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The map label for this gene is clpP [H]

Identifier: 116516216

GI number: 116516216

Start: 668967

End: 669557

Strand: Direct

Name: clpP [H]

Synonym: SPD_0650

Alternate gene names: 116516216

Gene position: 668967-669557 (Clockwise)

Preceding gene: 116515358

Following gene: 116516631

Centisome position: 32.69

GC content: 41.62

Gene sequence:

>591_bases
ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCACGTCTTCTCAAAGACCGCAT
CATTATGCTGACAGGTCCGGTTGAAGACAATATGGCTAACTCTGTTATTGCCCAACTGCTTTTCTTGGATGCCCAAGATA
GTACAAAAGATATTTACCTTTATGTCAATACACCAGGTGGTTCTGTTTCAGCTGGTTTGGCAATCGTAGATACCATGAAC
TTTATCAAGGCAGATGTCCAAACCATTGTTATGGGAATGGCTGCATCTATGGGAACAGTCATCGCATCAAGTGGAGCAAA
AGGCAAACGTTTCATGCTTCCAAATGCTGAATACATGATTCACCAACCAATGGGCGGTACAGGTGGTGGTACCCAACAAA
CTGATATGGCTATCGCTGCAGAACACTTGCTCAAAACTCGTAATACCTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
TCAATGGAAAAAGTCCATGCAGATGCAGAACGTGATAACTGGATGAGCGCCCAGGAAACACTTGAATATGGCTTTATTGA
TGAAATTATGGCCAACAATTCATTGAACTAA

Upstream 100 bases:

>100_bases
GAAAGCAGAGCAAAAATTTGACCTTTTTTGACCAAGATATTATAATAGTCTTATCTTCAGTCATTTGACCAACAAAATTA
AAACTCAAAAGGAGAAATGA

Downstream 100 bases:

>100_bases
TGATGATAGAAGGCAAACTCGACTGGGTTTGCTTTTTTTGGTATAATAGGGAGAGATTTCTTAGAAAGAGGATTTATCAT
GTTTGAAAAAGTCAATCGCT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
SMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN

Sequences:

>Translated_196_residues
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
SMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN
>Mature_196_residues
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
SMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=47.9166666666667, Blast_Score=202, Evalue=1e-52,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=56.1855670103093, Blast_Score=244, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17538017, Length=192, Percent_Identity=46.3541666666667, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=46.8421052631579, Blast_Score=193, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21359; Mature: 21359

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.1 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
7.1 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYL
CCCEEEECCCCCCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEE
YVNTPGGSVSAGLAIVDTMNFIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMI
EEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEE
HQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQSMEKVHADAERDNWMSAQET
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHH
LEYGFIDEIMANNSLN
HHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYL
CCCEEEECCCCCCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEE
YVNTPGGSVSAGLAIVDTMNFIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMI
EEECCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEE
HQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQSMEKVHADAERDNWMSAQET
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHH
LEYGFIDEIMANNSLN
HHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA