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The map label for this gene is gyrA [H]

Identifier: 116515057

GI number: 116515057

Start: 132701

End: 135184

Strand: Reverse

Name: gyrA [H]

Synonym: BCc_116

Alternate gene names: 116515057

Gene position: 135184-132701 (Counterclockwise)

Preceding gene: 116515058

Following gene: 116515051

Centisome position: 32.47

GC content: 24.28

Gene sequence:

>2484_bases
ATGAAAGACATTGCAAAAGAAATCAAACAGGTCAATATTGAAGAAGAGTTAAAAAGATCTTATCTTGATTATGCTATGTC
TGTAATAATTGGCCGAGCTTTACCTGATGTACGCGATGGTTTAAAACCAGTACATAGAAGAATACTTTTTGCTATGTATA
TATTAAATAATGAATGGAATAAACCATATAAAAAATCCGCTCGAATTGTAGGTGATGTAATTGGTAAATATCATCCACAT
GGTGACTCTGCAGTATATGATTCTATTGTTAGAATGGCTCAGAAATTTTCTTTAAGATATACTTTAATTGATGGACAAGG
AAACTTTGGATCAATTGATGGAGATCCAGCTGCTGCTATGAGATATACAGAAATCCGTATGTCTAGAATTGCTCATGAAA
TGTTAAGTGAATTAGAAAAAAATACAATTGATTTTGTCTTAAATTATGATGGAACTGAAAAAATACCAGAAATTTTACCT
ACAAAAATTCCTAATTTACTTATTAATGGTTCTTCAGGAATTGCAGTTGGTATGGCTACTAATATACCACCACATAATTT
AAAAGAAGTAATAAATGGATGTATTGCATATCTTTATAATCCTTCTATTTCTTTAAAAGAACTTATGCTATATATACCTG
GACCAGATTTTCCAACATCTGGAATTATTTATGGAAAAAATGGAATTAAAGAAGCCTATAAAACTGGAAAGGGGAAAATA
ATAGTAAGATCAAAATATAATATAGAAATTAATAAAAAAAATAAAAAAGAATCACTAATTATTTATGAATTACCATATCA
AGTAAATAAATCTAAATTAATTGAAAAAATTGCAATTTTAGTAAAAGAAAAAAAAATTAATGGAATAACAAACATTCGTG
ATGAATCAGATAAAGATGGTATGAGAATTGTTATTGATATAAAAAAAGATTTTATTAGTCAAATAATTCTAAACCAATTA
TATACTCTGACATCTTTACAAACATCTTTTGGAATTAATATGGTTGCATTATCATCTGGCAAACCAAAAACAATGAATTT
AAAAAAAATTCTAAAAGAATTTATAAAACATAGAAAAAAAATAATTAAAAGAAAATGTTTATTTAAATTAAAAAAATCAA
ATAAAAAAATGCATCTTTTAGAAGGATTTGCTATTGCGCTAAATAATATTAATACTATAATTCATTTAATAAAAAATTCA
GAAAATCATACTATTGCTAAAAAAAAATTAAAAAAAATCAATTGGAAAAAAGAAAATAATAGTTCAAAAAAAAATAAAAA
ATATTTTTATTTTAGTAATAAACAATCATTAGCAATATTAAATATAAAATTAAATAAACTAACTTCATTAGAAAAAAAAA
AAATTAATCTTGAATACAACAAATTAATTAAAAAAACAATTAAACTAAAAAAAATATTATCAAATAAAAATATTCTAGAA
AAAAAAATTGAAAAAGAATTAAATGAAATAAAAAAAAAATTTTCTGATACCAGAAAAACAAAAATAATTAGTAAAATGTC
AGAAATTAATATAGAAGATATGATTGTAAAAGAAACAGTAGTAGTTACCTTATCATATTCAGGATATGTTAAATATCAAC
CTATATCTGATTATAATGCACAAAAAAGAGGGGGAAGAGGAAAATCAGCTGCAAAAACAAAAGAAGAAGACTATATAACG
AATTTGTTAGTTGCTAATTCTCATGATACAATATTGTGTTTTTCTAGTAGAGGACTACTATATTGGATGAAAGTATACCA
ATTACCTGAAACTAGTCGAAATGCACGTGGAAAACCAATAGTTAATTTATTACCTTTAACATCAAAAGAAAGAATTACTA
CAATTTTACCTATTTCAAAATATAAATCTTCTATAAATATTTTTATGGCTACAGCTTTAGGATTCGTTAAAAAAACATCA
TTAATACAATTTAAAAAACCAAGAAATTCAGGTATTATTGCTATTAATTTAAGAAAAAATGATAAACTAATAGGTGTTTC
ATTAACTACTGGAAACAATAATATCTGTATGTTTACTTCAAAAGGAAAAGTTGTTCAGTTTTCTGAAAAAACAATACGAA
AAATGGGCCGAACTGCATCTGGAATTCGAGGAATGAAAATTACAAATAATGATCGATTAGTTTCATTATTAGTACCAAAT
AAAAAAGATGATATTTTAATAGTTACTGCAAATGGATATGGAAAAAGAACTAATATTAACCAATTTCCTATTAAATCACG
TGCAACTAAAGGTGTTCTCTCTATAAGGGTAACACAAAAAAATGGTGTTGTAATTGGAGCCATTCAAGTAAAACAGAATG
ATCAAATTATGATCATTACAAACGCGGGTACATTAGTACGAACTAGAGTGTCTGAAATTGCAATATTAAAAAGAAATACA
CAAGGTGTTATTTTAATAAGAACGATTAAAAAAGAAAAAGTAGTAGGATTACAAAAATTATCTAATAAACCTATTATATC
ATAA

Upstream 100 bases:

>100_bases
ACAATTAATTAATAACAAATTAAAAACTAAATTATCATATTATTATTTATATTATAATTATAAATTTTAAATAAAAATCA
TTTTATTGAGATTAAAATTA

Downstream 100 bases:

>100_bases
AATAACTATATTAAATAAAAAATCATTTATTATAGAAATTTTATGAATTTTAAATATTTTTAAAAAATATTTACTTTTAT
ATTATAAAAGTAAATATATG

Product: DNA gyrase, A subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 827; Mature: 827

Protein sequence:

>827_residues
MKDIAKEIKQVNIEEELKRSYLDYAMSVIIGRALPDVRDGLKPVHRRILFAMYILNNEWNKPYKKSARIVGDVIGKYHPH
GDSAVYDSIVRMAQKFSLRYTLIDGQGNFGSIDGDPAAAMRYTEIRMSRIAHEMLSELEKNTIDFVLNYDGTEKIPEILP
TKIPNLLINGSSGIAVGMATNIPPHNLKEVINGCIAYLYNPSISLKELMLYIPGPDFPTSGIIYGKNGIKEAYKTGKGKI
IVRSKYNIEINKKNKKESLIIYELPYQVNKSKLIEKIAILVKEKKINGITNIRDESDKDGMRIVIDIKKDFISQIILNQL
YTLTSLQTSFGINMVALSSGKPKTMNLKKILKEFIKHRKKIIKRKCLFKLKKSNKKMHLLEGFAIALNNINTIIHLIKNS
ENHTIAKKKLKKINWKKENNSSKKNKKYFYFSNKQSLAILNIKLNKLTSLEKKKINLEYNKLIKKTIKLKKILSNKNILE
KKIEKELNEIKKKFSDTRKTKIISKMSEINIEDMIVKETVVVTLSYSGYVKYQPISDYNAQKRGGRGKSAAKTKEEDYIT
NLLVANSHDTILCFSSRGLLYWMKVYQLPETSRNARGKPIVNLLPLTSKERITTILPISKYKSSINIFMATALGFVKKTS
LIQFKKPRNSGIIAINLRKNDKLIGVSLTTGNNNICMFTSKGKVVQFSEKTIRKMGRTASGIRGMKITNNDRLVSLLVPN
KKDDILIVTANGYGKRTNINQFPIKSRATKGVLSIRVTQKNGVVIGAIQVKQNDQIMIITNAGTLVRTRVSEIAILKRNT
QGVILIRTIKKEKVVGLQKLSNKPIIS

Sequences:

>Translated_827_residues
MKDIAKEIKQVNIEEELKRSYLDYAMSVIIGRALPDVRDGLKPVHRRILFAMYILNNEWNKPYKKSARIVGDVIGKYHPH
GDSAVYDSIVRMAQKFSLRYTLIDGQGNFGSIDGDPAAAMRYTEIRMSRIAHEMLSELEKNTIDFVLNYDGTEKIPEILP
TKIPNLLINGSSGIAVGMATNIPPHNLKEVINGCIAYLYNPSISLKELMLYIPGPDFPTSGIIYGKNGIKEAYKTGKGKI
IVRSKYNIEINKKNKKESLIIYELPYQVNKSKLIEKIAILVKEKKINGITNIRDESDKDGMRIVIDIKKDFISQIILNQL
YTLTSLQTSFGINMVALSSGKPKTMNLKKILKEFIKHRKKIIKRKCLFKLKKSNKKMHLLEGFAIALNNINTIIHLIKNS
ENHTIAKKKLKKINWKKENNSSKKNKKYFYFSNKQSLAILNIKLNKLTSLEKKKINLEYNKLIKKTIKLKKILSNKNILE
KKIEKELNEIKKKFSDTRKTKIISKMSEINIEDMIVKETVVVTLSYSGYVKYQPISDYNAQKRGGRGKSAAKTKEEDYIT
NLLVANSHDTILCFSSRGLLYWMKVYQLPETSRNARGKPIVNLLPLTSKERITTILPISKYKSSINIFMATALGFVKKTS
LIQFKKPRNSGIIAINLRKNDKLIGVSLTTGNNNICMFTSKGKVVQFSEKTIRKMGRTASGIRGMKITNNDRLVSLLVPN
KKDDILIVTANGYGKRTNINQFPIKSRATKGVLSIRVTQKNGVVIGAIQVKQNDQIMIITNAGTLVRTRVSEIAILKRNT
QGVILIRTIKKEKVVGLQKLSNKPIIS
>Mature_827_residues
MKDIAKEIKQVNIEEELKRSYLDYAMSVIIGRALPDVRDGLKPVHRRILFAMYILNNEWNKPYKKSARIVGDVIGKYHPH
GDSAVYDSIVRMAQKFSLRYTLIDGQGNFGSIDGDPAAAMRYTEIRMSRIAHEMLSELEKNTIDFVLNYDGTEKIPEILP
TKIPNLLINGSSGIAVGMATNIPPHNLKEVINGCIAYLYNPSISLKELMLYIPGPDFPTSGIIYGKNGIKEAYKTGKGKI
IVRSKYNIEINKKNKKESLIIYELPYQVNKSKLIEKIAILVKEKKINGITNIRDESDKDGMRIVIDIKKDFISQIILNQL
YTLTSLQTSFGINMVALSSGKPKTMNLKKILKEFIKHRKKIIKRKCLFKLKKSNKKMHLLEGFAIALNNINTIIHLIKNS
ENHTIAKKKLKKINWKKENNSSKKNKKYFYFSNKQSLAILNIKLNKLTSLEKKKINLEYNKLIKKTIKLKKILSNKNILE
KKIEKELNEIKKKFSDTRKTKIISKMSEINIEDMIVKETVVVTLSYSGYVKYQPISDYNAQKRGGRGKSAAKTKEEDYIT
NLLVANSHDTILCFSSRGLLYWMKVYQLPETSRNARGKPIVNLLPLTSKERITTILPISKYKSSINIFMATALGFVKKTS
LIQFKKPRNSGIIAINLRKNDKLIGVSLTTGNNNICMFTSKGKVVQFSEKTIRKMGRTASGIRGMKITNNDRLVSLLVPN
KKDDILIVTANGYGKRTNINQFPIKSRATKGVLSIRVTQKNGVVIGAIQVKQNDQIMIITNAGTLVRTRVSEIAILKRNT
QGVILIRTIKKEKVVGLQKLSNKPIIS

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=342, Percent_Identity=26.3157894736842, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI19913406, Length=168, Percent_Identity=32.1428571428571, Blast_Score=81, Evalue=4e-15,
Organism=Escherichia coli, GI1788562, Length=844, Percent_Identity=58.0568720379147, Blast_Score=1077, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=704, Percent_Identity=34.375, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17535065, Length=167, Percent_Identity=32.3353293413174, Blast_Score=80, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=166, Percent_Identity=31.9277108433735, Blast_Score=79, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=188, Percent_Identity=27.1276595744681, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17136538, Length=166, Percent_Identity=30.7228915662651, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 93813; Mature: 93813

Theoretical pI: Translated: 10.75; Mature: 10.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDIAKEIKQVNIEEELKRSYLDYAMSVIIGRALPDVRDGLKPVHRRILFAMYILNNEWN
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KPYKKSARIVGDVIGKYHPHGDSAVYDSIVRMAQKFSLRYTLIDGQGNFGSIDGDPAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCCCHHHHH
RYTEIRMSRIAHEMLSELEKNTIDFVLNYDGTEKIPEILPTKIPNLLINGSSGIAVGMAT
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCEEEECCCCEEEEEEC
NIPPHNLKEVINGCIAYLYNPSISLKELMLYIPGPDFPTSGIIYGKNGIKEAYKTGKGKI
CCCCHHHHHHHHHHHHHHCCCCCCHHHEEEEECCCCCCCCCEEECCCCHHHHHHCCCCEE
IVRSKYNIEINKKNKKESLIIYELPYQVNKSKLIEKIAILVKEKKINGITNIRDESDKDG
EEEEEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
MRIVIDIKKDFISQIILNQLYTLTSLQTSFGINMVALSSGKPKTMNLKKILKEFIKHRKK
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
IIKRKCLFKLKKSNKKMHLLEGFAIALNNINTIIHLIKNSENHTIAKKKLKKINWKKENN
HHHHHHHHHHHHCCCEEEEHHHHHHHHHCHHEEEEEEECCCCCHHHHHHHHHCCCCCCCC
SSKKNKKYFYFSNKQSLAILNIKLNKLTSLEKKKINLEYNKLIKKTIKLKKILSNKNILE
CCCCCCEEEEEECCCEEEEEEEEEHHHHCCHHHEECCHHHHHHHHHHHHHHHHCCCHHHH
KKIEKELNEIKKKFSDTRKTKIISKMSEINIEDMIVKETVVVTLSYSGYVKYQPISDYNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEEEEEEECCEEEEECCCCCCC
QKRGGRGKSAAKTKEEDYITNLLVANSHDTILCFSSRGLLYWMKVYQLPETSRNARGKPI
HHCCCCCCCCCCCCHHHHHEEEEEECCCCEEEEEECCCEEEEEEHHCCCCCCCCCCCCCE
VNLLPLTSKERITTILPISKYKSSINIFMATALGFVKKTSLIQFKKPRNSGIIAINLRKN
EEEECCCCCCCEEEEEEHHHHHCCHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECC
DKLIGVSLTTGNNNICMFTSKGKVVQFSEKTIRKMGRTASGIRGMKITNNDRLVSLLVPN
CEEEEEEEEECCCCEEEEECCCCEEEECHHHHHHHCCCCCCCCCEEEECCCCEEEEEECC
KKDDILIVTANGYGKRTNINQFPIKSRATKGVLSIRVTQKNGVVIGAIQVKQNDQIMIIT
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEEECCCCEEEEEE
NAGTLVRTRVSEIAILKRNTQGVILIRTIKKEKVVGLQKLSNKPIIS
CCCCEEHHHHHHEEEEEECCCCEEEEEEECHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKDIAKEIKQVNIEEELKRSYLDYAMSVIIGRALPDVRDGLKPVHRRILFAMYILNNEWN
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KPYKKSARIVGDVIGKYHPHGDSAVYDSIVRMAQKFSLRYTLIDGQGNFGSIDGDPAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCCCHHHHH
RYTEIRMSRIAHEMLSELEKNTIDFVLNYDGTEKIPEILPTKIPNLLINGSSGIAVGMAT
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCEEEECCCCEEEEEEC
NIPPHNLKEVINGCIAYLYNPSISLKELMLYIPGPDFPTSGIIYGKNGIKEAYKTGKGKI
CCCCHHHHHHHHHHHHHHCCCCCCHHHEEEEECCCCCCCCCEEECCCCHHHHHHCCCCEE
IVRSKYNIEINKKNKKESLIIYELPYQVNKSKLIEKIAILVKEKKINGITNIRDESDKDG
EEEEEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
MRIVIDIKKDFISQIILNQLYTLTSLQTSFGINMVALSSGKPKTMNLKKILKEFIKHRKK
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
IIKRKCLFKLKKSNKKMHLLEGFAIALNNINTIIHLIKNSENHTIAKKKLKKINWKKENN
HHHHHHHHHHHHCCCEEEEHHHHHHHHHCHHEEEEEEECCCCCHHHHHHHHHCCCCCCCC
SSKKNKKYFYFSNKQSLAILNIKLNKLTSLEKKKINLEYNKLIKKTIKLKKILSNKNILE
CCCCCCEEEEEECCCEEEEEEEEEHHHHCCHHHEECCHHHHHHHHHHHHHHHHCCCHHHH
KKIEKELNEIKKKFSDTRKTKIISKMSEINIEDMIVKETVVVTLSYSGYVKYQPISDYNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEEEEEEEECCEEEEECCCCCCC
QKRGGRGKSAAKTKEEDYITNLLVANSHDTILCFSSRGLLYWMKVYQLPETSRNARGKPI
HHCCCCCCCCCCCCHHHHHEEEEEECCCCEEEEEECCCEEEEEEHHCCCCCCCCCCCCCE
VNLLPLTSKERITTILPISKYKSSINIFMATALGFVKKTSLIQFKKPRNSGIIAINLRKN
EEEECCCCCCCEEEEEEHHHHHCCHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECC
DKLIGVSLTTGNNNICMFTSKGKVVQFSEKTIRKMGRTASGIRGMKITNNDRLVSLLVPN
CEEEEEEEEECCCCEEEEECCCCEEEECHHHHHHHCCCCCCCCCEEEECCCCEEEEEECC
KKDDILIVTANGYGKRTNINQFPIKSRATKGVLSIRVTQKNGVVIGAIQVKQNDQIMIIT
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEEECCCCEEEEEE
NAGTLVRTRVSEIAILKRNTQGVILIRTIKKEKVVGLQKLSNKPIIS
CCCCEEHHHHHHEEEEEECCCCEEEEEEECHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]