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The map label for this gene is nuoM [H]

Identifier: 116515049

GI number: 116515049

Start: 123412

End: 124650

Strand: Direct

Name: nuoM [H]

Synonym: BCc_108

Alternate gene names: 116515049

Gene position: 123412-124650 (Clockwise)

Preceding gene: 116515048

Following gene: 116515050

Centisome position: 29.64

GC content: 18.32

Gene sequence:

>1239_bases
ATGATTGTTTTAACTTCTATATTTGGTCTATTTTCAGTTTTTTGTGAATGGCATTCTAAACAAAAAAATTCTGGAATTTT
TTATTCTTTTTTATTATTAATAATTTCAGGTATGTTTGGAATTTTTTTATCTTTAGATTTATTTTTATTTTTTTTATTCT
GGGAAATGATTTTAATTCCATTATATTTTTTAATTGTTTTCTGGGGAAATATTAATAAAAATAAAAAAAATAATATTTTT
ATTGCTCATAAATTTTTTATATATTCTCAATTATCAGGATGTATGTTATTATTTTTTATTATTAATTTAGTTTGCTGTCA
TTATAATTATTCAAAAATTTGGACATTTGATTATTTTCTTTTAAAAAATACTCCTGTTTCTTTATTTACAGAATTTTTTT
TGATGTTTTTTTTATTATTGTCTTTTATTATAAAAATTCCATTAATTCCATTTCACAGTTGGTTACCTGATGTTCAAGAA
TGTTTACCTACTACTAATTCTATTGATTTAATTGGAATTTTATTAAAACCAGCAATATATGGAATATTAAGATTTAATTT
AATTTTTTTTCCTCATTCATCTTATTTATTTTCTCGTTTTTTTATGATATTCGGTTTATTATCTACATTATATGGTTCAA
TAATGGCTTTTTCTCAAAAAAATATAAAAAAATTTATTGCTTATTCTTCTATTTCAAGCATGGGTATTATTTTTTCCTCT
ATATATAGTTTTAATTTTTTTTCACATCAAGGTATTATTTTATACTTATTTTCTTATTGTATTTCTACTGCAGCATTATT
AATAATTATTGGAAAAATTTTTAGTCATATTTATACACAAAAAATTTTTAAAATGGGAGGATTATGGAATTATATGAGAT
TTATCCCATCATTTTTTTTGTTTTTTATTTTTTCAAATTTAAATATTCCTATGTCAGGAAATTTTGGTGGTGAATTTATG
ATGTTATTTGGAATTTTTTCATCATTTCCTTTTTTAGGTTATTTTTTTATTTTGAATTTATTTTTTTCTTCTATTTATTC
ATTAGTAACGATACAGAAAGTATGTTATGGTTTAAATAATAATTTTTTTATTAAACATGAATTAAGTTTTTTTGATTTTT
TTATCTTGTTTTTTTTAGTTTTTATGATTTTTTTTCTAGGTTTATATCCTAGTTTAATTTTAAATTTTTCTTTTAATATT
CAAAAAAATATATTTCAACATTATATATTTATAAAATAA

Upstream 100 bases:

>100_bases
AAGTTTTGTAATTTCGTCATTTTTTTTTTATTTTTCACAAAATGTGGTTTTCTAAATATGGAATTTCTATCTATTTAGGT
TAGATAGATTATCATTATTA

Downstream 100 bases:

>100_bases
TTAGGTAATAAAAATATGATTAGATTATTTAATGATATTATTCCTATTTTTCCTATTTTAATGTTAATTTTTTCAATTAT
AATTCTGTTTTTTATTCTTA

Product: NADH dehydrogenase I chain M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M; NUO13 [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MIVLTSIFGLFSVFCEWHSKQKNSGIFYSFLLLIISGMFGIFLSLDLFLFFLFWEMILIPLYFLIVFWGNINKNKKNNIF
IAHKFFIYSQLSGCMLLFFIINLVCCHYNYSKIWTFDYFLLKNTPVSLFTEFFLMFFLLLSFIIKIPLIPFHSWLPDVQE
CLPTTNSIDLIGILLKPAIYGILRFNLIFFPHSSYLFSRFFMIFGLLSTLYGSIMAFSQKNIKKFIAYSSISSMGIIFSS
IYSFNFFSHQGIILYLFSYCISTAALLIIIGKIFSHIYTQKIFKMGGLWNYMRFIPSFFLFFIFSNLNIPMSGNFGGEFM
MLFGIFSSFPFLGYFFILNLFFSSIYSLVTIQKVCYGLNNNFFIKHELSFFDFFILFFLVFMIFFLGLYPSLILNFSFNI
QKNIFQHYIFIK

Sequences:

>Translated_412_residues
MIVLTSIFGLFSVFCEWHSKQKNSGIFYSFLLLIISGMFGIFLSLDLFLFFLFWEMILIPLYFLIVFWGNINKNKKNNIF
IAHKFFIYSQLSGCMLLFFIINLVCCHYNYSKIWTFDYFLLKNTPVSLFTEFFLMFFLLLSFIIKIPLIPFHSWLPDVQE
CLPTTNSIDLIGILLKPAIYGILRFNLIFFPHSSYLFSRFFMIFGLLSTLYGSIMAFSQKNIKKFIAYSSISSMGIIFSS
IYSFNFFSHQGIILYLFSYCISTAALLIIIGKIFSHIYTQKIFKMGGLWNYMRFIPSFFLFFIFSNLNIPMSGNFGGEFM
MLFGIFSSFPFLGYFFILNLFFSSIYSLVTIQKVCYGLNNNFFIKHELSFFDFFILFFLVFMIFFLGLYPSLILNFSFNI
QKNIFQHYIFIK
>Mature_412_residues
MIVLTSIFGLFSVFCEWHSKQKNSGIFYSFLLLIISGMFGIFLSLDLFLFFLFWEMILIPLYFLIVFWGNINKNKKNNIF
IAHKFFIYSQLSGCMLLFFIINLVCCHYNYSKIWTFDYFLLKNTPVSLFTEFFLMFFLLLSFIIKIPLIPFHSWLPDVQE
CLPTTNSIDLIGILLKPAIYGILRFNLIFFPHSSYLFSRFFMIFGLLSTLYGSIMAFSQKNIKKFIAYSSISSMGIIFSS
IYSFNFFSHQGIILYLFSYCISTAALLIIIGKIFSHIYTQKIFKMGGLWNYMRFIPSFFLFFIFSNLNIPMSGNFGGEFM
MLFGIFSSFPFLGYFFILNLFFSSIYSLVTIQKVCYGLNNNFFIKHELSFFDFFILFFLVFMIFFLGLYPSLILNFSFNI
QKNIFQHYIFIK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=387, Percent_Identity=25.5813953488372, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1788613, Length=412, Percent_Identity=41.0194174757282, Blast_Score=346, Evalue=1e-96,
Organism=Escherichia coli, GI1788827, Length=311, Percent_Identity=22.508038585209, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI145693160, Length=305, Percent_Identity=26.2295081967213, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788831, Length=210, Percent_Identity=27.1428571428571, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788614, Length=311, Percent_Identity=23.1511254019293, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48665; Mature: 48665

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVLTSIFGLFSVFCEWHSKQKNSGIFYSFLLLIISGMFGIFLSLDLFLFFLFWEMILIP
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYFLIVFWGNINKNKKNNIFIAHKFFIYSQLSGCMLLFFIINLVCCHYNYSKIWTFDYFL
HHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHH
LKNTPVSLFTEFFLMFFLLLSFIIKIPLIPFHSWLPDVQECLPTTNSIDLIGILLKPAIY
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHCCCCCCHHHHHHHHHHHHH
GILRFNLIFFPHSSYLFSRFFMIFGLLSTLYGSIMAFSQKNIKKFIAYSSISSMGIIFSS
HHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYSFNFFSHQGIILYLFSYCISTAALLIIIGKIFSHIYTQKIFKMGGLWNYMRFIPSFFL
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
FFIFSNLNIPMSGNFGGEFMMLFGIFSSFPFLGYFFILNLFFSSIYSLVTIQKVCYGLNN
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NFFIKHELSFFDFFILFFLVFMIFFLGLYPSLILNFSFNIQKNIFQHYIFIK
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MIVLTSIFGLFSVFCEWHSKQKNSGIFYSFLLLIISGMFGIFLSLDLFLFFLFWEMILIP
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYFLIVFWGNINKNKKNNIFIAHKFFIYSQLSGCMLLFFIINLVCCHYNYSKIWTFDYFL
HHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHH
LKNTPVSLFTEFFLMFFLLLSFIIKIPLIPFHSWLPDVQECLPTTNSIDLIGILLKPAIY
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHHCCCCCCHHHHHHHHHHHHH
GILRFNLIFFPHSSYLFSRFFMIFGLLSTLYGSIMAFSQKNIKKFIAYSSISSMGIIFSS
HHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYSFNFFSHQGIILYLFSYCISTAALLIIIGKIFSHIYTQKIFKMGGLWNYMRFIPSFFL
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
FFIFSNLNIPMSGNFGGEFMMLFGIFSSFPFLGYFFILNLFFSSIYSLVTIQKVCYGLNN
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NFFIKHELSFFDFFILFFLVFMIFFLGLYPSLILNFSFNIQKNIFQHYIFIK
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]