Click here to switch to the map view.

The map label for this gene is upp [H]

Identifier: 116515358

GI number: 116515358

Start: 668143

End: 668793

Strand: Direct

Name: upp [H]

Synonym: SPD_0649

Alternate gene names: 116515358

Gene position: 668143-668793 (Clockwise)

Preceding gene: 116515918

Following gene: 116516216

Centisome position: 32.65

GC content: 41.63

Gene sequence:

>651_bases
TTGAAAGAAGGAATTCCAAAAATGGGAAAAATTGAAGTTATTAATCACCCACTGATTCAACACAAATTGTCAATCTTGCG
TCGTACAGATACTTCTACAAAAGCTTTTCGTGAGCTAGTAGATGAGATTGCAATGTTGATGGGGTATGAAGTACTTCGTG
ATCTTCCACTAGAAGATGTGGAAATCGAAACACCAATTACAAAAACAGTTCAAAAACAATTGGCAGGTAAGAAATTGGCC
ATCGTCCCAATCTTGCGTGCAGGTATCGGGATGGTTGATGGTCTCTTGAGCTTGGTTCCAGCTGCTAAAGTTGGCCACAT
CGGTATGTACCGTGATGAAGAAACACTTCAACCAGTTGAATACTTGGTGAAATTGCCTGAGGACATTGACCAACGTCAAA
TTTTTGTAGTAGACCCAATGTTGGCAACAGGTGGCTCAGCAATCTTGGCTGTTGATTCTCTTAAAAAACGTGGCGCATCA
AATATCAAATTTGTCTGCCTTGTATCTGCTCCAGAGGGTGTAAAAGCCCTTCAAGAAGCTCATCCAGATGTAGAAATCTT
TACAGCAGCCTTGGATGAACGTTTGAACGAACACGGTTATATCGTTCCAGGTCTTGGAGATGCTGGAGACCGCTTGTTCG
GTACAAAATAA

Upstream 100 bases:

>100_bases
CAGACAGCTCTTAAAGAGGCTGATCTAATGTAAAAATTATCAAAAATAAATGGTTTAGAAAGATTTTTAAACCGTTTTTT
GGTATAATAAGAAGAATAAA

Downstream 100 bases:

>100_bases
GATCGAAAAGAAGAATGACTTGGAAAAGTATTTCCAGTCACGAAAGGAGGTTGGGTTTTTGTTTCTGTCTAATGAAAGCA
GAGCAAAAATTTGACCTTTT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MKEGIPKMGKIEVINHPLIQHKLSILRRTDTSTKAFRELVDEIAMLMGYEVLRDLPLEDVEIETPITKTVQKQLAGKKLA
IVPILRAGIGMVDGLLSLVPAAKVGHIGMYRDEETLQPVEYLVKLPEDIDQRQIFVVDPMLATGGSAILAVDSLKKRGAS
NIKFVCLVSAPEGVKALQEAHPDVEIFTAALDERLNEHGYIVPGLGDAGDRLFGTK

Sequences:

>Translated_216_residues
MKEGIPKMGKIEVINHPLIQHKLSILRRTDTSTKAFRELVDEIAMLMGYEVLRDLPLEDVEIETPITKTVQKQLAGKKLA
IVPILRAGIGMVDGLLSLVPAAKVGHIGMYRDEETLQPVEYLVKLPEDIDQRQIFVVDPMLATGGSAILAVDSLKKRGAS
NIKFVCLVSAPEGVKALQEAHPDVEIFTAALDERLNEHGYIVPGLGDAGDRLFGTK
>Mature_216_residues
MKEGIPKMGKIEVINHPLIQHKLSILRRTDTSTKAFRELVDEIAMLMGYEVLRDLPLEDVEIETPITKTVQKQLAGKKLA
IVPILRAGIGMVDGLLSLVPAAKVGHIGMYRDEETLQPVEYLVKLPEDIDQRQIFVVDPMLATGGSAILAVDSLKKRGAS
NIKFVCLVSAPEGVKALQEAHPDVEIFTAALDERLNEHGYIVPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=31.6831683168317, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=31.6831683168317, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI21450816, Length=194, Percent_Identity=28.8659793814433, Blast_Score=74, Evalue=9e-14,
Organism=Escherichia coli, GI87082118, Length=207, Percent_Identity=56.5217391304348, Blast_Score=246, Evalue=9e-67,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=27.8606965174129, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=27.8606965174129, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=41.1458333333333, Blast_Score=139, Evalue=5e-34,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=30.5418719211823, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=30.5418719211823, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=30.5418719211823, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=30.5418719211823, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21358379, Length=195, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23656; Mature: 23656

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEGIPKMGKIEVINHPLIQHKLSILRRTDTSTKAFRELVDEIAMLMGYEVLRDLPLEDV
CCCCCCCCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
EIETPITKTVQKQLAGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHIGMYRDEETLQPVE
EECCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHH
YLVKLPEDIDQRQIFVVDPMLATGGSAILAVDSLKKRGASNIKFVCLVSAPEGVKALQEA
HHHHCCCCCCCCEEEEECCHHHCCCCEEEEHHHHHHCCCCCEEEEEEEECCHHHHHHHHC
HPDVEIFTAALDERLNEHGYIVPGLGDAGDRLFGTK
CCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKEGIPKMGKIEVINHPLIQHKLSILRRTDTSTKAFRELVDEIAMLMGYEVLRDLPLEDV
CCCCCCCCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
EIETPITKTVQKQLAGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHIGMYRDEETLQPVE
EECCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHH
YLVKLPEDIDQRQIFVVDPMLATGGSAILAVDSLKKRGASNIKFVCLVSAPEGVKALQEA
HHHHCCCCCCCCEEEEECCHHHCCCCEEEEHHHHHHCCCCCEEEEEEEECCHHHHHHHHC
HPDVEIFTAALDERLNEHGYIVPGLGDAGDRLFGTK
CCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA