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The map label for this gene is gltC [H]

Identifier: 116492053

GI number: 116492053

Start: 296579

End: 297463

Strand: Direct

Name: gltC [H]

Synonym: PEPE_0249

Alternate gene names: 116492053

Gene position: 296579-297463 (Clockwise)

Preceding gene: 116492051

Following gene: 116492054

Centisome position: 16.19

GC content: 31.64

Gene sequence:

>885_bases
ATGGATACAAAGAAACTAGTTACATTTGTAGATTTAGCTCAAACGAAAAACTACAGTAAAACTGCGGAACGCATTTTTAC
AACCCAGGCAACAGTTTCAAAACATATTATGGCTCTTGAAAAAGAGTGGAATGTCGAATTGTTTTCTAGGGCTCATCGAG
AAATAAATTTAACGGATGTAGGAAAGCTTTTGTTACCTCAAGTGAAGGAATTATTGAGAGTAGAACAAAAGATACATCAA
ACGATTAATTTGCAACAAACCCAGAAGGAACAGTCACTGGTAATCAAAGGAGTTCCTTCAATTTCTCAGTATCAAGCCTT
TGATATAATTACCAATTTTGCAAAACAAAATCCGGAAATAAAATTGAAGTTTAGTGAATCAGAAACAGAACTTTTAATTG
ATAGTTTGGAACAAGACGAAGCGGATATTATTTTTACTAGAACTTTCGACAAAGCTAATTCTAAATATGAAACTATCGTT
AGTGAACATGATTATTTTGTACTACTAGTTCCCAAAGAGAATCCACTAGCAAAAATCCAGCAAGTTGAAATTAAAATGCT
TCAAAATGAGTCTTTATTATTATTAGGTGATTCGACAAAGTTGTATACTCCAGTCATTTCAATGTTAAAAGAAGAAGGTA
TCAAACCCCATATTCTTTACGAAGGTAGGAGAATTAATCTAATTCTAGAAATGCTAAATCAAGGAATGGGAGTATCAATT
ATGATGAATAAATCTTTTGATTTAACTGATTATCCAGAAGTTGTTGCAATCCCAATTATTCCTAAAAAGACTAGCGAGTT
AATCTTTTTGAAAAAGAAAAGTAATATGACCAATGCAGTAAATTCTTTTTGGAAGTTTGCGATAGCAGAAACTCGATTAG
AATAA

Upstream 100 bases:

>100_bases
TTAAACTCACAAGAAAGTAGTTTACAGTTTTGAAAAGCACGGAACAATTCAAGTTTTATGGTAAAATATTCCAAACTAGA
ATAAGTTAGAAGGAACAAAG

Downstream 100 bases:

>100_bases
ACTAAAACCCCATATATTCCATAATGGAATGTATGGGGTTTTAGTTTGAATTGTTTCGTCGTCAAATTTAAATGATAATG
ACCTTGTAAAATAATTTAAG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MDTKKLVTFVDLAQTKNYSKTAERIFTTQATVSKHIMALEKEWNVELFSRAHREINLTDVGKLLLPQVKELLRVEQKIHQ
TINLQQTQKEQSLVIKGVPSISQYQAFDIITNFAKQNPEIKLKFSESETELLIDSLEQDEADIIFTRTFDKANSKYETIV
SEHDYFVLLVPKENPLAKIQQVEIKMLQNESLLLLGDSTKLYTPVISMLKEEGIKPHILYEGRRINLILEMLNQGMGVSI
MMNKSFDLTDYPEVVAIPIIPKKTSELIFLKKKSNMTNAVNSFWKFAIAETRLE

Sequences:

>Translated_294_residues
MDTKKLVTFVDLAQTKNYSKTAERIFTTQATVSKHIMALEKEWNVELFSRAHREINLTDVGKLLLPQVKELLRVEQKIHQ
TINLQQTQKEQSLVIKGVPSISQYQAFDIITNFAKQNPEIKLKFSESETELLIDSLEQDEADIIFTRTFDKANSKYETIV
SEHDYFVLLVPKENPLAKIQQVEIKMLQNESLLLLGDSTKLYTPVISMLKEEGIKPHILYEGRRINLILEMLNQGMGVSI
MMNKSFDLTDYPEVVAIPIIPKKTSELIFLKKKSNMTNAVNSFWKFAIAETRLE
>Mature_294_residues
MDTKKLVTFVDLAQTKNYSKTAERIFTTQATVSKHIMALEKEWNVELFSRAHREINLTDVGKLLLPQVKELLRVEQKIHQ
TINLQQTQKEQSLVIKGVPSISQYQAFDIITNFAKQNPEIKLKFSESETELLIDSLEQDEADIIFTRTFDKANSKYETIV
SEHDYFVLLVPKENPLAKIQQVEIKMLQNESLLLLGDSTKLYTPVISMLKEEGIKPHILYEGRRINLILEMLNQGMGVSI
MMNKSFDLTDYPEVVAIPIIPKKTSELIFLKKKSNMTNAVNSFWKFAIAETRLE

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=295, Percent_Identity=24.7457627118644, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI145693105, Length=254, Percent_Identity=24.8031496062992, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788748, Length=284, Percent_Identity=25.7042253521127, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI2367136, Length=280, Percent_Identity=21.4285714285714, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI87082132, Length=148, Percent_Identity=28.3783783783784, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787879, Length=263, Percent_Identity=25.0950570342205, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787530, Length=277, Percent_Identity=21.6606498194946, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788296, Length=229, Percent_Identity=21.8340611353712, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33867; Mature: 33867

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTKKLVTFVDLAQTKNYSKTAERIFTTQATVSKHIMALEKEWNVELFSRAHREINLTDV
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHH
GKLLLPQVKELLRVEQKIHQTINLQQTQKEQSLVIKGVPSISQYQAFDIITNFAKQNPEI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHCCCCE
KLKFSESETELLIDSLEQDEADIIFTRTFDKANSKYETIVSEHDYFVLLVPKENPLAKIQ
EEEECCCHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHCCCCCEEEEEEECCCCHHHHH
QVEIKMLQNESLLLLGDSTKLYTPVISMLKEEGIKPHILYEGRRINLILEMLNQGMGVSI
HHHHHEECCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCEEE
MMNKSFDLTDYPEVVAIPIIPKKTSELIFLKKKSNMTNAVNSFWKFAIAETRLE
EEECCCCCCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDTKKLVTFVDLAQTKNYSKTAERIFTTQATVSKHIMALEKEWNVELFSRAHREINLTDV
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHH
GKLLLPQVKELLRVEQKIHQTINLQQTQKEQSLVIKGVPSISQYQAFDIITNFAKQNPEI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHCCCCE
KLKFSESETELLIDSLEQDEADIIFTRTFDKANSKYETIVSEHDYFVLLVPKENPLAKIQ
EEEECCCHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHCCCCCEEEEEEECCCCHHHHH
QVEIKMLQNESLLLLGDSTKLYTPVISMLKEEGIKPHILYEGRRINLILEMLNQGMGVSI
HHHHHEECCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCEEE
MMNKSFDLTDYPEVVAIPIIPKKTSELIFLKKKSNMTNAVNSFWKFAIAETRLE
EEECCCCCCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]