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The map label for this gene is hisI [H]

Identifier: 116515012

GI number: 116515012

Start: 76640

End: 77257

Strand: Direct

Name: hisI [H]

Synonym: BCc_070

Alternate gene names: 116515012

Gene position: 76640-77257 (Clockwise)

Preceding gene: 116515011

Following gene: 116515013

Centisome position: 18.41

GC content: 20.87

Gene sequence:

>618_bases
ATGTTAATTGATCAAAATTTACAAAATTTAAATTGGACAAAAAATAATGGTTTAATTCCTGCTATTGCGCAACATTATAT
TTCTGGAGAAATATTGATGTTCGGTTATATGAATCAAAAAGCATTCGATAAAATGATTAGTAACAAATTGTTTACTTTAT
ATTCTAGAAAAAAAAAAAGAATTTGGATTAAAGGAGAAACTTCTAAAAATTTTTTATATGTTAAAAATATTAGTACTGAT
TGTGATACAGACGTTATTCTTGTAAAAGTTAATCCTGCAGGAAATACATGTCATTTAAATCGATTTAGTTGTTTTGAATC
TTCGCATCAATTACCATATACATTTTTATATAAATTAGAAAATAGAATTAGAAATAAAAAAGAGAATTTTTCTCGTTCTT
CTTATGTATCTAATTTATTTTCTTCTGGAAATAATAGAATTGCTCAAAAAATTGGAGAAGAATCTGTTGAAGTGATTATA
GCATTTTTAGAAAATAATCATGTTAATATAATTAATGAAACATCTGATTTAATATTTCATTTATTTATTTTATTACAATC
TATGAATATTAATTTATATAAAATTATTAAAAATTTACAAAAACGTGTTAAAAAATAA

Upstream 100 bases:

>100_bases
AAGTTGATGGTGCTTTAGCTGCTTCTGTTTTTCATAAAAATATTATTTCTATTTCAAATTTAAAAAATTTTTTGTTTAAT
CACGGAATTAGGGTAAGAGT

Downstream 100 bases:

>100_bases
TATTTTATAAATTTTAATTAAATTTTTATTTATAAATAATATTTTTTTTTATAAGAGGTTATACATGAAAAATAAAGATA
TTGGAATTATTGGAATGGGT

Product: hypothetical protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MLIDQNLQNLNWTKNNGLIPAIAQHYISGEILMFGYMNQKAFDKMISNKLFTLYSRKKKRIWIKGETSKNFLYVKNISTD
CDTDVILVKVNPAGNTCHLNRFSCFESSHQLPYTFLYKLENRIRNKKENFSRSSYVSNLFSSGNNRIAQKIGEESVEVII
AFLENNHVNIINETSDLIFHLFILLQSMNINLYKIIKNLQKRVKK

Sequences:

>Translated_205_residues
MLIDQNLQNLNWTKNNGLIPAIAQHYISGEILMFGYMNQKAFDKMISNKLFTLYSRKKKRIWIKGETSKNFLYVKNISTD
CDTDVILVKVNPAGNTCHLNRFSCFESSHQLPYTFLYKLENRIRNKKENFSRSSYVSNLFSSGNNRIAQKIGEESVEVII
AFLENNHVNIINETSDLIFHLFILLQSMNINLYKIIKNLQKRVKK
>Mature_205_residues
MLIDQNLQNLNWTKNNGLIPAIAQHYISGEILMFGYMNQKAFDKMISNKLFTLYSRKKKRIWIKGETSKNFLYVKNISTD
CDTDVILVKVNPAGNTCHLNRFSCFESSHQLPYTFLYKLENRIRNKKENFSRSSYVSNLFSSGNNRIAQKIGEESVEVII
AFLENNHVNIINETSDLIFHLFILLQSMNINLYKIIKNLQKRVKK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=203, Percent_Identity=46.7980295566502, Blast_Score=212, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319819, Length=170, Percent_Identity=31.1764705882353, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23950; Mature: 23950

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIDQNLQNLNWTKNNGLIPAIAQHYISGEILMFGYMNQKAFDKMISNKLFTLYSRKKKR
CCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCE
IWIKGETSKNFLYVKNISTDCDTDVILVKVNPAGNTCHLNRFSCFESSHQLPYTFLYKLE
EEEEECCCCCEEEEEECCCCCCCCEEEEEECCCCCEEECCHHHHHCCCCCCCHHHHHHHH
NRIRNKKENFSRSSYVSNLFSSGNNRIAQKIGEESVEVIIAFLENNHVNIINETSDLIFH
HHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHCHHHHHHEEEEECCCCEEEEECHHHHHHH
LFILLQSMNINLYKIIKNLQKRVKK
HHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLIDQNLQNLNWTKNNGLIPAIAQHYISGEILMFGYMNQKAFDKMISNKLFTLYSRKKKR
CCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCE
IWIKGETSKNFLYVKNISTDCDTDVILVKVNPAGNTCHLNRFSCFESSHQLPYTFLYKLE
EEEEECCCCCEEEEEECCCCCCCCEEEEEECCCCCEEECCHHHHHCCCCCCCHHHHHHHH
NRIRNKKENFSRSSYVSNLFSSGNNRIAQKIGEESVEVIIAFLENNHVNIINETSDLIFH
HHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHCHHHHHHEEEEECCCCEEEEECHHHHHHH
LFILLQSMNINLYKIIKNLQKRVKK
HHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9370271 [H]