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The map label for this gene is ribBA [H]

Identifier: 116493544

GI number: 116493544

Start: 1798003

End: 1799217

Strand: Reverse

Name: ribBA [H]

Synonym: PEPE_1818

Alternate gene names: 116493544

Gene position: 1799217-1798003 (Counterclockwise)

Preceding gene: 116493545

Following gene: 116493543

Centisome position: 98.19

GC content: 40.33

Gene sequence:

>1215_bases
ATGAAAAATAGAATAATCGAAAAAATTGAAAATGCTCTACAAACTTTGAAAAATGGCGGCCTCATTATCATAACGGACGA
TGAAAATCGTGAAAGTGAAGGAGACATGGTGGGGTTGGCCGAATATGTTACCCCAAAAGCAGTCAATACGATGGTTACCA
ATGCTCGAGGACTGTTGTGCGTACCGATGAGTGCGGAGATAGCTCAAAAATTGGGATTATCACCAATGGTTACTAATGCG
GAAGATGCTTTTGGAACGGCGTTTACCATCAGTACCGATGCTAAAACCACTAAAACAGGGATTTCAGCTTTTGACCGCGC
TAAAACCATTCAAAAGTTAGCGGATCCCCAAGCTAAATTTAGTGAATTTTATCATCCAGGGCATGTCTTTCCCCTAATTG
CTGAAGAAGGTGGGGTGCTAGCAAGAGGTGGGCATACTGAAGCGGCAGTTGATCTGGCTAAGTTAGCTGGAGTTCGGCCA
GTAGCCTACATTACGGAAGTTTTGAAAAAAGACGGCACAATGGCCCGTCGAAACACCCTTAAATCCTTGGCCGAAGGAAT
GCAAATGCCACTATTAACCATTGAAGAAATTAAAATATATCGTTATATGAAAGATGCTGGAATAGTTAAATCGGTTGCGA
AAGTCCATTTACCTACTAAATATGGGGAATTTGAGATGGAAGCTTTTGATACGGGGGCTGGGCAGGAACCAACTTTACTT
TTAACTAAAGGAAGTCTATCTGAAGTTCAACCCTTGTTACTTCGAATCCACTCCGAATGTTTAACTGGTGATATTTTTGG
TTCCAAGCGATGTGATTGTGGTGAGCAATTAGAACGTTCCTTAAAGGAAATCCAAAGCCGTGGAAGAGGAGCTTTGTTGT
ATTTACGTCAAGAGGGTAGAGGAATTGGTCTTGCTAATAAATTAAAGGCTTATGAACTTCAAGAGCAAGGGATGGATACA
GTTGAAGCTAATCTGAAGTTAGGATTTCAAGCTGACGAACGGCATTATGGAGTAGCTGCTGCAATTCTAAGAAAAAAAGG
AATCACGAAAGTTAATTTACTAACCAATAATCCTGACAAGATTAAACAATTAGAAACGTTGGGTATCAAGGTAGAGGAGC
GAGTGACAATCCAAATCCCAGCACGCCCCGAAAATCGAAGCTATTTAAAAGTTAAAAAAGAAAAAATGCATCATTTATTG
AAAGGAATGGATTAA

Upstream 100 bases:

>100_bases
CAAGTAACCACGCTAGGTAATTTAAAGGCTAATGATGTTGTGAATGTTGAAACTGATATTTTAGGAAAATACATTTTAAA
CGAAAATCGTGGTGTAAATA

Downstream 100 bases:

>100_bases
ATGACAGAATATTTAGGTACTTTTAATGGAAGTAAACTTAAAATCGCGATCATAGTAGCGCGTTTTAATGATTTAGTGAC
AAAGCGTTTACTGGATGGGG

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKNRIIEKIENALQTLKNGGLIIITDDENRESEGDMVGLAEYVTPKAVNTMVTNARGLLCVPMSAEIAQKLGLSPMVTNA
EDAFGTAFTISTDAKTTKTGISAFDRAKTIQKLADPQAKFSEFYHPGHVFPLIAEEGGVLARGGHTEAAVDLAKLAGVRP
VAYITEVLKKDGTMARRNTLKSLAEGMQMPLLTIEEIKIYRYMKDAGIVKSVAKVHLPTKYGEFEMEAFDTGAGQEPTLL
LTKGSLSEVQPLLLRIHSECLTGDIFGSKRCDCGEQLERSLKEIQSRGRGALLYLRQEGRGIGLANKLKAYELQEQGMDT
VEANLKLGFQADERHYGVAAAILRKKGITKVNLLTNNPDKIKQLETLGIKVEERVTIQIPARPENRSYLKVKKEKMHHLL
KGMD

Sequences:

>Translated_404_residues
MKNRIIEKIENALQTLKNGGLIIITDDENRESEGDMVGLAEYVTPKAVNTMVTNARGLLCVPMSAEIAQKLGLSPMVTNA
EDAFGTAFTISTDAKTTKTGISAFDRAKTIQKLADPQAKFSEFYHPGHVFPLIAEEGGVLARGGHTEAAVDLAKLAGVRP
VAYITEVLKKDGTMARRNTLKSLAEGMQMPLLTIEEIKIYRYMKDAGIVKSVAKVHLPTKYGEFEMEAFDTGAGQEPTLL
LTKGSLSEVQPLLLRIHSECLTGDIFGSKRCDCGEQLERSLKEIQSRGRGALLYLRQEGRGIGLANKLKAYELQEQGMDT
VEANLKLGFQADERHYGVAAAILRKKGITKVNLLTNNPDKIKQLETLGIKVEERVTIQIPARPENRSYLKVKKEKMHHLL
KGMD
>Mature_404_residues
MKNRIIEKIENALQTLKNGGLIIITDDENRESEGDMVGLAEYVTPKAVNTMVTNARGLLCVPMSAEIAQKLGLSPMVTNA
EDAFGTAFTISTDAKTTKTGISAFDRAKTIQKLADPQAKFSEFYHPGHVFPLIAEEGGVLARGGHTEAAVDLAKLAGVRP
VAYITEVLKKDGTMARRNTLKSLAEGMQMPLLTIEEIKIYRYMKDAGIVKSVAKVHLPTKYGEFEMEAFDTGAGQEPTLL
LTKGSLSEVQPLLLRIHSECLTGDIFGSKRCDCGEQLERSLKEIQSRGRGALLYLRQEGRGIGLANKLKAYELQEQGMDT
VEANLKLGFQADERHYGVAAAILRKKGITKVNLLTNNPDKIKQLETLGIKVEERVTIQIPARPENRSYLKVKKEKMHHLL
KGMD

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=50.7772020725389, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1789420, Length=197, Percent_Identity=41.6243654822335, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320695, Length=201, Percent_Identity=42.7860696517413, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319438, Length=195, Percent_Identity=44.1025641025641, Blast_Score=137, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44494; Mature: 44494

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNRIIEKIENALQTLKNGGLIIITDDENRESEGDMVGLAEYVTPKAVNTMVTNARGLLC
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEHHHHCCCHHHHHHHHCCCCEEE
VPMSAEIAQKLGLSPMVTNAEDAFGTAFTISTDAKTTKTGISAFDRAKTIQKLADPQAKF
ECCCHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHH
SEFYHPGHVFPLIAEEGGVLARGGHTEAAVDLAKLAGVRPVAYITEVLKKDGTMARRNTL
HHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHH
KSLAEGMQMPLLTIEEIKIYRYMKDAGIVKSVAKVHLPTKYGEFEMEAFDTGAGQEPTLL
HHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEE
LTKGSLSEVQPLLLRIHSECLTGDIFGSKRCDCGEQLERSLKEIQSRGRGALLYLRQEGR
EECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCC
GIGLANKLKAYELQEQGMDTVEANLKLGFQADERHYGVAAAILRKKGITKVNLLTNNPDK
CCCCHHHHHHHHHHHCCCCEEECCEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHH
IKQLETLGIKVEERVTIQIPARPENRSYLKVKKEKMHHLLKGMD
HHHHHHHCEEEECEEEEEECCCCCCCCHHEEHHHHHHHHHCCCC
>Mature Secondary Structure
MKNRIIEKIENALQTLKNGGLIIITDDENRESEGDMVGLAEYVTPKAVNTMVTNARGLLC
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEHHHHCCCHHHHHHHHCCCCEEE
VPMSAEIAQKLGLSPMVTNAEDAFGTAFTISTDAKTTKTGISAFDRAKTIQKLADPQAKF
ECCCHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHH
SEFYHPGHVFPLIAEEGGVLARGGHTEAAVDLAKLAGVRPVAYITEVLKKDGTMARRNTL
HHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHH
KSLAEGMQMPLLTIEEIKIYRYMKDAGIVKSVAKVHLPTKYGEFEMEAFDTGAGQEPTLL
HHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCEEE
LTKGSLSEVQPLLLRIHSECLTGDIFGSKRCDCGEQLERSLKEIQSRGRGALLYLRQEGR
EECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCC
GIGLANKLKAYELQEQGMDTVEANLKLGFQADERHYGVAAAILRKKGITKVNLLTNNPDK
CCCCHHHHHHHHHHHCCCCEEECCEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHH
IKQLETLGIKVEERVTIQIPARPENRSYLKVKKEKMHHLLKGMD
HHHHHHHCEEEECEEEEEECCCCCCCCHHEEHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA