTTATGGAGACCAGCAGTTTGCCTCTAGTTT
ACGGGAGTCTGTTCTCTATTCTATTCATGCTGGTGGCAAGCGTATTCGGCCTTTTCTCTTGTTAGAAGTTCTGGAAGCCT
TGCAGGTTGCCATCAAACCTGCTCACGCGCAGGTAGCTACTGCCTTGGAGATGATTCATACAGGGAGCTTGATTCACGAT
GACCTTCCTGCTATGGATGATGACGATTATCGAAGAGGGCGGTTAACCAATCACAAGAAATTCGGTGAAGCTATGGCCAT
TTTGGCTGGAGATGCCTTATTCTTAGACCCATATGCCTTGATTGCGCAGGCAGATTTGCCAAGTCAGATCAAGGTGGACT
TGATTGCCAACTTATCCCTTGCTTCAGGTAGTCTGGGTATGGTGGCAGGGCAAGTTTTGGATATGGAGGGCGAACACCAG
CACTTGTCTCTGGAAGAACTTCAGACTATTCATGCCAATAAGACTGGGAAGTTACTAGCCTATCCCTTCCAAGCGGCAGC
TATTATAGCTGAATTGTCACCTGAAATGCAGGTGAAGCTGAAAACTGTGGGTGAATTGATTGGACTTGCTTTTCAAGTCA
GAGATGATGTACTGGATGTGACAGCTAGTTTTGAGGAAATCGGTAAGACACCTCAAAAGGATCTGCAGGCAGAAAAATCA
ACCTATCCTGCCTTGTTGGGCTTGGAAGAGTCCATTGCCTTTTGTAACCAAACCCTGGATCAAGCTAATGAAAAATTGGA
AGAAATTGCCCAGCAGGTTCCCTTTGAAACAGAATCGATTGTAAGTGTAGTAGAAAGTTTGAGAATCAATGGCTAA

Upstream 100 bases:

>100_bases
AGGGCATGGTCTTGTCAAAAGAGCTCCAAGCTACGCTGGACAAGGCTGAAAAGACCTTGGTCAAGGTCATGCAAGAAGAC
GGAACAGAAAGTGATTTTGA

Downstream 100 bases:

>100_bases
GGAAAGAGTGGATGTACTAGCTTATAAACAGGGGTTGTTTGAAACGAGAGAGCAGGCCAAGCGAGGTGTGATGGCTGGTC
TAGTCGTAGCAGTCCTTAAT

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPFLLLEVLEALQVAIKPAHAQVATALEMIHTGSLIHD
DLPAMDDDDYRRGRLTNHKKFGEAMAILAGDALFLDPYALIAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQ
HLSLEELQTIHANKTGKLLAYPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVLDVTASFEEIGKTPQKDLQAEKS
TYPALLGLEESIAFCNQTLDQANEKLEEIAQQVPFETESIVSVVESLRING

Sequences:

>Translated_291_residues
MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPFLLLEVLEALQVAIKPAHAQVATALEMIHTGSLIHD
DLPAMDDDDYRRGRLTNHKKFGEAMAILAGDALFLDPYALIAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQ
HLSLEELQTIHANKTGKLLAYPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVLDVTASFEEIGKTPQKDLQAEKS
TYPALLGLEESIAFCNQTLDQANEKLEEIAQQVPFETESIVSVVESLRING
>Mature_291_residues
MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPFLLLEVLEALQVAIKPAHAQVATALEMIHTGSLIHD
DLPAMDDDDYRRGRLTNHKKFGEAMAILAGDALFLDPYALIAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQ
HLSLEELQTIHANKTGKLLAYPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVLDVTASFEEIGKTPQKDLQAEKS
TYPALLGLEESIAFCNQTLDQANEKLEEIAQQVPFETESIVSVVESLRING

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=235, Percent_Identity=28.936170212766, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1786623, Length=248, Percent_Identity=43.9516129032258, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI1789578, Length=248, Percent_Identity=31.8548387096774, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17505681, Length=274, Percent_Identity=27.3722627737226, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24651612, Length=240, Percent_Identity=30, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31835; Mature: 31835

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPFLLLEVLEALQVAIKP
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
AHAQVATALEMIHTGSLIHDDLPAMDDDDYRRGRLTNHKKFGEAMAILAGDALFLDPYAL
HHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCHHHH
IAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQHLSLEELQTIHANKTGKLLA
HHCCCCCCCEEHHHHEECCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEEE
YPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVLDVTASFEEIGKTPQKDLQAEKS
ECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
TYPALLGLEESIAFCNQTLDQANEKLEEIAQQVPFETESIVSVVESLRING
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKQEKLALVESALEDFYGDQQFASSLRESVLYSIHAGGKRIRPFLLLEVLEALQVAIKP
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
AHAQVATALEMIHTGSLIHDDLPAMDDDDYRRGRLTNHKKFGEAMAILAGDALFLDPYAL
HHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCHHHH
IAQADLPSQIKVDLIANLSLASGSLGMVAGQVLDMEGEHQHLSLEELQTIHANKTGKLLA
HHCCCCCCCEEHHHHEECCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEEE
YPFQAAAIIAELSPEMQVKLKTVGELIGLAFQVRDDVLDVTASFEEIGKTPQKDLQAEKS
ECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
TYPALLGLEESIAFCNQTLDQANEKLEEIAQQVPFETESIVSVVESLRING
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]