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The map label for this gene is neuB-2

Identifier: 116327884

GI number: 116327884

Start: 1380215

End: 1381309

Strand: Direct

Name: neuB-2

Synonym: LBL_1168

Alternate gene names: NA

Gene position: 1380215-1381309 (Clockwise)

Preceding gene: 116327883

Following gene: 116327885

Centisome position: 38.19

GC content: 37.99

Gene sequence:

>1095_bases
TTGATCTTTTATAGCTTAAGGGTGCATTGTATGCCACAACCGATTCAATTGGGAAATAAAATTATTGCTGGTTTTTTCGA
TCCTTATGTGATCGCTGAGATAGGGGTCAATCATGAAGGATCGATCGATATAGCGAAACGATTGATTGACGAAGCCAAAG
ACGGTGGGGCGGACGGAGCAAAATTTCAAACCTATAAAGCGGAGACGTTAGCATCTAAGAATTCACCATCCTATTGGGAT
AGAACTCAAGAGCCCACCGCTAGTCAATTTGAATTATTTAAAAAATATGATTCTTTCGGTTGGAAAGAGTATGAAATACT
CGCCAAACATTGCCAATCGGTCGGGATTGATTTTCTTTCGACCCCTTTCGATCTGGAGGCGGTGGAACATTTGGCTTCTC
AAATGCCTTTTATAAAAGTCGCTTCGGCGGATATAACTTCTGTTCCTTTGTTAAGAAGCGTTGCTAAATATTCTAAGCCA
GTAATTTTATCAACTGGTAGTTCGACTATTCCAGAGATTGATTTTGCAATGAGAGAGTTGCATGCAAATGGAGCAAACGA
GATTATTCTTTTGCATTGTATATTAAATTATCCCACTAAACCTGAAAATGCAAATTTGGGTATGATCCAGGACTTACAAA
GAATATTTCCGCACCACTGGGTTGGATATTCAGACCACACTCCTCCAGATCTTGAGATGAAATCTTTGATAACCGCGACC
TTGTTTGGTTCCGTCGTTTTGGAAAAACATTTTACTCATGACAAAACTCTCCCTGGAAATGATCATTATCATGCGATGGA
TAAGGAAGATCTTAAAAGATTCAAAAGAAAACTTAAGGAATTTGAATCTTTAATCGGCAGTAGTGAAAAAGCACCGCTTC
AATCTGAAGAACTGAGCCGGAAAAACGCAAGAAGATCTATTGTCCTTTCTAAAAATCTTTCGAAAGGTAGCAAAATCAAA
GAACAAGATATAACTTTTAAAAGGCCTGCGCATGGGATTAGCCCTATTTTTTGGGATGATGTAATTGGAAGAGTGATCAA
TAGAGATCTTTTAGAAGACCATATTTTAAATTGGGAAGATTTGGTTCAACTTTAG

Upstream 100 bases:

>100_bases
CTCTTTATCGGTATAGAAGGCATGATTCAAATATGACGAATGACTCTGAATTGATGGACGAGCGAATGAAAAGTTTGAGG
GAAAAACATAAAGATCAGCC

Downstream 100 bases:

>100_bases
GAAAATGGGTTCGTCAACACTTGCCATAGTTCAAGCAAGGATGGGCTCTACAAGACTTCCGGGGAAAATGTTATTAAAAC
TTGGACAATTCACTATTTTA

Product: N-acetylneuraminic acid (sialic acid) synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MIFYSLRVHCMPQPIQLGNKIIAGFFDPYVIAEIGVNHEGSIDIAKRLIDEAKDGGADGAKFQTYKAETLASKNSPSYWD
RTQEPTASQFELFKKYDSFGWKEYEILAKHCQSVGIDFLSTPFDLEAVEHLASQMPFIKVASADITSVPLLRSVAKYSKP
VILSTGSSTIPEIDFAMRELHANGANEIILLHCILNYPTKPENANLGMIQDLQRIFPHHWVGYSDHTPPDLEMKSLITAT
LFGSVVLEKHFTHDKTLPGNDHYHAMDKEDLKRFKRKLKEFESLIGSSEKAPLQSEELSRKNARRSIVLSKNLSKGSKIK
EQDITFKRPAHGISPIFWDDVIGRVINRDLLEDHILNWEDLVQL

Sequences:

>Translated_364_residues
MIFYSLRVHCMPQPIQLGNKIIAGFFDPYVIAEIGVNHEGSIDIAKRLIDEAKDGGADGAKFQTYKAETLASKNSPSYWD
RTQEPTASQFELFKKYDSFGWKEYEILAKHCQSVGIDFLSTPFDLEAVEHLASQMPFIKVASADITSVPLLRSVAKYSKP
VILSTGSSTIPEIDFAMRELHANGANEIILLHCILNYPTKPENANLGMIQDLQRIFPHHWVGYSDHTPPDLEMKSLITAT
LFGSVVLEKHFTHDKTLPGNDHYHAMDKEDLKRFKRKLKEFESLIGSSEKAPLQSEELSRKNARRSIVLSKNLSKGSKIK
EQDITFKRPAHGISPIFWDDVIGRVINRDLLEDHILNWEDLVQL
>Mature_364_residues
MIFYSLRVHCMPQPIQLGNKIIAGFFDPYVIAEIGVNHEGSIDIAKRLIDEAKDGGADGAKFQTYKAETLASKNSPSYWD
RTQEPTASQFELFKKYDSFGWKEYEILAKHCQSVGIDFLSTPFDLEAVEHLASQMPFIKVASADITSVPLLRSVAKYSKP
VILSTGSSTIPEIDFAMRELHANGANEIILLHCILNYPTKPENANLGMIQDLQRIFPHHWVGYSDHTPPDLEMKSLITAT
LFGSVVLEKHFTHDKTLPGNDHYHAMDKEDLKRFKRKLKEFESLIGSSEKAPLQSEELSRKNARRSIVLSKNLSKGSKIK
EQDITFKRPAHGISPIFWDDVIGRVINRDLLEDHILNWEDLVQL

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=358, Percent_Identity=29.608938547486, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21357081, Length=369, Percent_Identity=30.0813008130081, Blast_Score=169, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 41249; Mature: 41249

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50844 AFP_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFYSLRVHCMPQPIQLGNKIIAGFFDPYVIAEIGVNHEGSIDIAKRLIDEAKDGGADGA
CEEEEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
KFQTYKAETLASKNSPSYWDRTQEPTASQFELFKKYDSFGWKEYEILAKHCQSVGIDFLS
EEEEEHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHC
TPFDLEAVEHLASQMPFIKVASADITSVPLLRSVAKYSKPVILSTGSSTIPEIDFAMREL
CCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHH
HANGANEIILLHCILNYPTKPENANLGMIQDLQRIFPHHWVGYSDHTPPDLEMKSLITAT
HCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LFGSVVLEKHFTHDKTLPGNDHYHAMDKEDLKRFKRKLKEFESLIGSSEKAPLQSEELSR
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
KNARRSIVLSKNLSKGSKIKEQDITFKRPAHGISPIFWDDVIGRVINRDLLEDHILNWED
HHHHHEEEEECCCCCCCCCHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
LVQL
HHCC
>Mature Secondary Structure
MIFYSLRVHCMPQPIQLGNKIIAGFFDPYVIAEIGVNHEGSIDIAKRLIDEAKDGGADGA
CEEEEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
KFQTYKAETLASKNSPSYWDRTQEPTASQFELFKKYDSFGWKEYEILAKHCQSVGIDFLS
EEEEEHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHC
TPFDLEAVEHLASQMPFIKVASADITSVPLLRSVAKYSKPVILSTGSSTIPEIDFAMREL
CCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHH
HANGANEIILLHCILNYPTKPENANLGMIQDLQRIFPHHWVGYSDHTPPDLEMKSLITAT
HCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LFGSVVLEKHFTHDKTLPGNDHYHAMDKEDLKRFKRKLKEFESLIGSSEKAPLQSEELSR
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
KNARRSIVLSKNLSKGSKIKEQDITFKRPAHGISPIFWDDVIGRVINRDLLEDHILNWED
HHHHHEEEEECCCCCCCCCHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
LVQL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]