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The map label for this gene is gnsD [H]

Identifier: 116515013

GI number: 116515013

Start: 77322

End: 78734

Strand: Direct

Name: gnsD [H]

Synonym: BCc_071

Alternate gene names: 116515013

Gene position: 77322-78734 (Clockwise)

Preceding gene: 116515012

Following gene: 116515014

Centisome position: 18.57

GC content: 24.42

Gene sequence:

>1413_bases
ATGAAAAATAAAGATATTGGAATTATTGGAATGGGTGTTATGGGAAAAAATTTAGCAGTTAATATTGCTAATCATGGATA
TAAAGTTTCTGTTTTTAATAGATCTTATAATTTTACTTTTAAAAAATTAGTAAATGAACCAATTAAAAATATTTTTCCGT
ATAGATCTGTCAAAGACTTCATTTCTTCTTTATGTATTCCGCGTTGTATTTTATTGATGATTCAATCCGGTACACCTATA
GATGATATGATAAAAAAAATATTACCTTATTTAAATAAAAATGATGTAATTATTGATGGAGGTAATTCTTTTTATATTGA
TTCTATAAGAAGATATAATGTTCTTAAAGAAAAATCAATTCATTTTCTTGGTGTAGGAATTTCAGGAGGAGAAGAAGGTG
CATTAAAAGGACCATCTATCATGCCTGGTGGTAATAAAGAAGCATATAAAATTGTTTCTCCTATATTTAAAAAAATTGCT
GCAAAGTATAAAGATACTGCATGTGTTAAATATATTGGTTCAGATGGATCTGGTCATTATGTTAAAATGGTTCATAATGG
TATTGAATATAGTGATATGCAATTAATTTCAGAATCATATACATTATTAAAATATTTAATAGGTATGGATAACTTAGAAA
TTTCAGATACATTTAAAAAATGGAATTCAGGAGAATTATCAAGTTATTTAATTGAAATTACAAGTAATATTTTTTGTAAA
AAAGATGACAAAAATCATTTTATTATTGATAATATTTTAGATGTAGCTTCTAATAAAGGTACTGGTAAATGGACAGCACA
AAATTCTTTAGAACTACAAATTCCTTGTTCTATATTAACAGAATCTGTTTTTTGTCGTTATCTTTCTTCTTTAAAAGCAA
ATCGTATGATTGCTTCTACAATATTATCTGGACCAAAATTATTTATTGTTAAAGATTCTAAAAAAGAAGAAATTATTGAA
GATATTCGTAGAGCTTTGTATCTTGGAAAAATTATTTCATATGCGCAGGGTTTTTCTTTAATGAAAAAAGCTTCAGAATA
TTATAACTGGAAGTTAAAATTTTTTGATATTGCAAAAATTTTTCGTTCAGGATGTATTATCAGAGCAAAATTATTAAATG
AAATTGTATTTTCTTATAGTGAAAATAATGATTTAGTGGATTTATTATTTACTTCTAATTTCAAGAAAATCATTAATTTA
TATACATCTTCTTTACGAAATATTGTTATACTTTCGATAAAAAATGGTATATCTATCCCAATATTTACTAATGTTTTATC
ATATTATGATGCATATCGTACTGTTAACTCCTCAGCAAATTTAATACAAGCTCAAAGAGATTATTTTGGTTCACATACAT
ATGAAAGAATTGATCAGATTGGTTCTTTTCATACTAATTGGTTAGATAAATAA

Upstream 100 bases:

>100_bases
ATTATTAAAAATTTACAAAAACGTGTTAAAAAATAATATTTTATAAATTTTAATTAAATTTTTATTTATAAATAATATTT
TTTTTTATAAGAGGTTATAC

Downstream 100 bases:

>100_bases
TTTCTTATTATATTTTTTTTATTTATATAAAAGTATATTATAATTTTTATATAAAAATTAATTAATATATTTTTATTGTA
TAAATACATTTTTTTATTTT

Product: 6-phosphogluconate dehydrogenase, decarboxylating

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MKNKDIGIIGMGVMGKNLAVNIANHGYKVSVFNRSYNFTFKKLVNEPIKNIFPYRSVKDFISSLCIPRCILLMIQSGTPI
DDMIKKILPYLNKNDVIIDGGNSFYIDSIRRYNVLKEKSIHFLGVGISGGEEGALKGPSIMPGGNKEAYKIVSPIFKKIA
AKYKDTACVKYIGSDGSGHYVKMVHNGIEYSDMQLISESYTLLKYLIGMDNLEISDTFKKWNSGELSSYLIEITSNIFCK
KDDKNHFIIDNILDVASNKGTGKWTAQNSLELQIPCSILTESVFCRYLSSLKANRMIASTILSGPKLFIVKDSKKEEIIE
DIRRALYLGKIISYAQGFSLMKKASEYYNWKLKFFDIAKIFRSGCIIRAKLLNEIVFSYSENNDLVDLLFTSNFKKIINL
YTSSLRNIVILSIKNGISIPIFTNVLSYYDAYRTVNSSANLIQAQRDYFGSHTYERIDQIGSFHTNWLDK

Sequences:

>Translated_470_residues
MKNKDIGIIGMGVMGKNLAVNIANHGYKVSVFNRSYNFTFKKLVNEPIKNIFPYRSVKDFISSLCIPRCILLMIQSGTPI
DDMIKKILPYLNKNDVIIDGGNSFYIDSIRRYNVLKEKSIHFLGVGISGGEEGALKGPSIMPGGNKEAYKIVSPIFKKIA
AKYKDTACVKYIGSDGSGHYVKMVHNGIEYSDMQLISESYTLLKYLIGMDNLEISDTFKKWNSGELSSYLIEITSNIFCK
KDDKNHFIIDNILDVASNKGTGKWTAQNSLELQIPCSILTESVFCRYLSSLKANRMIASTILSGPKLFIVKDSKKEEIIE
DIRRALYLGKIISYAQGFSLMKKASEYYNWKLKFFDIAKIFRSGCIIRAKLLNEIVFSYSENNDLVDLLFTSNFKKIINL
YTSSLRNIVILSIKNGISIPIFTNVLSYYDAYRTVNSSANLIQAQRDYFGSHTYERIDQIGSFHTNWLDK
>Mature_470_residues
MKNKDIGIIGMGVMGKNLAVNIANHGYKVSVFNRSYNFTFKKLVNEPIKNIFPYRSVKDFISSLCIPRCILLMIQSGTPI
DDMIKKILPYLNKNDVIIDGGNSFYIDSIRRYNVLKEKSIHFLGVGISGGEEGALKGPSIMPGGNKEAYKIVSPIFKKIA
AKYKDTACVKYIGSDGSGHYVKMVHNGIEYSDMQLISESYTLLKYLIGMDNLEISDTFKKWNSGELSSYLIEITSNIFCK
KDDKNHFIIDNILDVASNKGTGKWTAQNSLELQIPCSILTESVFCRYLSSLKANRMIASTILSGPKLFIVKDSKKEEIIE
DIRRALYLGKIISYAQGFSLMKKASEYYNWKLKFFDIAKIFRSGCIIRAKLLNEIVFSYSENNDLVDLLFTSNFKKIINL
YTSSLRNIVILSIKNGISIPIFTNVLSYYDAYRTVNSSANLIQAQRDYFGSHTYERIDQIGSFHTNWLDK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=470, Percent_Identity=47.2340425531915, Blast_Score=417, Evalue=1e-116,
Organism=Escherichia coli, GI1788341, Length=470, Percent_Identity=56.3829787234042, Blast_Score=572, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17542558, Length=472, Percent_Identity=45.3389830508475, Blast_Score=432, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321695, Length=463, Percent_Identity=45.5723542116631, Blast_Score=434, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6321977, Length=474, Percent_Identity=46.8354430379747, Blast_Score=422, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24639279, Length=467, Percent_Identity=44.5396145610278, Blast_Score=400, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 53285; Mature: 53285

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKDIGIIGMGVMGKNLAVNIANHGYKVSVFNRSYNFTFKKLVNEPIKNIFPYRSVKDF
CCCCCEEEEEECCCCCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHH
ISSLCIPRCILLMIQSGTPIDDMIKKILPYLNKNDVIIDGGNSFYIDSIRRYNVLKEKSI
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCEEEECCHHHHHHHHHCCE
HFLGVGISGGEEGALKGPSIMPGGNKEAYKIVSPIFKKIAAKYKDTACVKYIGSDGSGHY
EEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCE
VKMVHNGIEYSDMQLISESYTLLKYLIGMDNLEISDTFKKWNSGELSSYLIEITSNIFCK
EEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCCHHHHHHHHHCCCEEE
KDDKNHFIIDNILDVASNKGTGKWTAQNSLELQIPCSILTESVFCRYLSSLKANRMIAST
ECCCCCEEHHHHHHHHCCCCCCCEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
ILSGPKLFIVKDSKKEEIIEDIRRALYLGKIISYAQGFSLMKKASEYYNWKLKFFDIAKI
HHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEHHHHHH
FRSGCIIRAKLLNEIVFSYSENNDLVDLLFTSNFKKIINLYTSSLRNIVILSIKNGISIP
HHCCCEEHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCCH
IFTNVLSYYDAYRTVNSSANLIQAQRDYFGSHTYERIDQIGSFHTNWLDK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure
MKNKDIGIIGMGVMGKNLAVNIANHGYKVSVFNRSYNFTFKKLVNEPIKNIFPYRSVKDF
CCCCCEEEEEECCCCCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHH
ISSLCIPRCILLMIQSGTPIDDMIKKILPYLNKNDVIIDGGNSFYIDSIRRYNVLKEKSI
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCEEEECCHHHHHHHHHCCE
HFLGVGISGGEEGALKGPSIMPGGNKEAYKIVSPIFKKIAAKYKDTACVKYIGSDGSGHY
EEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCE
VKMVHNGIEYSDMQLISESYTLLKYLIGMDNLEISDTFKKWNSGELSSYLIEITSNIFCK
EEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCCHHHHHHHHHCCCEEE
KDDKNHFIIDNILDVASNKGTGKWTAQNSLELQIPCSILTESVFCRYLSSLKANRMIAST
ECCCCCEEHHHHHHHHCCCCCCCEEECCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
ILSGPKLFIVKDSKKEEIIEDIRRALYLGKIISYAQGFSLMKKASEYYNWKLKFFDIAKI
HHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEHHHHHH
FRSGCIIRAKLLNEIVFSYSENNDLVDLLFTSNFKKIINLYTSSLRNIVILSIKNGISIP
HHCCCEEHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEEECCCCCCH
IFTNVLSYYDAYRTVNSSANLIQAQRDYFGSHTYERIDQIGSFHTNWLDK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]