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The map label for this gene is parC [H]

Identifier: 116492721

GI number: 116492721

Start: 958636

End: 961089

Strand: Reverse

Name: parC [H]

Synonym: PEPE_0958

Alternate gene names: 116492721

Gene position: 961089-958636 (Counterclockwise)

Preceding gene: 116492722

Following gene: 116492720

Centisome position: 52.45

GC content: 37.98

Gene sequence:

>2454_bases
ATGGCTGATAATCAATCTAAAATTCAAGAACTGGCTCTTGAAGATATTATGGGCGATCGTTTTGGACGATATTCAAAATA
TATCATTCAAGAACGGGCTCTGCCTGACGTCCGAGATGGGTTAAAACCCGTTCAGCGTCGAATCCTCTTTGCAATGAATA
AAGACGGTAACACGCATGATAAAGCTTTTAGAAAATCGGCAAAATCAGTCGGTAATGTAATGGGTAATTTTCACCCCCAC
GGTGATAGTTCAATTTACGAAGCTTTAGTTCGGATGAGTCAGGACTGGAAACTACGAGTTCCATTAATTGAAATGCATGG
GAATAATGGATCAATTGATAATGATCCTCCTGCTGCAATGCGTTATACGGAAGCGCGTTTAAGTGAAGCTGCTGAAGAGA
TGCTAAATGACATTGATAAAGAGACTGTTGATATGGTTTTAAATTTCGATGATACAGAGTATGAACCAACCGTTTTACCA
GCACGTTTTCCTAACCTCCTAGTTAACGGAGCAACCGGAATTTCAGCAGGTTACGCTACTGAAATTCCACCACATAATCT
GGGTGAAGTTATTGACGCAGTCCTTTATACAATCAAACACCCTAATCCTTCTTTAGAAAAATTAATGGAATTTGTGAAGG
GTCCTGATTTTCCAACTGGAGGGATTATCCAAGGAATTAATGGATTGAAGCAAGCTTACCGTACCGGAAAAGGACGAGTA
GTAGTGCGGTCTAAGACTTCCGTTGAAGAAATTCGTGGTAATAAAAAACAAATCATTGTTTCTGAAATTCCCTACGAAGT
TAATAAAGCTTTGTTAGTTAAAAAAATCGATGAAATCCGCGTTATGAAAAAAGTCGATGGAATTGCTGAAATTCGCGATG
AATCTGACCGTGATGGACTCTCAATTGCCATTGAATTAAAGAAAGATGTCGACGCTCGTGGAATTCTAAATTACTTGTTT
AAGAACACTGATTTACAGGTTTCTTATAACTTCAACATGGTAGCGATTAATAAACTAAGACCTGAACGCATGGGTCTTAA
AGAAATTATTCAAGCATATGTTGATTTCCAAAAAGAAGTCATTACCAAACGAACAAAATTCAACTTGAAGAAGGCTGAAG
ACCGTTTACACATTGTTGCTGGTTTAATCAAAGCTCTTTCGATTTTGGATCAAGTTATTAAAACCATTCGAGGTAGTAAA
GACAAGAAGGATGCTAAGCAAAACTTGATTACTAGTTTTGACTTTTCTGAACGACAAGCAGAAGCCATCGTGTCCTTACA
ACTTTACCGCTTAACCAATACCGATGTAACGGAGCTTAAAAGCGAAGCTAAGGCACTTAATGATTCAATCGATGAGTTCA
ATAACATTCTTAATAATCCTAATGAATTATCAAAAGTCTTGTCGGCGGAATTACGTCAAGTTAAAAAACGATATGCCACA
CCACGTTTGTCTGAAATTCAGGAACATATTGAAGAGTTAGTGGTTGACCGAACCATTACAGTACCAGAAGAACAAGTTAT
GGTTTTAGTTAGTCAATCGGGTTATTTGAAACGTAGTAGTTTACGTTCCTACAAGGCTTCCGCAGAAGAGGATGGTCTCA
AGGAGGGCGATTTTACTGTCTTCAAAAAGGAACTAAATACTTTGGATCATCTAATCATGTTAACTAATAAAGGAAATCTG
ATTTATCGTCCGGTACATGAAATCATGGAAACTCGCTGGAAGGATACTGGGGAGCATATTTCTCAAGCAATCGGTTTAGC
AGACGATGAAATCATTCTAAAGGCCTTTGACGTTAAGAACTTTGATGAACCAGTGTCATTCTTGATCGCCACAAGTGATG
GTTACATTAAGCGTACGAGTCTCAAAGATTTCAAACCAGGACGCACGTATCGTAAAAAAGCCGCCGTTTATATTAAATTA
AAAGCAGCTGATGCTAAAGTGGTCAATGTGGCTAAGCTAACTAGTCAATCGACTAAAGAAACCATTCTTTTGGCCACTCG
TAATGGTTATGGATTACGGTATGATTTAATTGAAGTTCCAGAAGTTGGTCCTCGCGCAGCCGGTGTTAAATCAATGGATC
TTCGTGAAGATGAAATCGCTAATTTTGTACTGGTAAACGATCATGATCAGATTGGTTTAATTACTAATCGAGGTTCGTTT
AAGAAGATGAAGGTTAGTGAAATTAGTGTGACTAGCCGTGCTCGCCGCGGTGTTCAAATTCTAAGAGAACTTAAAAAAGA
ACCACATCGAGTTGCAGATATTGAAGTGGTCGAACCAGGTGAAGCTTTTGAAGTCCGAACTTCACGAGGATTAATTCATG
ATATTATTCCACTAGAGCATCCACTAAATGAACGTTACTCCAATGGAAGCTTTTTGGTCGATGTAGATTCAGAAGGTGTA
CCAGTATCGATGAATTTAAAGGAATTAGATTCTGAAATTTTAAATAATAAATAA

Upstream 100 bases:

>100_bases
GTGAAACATGAGCATGAAGCTGGAGATCCAACCAATACTTCAAATGAAACTTTTGAAGAAATTAAACTTGATATAGAAAA
CAATTAGAAGGGGAATATGA

Downstream 100 bases:

>100_bases
ATTAAGCAGATTATTACTTGCCCTTTATGAATACTAATATTAGACTTATTATTGGAGATTGTTAGTTCGTTTAGGCTAAC
TGAAAGGAGTGCTCTAGTAT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 817; Mature: 816

Protein sequence:

>817_residues
MADNQSKIQELALEDIMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNKDGNTHDKAFRKSAKSVGNVMGNFHPH
GDSSIYEALVRMSQDWKLRVPLIEMHGNNGSIDNDPPAAMRYTEARLSEAAEEMLNDIDKETVDMVLNFDDTEYEPTVLP
ARFPNLLVNGATGISAGYATEIPPHNLGEVIDAVLYTIKHPNPSLEKLMEFVKGPDFPTGGIIQGINGLKQAYRTGKGRV
VVRSKTSVEEIRGNKKQIIVSEIPYEVNKALLVKKIDEIRVMKKVDGIAEIRDESDRDGLSIAIELKKDVDARGILNYLF
KNTDLQVSYNFNMVAINKLRPERMGLKEIIQAYVDFQKEVITKRTKFNLKKAEDRLHIVAGLIKALSILDQVIKTIRGSK
DKKDAKQNLITSFDFSERQAEAIVSLQLYRLTNTDVTELKSEAKALNDSIDEFNNILNNPNELSKVLSAELRQVKKRYAT
PRLSEIQEHIEELVVDRTITVPEEQVMVLVSQSGYLKRSSLRSYKASAEEDGLKEGDFTVFKKELNTLDHLIMLTNKGNL
IYRPVHEIMETRWKDTGEHISQAIGLADDEIILKAFDVKNFDEPVSFLIATSDGYIKRTSLKDFKPGRTYRKKAAVYIKL
KAADAKVVNVAKLTSQSTKETILLATRNGYGLRYDLIEVPEVGPRAAGVKSMDLREDEIANFVLVNDHDQIGLITNRGSF
KKMKVSEISVTSRARRGVQILRELKKEPHRVADIEVVEPGEAFEVRTSRGLIHDIIPLEHPLNERYSNGSFLVDVDSEGV
PVSMNLKELDSEILNNK

Sequences:

>Translated_817_residues
MADNQSKIQELALEDIMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNKDGNTHDKAFRKSAKSVGNVMGNFHPH
GDSSIYEALVRMSQDWKLRVPLIEMHGNNGSIDNDPPAAMRYTEARLSEAAEEMLNDIDKETVDMVLNFDDTEYEPTVLP
ARFPNLLVNGATGISAGYATEIPPHNLGEVIDAVLYTIKHPNPSLEKLMEFVKGPDFPTGGIIQGINGLKQAYRTGKGRV
VVRSKTSVEEIRGNKKQIIVSEIPYEVNKALLVKKIDEIRVMKKVDGIAEIRDESDRDGLSIAIELKKDVDARGILNYLF
KNTDLQVSYNFNMVAINKLRPERMGLKEIIQAYVDFQKEVITKRTKFNLKKAEDRLHIVAGLIKALSILDQVIKTIRGSK
DKKDAKQNLITSFDFSERQAEAIVSLQLYRLTNTDVTELKSEAKALNDSIDEFNNILNNPNELSKVLSAELRQVKKRYAT
PRLSEIQEHIEELVVDRTITVPEEQVMVLVSQSGYLKRSSLRSYKASAEEDGLKEGDFTVFKKELNTLDHLIMLTNKGNL
IYRPVHEIMETRWKDTGEHISQAIGLADDEIILKAFDVKNFDEPVSFLIATSDGYIKRTSLKDFKPGRTYRKKAAVYIKL
KAADAKVVNVAKLTSQSTKETILLATRNGYGLRYDLIEVPEVGPRAAGVKSMDLREDEIANFVLVNDHDQIGLITNRGSF
KKMKVSEISVTSRARRGVQILRELKKEPHRVADIEVVEPGEAFEVRTSRGLIHDIIPLEHPLNERYSNGSFLVDVDSEGV
PVSMNLKELDSEILNNK
>Mature_816_residues
ADNQSKIQELALEDIMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNKDGNTHDKAFRKSAKSVGNVMGNFHPHG
DSSIYEALVRMSQDWKLRVPLIEMHGNNGSIDNDPPAAMRYTEARLSEAAEEMLNDIDKETVDMVLNFDDTEYEPTVLPA
RFPNLLVNGATGISAGYATEIPPHNLGEVIDAVLYTIKHPNPSLEKLMEFVKGPDFPTGGIIQGINGLKQAYRTGKGRVV
VRSKTSVEEIRGNKKQIIVSEIPYEVNKALLVKKIDEIRVMKKVDGIAEIRDESDRDGLSIAIELKKDVDARGILNYLFK
NTDLQVSYNFNMVAINKLRPERMGLKEIIQAYVDFQKEVITKRTKFNLKKAEDRLHIVAGLIKALSILDQVIKTIRGSKD
KKDAKQNLITSFDFSERQAEAIVSLQLYRLTNTDVTELKSEAKALNDSIDEFNNILNNPNELSKVLSAELRQVKKRYATP
RLSEIQEHIEELVVDRTITVPEEQVMVLVSQSGYLKRSSLRSYKASAEEDGLKEGDFTVFKKELNTLDHLIMLTNKGNLI
YRPVHEIMETRWKDTGEHISQAIGLADDEIILKAFDVKNFDEPVSFLIATSDGYIKRTSLKDFKPGRTYRKKAAVYIKLK
AADAKVVNVAKLTSQSTKETILLATRNGYGLRYDLIEVPEVGPRAAGVKSMDLREDEIANFVLVNDHDQIGLITNRGSFK
KMKVSEISVTSRARRGVQILRELKKEPHRVADIEVVEPGEAFEVRTSRGLIHDIIPLEHPLNERYSNGSFLVDVDSEGVP
VSMNLKELDSEILNNK

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=195, Percent_Identity=29.2307692307692, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI19913408, Length=238, Percent_Identity=28.1512605042017, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI1788562, Length=833, Percent_Identity=37.8151260504202, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI1789396, Length=536, Percent_Identity=37.3134328358209, Blast_Score=351, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6324241, Length=213, Percent_Identity=26.7605633802817, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17136538, Length=212, Percent_Identity=28.7735849056604, Blast_Score=69, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 92205; Mature: 92074

