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The map label for this gene is mutS2

Identifier: 116494335

GI number: 116494335

Start: 786431

End: 788791

Strand: Direct

Name: mutS2

Synonym: LSEI_0791

Alternate gene names: 116494335

Gene position: 786431-788791 (Clockwise)

Preceding gene: 116494334

Following gene: 116494336

Centisome position: 27.16

GC content: 49.0

Gene sequence:

>2361_bases
ATGAATGAAAAGATTTTAAAAACCCTTGAATACGACAAGATTCAGCAGGCATTGTTGGGTCAGGTCGTGACAGCAAATGG
CCGCCAGCTGGTGCAGGCCATGCAGCCGCTGACCGATCCAGTCGCCGTACAACAGGCACTAGATGAAACCGCAGACGGCG
CATCGGCGTTGCGATTAAAAGGCGGCATTCCAGTGCCGCAACTCGAGAATATTGATCCGGCGCTTAAACGAGTCGACATT
GGGGCCGTTTTGAATGGTCAAGAACTAGCCAGCATCAGCCGTGTCTTGCAAACGGTGAGTGCCATTGATAAATTTTTGAC
TGATTTACAGGATCAGATTGATTTTCGCCAGCTTTACACACTTCAAGAGTCGTTAACCGTGTTACCGCAATTATCACGGC
GCTTGAAGACAGCCGTTGATCCTGATGGGACATTGACCGATGAGGCTAGTCCTCAGCTGCATGGTGTTCGTGAACAGATC
AAAAGTATTGAAGGCGAAATCCGCGGTAAAATGACAAATTATACTCGCGGCGCCCAATCAAAGTATTTAAGTGACCCGAT
TGTGACGATTCGGGATGATCGGTACGTGATTCCGGTTAAGGCTGAGTATCGCGCCAAATTTGGCGGTGTTGTCCATGATC
AAAGTGCGACCGGCCAAACCTTGTTTATTGAACCGCAAGCAATTGTCGCCTTGAATAATCGACTGCGTGAGGCACAACTG
GCCGAGGTAGCTGAGATTAACCGCATCTTAGCCGAATTGTCTAATGAATTAGCGCCTTATACCGGTCAAATCAAGGCGAA
TGCGGCGGTTCTTGGGCATTTTGACTTCATCAATGCGAAGGCGAGATTAGCCAAGGCGGAAAAAGCGACAGAGCCGTTAG
TGTCGGCTGATAATGACGTATTGTTGCGTGATGCTCGGCACCCCTTGATCGATCCGCATAAGGTGGTTGGTAACGATATT
CCGTTGGGCGACAAGTACCAAGCTATGGTTATCACCGGTCCGAATACCGGTGGGAAAACAATCACCCTCAAAACATTAGG
GCTGTTGCAGTTGATGGGGCAGTCCGGATTGTTTATTCCAGCTGATGATGAAAGTCGTATCGGCATTTTCGATGAAGTCT
TTGCAGATATTGGCGATGAACAATCCATTGAGCAAAATTTGTCGACTTTTTCTGCACATATGGACAATATTGTTCATATT
CTCAAACAATTGTCACAGAATAGTTTAGTGCTGTTTGATGAACTTGGCGCCGGCACTGATCCGCAAGAAGGTGCGGCGCT
GGCGATCGCGATCTTGGACGCAGTGGGTGAAGTTGGCGCGTATGTAGTTGCCACGACCCATTATCCGGAATTGAAGTTGT
ATGGGTACAATACAGCAAAGACGATTAACGCATCGATGGAATTTGACAGCAAAACGCTGCAGCCAACTTATCGCCTTTTG
GTCGGGGTACCTGGGCGCTCAAATGCGTTTGATATTTCTGCACGTTTGGGGCTGCCGGGCGTGATCGTTGAGCGTGCTAA
GTCAATGATCAGCTCGGACAGCCATGAGTTGAATAATATGATCAGCGACTTGGAAAAACAGCGAAAGGCAGCGGAAACCG
CTTATGAAGCCGCTCGTCGTCAACTAGCCGATGCACAGTCTGTCCATGACGAGCTAGCGGCAGCCTACAAGAAGTTCACA
ACGGAACGCGATGCCCAGTTGCAGCAGGCTAAGGACAAGGCCAACACGTTGGTTGACAAGGCCCAAACGAAGGCCGATAA
AATCATCAAGCAACTGCGCCAAATGCAATTGACGAATCCGGGAACCGTGAAAGAGAATCAATTGATTGCTGCCAAAACGG
CGCTTAAACAATTGCATCAAGACGAGCCGCTTCAGAAAAATCGCATCTTGCGCCGTGAACGTGAGAAACAGGCATTGCAT
GTTGGTGATGAGGTTAAAGTGGCAAGTTACGATCAAACTGGTACCTTGCTGGAGCAATTCGATAAGAAGCATTGGCAGGT
TCAACTAGGCATTTTGAAAATGAAGGTACCAACTGATGAGCTGAAAAAAATCAAGTCAAGTAAGCAATCAGCGGCGCAAC
GTCCGGTTGTCAAAGTAAGTGGTGGCGGGATGAGCGGCCCATCGACCACGCTGGATTTGCGCGGCGAGCGGTATGATCAG
GCGATGGCGGATTTGGATCAATACATTGATGCCGCCTTATTGGCCGGTTATCCATCTGTGACGATTATTCACGGGCTGGG
CACTGGCGCGATTCGCAACGGGGTGACCCAGTATCTTAAACGCAATCGGCAGGTTAAAACGTATGGCTTTGCACCACAAA
ATGCCGGTGGCTCAGGAGCTACCATCGTAAACTTTAAGTAG

Upstream 100 bases:

>100_bases
TAACACAATTTGTGAATGCTTTGTGGCTATGAATGTTGACGACGCTCAGGGACGATTTATCACGTCTTTGAGCGCTTCTT
GGTTATAGGAGCAATTATTT

Downstream 100 bases:

>100_bases
CAGGTAGTTTTTTACACTTCATTGTGCTATGATTTAGTTACAAAAAGTAAGAGGAGGGATCCGTTCATGGTTCAAGCAGT
AACAGATTCAAACTACAAGA

Product: MutS family ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 786; Mature: 786

Protein sequence:

>786_residues
MNEKILKTLEYDKIQQALLGQVVTANGRQLVQAMQPLTDPVAVQQALDETADGASALRLKGGIPVPQLENIDPALKRVDI
GAVLNGQELASISRVLQTVSAIDKFLTDLQDQIDFRQLYTLQESLTVLPQLSRRLKTAVDPDGTLTDEASPQLHGVREQI
KSIEGEIRGKMTNYTRGAQSKYLSDPIVTIRDDRYVIPVKAEYRAKFGGVVHDQSATGQTLFIEPQAIVALNNRLREAQL
AEVAEINRILAELSNELAPYTGQIKANAAVLGHFDFINAKARLAKAEKATEPLVSADNDVLLRDARHPLIDPHKVVGNDI
PLGDKYQAMVITGPNTGGKTITLKTLGLLQLMGQSGLFIPADDESRIGIFDEVFADIGDEQSIEQNLSTFSAHMDNIVHI
LKQLSQNSLVLFDELGAGTDPQEGAALAIAILDAVGEVGAYVVATTHYPELKLYGYNTAKTINASMEFDSKTLQPTYRLL
VGVPGRSNAFDISARLGLPGVIVERAKSMISSDSHELNNMISDLEKQRKAAETAYEAARRQLADAQSVHDELAAAYKKFT
TERDAQLQQAKDKANTLVDKAQTKADKIIKQLRQMQLTNPGTVKENQLIAAKTALKQLHQDEPLQKNRILRREREKQALH
VGDEVKVASYDQTGTLLEQFDKKHWQVQLGILKMKVPTDELKKIKSSKQSAAQRPVVKVSGGGMSGPSTTLDLRGERYDQ
AMADLDQYIDAALLAGYPSVTIIHGLGTGAIRNGVTQYLKRNRQVKTYGFAPQNAGGSGATIVNFK

Sequences:

>Translated_786_residues
MNEKILKTLEYDKIQQALLGQVVTANGRQLVQAMQPLTDPVAVQQALDETADGASALRLKGGIPVPQLENIDPALKRVDI
GAVLNGQELASISRVLQTVSAIDKFLTDLQDQIDFRQLYTLQESLTVLPQLSRRLKTAVDPDGTLTDEASPQLHGVREQI
KSIEGEIRGKMTNYTRGAQSKYLSDPIVTIRDDRYVIPVKAEYRAKFGGVVHDQSATGQTLFIEPQAIVALNNRLREAQL
AEVAEINRILAELSNELAPYTGQIKANAAVLGHFDFINAKARLAKAEKATEPLVSADNDVLLRDARHPLIDPHKVVGNDI
PLGDKYQAMVITGPNTGGKTITLKTLGLLQLMGQSGLFIPADDESRIGIFDEVFADIGDEQSIEQNLSTFSAHMDNIVHI
LKQLSQNSLVLFDELGAGTDPQEGAALAIAILDAVGEVGAYVVATTHYPELKLYGYNTAKTINASMEFDSKTLQPTYRLL
VGVPGRSNAFDISARLGLPGVIVERAKSMISSDSHELNNMISDLEKQRKAAETAYEAARRQLADAQSVHDELAAAYKKFT
TERDAQLQQAKDKANTLVDKAQTKADKIIKQLRQMQLTNPGTVKENQLIAAKTALKQLHQDEPLQKNRILRREREKQALH
VGDEVKVASYDQTGTLLEQFDKKHWQVQLGILKMKVPTDELKKIKSSKQSAAQRPVVKVSGGGMSGPSTTLDLRGERYDQ
AMADLDQYIDAALLAGYPSVTIIHGLGTGAIRNGVTQYLKRNRQVKTYGFAPQNAGGSGATIVNFK
>Mature_786_residues
MNEKILKTLEYDKIQQALLGQVVTANGRQLVQAMQPLTDPVAVQQALDETADGASALRLKGGIPVPQLENIDPALKRVDI
GAVLNGQELASISRVLQTVSAIDKFLTDLQDQIDFRQLYTLQESLTVLPQLSRRLKTAVDPDGTLTDEASPQLHGVREQI
KSIEGEIRGKMTNYTRGAQSKYLSDPIVTIRDDRYVIPVKAEYRAKFGGVVHDQSATGQTLFIEPQAIVALNNRLREAQL
AEVAEINRILAELSNELAPYTGQIKANAAVLGHFDFINAKARLAKAEKATEPLVSADNDVLLRDARHPLIDPHKVVGNDI
PLGDKYQAMVITGPNTGGKTITLKTLGLLQLMGQSGLFIPADDESRIGIFDEVFADIGDEQSIEQNLSTFSAHMDNIVHI
LKQLSQNSLVLFDELGAGTDPQEGAALAIAILDAVGEVGAYVVATTHYPELKLYGYNTAKTINASMEFDSKTLQPTYRLL
VGVPGRSNAFDISARLGLPGVIVERAKSMISSDSHELNNMISDLEKQRKAAETAYEAARRQLADAQSVHDELAAAYKKFT
TERDAQLQQAKDKANTLVDKAQTKADKIIKQLRQMQLTNPGTVKENQLIAAKTALKQLHQDEPLQKNRILRREREKQALH
VGDEVKVASYDQTGTLLEQFDKKHWQVQLGILKMKVPTDELKKIKSSKQSAAQRPVVKVSGGGMSGPSTTLDLRGERYDQ
AMADLDQYIDAALLAGYPSVTIIHGLGTGAIRNGVTQYLKRNRQVKTYGFAPQNAGGSGATIVNFK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain

Homologues:

Organism=Homo sapiens, GI284813531, Length=324, Percent_Identity=28.3950617283951, Blast_Score=124, Evalue=5e-28,
Organism=Homo sapiens, GI26638666, Length=314, Percent_Identity=30.2547770700637, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI4505253, Length=314, Percent_Identity=30.2547770700637, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI36949366, Length=356, Percent_Identity=25.8426966292135, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI4557761, Length=215, Percent_Identity=30.2325581395349, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI26638664, Length=315, Percent_Identity=30.1587301587302, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4504191, Length=270, Percent_Identity=28.1481481481481, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI262231786, Length=201, Percent_Identity=34.3283582089552, Blast_Score=89, Evalue=2e-17,
Organism=Escherichia coli, GI1789089, Length=321, Percent_Identity=24.9221183800623, Blast_Score=102, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17534743, Length=335, Percent_Identity=25.6716417910448, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17508445, Length=238, Percent_Identity=27.7310924369748, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17539736, Length=256, Percent_Identity=26.171875, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508447, Length=195, Percent_Identity=28.2051282051282, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6319935, Length=316, Percent_Identity=30.6962025316456, Blast_Score=113, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6324482, Length=304, Percent_Identity=27.3026315789474, Blast_Score=107, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6321912, Length=333, Percent_Identity=24.024024024024, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6321109, Length=226, Percent_Identity=27.8761061946903, Blast_Score=88, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6320047, Length=209, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320302, Length=241, Percent_Identity=26.1410788381743, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24664545, Length=480, Percent_Identity=25.4166666666667, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24584320, Length=256, Percent_Identity=25.78125, Blast_Score=94, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTS2_LACC3 (Q03AZ5)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_806069.1
- ProteinModelPortal:   Q03AZ5
- SMR:   Q03AZ5
- STRING:   Q03AZ5
- GeneID:   4419379
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_0791
- eggNOG:   COG1193
- HOGENOM:   HBG486560
- OMA:   PGLVHDQ
- ProtClustDB:   CLSK842761
- BioCyc:   LCAS321967:LSEI_0791-MONOMER
- HAMAP:   MF_00092
- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625
- PANTHER:   PTHR11361
- PIRSF:   PIRSF005814
- SMART:   SM00534
- SMART:   SM00533
- SMART:   SM00463
- TIGRFAMs:   TIGR01069

Pfam domain/function: PF00488 MutS_V; PF01713 Smr; SSF48334 DNA_repair_MutS_domIII

EC number: NA

Molecular weight: Translated: 86011; Mature: 86011

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2; PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEKILKTLEYDKIQQALLGQVVTANGRQLVQAMQPLTDPVAVQQALDETADGASALRLK
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEC
GGIPVPQLENIDPALKRVDIGAVLNGQELASISRVLQTVSAIDKFLTDLQDQIDFRQLYT
CCCCCCCCCCCCHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQESLTVLPQLSRRLKTAVDPDGTLTDEASPQLHGVREQIKSIEGEIRGKMTNYTRGAQS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCHHH
KYLSDPIVTIRDDRYVIPVKAEYRAKFGGVVHDQSATGQTLFIEPQAIVALNNRLREAQL
HHCCCCCEEEECCCEEEEECHHHHHHHCCEEECCCCCCCEEEECCHHHHHHHHHHHHHHH
AEVAEINRILAELSNELAPYTGQIKANAAVLGHFDFINAKARLAKAEKATEPLVSADNDV
HHHHHHHHHHHHHHHHCCCCCCCEEECEEEEECHHHHHHHHHHHHHHHHCCCHHCCCCCE
LLRDARHPLIDPHKVVGNDIPLGDKYQAMVITGPNTGGKTITLKTLGLLQLMGQSGLFIP
EEECCCCCCCCCHHHCCCCCCCCCCEEEEEEECCCCCCCEEEEHHHHHHHHHCCCCCEEE
ADDESRIGIFDEVFADIGDEQSIEQNLSTFSAHMDNIVHILKQLSQNSLVLFDELGAGTD
CCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
PQEGAALAIAILDAVGEVGAYVVATTHYPELKLYGYNTAKTINASMEFDSKTLQPTYRLL
CCCCHHHHHHHHHHHHHCCEEEEEEECCCCEEEEECCCCCEEECCCCCCCCCCCCCEEEE
VGVPGRSNAFDISARLGLPGVIVERAKSMISSDSHELNNMISDLEKQRKAAETAYEAARR
EECCCCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLADAQSVHDELAAAYKKFTTERDAQLQQAKDKANTLVDKAQTKADKIIKQLRQMQLTNP
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GTVKENQLIAAKTALKQLHQDEPLQKNRILRREREKQALHVGDEVKVASYDQTGTLLEQF
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHH
DKKHWQVQLGILKMKVPTDELKKIKSSKQSAAQRPVVKVSGGGMSGPSTTLDLRGERYDQ
CHHHEEEEEEEEEEECCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEECCCCHHHH
AMADLDQYIDAALLAGYPSVTIIHGLGTGAIRNGVTQYLKRNRQVKTYGFAPQNAGGSGA
HHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCC
TIVNFK
EEEEEC
>Mature Secondary Structure
MNEKILKTLEYDKIQQALLGQVVTANGRQLVQAMQPLTDPVAVQQALDETADGASALRLK
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEC
GGIPVPQLENIDPALKRVDIGAVLNGQELASISRVLQTVSAIDKFLTDLQDQIDFRQLYT
CCCCCCCCCCCCHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQESLTVLPQLSRRLKTAVDPDGTLTDEASPQLHGVREQIKSIEGEIRGKMTNYTRGAQS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCHHH
KYLSDPIVTIRDDRYVIPVKAEYRAKFGGVVHDQSATGQTLFIEPQAIVALNNRLREAQL
HHCCCCCEEEECCCEEEEECHHHHHHHCCEEECCCCCCCEEEECCHHHHHHHHHHHHHHH
AEVAEINRILAELSNELAPYTGQIKANAAVLGHFDFINAKARLAKAEKATEPLVSADNDV
HHHHHHHHHHHHHHHHCCCCCCCEEECEEEEECHHHHHHHHHHHHHHHHCCCHHCCCCCE
LLRDARHPLIDPHKVVGNDIPLGDKYQAMVITGPNTGGKTITLKTLGLLQLMGQSGLFIP
EEECCCCCCCCCHHHCCCCCCCCCCEEEEEEECCCCCCCEEEEHHHHHHHHHCCCCCEEE
ADDESRIGIFDEVFADIGDEQSIEQNLSTFSAHMDNIVHILKQLSQNSLVLFDELGAGTD
CCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
PQEGAALAIAILDAVGEVGAYVVATTHYPELKLYGYNTAKTINASMEFDSKTLQPTYRLL
CCCCHHHHHHHHHHHHHCCEEEEEEECCCCEEEEECCCCCEEECCCCCCCCCCCCCEEEE
VGVPGRSNAFDISARLGLPGVIVERAKSMISSDSHELNNMISDLEKQRKAAETAYEAARR
EECCCCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLADAQSVHDELAAAYKKFTTERDAQLQQAKDKANTLVDKAQTKADKIIKQLRQMQLTNP
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GTVKENQLIAAKTALKQLHQDEPLQKNRILRREREKQALHVGDEVKVASYDQTGTLLEQF
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHH
DKKHWQVQLGILKMKVPTDELKKIKSSKQSAAQRPVVKVSGGGMSGPSTTLDLRGERYDQ
CHHHEEEEEEEEEEECCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEECCCCHHHH
AMADLDQYIDAALLAGYPSVTIIHGLGTGAIRNGVTQYLKRNRQVKTYGFAPQNAGGSGA
HHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCC
TIVNFK
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA