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The map label for this gene is bdhA [H]

Identifier: 114799375

GI number: 114799375

Start: 940915

End: 941976

Strand: Reverse

Name: bdhA [H]

Synonym: HNE_0923

Alternate gene names: 114799375

Gene position: 941976-940915 (Counterclockwise)

Preceding gene: 114800243

Following gene: 114797378

Centisome position: 25.42

GC content: 65.16

Gene sequence:

>1062_bases
ATGCGCGCCGCTGTGCTTCAGGGCAATTCCATCCGCATCCGCCAGATGCCGGACCCGTCACCGCTGGCGGGACAGCTCCT
CGTCCGCCCGATCTTCACCGGCATCTGCGGCAGCGACCTCAGCGCCCGCAAGCAGATGGCCGCGATGGCCGATACCCTGC
CGCCCGAGGCGCAAGGCCAGATGCCCGCCATCATTCCCGGCCACGAATTTTCCGCCGAAATCATCGGTATCGCGCCGGGA
ACCGATACCAGATTGAAGGCAGGGGACATCATTACAGGCCTTCCCTTCACGCACACGCATGAAGGCCCCCAGACCATCGG
GCTTTCCCCCGCCCATGGCGGCGGCCTGGCGGAACTCTCATGTATCGACGCTTCCCGCAGCTTCCGTATTCCAGACGGCG
TGCCCCACGACCTTGCCGCCCTCACCGAGCCGCTCGCCGTGGGCCTTCATGCTGCCAATCTGGCAAGCCGCAACCGGGCG
CCCAATGTTGTCATCGGCTGCGGGCCGGTGGGTCTTGCCGTGATCCTCTCCCTCAGCCTGCAGGGGCGCGGGCCGATCCT
GGCGGCGGACTTTTCTGCTGAGCGCCGCCACGCCGCAAGTCTTCTGGGGGCGGATATTGTCATAGATCCGCGTGCAGACT
CCGCCTTCACGCATTGGGGCGATCTCGGGCTCCAGCCATTTCCAATGTCGCCCCTGCTGGAACGGGATTTCCGCGGCCTG
CCGCCGGGCGCGAACATCTTCGAATGCACGGGCGCGCAAGGCCTGATCGATCAGGTCATCAAAGGCGCCCCGCCGCACAG
CCACATCATCGTCGCCGGGGTCTGCCCGCATGAGGAAAAGCTGACCCCGCTCGACGGTATCCTGCGCGAACTGACGCTCG
AATTCAGCTTTGCCTACCGCCCTGAAGAGTTCGCCGCCGCCCTCGCCATGATCGAGGCCCACCCGGATAAAGCCGCCCGC
CTCATCACCAGCCGTCAACCGCTGGCGAACACCGAAGCCGCCTTCGACAGCCTCGCCAGCAGCCCCAGCGAAATCAAGAT
ACTGATTGATCCGAACGCTTAA

Upstream 100 bases:

>100_bases
GCCGATGGCGGACGCACCGCCCATACCGGCCAGCCGGAAGTCGCCCAGTTCGCCCTGCCGCCCGAGAACTGAAACTTCCA
GGAAATCAGGATTAGAGATC

Downstream 100 bases:

>100_bases
GGCTTCAGCGCCCGCCAGCCAATGTCCCGGCGGCAGAAACCGCCCGGCCAGTCAATGGCGTCCACGCCCGCATAGGCACG
GTCGATCGCTTCGCGCAAGG

Product: zinc-binding dehydrogenase family oxidoreductase

Products: NA

Alternate protein names: Acetoin reductase/2,3-butanediol dehydrogenase; AR/BDH [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MRAAVLQGNSIRIRQMPDPSPLAGQLLVRPIFTGICGSDLSARKQMAAMADTLPPEAQGQMPAIIPGHEFSAEIIGIAPG
TDTRLKAGDIITGLPFTHTHEGPQTIGLSPAHGGGLAELSCIDASRSFRIPDGVPHDLAALTEPLAVGLHAANLASRNRA
PNVVIGCGPVGLAVILSLSLQGRGPILAADFSAERRHAASLLGADIVIDPRADSAFTHWGDLGLQPFPMSPLLERDFRGL
PPGANIFECTGAQGLIDQVIKGAPPHSHIIVAGVCPHEEKLTPLDGILRELTLEFSFAYRPEEFAAALAMIEAHPDKAAR
LITSRQPLANTEAAFDSLASSPSEIKILIDPNA

Sequences:

>Translated_353_residues
MRAAVLQGNSIRIRQMPDPSPLAGQLLVRPIFTGICGSDLSARKQMAAMADTLPPEAQGQMPAIIPGHEFSAEIIGIAPG
TDTRLKAGDIITGLPFTHTHEGPQTIGLSPAHGGGLAELSCIDASRSFRIPDGVPHDLAALTEPLAVGLHAANLASRNRA
PNVVIGCGPVGLAVILSLSLQGRGPILAADFSAERRHAASLLGADIVIDPRADSAFTHWGDLGLQPFPMSPLLERDFRGL
PPGANIFECTGAQGLIDQVIKGAPPHSHIIVAGVCPHEEKLTPLDGILRELTLEFSFAYRPEEFAAALAMIEAHPDKAAR
LITSRQPLANTEAAFDSLASSPSEIKILIDPNA
>Mature_353_residues
MRAAVLQGNSIRIRQMPDPSPLAGQLLVRPIFTGICGSDLSARKQMAAMADTLPPEAQGQMPAIIPGHEFSAEIIGIAPG
TDTRLKAGDIITGLPFTHTHEGPQTIGLSPAHGGGLAELSCIDASRSFRIPDGVPHDLAALTEPLAVGLHAANLASRNRA
PNVVIGCGPVGLAVILSLSLQGRGPILAADFSAERRHAASLLGADIVIDPRADSAFTHWGDLGLQPFPMSPLLERDFRGL
PPGANIFECTGAQGLIDQVIKGAPPHSHIIVAGVCPHEEKLTPLDGILRELTLEFSFAYRPEEFAAALAMIEAHPDKAAR
LITSRQPLANTEAAFDSLASSPSEIKILIDPNA

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=360, Percent_Identity=24.7222222222222, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1788073, Length=362, Percent_Identity=24.585635359116, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788407, Length=345, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790045, Length=359, Percent_Identity=23.6768802228412, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1787863, Length=226, Percent_Identity=26.1061946902655, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=362, Percent_Identity=27.0718232044199, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=273, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319257, Length=401, Percent_Identity=25.4364089775561, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=371, Percent_Identity=24.2587601078167, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323099, Length=357, Percent_Identity=23.8095238095238, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17137530, Length=350, Percent_Identity=28, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737897, Length=365, Percent_Identity=27.6712328767123, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.4 [H]

Molecular weight: Translated: 37060; Mature: 37060

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAVLQGNSIRIRQMPDPSPLAGQLLVRPIFTGICGSDLSARKQMAAMADTLPPEAQGQ
CCCEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCC
MPAIIPGHEFSAEIIGIAPGTDTRLKAGDIITGLPFTHTHEGPQTIGLSPAHGGGLAELS
CCEEECCCCCCCEEEEECCCCCCCEECCCEEECCCCCCCCCCCCEECCCCCCCCCCEEEE
CIDASRSFRIPDGVPHDLAALTEPLAVGLHAANLASRNRAPNVVIGCGPVGLAVILSLSL
EECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCC
QGRGPILAADFSAERRHAASLLGADIVIDPRADSAFTHWGDLGLQPFPMSPLLERDFRGL
CCCCCEEEECCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCC
PPGANIFECTGAQGLIDQVIKGAPPHSHIIVAGVCPHEEKLTPLDGILRELTLEFSFAYR
CCCCCEEEECCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHEEEEEC
PEEFAAALAMIEAHPDKAARLITSRQPLANTEAAFDSLASSPSEIKILIDPNA
CHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCC
>Mature Secondary Structure
MRAAVLQGNSIRIRQMPDPSPLAGQLLVRPIFTGICGSDLSARKQMAAMADTLPPEAQGQ
CCCEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCC
MPAIIPGHEFSAEIIGIAPGTDTRLKAGDIITGLPFTHTHEGPQTIGLSPAHGGGLAELS
CCEEECCCCCCCEEEEECCCCCCCEECCCEEECCCCCCCCCCCCEECCCCCCCCCCEEEE
CIDASRSFRIPDGVPHDLAALTEPLAVGLHAANLASRNRAPNVVIGCGPVGLAVILSLSL
EECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCC
QGRGPILAADFSAERRHAASLLGADIVIDPRADSAFTHWGDLGLQPFPMSPLLERDFRGL
CCCCCEEEECCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCC
PPGANIFECTGAQGLIDQVIKGAPPHSHIIVAGVCPHEEKLTPLDGILRELTLEFSFAYR
CCCCCEEEECCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHEEEEEC
PEEFAAALAMIEAHPDKAARLITSRQPLANTEAAFDSLASSPSEIKILIDPNA
CHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9455482; 9384377 [H]