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The map label for this gene is ribH

Identifier: 116493543

GI number: 116493543

Start: 1797532

End: 1798002

Strand: Reverse

Name: ribH

Synonym: PEPE_1817

Alternate gene names: 116493543

Gene position: 1798002-1797532 (Counterclockwise)

Preceding gene: 116493544

Following gene: 116493542

Centisome position: 98.12

GC content: 39.49

Gene sequence:

>471_bases
ATGACAGAATATTTAGGTACTTTTAATGGAAGTAAACTTAAAATCGCGATCATAGTAGCGCGTTTTAATGATTTAGTGAC
AAAGCGTTTACTGGATGGGGCTTTTCAAACTTTAGCTCAAAATGGAGTTTCCAAGGAAGATATCGATATTTATTGGGTAC
CTGGAGCGTTTGAAATTCCACGCGTAGCTCAAAAAATAAGCCAGAAAGGTAATGTAGATGGAATAATTACTTTAGGAGCA
GTCGTTCGAGGTGAAACATCGCATTATGAATCGGTTTGTTCAGGAGTAACAAGTGGAATCGCTCAAATAGCGTTAGAAGG
AAAAGTACCGGTGATGTTTGGAGTGCTCATGACAGAAAATATGGAACAGGCTCTTAATCGAGCGGGTGGTAAAGCCGGAA
ATAAGGGTAGTGAATGTGCAACGGGGCTACTGGAAATGATTGATATTGAGCAAACAATAGATAGGGAATAG

Upstream 100 bases:

>100_bases
GGAGCGAGTGACAATCCAAATCCCAGCACGCCCCGAAAATCGAAGCTATTTAAAAGTTAAAAAAGAAAAAATGCATCATT
TATTGAAAGGAATGGATTAA

Downstream 100 bases:

>100_bases
TGATACAAGGATTTAATGGTTGTTCAAAAAAGCGGTCTACGGAGGTTGAAACCAATATTTTTTTGAAAAACTTTAGTCCT
TTAGACCACGGTAAATTTAA

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 156; Mature: 155

Protein sequence:

>156_residues
MTEYLGTFNGSKLKIAIIVARFNDLVTKRLLDGAFQTLAQNGVSKEDIDIYWVPGAFEIPRVAQKISQKGNVDGIITLGA
VVRGETSHYESVCSGVTSGIAQIALEGKVPVMFGVLMTENMEQALNRAGGKAGNKGSECATGLLEMIDIEQTIDRE

Sequences:

>Translated_156_residues
MTEYLGTFNGSKLKIAIIVARFNDLVTKRLLDGAFQTLAQNGVSKEDIDIYWVPGAFEIPRVAQKISQKGNVDGIITLGA
VVRGETSHYESVCSGVTSGIAQIALEGKVPVMFGVLMTENMEQALNRAGGKAGNKGSECATGLLEMIDIEQTIDRE
>Mature_155_residues
TEYLGTFNGSKLKIAIIVARFNDLVTKRLLDGAFQTLAQNGVSKEDIDIYWVPGAFEIPRVAQKISQKGNVDGIITLGAV
VRGETSHYESVCSGVTSGIAQIALEGKVPVMFGVLMTENMEQALNRAGGKAGNKGSECATGLLEMIDIEQTIDRE

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=141, Percent_Identity=46.8085106382979, Blast_Score=142, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324429, Length=148, Percent_Identity=31.7567567567568, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_PEDPA (Q03D86)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_805278.1
- ProteinModelPortal:   Q03D86
- SMR:   Q03D86
- STRING:   Q03D86
- GeneID:   4417363
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_1817
- NMPDR:   fig|278197.10.peg.1609
- eggNOG:   COG0054
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- PhylomeDB:   Q03D86
- BioCyc:   PPEN278197:PEPE_1817-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 16751; Mature: 16620

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEYLGTFNGSKLKIAIIVARFNDLVTKRLLDGAFQTLAQNGVSKEDIDIYWVPGAFEIP
CCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHH
RVAQKISQKGNVDGIITLGAVVRGETSHYESVCSGVTSGIAQIALEGKVPVMFGVLMTEN
HHHHHHHHCCCCCEEEEECHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MEQALNRAGGKAGNKGSECATGLLEMIDIEQTIDRE
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEYLGTFNGSKLKIAIIVARFNDLVTKRLLDGAFQTLAQNGVSKEDIDIYWVPGAFEIP
CCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHH
RVAQKISQKGNVDGIITLGAVVRGETSHYESVCSGVTSGIAQIALEGKVPVMFGVLMTEN
HHHHHHHHCCCCCEEEEECHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MEQALNRAGGKAGNKGSECATGLLEMIDIEQTIDRE
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA