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The map label for this gene is pdhB [H]

Identifier: 116493500

GI number: 116493500

Start: 1746605

End: 1747585

Strand: Reverse

Name: pdhB [H]

Synonym: PEPE_1772

Alternate gene names: 116493500

Gene position: 1747585-1746605 (Counterclockwise)

Preceding gene: 116493501

Following gene: 116493499

Centisome position: 95.37

GC content: 42.92

Gene sequence:

>981_bases
ATGGCACAAAAAACATATATCCAAGCGATTACTGAAGCTCAAGATTTAGCTCTTGCTAACGATGAAAATGTAGTTATCTT
TGGTGAAGACGTTGGTAAAAATGGTGGTGTATTTAGAGCTACGGATGGTCTTCAGGCGAAATATGGTGAAGATCGGGTTT
TCAACACTCCACTAGCTGAAAGTGGAATTGGTGGAATGGCAATTGGGATGACAACCCAAAACTACCGTCCAATTATGGAA
ATCCAATTCTTCGGCTTTGTATATGAAGTTATGGATTCACTTGCAGGACAGATGGCACGTGGACGTTTCCGTTTCCATGG
AACACGTACATTTCCAATTGTGGTTCGCTCTCCTTATGGCGGTGGAACTAAGACCCCTGAAATGCATGCGGACTCCTTGG
AAGGTTTAGTAGCTCAAACACCTGGTCTACGAGTAGTTATGCCAGCTACTCCAGCAGATGCTAAAGGATTGTTACTATCA
GCTGTTGAAAGTAATGATCCGGTAATCTTCCTTGAAAATCTTCGTTTATATCGTTCAATTCGTGGCGATGTTCCAGAAGG
TTACTACACCACACCATTGGATAAGGCCAATGTGATTCGTGAAGGTAAGGACGTATCAATTATCACCTATGGTGGAATGG
TACATACAAGCTTAGCGGCCGCAGAAGAACTTGCTAAAGACGGCATTGACGCTGAAGTTGTAGATTTGAGAACGGTTAGT
CCACTTGATCTCGACACAATTGGAGAAAGCGTTGAAAAGACTGGTCGAGTTGTTGTAGCTCAAGAAGCACAACGGCAAGC
TGGTATTGGTGCAATGGTAATGAGTGAAATTAGTGAACGCTTCATTATGAGTTTGAAAGCACCAATCGGACGGGTAGCTG
CTCCAGATTCAGTATATCCATTTGCCCTTGCTGAAAATGAATGGTTACCAAAAGCAGACGATATCATCGAAAAAGTTAAG
GAGGTCGTGAACTTTGACTGA

Upstream 100 bases:

>100_bases
ATAAACAAAAGATTTCAGACTTTATTGAACAAACTCTAGAAGTTCCAGGACAAGCTGCACAAGAACAAATTAACAAATTT
AGAGGGGAGGGCAAGTAATC

Downstream 100 bases:

>100_bases
AATTTTTAAGATGCCAGATATTGGCGAAGGAATGGCTGAAGGCGAAATTGCAAACTGGTTAGTAAAAGTCGGCGATACGA
TTAAAGAAGAAGATGCAGTA

Product: pyruvate dehydrogenase (E1) component, beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MAQKTYIQAITEAQDLALANDENVVIFGEDVGKNGGVFRATDGLQAKYGEDRVFNTPLAESGIGGMAIGMTTQNYRPIME
IQFFGFVYEVMDSLAGQMARGRFRFHGTRTFPIVVRSPYGGGTKTPEMHADSLEGLVAQTPGLRVVMPATPADAKGLLLS
AVESNDPVIFLENLRLYRSIRGDVPEGYYTTPLDKANVIREGKDVSIITYGGMVHTSLAAAEELAKDGIDAEVVDLRTVS
PLDLDTIGESVEKTGRVVVAQEAQRQAGIGAMVMSEISERFIMSLKAPIGRVAAPDSVYPFALAENEWLPKADDIIEKVK
EVVNFD

Sequences:

>Translated_326_residues
MAQKTYIQAITEAQDLALANDENVVIFGEDVGKNGGVFRATDGLQAKYGEDRVFNTPLAESGIGGMAIGMTTQNYRPIME
IQFFGFVYEVMDSLAGQMARGRFRFHGTRTFPIVVRSPYGGGTKTPEMHADSLEGLVAQTPGLRVVMPATPADAKGLLLS
AVESNDPVIFLENLRLYRSIRGDVPEGYYTTPLDKANVIREGKDVSIITYGGMVHTSLAAAEELAKDGIDAEVVDLRTVS
PLDLDTIGESVEKTGRVVVAQEAQRQAGIGAMVMSEISERFIMSLKAPIGRVAAPDSVYPFALAENEWLPKADDIIEKVK
EVVNFD
>Mature_325_residues
AQKTYIQAITEAQDLALANDENVVIFGEDVGKNGGVFRATDGLQAKYGEDRVFNTPLAESGIGGMAIGMTTQNYRPIMEI
QFFGFVYEVMDSLAGQMARGRFRFHGTRTFPIVVRSPYGGGTKTPEMHADSLEGLVAQTPGLRVVMPATPADAKGLLLSA
VESNDPVIFLENLRLYRSIRGDVPEGYYTTPLDKANVIREGKDVSIITYGGMVHTSLAAAEELAKDGIDAEVVDLRTVSP
LDLDTIGESVEKTGRVVVAQEAQRQAGIGAMVMSEISERFIMSLKAPIGRVAAPDSVYPFALAENEWLPKADDIIEKVKE
VVNFD

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=325, Percent_Identity=40, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI34101272, Length=325, Percent_Identity=40, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI156564403, Length=327, Percent_Identity=33.6391437308869, Blast_Score=197, Evalue=9e-51,
Organism=Homo sapiens, GI291084858, Length=327, Percent_Identity=32.1100917431193, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17506935, Length=324, Percent_Identity=40.7407407407407, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17538422, Length=321, Percent_Identity=33.6448598130841, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319698, Length=329, Percent_Identity=34.0425531914894, Blast_Score=183, Evalue=4e-47,
Organism=Drosophila melanogaster, GI160714828, Length=322, Percent_Identity=40.9937888198758, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI160714832, Length=322, Percent_Identity=40.9937888198758, Blast_Score=237, Evalue=7e-63,
Organism=Drosophila melanogaster, GI21358145, Length=326, Percent_Identity=36.5030674846626, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24650940, Length=326, Percent_Identity=36.5030674846626, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24650943, Length=90, Percent_Identity=36.6666666666667, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24650945, Length=90, Percent_Identity=36.6666666666667, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI160714826, Length=62, Percent_Identity=54.8387096774194, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35356; Mature: 35224

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQKTYIQAITEAQDLALANDENVVIFGEDVGKNGGVFRATDGLQAKYGEDRVFNTPLAE
CCCHHHHHHHHHHHHHEEECCCCEEEECCCCCCCCCEEEECCCCCCCCCCCCEECCCCCC
SGIGGMAIGMTTQNYRPIMEIQFFGFVYEVMDSLAGQMARGRFRFHGTRTFPIVVRSPYG
CCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHCCEEEEECCEEEEEEEECCCC
GGTKTPEMHADSLEGLVAQTPGLRVVMPATPADAKGLLLSAVESNDPVIFLENLRLYRSI
CCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCCEEEECCHHHHHHH
RGDVPEGYYTTPLDKANVIREGKDVSIITYGGMVHTSLAAAEELAKDGIDAEVVDLRTVS
CCCCCCCCEECCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCC
PLDLDTIGESVEKTGRVVVAQEAQRQAGIGAMVMSEISERFIMSLKAPIGRVAAPDSVYP
CCCHHHHHHHHHHCCCEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
FALAENEWLPKADDIIEKVKEVVNFD
EEEECCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AQKTYIQAITEAQDLALANDENVVIFGEDVGKNGGVFRATDGLQAKYGEDRVFNTPLAE
CCHHHHHHHHHHHHHEEECCCCEEEECCCCCCCCCEEEECCCCCCCCCCCCEECCCCCC
SGIGGMAIGMTTQNYRPIMEIQFFGFVYEVMDSLAGQMARGRFRFHGTRTFPIVVRSPYG
CCCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHCCEEEEECCEEEEEEEECCCC
GGTKTPEMHADSLEGLVAQTPGLRVVMPATPADAKGLLLSAVESNDPVIFLENLRLYRSI
CCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCCEEEECCHHHHHHH
RGDVPEGYYTTPLDKANVIREGKDVSIITYGGMVHTSLAAAEELAKDGIDAEVVDLRTVS
CCCCCCCCEECCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEEECCC
PLDLDTIGESVEKTGRVVVAQEAQRQAGIGAMVMSEISERFIMSLKAPIGRVAAPDSVYP
CCCHHHHHHHHHHCCCEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
FALAENEWLPKADDIIEKVKEVVNFD
EEEECCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674; 2253629 [H]