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The map label for this gene is trxA [H]

Identifier: 116494336

GI number: 116494336

Start: 788858

End: 789169

Strand: Direct

Name: trxA [H]

Synonym: LSEI_0792

Alternate gene names: 116494336

Gene position: 788858-789169 (Clockwise)

Preceding gene: 116494335

Following gene: 116494337

Centisome position: 27.25

GC content: 47.12

Gene sequence:

>312_bases
ATGGTTCAAGCAGTAACAGATTCAAACTACAAGACGGAGACCGACACTGGCGTCACCCTAACAGATTTTTGGGCGACTTG
GTGCGGCCCTTGCCGGATGCAGAGTCCGGTCATCGACAAATTGGCAGAAAGTCGCGATGACGTTAAATTCGTGAAAATGG
ACGTCGACGCCAATCCAGAGACACCAAAGTCTTTTGGCATTATGGCCATTCCAACCTTGGTCATCAAAAAAGATGGCGAG
GTTGTTGAGAAGCTTGTTGGCTATCAAACCAAGGATCAGTTGGAGTCAACCTTGAACAAATATACGGCTTAA

Upstream 100 bases:

>100_bases
TGGCTCAGGAGCTACCATCGTAAACTTTAAGTAGCAGGTAGTTTTTTACACTTCATTGTGCTATGATTTAGTTACAAAAA
GTAAGAGGAGGGATCCGTTC

Downstream 100 bases:

>100_bases
TGAATAAGTGAACAGACACGCATCGACGCTACTGGTCGATGCGTGTTTTTTTGCACTAAAACATGTTGAATGGGATGTCG
CTTAAGATGAAGCTGACAGG

Product: Thiol-disulfide isomerase and thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 103; Mature: 103

Protein sequence:

>103_residues
MVQAVTDSNYKTETDTGVTLTDFWATWCGPCRMQSPVIDKLAESRDDVKFVKMDVDANPETPKSFGIMAIPTLVIKKDGE
VVEKLVGYQTKDQLESTLNKYTA

Sequences:

>Translated_103_residues
MVQAVTDSNYKTETDTGVTLTDFWATWCGPCRMQSPVIDKLAESRDDVKFVKMDVDANPETPKSFGIMAIPTLVIKKDGE
VVEKLVGYQTKDQLESTLNKYTA
>Mature_103_residues
MVQAVTDSNYKTETDTGVTLTDFWATWCGPCRMQSPVIDKLAESRDDVKFVKMDVDANPETPKSFGIMAIPTLVIKKDGE
VVEKLVGYQTKDQLESTLNKYTA

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=82, Percent_Identity=37.8048780487805, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87082331, Length=102, Percent_Identity=40.1960784313725, Blast_Score=85, Evalue=9e-19,
Organism=Escherichia coli, GI1788936, Length=82, Percent_Identity=43.9024390243902, Blast_Score=77, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71980562, Length=70, Percent_Identity=34.2857142857143, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=86, Percent_Identity=30.2325581395349, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319925, Length=68, Percent_Identity=47.0588235294118, Blast_Score=80, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6321648, Length=87, Percent_Identity=37.9310344827586, Blast_Score=72, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=88, Percent_Identity=37.5, Blast_Score=69, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639826, Length=87, Percent_Identity=34.4827586206897, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11495; Mature: 11495

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQAVTDSNYKTETDTGVTLTDFWATWCGPCRMQSPVIDKLAESRDDVKFVKMDVDANPE
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCC
TPKSFGIMAIPTLVIKKDGEVVEKLVGYQTKDQLESTLNKYTA
CCCCCCCEECCEEEEECCCHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MVQAVTDSNYKTETDTGVTLTDFWATWCGPCRMQSPVIDKLAESRDDVKFVKMDVDANPE
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCC
TPKSFGIMAIPTLVIKKDGEVVEKLVGYQTKDQLESTLNKYTA
CCCCCCCEECCEEEEECCCHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]