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The map label for this gene is pdhA [H]

Identifier: 116493501

GI number: 116493501

Start: 1747588

End: 1748706

Strand: Reverse

Name: pdhA [H]

Synonym: PEPE_1773

Alternate gene names: 116493501

Gene position: 1748706-1747588 (Counterclockwise)

Preceding gene: 116493502

Following gene: 116493500

Centisome position: 95.43

GC content: 40.39

Gene sequence:

>1119_bases
ATGGCTGTAAAAGATGACAATAAACAAGTGTTAGATTTCAATCTTCAAATGGAAAAACAAACAGACAGTTTTCCAATGCT
ACAAGTTCTAAATAATGATGGTGAGATTGTAGACGAGGATGCTCTTAAAGAGGCTGGTTTGAGTGACGATCAGCTCGTTG
AACTTATGAAACAGATGGTATTTAGTCGTGTGCTACATGAACGTTCCACTAAACTAGCAAAACAAGGACGCCTAGGTTTC
TATGCTCCAACCATTGGGGAAGAAGCCTCTCAAATTGCTTCGAATTATGCGTTTGAAAAAGGAGATTGGCTTTTCCCAGG
TTATCGTGATATTCCGCAATTAGTAATGAAAGGTTGGCCGATTTATAAGGCTTTCTTGTGGTCACGTGGCCATTATGAAG
GAAATGAATTTGACGATGTTAATGGCTGGATGCCACAAATTATTATCGGTGCTCAATATGTTGAAGCTGCTGGTGCAGCC
CTAGGTTTGAAGATGCGTAAACAACCTAATGTGGCTTATGCCTACACTGGTGATGGTGGTACTTCGCAAGGTGATTTTTA
CGAAGGAATGAACTTTGCTGGCGCATATAACGCACCCGCCGTATTCTTCTCACAAAATAATGAATACGCTATCTCAACAC
CACGTAAATTACAAACTAAGGCTCCTCATCTAGCAGCTAAAGGTTGGGCAGCTGGTCTTCCAAGTTTGGTTGTGGATGGA
ATGGATCCAATTGCAATGTACCTAGCATCTAAGAAGGCACGTCAATGGGCAGTTGATGGTAATGGACCTGTATTTATTGA
AACAATTACTAATCGTTTGGGTGCACACTCGATGTCTGGTGATGATCCACTTCGTTACCGTACTCAAGAAGAAATTGATG
AATGGACTAAGAAAGAACCACTTATCCGTTTCAGAAAATATCTTGAAGGATTGGGTTTCTGGTCTGAAGAAATTGAAAAT
GACTGGACCGAAGTGGTTAATGAACAAATTGATGACGGCGTAAAACAAGCAGATGGAATCGATAAACAAAAGATTTCAGA
CTTTATTGAACAAACTCTAGAAGTTCCAGGACAAGCTGCACAAGAACAAATTAACAAATTTAGAGGGGAGGGCAAGTAA

Upstream 100 bases:

>100_bases
AGATTAAGCCCGTCTTTGAACGTAACCATGAAGGCCGGTACTTCGGAAACATTACGGATGATGAATTAATTAAATTATTT
GAAGCTTAGGAGGTTTAGTT

Downstream 100 bases:

>100_bases
TCATGGCACAAAAAACATATATCCAAGCGATTACTGAAGCTCAAGATTTAGCTCTTGCTAACGATGAAAATGTAGTTATC
TTTGGTGAAGACGTTGGTAA

Product: pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MAVKDDNKQVLDFNLQMEKQTDSFPMLQVLNNDGEIVDEDALKEAGLSDDQLVELMKQMVFSRVLHERSTKLAKQGRLGF
YAPTIGEEASQIASNYAFEKGDWLFPGYRDIPQLVMKGWPIYKAFLWSRGHYEGNEFDDVNGWMPQIIIGAQYVEAAGAA
LGLKMRKQPNVAYAYTGDGGTSQGDFYEGMNFAGAYNAPAVFFSQNNEYAISTPRKLQTKAPHLAAKGWAAGLPSLVVDG
MDPIAMYLASKKARQWAVDGNGPVFIETITNRLGAHSMSGDDPLRYRTQEEIDEWTKKEPLIRFRKYLEGLGFWSEEIEN
DWTEVVNEQIDDGVKQADGIDKQKISDFIEQTLEVPGQAAQEQINKFRGEGK

Sequences:

>Translated_372_residues
MAVKDDNKQVLDFNLQMEKQTDSFPMLQVLNNDGEIVDEDALKEAGLSDDQLVELMKQMVFSRVLHERSTKLAKQGRLGF
YAPTIGEEASQIASNYAFEKGDWLFPGYRDIPQLVMKGWPIYKAFLWSRGHYEGNEFDDVNGWMPQIIIGAQYVEAAGAA
LGLKMRKQPNVAYAYTGDGGTSQGDFYEGMNFAGAYNAPAVFFSQNNEYAISTPRKLQTKAPHLAAKGWAAGLPSLVVDG
MDPIAMYLASKKARQWAVDGNGPVFIETITNRLGAHSMSGDDPLRYRTQEEIDEWTKKEPLIRFRKYLEGLGFWSEEIEN
DWTEVVNEQIDDGVKQADGIDKQKISDFIEQTLEVPGQAAQEQINKFRGEGK
>Mature_371_residues
AVKDDNKQVLDFNLQMEKQTDSFPMLQVLNNDGEIVDEDALKEAGLSDDQLVELMKQMVFSRVLHERSTKLAKQGRLGFY
APTIGEEASQIASNYAFEKGDWLFPGYRDIPQLVMKGWPIYKAFLWSRGHYEGNEFDDVNGWMPQIIIGAQYVEAAGAAL
GLKMRKQPNVAYAYTGDGGTSQGDFYEGMNFAGAYNAPAVFFSQNNEYAISTPRKLQTKAPHLAAKGWAAGLPSLVVDGM
DPIAMYLASKKARQWAVDGNGPVFIETITNRLGAHSMSGDDPLRYRTQEEIDEWTKKEPLIRFRKYLEGLGFWSEEIEND
WTEVVNEQIDDGVKQADGIDKQKISDFIEQTLEVPGQAAQEQINKFRGEGK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=359, Percent_Identity=32.033426183844, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI258645172, Length=359, Percent_Identity=31.7548746518106, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI4885543, Length=306, Percent_Identity=27.7777777777778, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI4505685, Length=326, Percent_Identity=25.1533742331288, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI291084742, Length=320, Percent_Identity=25.9375, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI291084744, Length=191, Percent_Identity=31.413612565445, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI291084757, Length=165, Percent_Identity=30.3030303030303, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI86563355, Length=356, Percent_Identity=32.3033707865169, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI86563357, Length=356, Percent_Identity=32.3033707865169, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17536047, Length=306, Percent_Identity=28.1045751633987, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32564172, Length=306, Percent_Identity=28.1045751633987, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321026, Length=301, Percent_Identity=28.9036544850498, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21355903, Length=339, Percent_Identity=31.5634218289086, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24639744, Length=322, Percent_Identity=27.639751552795, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28571106, Length=322, Percent_Identity=27.639751552795, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24639740, Length=323, Percent_Identity=27.5541795665635, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24639748, Length=323, Percent_Identity=28.4829721362229, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24639746, Length=197, Percent_Identity=32.48730964467, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 41780; Mature: 41649

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVKDDNKQVLDFNLQMEKQTDSFPMLQVLNNDGEIVDEDALKEAGLSDDQLVELMKQMV
CCCCCCCCEEEEEEEEECCCCCCCHHHHHHCCCCCEECHHHHHHCCCCHHHHHHHHHHHH
FSRVLHERSTKLAKQGRLGFYAPTIGEEASQIASNYAFEKGDWLFPGYRDIPQLVMKGWP
HHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCH
IYKAFLWSRGHYEGNEFDDVNGWMPQIIIGAQYVEAAGAALGLKMRKQPNVAYAYTGDGG
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCC
TSQGDFYEGMNFAGAYNAPAVFFSQNNEYAISTPRKLQTKAPHLAAKGWAAGLPSLVVDG
CCCCCHHHCCCCCCCCCCCEEEEECCCCEEECCCHHHHHCCCCHHHCCHHHCCHHHHHCC
MDPIAMYLASKKARQWAVDGNGPVFIETITNRLGAHSMSGDDPLRYRTQEEIDEWTKKEP
CCHHHHHHHHHHHHEEEECCCCCEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCH
LIRFRKYLEGLGFWSEEIENDWTEVVNEQIDDGVKQADGIDKQKISDFIEQTLEVPGQAA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHH
QEQINKFRGEGK
HHHHHHHCCCCC
>Mature Secondary Structure 
AVKDDNKQVLDFNLQMEKQTDSFPMLQVLNNDGEIVDEDALKEAGLSDDQLVELMKQMV
CCCCCCCEEEEEEEEECCCCCCCHHHHHHCCCCCEECHHHHHHCCCCHHHHHHHHHHHH
FSRVLHERSTKLAKQGRLGFYAPTIGEEASQIASNYAFEKGDWLFPGYRDIPQLVMKGWP
HHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCH
IYKAFLWSRGHYEGNEFDDVNGWMPQIIIGAQYVEAAGAALGLKMRKQPNVAYAYTGDGG
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCC
TSQGDFYEGMNFAGAYNAPAVFFSQNNEYAISTPRKLQTKAPHLAAKGWAAGLPSLVVDG
CCCCCHHHCCCCCCCCCCCEEEEECCCCEEECCCHHHHHCCCCHHHCCHHHCCHHHHHCC
MDPIAMYLASKKARQWAVDGNGPVFIETITNRLGAHSMSGDDPLRYRTQEEIDEWTKKEP
CCHHHHHHHHHHHHEEEECCCCCEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCH
LIRFRKYLEGLGFWSEEIENDWTEVVNEQIDDGVKQADGIDKQKISDFIEQTLEVPGQAA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHH
QEQINKFRGEGK
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2200674 [H]