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNQSKIQELALEDIMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNKDGNTHD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEECCCCCHHH
KAFRKSAKSVGNVMGNFHPHGDSSIYEALVRMSQDWKLRVPLIEMHGNNGSIDNDPPAAM
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCCHHH
RYTEARLSEAAEEMLNDIDKETVDMVLNFDDTEYEPTVLPARFPNLLVNGATGISAGYAT
HHHHHHHHHHHHHHHHHHCHHHHHEEECCCCCCCCCCCCCCCCCHHEEECCCCCCCCCCC
EIPPHNLGEVIDAVLYTIKHPNPSLEKLMEFVKGPDFPTGGIIQGINGLKQAYRTGKGRV
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEE
VVRSKTSVEEIRGNKKQIIVSEIPYEVNKALLVKKIDEIRVMKKVDGIAEIRDESDRDGL
EEECCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
SIAIELKKDVDARGILNYLFKNTDLQVSYNFNMVAINKLRPERMGLKEIIQAYVDFQKEV
EEEEEECCCCCHHHHHHHHHCCCCEEEEECCEEEEEECCCCHHCCHHHHHHHHHHHHHHH
ITKRTKFNLKKAEDRLHIVAGLIKALSILDQVIKTIRGSKDKKDAKQNLITSFDFSERQA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHH
EAIVSLQLYRLTNTDVTELKSEAKALNDSIDEFNNILNNPNELSKVLSAELRQVKKRYAT
HHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
PRLSEIQEHIEELVVDRTITVPEEQVMVLVSQSGYLKRSSLRSYKASAEEDGLKEGDFTV
CCHHHHHHHHHHHHHCCCCCCCCHHEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHH
FKKELNTLDHLIMLTNKGNLIYRPVHEIMETRWKDTGEHISQAIGLADDEIILKAFDVKN
HHHHHHHHHEEEEEECCCCEEEHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCC
FDEPVSFLIATSDGYIKRTSLKDFKPGRTYRKKAAVYIKLKAADAKVVNVAKLTSQSTKE
CCCCEEEEEECCCCCEEECCCCCCCCCCHHCCCEEEEEEEEECCCHHHHHHHHHCCCCCC
TILLATRNGYGLRYDLIEVPEVGPRAAGVKSMDLREDEIANFVLVNDHDQIGLITNRGSF
EEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHCCEEEECCCCCEEEEECCCCC
KKMKVSEISVTSRARRGVQILRELKKEPHRVADIEVVEPGEAFEVRTSRGLIHDIIPLEH
CEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEHHCCHHHHHCCCCC
PLNERYSNGSFLVDVDSEGVPVSMNLKELDSEILNNK
CHHHCCCCCCEEEEECCCCCEEECCHHHHHHHHHCCC
>Mature Secondary Structure 
ADNQSKIQELALEDIMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNKDGNTHD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEECCCCCHHH
KAFRKSAKSVGNVMGNFHPHGDSSIYEALVRMSQDWKLRVPLIEMHGNNGSIDNDPPAAM
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCCHHH
RYTEARLSEAAEEMLNDIDKETVDMVLNFDDTEYEPTVLPARFPNLLVNGATGISAGYAT
HHHHHHHHHHHHHHHHHHCHHHHHEEECCCCCCCCCCCCCCCCCHHEEECCCCCCCCCCC
EIPPHNLGEVIDAVLYTIKHPNPSLEKLMEFVKGPDFPTGGIIQGINGLKQAYRTGKGRV
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEE
VVRSKTSVEEIRGNKKQIIVSEIPYEVNKALLVKKIDEIRVMKKVDGIAEIRDESDRDGL
EEECCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
SIAIELKKDVDARGILNYLFKNTDLQVSYNFNMVAINKLRPERMGLKEIIQAYVDFQKEV
EEEEEECCCCCHHHHHHHHHCCCCEEEEECCEEEEEECCCCHHCCHHHHHHHHHHHHHHH
ITKRTKFNLKKAEDRLHIVAGLIKALSILDQVIKTIRGSKDKKDAKQNLITSFDFSERQA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHH
EAIVSLQLYRLTNTDVTELKSEAKALNDSIDEFNNILNNPNELSKVLSAELRQVKKRYAT
HHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
PRLSEIQEHIEELVVDRTITVPEEQVMVLVSQSGYLKRSSLRSYKASAEEDGLKEGDFTV
CCHHHHHHHHHHHHHCCCCCCCCHHEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHH
FKKELNTLDHLIMLTNKGNLIYRPVHEIMETRWKDTGEHISQAIGLADDEIILKAFDVKN
HHHHHHHHHEEEEEECCCCEEEHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCC
FDEPVSFLIATSDGYIKRTSLKDFKPGRTYRKKAAVYIKLKAADAKVVNVAKLTSQSTKE
CCCCEEEEEECCCCCEEECCCCCCCCCCHHCCCEEEEEEEEECCCHHHHHHHHHCCCCCC
TILLATRNGYGLRYDLIEVPEVGPRAAGVKSMDLREDEIANFVLVNDHDQIGLITNRGSF
EEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHCCEEEECCCCCEEEEECCCCC
KKMKVSEISVTSRARRGVQILRELKKEPHRVADIEVVEPGEAFEVRTSRGLIHDIIPLEH
CEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEHHCCHHHHHCCCCC
PLNERYSNGSFLVDVDSEGVPVSMNLKELDSEILNNK
CHHHCCCCCCEEEEECCCCCEEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]