Click here to switch to the map view.

The map label for this gene is xseA

Identifier: 116515460

GI number: 116515460

Start: 1091500

End: 1092840

Strand: Reverse

Name: xseA

Synonym: SPD_1067

Alternate gene names: 116515460

Gene position: 1092840-1091500 (Counterclockwise)

Preceding gene: 116516339

Following gene: 116516524

Centisome position: 53.41

GC content: 43.25

Gene sequence:

>1341_bases
ATGGAAAAGTATTTATCGGTAACAACTTTGACCAAGTATCTGAAAATGAAATTCGATAAAGACCCATACTTGGAACGGGT
CTATTTAACTGGTCAAGTTTCCAACTTTCGTAAACGACCTACTCACCAATATTTCTCCCTAAAGGATGACCATGCAGTTA
TTCAAGCGACCATCTGGTCTGGGATTTATCAGAAATTAGGGTTTGACCTGGAAGAAGGAATGAAGATCAATGTGATTGGG
CGTGTACAGGTCTATGAACCAAGTGGTAGCTACTCCATCATCATTGAAAAAGTTGAGCCTGATGGGGTTGGGGCGCTTGC
GATTCAGTTTGAACAACTTAAGAAAAAATTGACAGAAGAAGGCCTGTTTCAAGAACGCTTCAAGCAAGCTCTGCCCCAAT
TTTCTAAGAGAATTGGGGTAGTAACCAGCCGTAGTGGAGCCGTTATTCGAGATATTATCACGACCGTCAGCAGGCGATTC
CCAGGTGTTGACATCCTTCTTTATCCGACCAAGGTTCAAGGTGAAGGGGCTGCGGAGGAAATTGCTAGAAATATTGCGCG
TGCTAATCAACGGGACGATTTGGATTTGCTCATTATTGGTCGTGGAGGTGGTTCTATTGAGGATCTCTGGGCCTTTAACG
AAGAAATTGTGGTACGAGCTATTTTTGAATCTCGTTTGCCAGTTATCTCTAGTGTGGGGCATGAGACGGATGTGACCTTG
GCAGATTTTGTGGCAGATCGACGCGCTGCAACGCCAACAGCGGCGGCTGAACTGGCAACACCTGTGACCAAGTTGGATGT
ATTAGCTCATTTGCAAAATCAGGAAAAACGGATGGTAACGGCAGTCCGAAATGTTCTATCTAAGAAACAAGAGGCTTTGA
AAAAATGCAGTCAGTCTGTTATCTTTAGACAACCTGAGCGCTTGTATGACGGTTATTTGCAACGCTTGGACCAACTGCAA
CTGCGTTTGAAACAAAGTTTGCGAACTCGGATTTCTGATAACAAACAATTAGTTCAAGCAAGAACTCATCAATTAGTACA
ATTATCACCTGTTACCAAAATCCAACGCTATCAAGACCGTTTAGGACAGTTGGACAAGCTCTTAGGTAGCCAAATGGCGT
TAGTTTATGACGCCAAGGTTGCTGAGGCCAAGCGACTTTCGGAAGCTTTGCTCATGTTGGATACTAGCCGAATCGTGGCG
CGTGGTTATGCTATTGTCAAAAAAGAAGAGTCCGTTGTAGATTCGGTTGAGAGTTTGAAGAAAAAAGACCAAGTAACGCT
TTTGATGCGAGATGGTCAAGTAGAATTAGAGGTTAAAGATGTCAAAACAAAAGAAATTTGA

Upstream 100 bases:

>100_bases
TCTATTTTTCCCTCATAATGGTACATAAATGGAGATTTTTAGGCATATTTTTGGTATAATAATACCCATGAAAGAGCAAG
TAAATGAATAGTAGGTGGAG

Downstream 100 bases:

>100_bases
GGAAAATCTAGCAGAACTGGAAACCATTGTCCAAAGTTTGGAAAATGGTGAAATTGCTCTGGAAGATGCGATTACTGCCT
TTCAAAAGGGCATGGTCTTG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQYFSLKDDHAVIQATIWSGIYQKLGFDLEEGMKINVIG
RVQVYEPSGSYSIIIEKVEPDGVGALAIQFEQLKKKLTEEGLFQERFKQALPQFSKRIGVVTSRSGAVIRDIITTVSRRF
PGVDILLYPTKVQGEGAAEEIARNIARANQRDDLDLLIIGRGGGSIEDLWAFNEEIVVRAIFESRLPVISSVGHETDVTL
ADFVADRRAATPTAAAELATPVTKLDVLAHLQNQEKRMVTAVRNVLSKKQEALKKCSQSVIFRQPERLYDGYLQRLDQLQ
LRLKQSLRTRISDNKQLVQARTHQLVQLSPVTKIQRYQDRLGQLDKLLGSQMALVYDAKVAEAKRLSEALLMLDTSRIVA
RGYAIVKKEESVVDSVESLKKKDQVTLLMRDGQVELEVKDVKTKEI

Sequences:

>Translated_446_residues
MEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQYFSLKDDHAVIQATIWSGIYQKLGFDLEEGMKINVIG
RVQVYEPSGSYSIIIEKVEPDGVGALAIQFEQLKKKLTEEGLFQERFKQALPQFSKRIGVVTSRSGAVIRDIITTVSRRF
PGVDILLYPTKVQGEGAAEEIARNIARANQRDDLDLLIIGRGGGSIEDLWAFNEEIVVRAIFESRLPVISSVGHETDVTL
ADFVADRRAATPTAAAELATPVTKLDVLAHLQNQEKRMVTAVRNVLSKKQEALKKCSQSVIFRQPERLYDGYLQRLDQLQ
LRLKQSLRTRISDNKQLVQARTHQLVQLSPVTKIQRYQDRLGQLDKLLGSQMALVYDAKVAEAKRLSEALLMLDTSRIVA
RGYAIVKKEESVVDSVESLKKKDQVTLLMRDGQVELEVKDVKTKEI
>Mature_446_residues
MEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQYFSLKDDHAVIQATIWSGIYQKLGFDLEEGMKINVIG
RVQVYEPSGSYSIIIEKVEPDGVGALAIQFEQLKKKLTEEGLFQERFKQALPQFSKRIGVVTSRSGAVIRDIITTVSRRF
PGVDILLYPTKVQGEGAAEEIARNIARANQRDDLDLLIIGRGGGSIEDLWAFNEEIVVRAIFESRLPVISSVGHETDVTL
ADFVADRRAATPTAAAELATPVTKLDVLAHLQNQEKRMVTAVRNVLSKKQEALKKCSQSVIFRQPERLYDGYLQRLDQLQ
LRLKQSLRTRISDNKQLVQARTHQLVQLSPVTKIQRYQDRLGQLDKLLGSQMALVYDAKVAEAKRLSEALLMLDTSRIVA
RGYAIVKKEESVVDSVESLKKKDQVTLLMRDGQVELEVKDVKTKEI

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=443, Percent_Identity=36.117381489842, Blast_Score=281, Evalue=8e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_STRP2 (Q04KB0)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_816538.1
- STRING:   Q04KB0
- EnsemblBacteria:   EBSTRT00000020275
- GeneID:   4441185
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_1067
- eggNOG:   COG1570
- GeneTree:   EBGT00050000027533
- HOGENOM:   HBG634411
- OMA:   PWPVRTV
- ProtClustDB:   PRK00286
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 50537; Mature: 50537

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQYFSLKDDHAVIQATIWS
CCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHCCCCCHHCCCCCCCHHHHHHHHH
GIYQKLGFDLEEGMKINVIGRVQVYEPSGSYSIIIEKVEPDGVGALAIQFEQLKKKLTEE
HHHHHHCCCHHCCCEEEEEEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHC
GLFQERFKQALPQFSKRIGVVTSRSGAVIRDIITTVSRRFPGVDILLYPTKVQGEGAAEE
CHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHCCCCEEEEECCEECCCCHHHH
IARNIARANQRDDLDLLIIGRGGGSIEDLWAFNEEIVVRAIFESRLPVISSVGHETDVTL
HHHHHHHCCCCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHHCCCHHHHCCCCCCCHH
ADFVADRRAATPTAAAELATPVTKLDVLAHLQNQEKRMVTAVRNVLSKKQEALKKCSQSV
HHHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFRQPERLYDGYLQRLDQLQLRLKQSLRTRISDNKQLVQARTHQLVQLSPVTKIQRYQDR
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEECHHHHHHHHHHH
LGQLDKLLGSQMALVYDAKVAEAKRLSEALLMLDTSRIVARGYAIVKKEESVVDSVESLK
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECHHHHHHHHHHHH
KKDQVTLLMRDGQVELEVKDVKTKEI
CCCCEEEEEECCEEEEEEECCCCCCC
>Mature Secondary Structure
MEKYLSVTTLTKYLKMKFDKDPYLERVYLTGQVSNFRKRPTHQYFSLKDDHAVIQATIWS
CCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHCCCCCHHCCCCCCCHHHHHHHHH
GIYQKLGFDLEEGMKINVIGRVQVYEPSGSYSIIIEKVEPDGVGALAIQFEQLKKKLTEE
HHHHHHCCCHHCCCEEEEEEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHC
GLFQERFKQALPQFSKRIGVVTSRSGAVIRDIITTVSRRFPGVDILLYPTKVQGEGAAEE
CHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHCCCCEEEEECCEECCCCHHHH
IARNIARANQRDDLDLLIIGRGGGSIEDLWAFNEEIVVRAIFESRLPVISSVGHETDVTL
HHHHHHHCCCCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHHCCCHHHHCCCCCCCHH
ADFVADRRAATPTAAAELATPVTKLDVLAHLQNQEKRMVTAVRNVLSKKQEALKKCSQSV
HHHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFRQPERLYDGYLQRLDQLQLRLKQSLRTRISDNKQLVQARTHQLVQLSPVTKIQRYQDR
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEECHHHHHHHHHHH
LGQLDKLLGSQMALVYDAKVAEAKRLSEALLMLDTSRIVARGYAIVKKEESVVDSVESLK
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECHHHHHHHHHHHH
KKDQVTLLMRDGQVELEVKDVKTKEI
CCCCEEEEEECCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA