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The map label for this gene is prsA [H]

Identifier: 116515051

GI number: 116515051

Start: 126199

End: 127152

Strand: Reverse

Name: prsA [H]

Synonym: BCc_110

Alternate gene names: 116515051

Gene position: 127152-126199 (Counterclockwise)

Preceding gene: 116515057

Following gene: 116515037

Centisome position: 30.54

GC content: 25.16

Gene sequence:

>954_bases
ATGGAAAAAATTAAGTTATTCTCTGGAAATTCTGTATTAACTTTAGCGAAAAAAATTGCTAATCAATTAAAAATTGATTT
AGGGAATGCAACAGTTAGCAAATTTAGTGATGGTGAAATTAGTGTACAAATTAATGAAAACATTAGAGGATCTGATGTAT
TTTTAATTCAATCTACTTGTTCTCCAACAAATGATAATTTTATGGAATTAATTATCATGATAGATGCACTTAGAAGAGCA
TCTGCAGGAAGAATTACTGCGGTAATTCCATATTTTGGTTATGCTAGACAAGATAGAAGAATACGATCATCAAGAGTACC
AATTACAGCTAAAGTAATTGCTGACTTTTTATCAAATGTAGGAGTAAATCGTATTTTAACTATTGATTTACATTCTGAAC
AAATTCAAGGTTTTTTTAATATTCCTATAGATAATATTTCTAGTAGTACAATATTATTAAAAAATTTATTAGAATATAAA
TTTTTTAATCCTATTTTTGTATCTCCAGATATTGGAGGAATTATTAGAACAAGAGAAATAGCAAAATTATTATTTGATTC
AGAAATAGCAATTATTGATAAACGTCGACCTAGTGCAAATAAATCTCAAGTTATGAATATTATTGGAAAAGTAAAAAACC
GAGATTGTATTCTAATAGATGATATTATTGATACAGGAACTACTTTATATAATGCAGCAAAAGCACTTAAAAAAAATGGA
GCAAATCGAATTTTTGCATATGCTACACATCCAATTTTTTCAGGACAGGCAGAAAAAAATCTTAAAAAATCATATATTGA
TAATATTATCATTTGTGATACTATTCCTTTATCAAATAAGATTCAAAATCTTAAAAAAATATATATAATATCAGTTTCCA
AAATATTAGCTGAAGCAATTAGAAGAATTAATAACGAAGAATCTATTTCTGAGATGTTTAATTTATTGTTATAA

Upstream 100 bases:

>100_bases
AAAAAACTTTTTTTATAAAATTATTTGAAATATTTATATTTTCTATATAATAAAATATATCTTAATAAATTAATCTCATA
TATTTTATTAAAAGGTAAAA

Downstream 100 bases:

>100_bases
TAACATCATTTCAAAATGTTAAATAATAAATGTTGGAAAATATTCCAACATTATATTATAAAGATAATTTTAAAATTTAA
TAAATATTTAAAAAATATAT

Product: hypothetical protein

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MEKIKLFSGNSVLTLAKKIANQLKIDLGNATVSKFSDGEISVQINENIRGSDVFLIQSTCSPTNDNFMELIIMIDALRRA
SAGRITAVIPYFGYARQDRRIRSSRVPITAKVIADFLSNVGVNRILTIDLHSEQIQGFFNIPIDNISSSTILLKNLLEYK
FFNPIFVSPDIGGIIRTREIAKLLFDSEIAIIDKRRPSANKSQVMNIIGKVKNRDCILIDDIIDTGTTLYNAAKALKKNG
ANRIFAYATHPIFSGQAEKNLKKSYIDNIIICDTIPLSNKIQNLKKIYIISVSKILAEAIRRINNEESISEMFNLLL

Sequences:

>Translated_317_residues
MEKIKLFSGNSVLTLAKKIANQLKIDLGNATVSKFSDGEISVQINENIRGSDVFLIQSTCSPTNDNFMELIIMIDALRRA
SAGRITAVIPYFGYARQDRRIRSSRVPITAKVIADFLSNVGVNRILTIDLHSEQIQGFFNIPIDNISSSTILLKNLLEYK
FFNPIFVSPDIGGIIRTREIAKLLFDSEIAIIDKRRPSANKSQVMNIIGKVKNRDCILIDDIIDTGTTLYNAAKALKKNG
ANRIFAYATHPIFSGQAEKNLKKSYIDNIIICDTIPLSNKIQNLKKIYIISVSKILAEAIRRINNEESISEMFNLLL
>Mature_317_residues
MEKIKLFSGNSVLTLAKKIANQLKIDLGNATVSKFSDGEISVQINENIRGSDVFLIQSTCSPTNDNFMELIIMIDALRRA
SAGRITAVIPYFGYARQDRRIRSSRVPITAKVIADFLSNVGVNRILTIDLHSEQIQGFFNIPIDNISSSTILLKNLLEYK
FFNPIFVSPDIGGIIRTREIAKLLFDSEIAIIDKRRPSANKSQVMNIIGKVKNRDCILIDDIIDTGTTLYNAAKALKKNG
ANRIFAYATHPIFSGQAEKNLKKSYIDNIIICDTIPLSNKIQNLKKIYIISVSKILAEAIRRINNEESISEMFNLLL

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=316, Percent_Identity=45.8860759493671, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI84875539, Length=320, Percent_Identity=45.625, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI4506129, Length=318, Percent_Identity=45.9119496855346, Blast_Score=279, Evalue=2e-75,
Organism=Homo sapiens, GI28557709, Length=318, Percent_Identity=45.5974842767296, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI4506133, Length=346, Percent_Identity=35.5491329479769, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI194018537, Length=346, Percent_Identity=34.1040462427746, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI310128524, Length=138, Percent_Identity=30.4347826086957, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI310115209, Length=138, Percent_Identity=30.4347826086957, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI310118259, Length=138, Percent_Identity=30.4347826086957, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI310119946, Length=138, Percent_Identity=30.4347826086957, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1787458, Length=313, Percent_Identity=67.0926517571885, Blast_Score=463, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17554702, Length=316, Percent_Identity=42.7215189873418, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI25149168, Length=316, Percent_Identity=42.7215189873418, Blast_Score=260, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI71989924, Length=316, Percent_Identity=42.7215189873418, Blast_Score=259, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=42.443729903537, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17570245, Length=338, Percent_Identity=32.5443786982249, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321776, Length=312, Percent_Identity=40.7051282051282, Blast_Score=239, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6319403, Length=314, Percent_Identity=42.6751592356688, Blast_Score=237, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6320946, Length=314, Percent_Identity=43.312101910828, Blast_Score=234, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6322667, Length=186, Percent_Identity=38.7096774193548, Blast_Score=136, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6324511, Length=113, Percent_Identity=44.2477876106195, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21355239, Length=318, Percent_Identity=45.2830188679245, Blast_Score=270, Evalue=9e-73,
Organism=Drosophila melanogaster, GI45551540, Length=340, Percent_Identity=42.3529411764706, Blast_Score=261, Evalue=4e-70,
Organism=Drosophila melanogaster, GI24651458, Length=356, Percent_Identity=32.8651685393258, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24651456, Length=356, Percent_Identity=32.8651685393258, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI281362873, Length=356, Percent_Identity=32.8651685393258, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24651454, Length=356, Percent_Identity=32.8651685393258, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24651462, Length=155, Percent_Identity=38.0645161290323, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24651464, Length=155, Percent_Identity=38.0645161290323, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI45552010, Length=155, Percent_Identity=38.0645161290323, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35484; Mature: 35484

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIKLFSGNSVLTLAKKIANQLKIDLGNATVSKFSDGEISVQINENIRGSDVFLIQSTC
CCCEEEECCCCHHHHHHHHHHHHEEECCCCEECCCCCCEEEEEECCCCCCCEEEEEECCC
SPTNDNFMELIIMIDALRRASAGRITAVIPYFGYARQDRRIRSSRVPITAKVIADFLSNV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHCC
GVNRILTIDLHSEQIQGFFNIPIDNISSSTILLKNLLEYKFFNPIFVSPDIGGIIRTREI
CCCEEEEEEECHHHCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHH
AKLLFDSEIAIIDKRRPSANKSQVMNIIGKVKNRDCILIDDIIDTGTTLYNAAKALKKNG
HHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECHHHCCHHHHHHHHHHHHCC
ANRIFAYATHPIFSGQAEKNLKKSYIDNIIICDTIPLSNKIQNLKKIYIISVSKILAEAI
CCEEEEEEECCEECCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHEEEEEEHHHHHHHHH
RRINNEESISEMFNLLL
HHCCCHHHHHHHHHHHC
>Mature Secondary Structure
MEKIKLFSGNSVLTLAKKIANQLKIDLGNATVSKFSDGEISVQINENIRGSDVFLIQSTC
CCCEEEECCCCHHHHHHHHHHHHEEECCCCEECCCCCCEEEEEECCCCCCCEEEEEECCC
SPTNDNFMELIIMIDALRRASAGRITAVIPYFGYARQDRRIRSSRVPITAKVIADFLSNV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHCC
GVNRILTIDLHSEQIQGFFNIPIDNISSSTILLKNLLEYKFFNPIFVSPDIGGIIRTREI
CCCEEEEEEECHHHCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHH
AKLLFDSEIAIIDKRRPSANKSQVMNIIGKVKNRDCILIDDIIDTGTTLYNAAKALKKNG
HHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECHHHCCHHHHHHHHHHHHCC
ANRIFAYATHPIFSGQAEKNLKKSYIDNIIICDTIPLSNKIQNLKKIYIISVSKILAEAI
CCEEEEEEECCEECCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHEEEEEEHHHHHHHHH
RRINNEESISEMFNLLL
HHCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]