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The map label for this gene is hisA

Identifier: 116515010

GI number: 116515010

Start: 75151

End: 75888

Strand: Direct

Name: hisA

Synonym: BCc_068

Alternate gene names: 116515010

Gene position: 75151-75888 (Clockwise)

Preceding gene: 116515009

Following gene: 116515011

Centisome position: 18.05

GC content: 22.63

Gene sequence:

>738_bases
ATGATTATTCCATCATTAGATTTTATTCATGGCAAAATTGTACGATTATATCAGGGAAATTATAATAATAAAATATCTTA
TAAGAAAGATATATTTAAACAAATTGAGAAATATATATATCAGGGAGCTACATATATACATTTAGTTGACTTAGATGGAT
GTAATAATCCAGAAAATCGACAAAAAAGCATGTTTAATATTTTTTCTAATTTTAAGAATGTTTCTTTTCAAGTTGGTGGT
GGTATTCGTTCAAAAAGAGATATAGAAAATTTATTTCATGCTGGAGTTTCTAAAATTGTTATTGGAACTTCTGCAATTTT
ATATCCTAATAAATTTAAAAAATGGTTAAAAAATTACGGTTCTAAAAATTTTGTTTTATCTGTTGATATTAATATCAATA
CAAAAAAAGAAAATAAAATAGCTATTCAAGGATGGAAAAAAACTACTGAAATTAATTTAGATGATGCAATTAAACAATTT
ATACCATATGGTTTAAAAAATATTTTATGTACTGATATTTCAAGAGATGGAACTTTTTCAGGTCCTAATATATCATTATA
TAAGTATTTAAAAAATAAATTTCCAAATATTGTTTTACAATCATCTGGAGGAATAAATTCTATTTCTGATATATATAATT
TAAAAAAAAATAATGTTGAACATGTTATTGTTGGTCGAGCGTTATTAGAAAACAAATTTACTTTTTTGGAGGCAAGTAAA
TGTTGGCTAAAAGAATAA

Upstream 100 bases:

>100_bases
TCTATAGCAATAAATAATTTTTTTGGTGTACAATTTCATCCTGAAAAATCAGGAATTCCTGGAGAACAATTAATTAAAAA
TTTTTTAGAGATATAAATAT

Downstream 100 bases:

>100_bases
TTGCATGTTTAGATGTTAAAAATGGAAAAGTGGTTAAAGGTATTAAATTTCGTAATCAAATTATTATAGGAGAAATTTTA
GATTTAGCAGAATATTATTC

Product: hypothetical protein

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MIIPSLDFIHGKIVRLYQGNYNNKISYKKDIFKQIEKYIYQGATYIHLVDLDGCNNPENRQKSMFNIFSNFKNVSFQVGG
GIRSKRDIENLFHAGVSKIVIGTSAILYPNKFKKWLKNYGSKNFVLSVDININTKKENKIAIQGWKKTTEINLDDAIKQF
IPYGLKNILCTDISRDGTFSGPNISLYKYLKNKFPNIVLQSSGGINSISDIYNLKKNNVEHVIVGRALLENKFTFLEASK
CWLKE

Sequences:

>Translated_245_residues
MIIPSLDFIHGKIVRLYQGNYNNKISYKKDIFKQIEKYIYQGATYIHLVDLDGCNNPENRQKSMFNIFSNFKNVSFQVGG
GIRSKRDIENLFHAGVSKIVIGTSAILYPNKFKKWLKNYGSKNFVLSVDININTKKENKIAIQGWKKTTEINLDDAIKQF
IPYGLKNILCTDISRDGTFSGPNISLYKYLKNKFPNIVLQSSGGINSISDIYNLKKNNVEHVIVGRALLENKFTFLEASK
CWLKE
>Mature_245_residues
MIIPSLDFIHGKIVRLYQGNYNNKISYKKDIFKQIEKYIYQGATYIHLVDLDGCNNPENRQKSMFNIFSNFKNVSFQVGG
GIRSKRDIENLFHAGVSKIVIGTSAILYPNKFKKWLKNYGSKNFVLSVDININTKKENKIAIQGWKKTTEINLDDAIKQF
IPYGLKNILCTDISRDGTFSGPNISLYKYLKNKFPNIVLQSSGGINSISDIYNLKKNNVEHVIVGRALLENKFTFLEASK
CWLKE

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=242, Percent_Identity=42.5619834710744, Blast_Score=246, Evalue=9e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_BUCCC (Q058A3)

Other databases:

- EMBL:   CP000263
- RefSeq:   YP_802639.1
- ProteinModelPortal:   Q058A3
- SMR:   Q058A3
- STRING:   Q058A3
- EnsemblBacteria:   EBBUCT00000001365
- GeneID:   4440772
- GenomeReviews:   CP000263_GR
- KEGG:   bcc:BCc_068
- eggNOG:   COG0106
- GeneTree:   EBGT00050000007994
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- BioCyc:   BAPH372461:BCC_068-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 28079; Mature: 28079

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: NA

Important sites: ACT_SITE 7-7 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIPSLDFIHGKIVRLYQGNYNNKISYKKDIFKQIEKYIYQGATYIHLVDLDGCNNPENR
CCCCCCCHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHH
QKSMFNIFSNFKNVSFQVGGGIRSKRDIENLFHAGVSKIVIGTSAILYPNKFKKWLKNYG
HHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHCHHHEEECCEEEECCHHHHHHHHHCC
SKNFVLSVDININTKKENKIAIQGWKKTTEINLDDAIKQFIPYGLKNILCTDISRDGTFS
CCCEEEEEEEEEECCCCCEEEEECCCCCEECCHHHHHHHHHHHHHHHHHECCCCCCCCCC
GPNISLYKYLKNKFPNIVLQSSGGINSISDIYNLKKNNVEHVIVGRALLENKFTFLEASK
CCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEHHHHHHCCCCEEECCH
CWLKE
HHCCC
>Mature Secondary Structure
MIIPSLDFIHGKIVRLYQGNYNNKISYKKDIFKQIEKYIYQGATYIHLVDLDGCNNPENR
CCCCCCCHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHH
QKSMFNIFSNFKNVSFQVGGGIRSKRDIENLFHAGVSKIVIGTSAILYPNKFKKWLKNYG
HHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHCHHHEEECCEEEECCHHHHHHHHHCC
SKNFVLSVDININTKKENKIAIQGWKKTTEINLDDAIKQFIPYGLKNILCTDISRDGTFS
CCCEEEEEEEEEECCCCCEEEEECCCCCEECCHHHHHHHHHHHHHHHHHECCCCCCCCCC
GPNISLYKYLKNKFPNIVLQSSGGINSISDIYNLKKNNVEHVIVGRALLENKFTFLEASK
CCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEHHHHHHCCCCEEECCH
CWLKE
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA