Click here to switch to the map view.

The map label for this gene is parE [H]

Identifier: 116492722

GI number: 116492722

Start: 961103

End: 963142

Strand: Reverse

Name: parE [H]

Synonym: PEPE_0959

Alternate gene names: 116492722

Gene position: 963142-961103 (Counterclockwise)

Preceding gene: 116492724

Following gene: 116492721

Centisome position: 52.56

GC content: 40.78

Gene sequence:

>2040_bases
ATGGCAAAAACAAGTAAAACATCGTATGATGATTCATCCATCCAGGTCTTAGAAGGACTTGAAGCAGTTCGGAAGCGTCC
TGGTATGTATATTGGTTCGACCGATGGCCGTGGACTACATCATTTAGTTTACGAAATCGTCGATAACGCCGTAGATGAAG
CTCTCGGTGGATATGGAAAAGAAATTAACGTAACAATCCAAGCAGATAACAGCATTACTGTGGTCGATCACGGGCGCGGA
ATGCCGGTAGGGATGCATAAATCTGGCAAACCTACACCTGAAGTTATTTTTACCGTTTTACATGCAGGTGGAAAATTTGG
ACAGGGTGGTTATAAGACATCCGGCGGACTTCATGGTGTGGGTGCTAGTGTTGTTAATGCTCTATCTGAAAAATTAACCG
TTGAGATTGTGCGAGACAAAGTTAAATATGAAGAAACTTTCGTTAACGGGGGGCACCCAGTTGGAACCCTAAAAAAAGTT
GGTAAAACAACTAACAAAAACGGTACAACTGTCACATTCAAACCTGACAAAGAAATCTTCACAACAACTGTGTTTAACTT
CAATACGTTAGCAGTACGATTACGCGAATCGGCGTTCTTACTCCGTGGGGTTAAAATTACTTTAACGGATCGGCGTGAAG
GACACGAACAACACGAAGAATACCTTTACGATGAGGGAATTAAGCAATTCGTTGACTATCTTAATGAAGATAAAGATACC
CTTGGTAATATCATGTATTTCGATGGTACAAAAAAGGGAATCGAAGTAGAAGTAGCTGGTCAGTACAATGATGGCTATTC
TGAAACGATCCTCTCCTTTGTGAATAATGTACGTACTCGTGATGGAGGGACCCATGAGGTCGGGATGCGTTCCGGTTGGA
CCAAAGCCTTCAATGAATTTGCCCGTAAAATGGGACTGTTAAAAGAAAAAGATAAAAATTTAGAAGGCTCGGATGTGCGA
GAAGGTTTGTCTGCAGTTATTTCAGTTCGCATCCCAGAAGAATTATTGGAATTCGAAGGCCAAACCAAAGAAAAATTAGG
TACTCCTGAAGCTCGTCCGATTGTGGATGCCATTGTTAGTGAGCAACTTGGCTTTTTCTTGATGGAAAATGGTGAATTTG
CCCAACAGTTAGTTCGTAAAGCGATCAATGCCCGTGAAGCTCGAGTAGCGGCGCGAAAAGCTCGCGATGAGTCGCGGACC
GGAAAACGGAAAAAGAAACAAGAACGTATTTTATCTGGTAAATTAACTCCAGCACAATCTAAAAACTCTAAGAAAAATGA
ATTATTCTTAGTCGAAGGGGATTCTGCTGGTGGTAGTGCTAAACAGGGACGAAACCGTAAATTTCAAGCCATCTTGCCAT
TACGGGGAAAGGTTTTGAATACGGAAAAGGCTAAACTACAAGATATCGTTAAAAATGAAGAAATTAATACCATTATTTAT
ACTATTGGAGCTGGAGTTGGAACGGAATTCAATGTTCAAGACAGCAATTACGATAAAGTAATCATTATGACCGATGCCGA
TACTGATGGAGCTCATATTCAAACGTTGCTTTTAACTTTCTTCTATAAATATATGCGGCCAATGATTGATGCCGGAAAAA
TTTACATCGCTTTGCCACCGCTTTATAAGTTACAAAAAGGACTCAATAAGAAGGTTAAAATTGCATATGCTTGGACAGAT
GAAGAACTCGAAAGTGTCAGCAAACAGATGGGTCGAGGATTCTCCCTCCAACGTTTTAAGGGACTTGGTGAAATGAATGC
AGACCAACTTTGGGAAACTACGATGAATCCTGAAACTAGAACCTTAGTTCGAGTTCGTATTGATGATGACACTTTAGCTG
AACGTCGAGTAACCACCCTGATGGGCGATAAAGTTGAACCTCGCCGGAAATGGATTGAAAGCAACGTGGCTTTCACGCTT
GAAGAAGATGGTAGTATCCTAGACAACGAAGCTGTGAAACATGAGCATGAAGCTGGAGATCCAACCAATACTTCAAATGA
AACTTTTGAAGAAATTAAACTTGATATAGAAAACAATTAG

Upstream 100 bases:

>100_bases
AATTACAGTAACAATGCAGTATTATAACATTTATCGAAATGTTTTCATCAGTTTAAAAATAAGTTATGATAATAGTACTG
ACCTTAAAGGAGTAACATGA

Downstream 100 bases:

>100_bases
AAGGGGAATATGAATGGCTGATAATCAATCTAAAATTCAAGAACTGGCTCTTGAAGATATTATGGGCGATCGTTTTGGAC
GATATTCAAAATATATCATT

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MAKTSKTSYDDSSIQVLEGLEAVRKRPGMYIGSTDGRGLHHLVYEIVDNAVDEALGGYGKEINVTIQADNSITVVDHGRG
MPVGMHKSGKPTPEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEKLTVEIVRDKVKYEETFVNGGHPVGTLKKV
GKTTNKNGTTVTFKPDKEIFTTTVFNFNTLAVRLRESAFLLRGVKITLTDRREGHEQHEEYLYDEGIKQFVDYLNEDKDT
LGNIMYFDGTKKGIEVEVAGQYNDGYSETILSFVNNVRTRDGGTHEVGMRSGWTKAFNEFARKMGLLKEKDKNLEGSDVR
EGLSAVISVRIPEELLEFEGQTKEKLGTPEARPIVDAIVSEQLGFFLMENGEFAQQLVRKAINAREARVAARKARDESRT
GKRKKKQERILSGKLTPAQSKNSKKNELFLVEGDSAGGSAKQGRNRKFQAILPLRGKVLNTEKAKLQDIVKNEEINTIIY
TIGAGVGTEFNVQDSNYDKVIIMTDADTDGAHIQTLLLTFFYKYMRPMIDAGKIYIALPPLYKLQKGLNKKVKIAYAWTD
EELESVSKQMGRGFSLQRFKGLGEMNADQLWETTMNPETRTLVRVRIDDDTLAERRVTTLMGDKVEPRRKWIESNVAFTL
EEDGSILDNEAVKHEHEAGDPTNTSNETFEEIKLDIENN

Sequences:

>Translated_679_residues
MAKTSKTSYDDSSIQVLEGLEAVRKRPGMYIGSTDGRGLHHLVYEIVDNAVDEALGGYGKEINVTIQADNSITVVDHGRG
MPVGMHKSGKPTPEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEKLTVEIVRDKVKYEETFVNGGHPVGTLKKV
GKTTNKNGTTVTFKPDKEIFTTTVFNFNTLAVRLRESAFLLRGVKITLTDRREGHEQHEEYLYDEGIKQFVDYLNEDKDT
LGNIMYFDGTKKGIEVEVAGQYNDGYSETILSFVNNVRTRDGGTHEVGMRSGWTKAFNEFARKMGLLKEKDKNLEGSDVR
EGLSAVISVRIPEELLEFEGQTKEKLGTPEARPIVDAIVSEQLGFFLMENGEFAQQLVRKAINAREARVAARKARDESRT
GKRKKKQERILSGKLTPAQSKNSKKNELFLVEGDSAGGSAKQGRNRKFQAILPLRGKVLNTEKAKLQDIVKNEEINTIIY
TIGAGVGTEFNVQDSNYDKVIIMTDADTDGAHIQTLLLTFFYKYMRPMIDAGKIYIALPPLYKLQKGLNKKVKIAYAWTD
EELESVSKQMGRGFSLQRFKGLGEMNADQLWETTMNPETRTLVRVRIDDDTLAERRVTTLMGDKVEPRRKWIESNVAFTL
EEDGSILDNEAVKHEHEAGDPTNTSNETFEEIKLDIENN
>Mature_678_residues
AKTSKTSYDDSSIQVLEGLEAVRKRPGMYIGSTDGRGLHHLVYEIVDNAVDEALGGYGKEINVTIQADNSITVVDHGRGM
PVGMHKSGKPTPEVIFTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEKLTVEIVRDKVKYEETFVNGGHPVGTLKKVG
KTTNKNGTTVTFKPDKEIFTTTVFNFNTLAVRLRESAFLLRGVKITLTDRREGHEQHEEYLYDEGIKQFVDYLNEDKDTL
GNIMYFDGTKKGIEVEVAGQYNDGYSETILSFVNNVRTRDGGTHEVGMRSGWTKAFNEFARKMGLLKEKDKNLEGSDVRE
GLSAVISVRIPEELLEFEGQTKEKLGTPEARPIVDAIVSEQLGFFLMENGEFAQQLVRKAINAREARVAARKARDESRTG
KRKKKQERILSGKLTPAQSKNSKKNELFLVEGDSAGGSAKQGRNRKFQAILPLRGKVLNTEKAKLQDIVKNEEINTIIYT
IGAGVGTEFNVQDSNYDKVIIMTDADTDGAHIQTLLLTFFYKYMRPMIDAGKIYIALPPLYKLQKGLNKKVKIAYAWTDE
ELESVSKQMGRGFSLQRFKGLGEMNADQLWETTMNPETRTLVRVRIDDDTLAERRVTTLMGDKVEPRRKWIESNVAFTLE
EDGSILDNEAVKHEHEAGDPTNTSNETFEEIKLDIENN

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=614, Percent_Identity=25.8957654723127, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI19913408, Length=674, Percent_Identity=25.0741839762611, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI48994957, Length=546, Percent_Identity=52.014652014652, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1789408, Length=643, Percent_Identity=39.0357698289269, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17535065, Length=666, Percent_Identity=25.0750750750751, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI212645845, Length=613, Percent_Identity=25.2854812398042, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI212645657, Length=180, Percent_Identity=26.1111111111111, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=637, Percent_Identity=25.74568288854, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17136538, Length=669, Percent_Identity=26.9058295964126, Blast_Score=134, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005740 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 75743; Mature: 75612

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTSKTSYDDSSIQVLEGLEAVRKRPGMYIGSTDGRGLHHLVYEIVDNAVDEALGGYGK
CCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC
EINVTIQADNSITVVDHGRGMPVGMHKSGKPTPEVIFTVLHAGGKFGQGGYKTSGGLHGV
EEEEEEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCH
GASVVNALSEKLTVEIVRDKVKYEETFVNGGHPVGTLKKVGKTTNKNGTTVTFKPDKEIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEECCCCCEE
TTTVFNFNTLAVRLRESAFLLRGVKITLTDRREGHEQHEEYLYDEGIKQFVDYLNEDKDT
EEEEEECCEEEEEEHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHH
LGNIMYFDGTKKGIEVEVAGQYNDGYSETILSFVNNVRTRDGGTHEVGMRSGWTKAFNEF
HCCEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
ARKMGLLKEKDKNLEGSDVREGLSAVISVRIPEELLEFEGQTKEKLGTPEARPIVDAIVS
HHHHCCHHHHCCCCCCHHHHHHHHHHEEEECCHHHHHCCCCCHHHCCCCCCHHHHHHHHH
EQLGFFLMENGEFAQQLVRKAINAREARVAARKARDESRTGKRKKKQERILSGKLTPAQS
HHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCC
KNSKKNELFLVEGDSAGGSAKQGRNRKFQAILPLRGKVLNTEKAKLQDIVKNEEINTIIY
CCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEECCHHHHHHHHHCCCCCCEEEE
TIGAGVGTEFNVQDSNYDKVIIMTDADTDGAHIQTLLLTFFYKYMRPMIDAGKIYIALPP
EECCCCCCEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
LYKLQKGLNKKVKIAYAWTDEELESVSKQMGRGFSLQRFKGLGEMNADQLWETTMNPETR
HHHHHHCCCCEEEEEEEECHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHCCCCCCE
TLVRVRIDDDTLAERRVTTLMGDKVEPRRKWIESNVAFTLEEDGSILDNEAVKHEHEAGD
EEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCCCCCCCHHHHHHHCCCC
PTNTSNETFEEIKLDIENN
CCCCCCCCHHHEEEEECCC
>Mature Secondary Structure 
AKTSKTSYDDSSIQVLEGLEAVRKRPGMYIGSTDGRGLHHLVYEIVDNAVDEALGGYGK
CCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC
EINVTIQADNSITVVDHGRGMPVGMHKSGKPTPEVIFTVLHAGGKFGQGGYKTSGGLHGV
EEEEEEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCH
GASVVNALSEKLTVEIVRDKVKYEETFVNGGHPVGTLKKVGKTTNKNGTTVTFKPDKEIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEECCCCCEE
TTTVFNFNTLAVRLRESAFLLRGVKITLTDRREGHEQHEEYLYDEGIKQFVDYLNEDKDT
EEEEEECCEEEEEEHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHH
LGNIMYFDGTKKGIEVEVAGQYNDGYSETILSFVNNVRTRDGGTHEVGMRSGWTKAFNEF
HCCEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
ARKMGLLKEKDKNLEGSDVREGLSAVISVRIPEELLEFEGQTKEKLGTPEARPIVDAIVS
HHHHCCHHHHCCCCCCHHHHHHHHHHEEEECCHHHHHCCCCCHHHCCCCCCHHHHHHHHH
EQLGFFLMENGEFAQQLVRKAINAREARVAARKARDESRTGKRKKKQERILSGKLTPAQS
HHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCC
KNSKKNELFLVEGDSAGGSAKQGRNRKFQAILPLRGKVLNTEKAKLQDIVKNEEINTIIY
CCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEECCHHHHHHHHHCCCCCCEEEE
TIGAGVGTEFNVQDSNYDKVIIMTDADTDGAHIQTLLLTFFYKYMRPMIDAGKIYIALPP
EECCCCCCEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
LYKLQKGLNKKVKIAYAWTDEELESVSKQMGRGFSLQRFKGLGEMNADQLWETTMNPETR
HHHHHHCCCCEEEEEEEECHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHCCCCCCE
TLVRVRIDDDTLAERRVTTLMGDKVEPRRKWIESNVAFTLEEDGSILDNEAVKHEHEAGD
EEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHCCCEEEECCCCCCCCCHHHHHHHCCCC
PTNTSNETFEEIKLDIENN
CCCCCCCCHHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]