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The map label for this gene is hutI

Identifier: 114798638

GI number: 114798638

Start: 2500009

End: 2501229

Strand: Direct

Name: hutI

Synonym: HNE_2395

Alternate gene names: 114798638

Gene position: 2500009-2501229 (Clockwise)

Preceding gene: 114799861

Following gene: 114797854

Centisome position: 67.48

GC content: 62.24

Gene sequence:

>1221_bases
ATGCAGAAGAAGCGGATCTGGACAAATGCACGCTTGGCCACAATGGCCGCAGGCCTGCCGGGCCTGGGCATTGTGGAAGA
CGGCCTCATCGCGGCAGAAGGCGACCGGATCACCTTTGCCGGCCTGGCATCTGACTTTCCCTATACGGAGGGGCCCTCTA
CGCAGGGATATGAGGTAACCGATTGCGGCGGCCGCTGGATACTTCCCGGCCTGATCGACTGTCATACACATCTCGTCTGG
GCAGGCAGCCGCGCAGACGAATTTGAACGACGCCTCGCCGGCGCCAGTTATGAGGAGATTGCCCGCTCTGGCGGCGGTAT
CCGCTCAACCGTCAGCGCTGTTCGCGCGGCCAGTGAGGCTGAGCTGGTTGCTGAAAGTCTTCCCCGCCTTAACGCCTTGA
TTGGTGAAGGCGTCACGACGATAGAAATAAAATCCGGATACGGATTGAACATTGAAGATGAACTCAAACAGCTCCGCGCC
GCCCGCGCGCTCGGTGAAGTCCGCCCCATCGATGTGGAAACCACCCTTCTCGCCGCGCACACTCTACCCCCGGAATATGA
AGGCCGCGCCGACGCCTATATCGACCTCGTCTGCAACGAGATCATCCCTGCCGCCGCCCAGGCAGGGCTTGCAAGCGCCG
TGGACGCCTTCTGCGAAACCATTGGCTTCACACCGGAACAGACTGGCCGTGTACTGAGCGCGGCCCGCCATCATGGCCTT
GCCGTGAAGCTTCACGCCGACCAGCTCTCAAACCTTCAGGGCGGCGCTCTTGCCGCCCGCCACAACGCACTCTCTGCCGA
TCACCTGGAATATCTCGACGAGGCGGGCATTGCGGCGATGGCTCAGGCAGGGATGGTCGCCGTGATGCTTCCCGGCGCCT
ATTACGTGCTGCGCGAGACACATCCCCCGCCGCTGGAGGGACTGCGGCGCGCGGGCGTTTCCCTTGCGATTTCAACGGAT
TGCAATCCCGGAACCTCTCCCCTCACCTCCATCCTTCTGGCCATGAACATGGGCGCCACGCTCTTTCGCATGACCGTCGA
GGAGTGCCTGCTCGGCACGACACGCCACGCCGCCCGCGCGCTTGGCCTCGAAAAAGCAACCGGCACACTGGAGGCCGGAA
AGCTCTGCAATCTGAGTATCTGGGACATTGATCGTCCGGCAGAGCTCGTCAACGCCATGGGCCTAAACCCCCTTCACACG
CGCGTCTGGAGAGGCCAATGA

Upstream 100 bases:

>100_bases
CGCTCTGAAGATTTCCCGGCCACTGGACATCCCTCCGACTCTTCTATTATGTCTATACATATTAAAAGAAGTCCGATGCG
AAGACAACGGGACCCTGGAG

Downstream 100 bases:

>100_bases
CCACCATCACGCTGACGCCTGGCTCTGTCCCACTCTCCAGTTGGCGCGCCCTCTGGCAAGGCGCCACGCCCAAGCTTGAT
CCGGCCTGCCGCCCCACCAT

Product: imidazolonepropionase

Products: NA

Alternate protein names: Imidazolone-5-propionate hydrolase

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MQKKRIWTNARLATMAAGLPGLGIVEDGLIAAEGDRITFAGLASDFPYTEGPSTQGYEVTDCGGRWILPGLIDCHTHLVW
AGSRADEFERRLAGASYEEIARSGGGIRSTVSAVRAASEAELVAESLPRLNALIGEGVTTIEIKSGYGLNIEDELKQLRA
ARALGEVRPIDVETTLLAAHTLPPEYEGRADAYIDLVCNEIIPAAAQAGLASAVDAFCETIGFTPEQTGRVLSAARHHGL
AVKLHADQLSNLQGGALAARHNALSADHLEYLDEAGIAAMAQAGMVAVMLPGAYYVLRETHPPPLEGLRRAGVSLAISTD
CNPGTSPLTSILLAMNMGATLFRMTVEECLLGTTRHAARALGLEKATGTLEAGKLCNLSIWDIDRPAELVNAMGLNPLHT
RVWRGQ

Sequences:

>Translated_406_residues
MQKKRIWTNARLATMAAGLPGLGIVEDGLIAAEGDRITFAGLASDFPYTEGPSTQGYEVTDCGGRWILPGLIDCHTHLVW
AGSRADEFERRLAGASYEEIARSGGGIRSTVSAVRAASEAELVAESLPRLNALIGEGVTTIEIKSGYGLNIEDELKQLRA
ARALGEVRPIDVETTLLAAHTLPPEYEGRADAYIDLVCNEIIPAAAQAGLASAVDAFCETIGFTPEQTGRVLSAARHHGL
AVKLHADQLSNLQGGALAARHNALSADHLEYLDEAGIAAMAQAGMVAVMLPGAYYVLRETHPPPLEGLRRAGVSLAISTD
CNPGTSPLTSILLAMNMGATLFRMTVEECLLGTTRHAARALGLEKATGTLEAGKLCNLSIWDIDRPAELVNAMGLNPLHT
RVWRGQ
>Mature_406_residues
MQKKRIWTNARLATMAAGLPGLGIVEDGLIAAEGDRITFAGLASDFPYTEGPSTQGYEVTDCGGRWILPGLIDCHTHLVW
AGSRADEFERRLAGASYEEIARSGGGIRSTVSAVRAASEAELVAESLPRLNALIGEGVTTIEIKSGYGLNIEDELKQLRA
ARALGEVRPIDVETTLLAAHTLPPEYEGRADAYIDLVCNEIIPAAAQAGLASAVDAFCETIGFTPEQTGRVLSAARHHGL
AVKLHADQLSNLQGGALAARHNALSADHLEYLDEAGIAAMAQAGMVAVMLPGAYYVLRETHPPPLEGLRRAGVSLAISTD
CNPGTSPLTSILLAMNMGATLFRMTVEECLLGTTRHAARALGLEKATGTLEAGKLCNLSIWDIDRPAELVNAMGLNPLHT
RVWRGQ

Specific function: Unknown

COG id: COG1228

COG function: function code Q; Imidazolonepropionase and related amidohydrolases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hutI family

Homologues:

Organism=Homo sapiens, GI223972677, Length=343, Percent_Identity=37.0262390670554, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17555004, Length=353, Percent_Identity=32.2946175637394, Blast_Score=185, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTI_HYPNA (Q0BZK3)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_761090.1
- ProteinModelPortal:   Q0BZK3
- SMR:   Q0BZK3
- STRING:   Q0BZK3
- GeneID:   4289897
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_2395
- NMPDR:   fig|228405.5.peg.2309
- TIGR:   HNE_2395
- eggNOG:   COG1228
- HOGENOM:   HBG686142
- OMA:   MNMACTL
- BioCyc:   HNEP81032:HNE_2395-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00372
- InterPro:   IPR006680
- InterPro:   IPR005920
- InterPro:   IPR011059
- TIGRFAMs:   TIGR01224

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.7

Molecular weight: Translated: 43061; Mature: 43061

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: BINDING 84-84 BINDING 97-97 BINDING 147-147 BINDING 180-180 BINDING 248-248

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKRIWTNARLATMAAGLPGLGIVEDGLIAAEGDRITFAGLASDFPYTEGPSTQGYEVT
CCCCCEECCCHHHHHHCCCCCCCEECCCEEEECCCEEEEEECCCCCCCCCCCCCCCEEEE
DCGGRWILPGLIDCHTHLVWAGSRADEFERRLAGASYEEIARSGGGIRSTVSAVRAASEA
CCCCCCCCCCHHHHHHEEEEECCCHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHH
ELVAESLPRLNALIGEGVTTIEIKSGYGLNIEDELKQLRAARALGEVRPIDVETTLLAAH
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHEEEEE
TLPPEYEGRADAYIDLVCNEIIPAAAQAGLASAVDAFCETIGFTPEQTGRVLSAARHHGL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCE
AVKLHADQLSNLQGGALAARHNALSADHLEYLDEAGIAAMAQAGMVAVMLPGAYYVLRET
EEEEEHHHHCCCCCCCCHHHHCCCCHHHHHHHHHCCHHHHHHCCEEEEEECCEEEEEECC
HPPPLEGLRRAGVSLAISTDCNPGTSPLTSILLAMNMGATLFRMTVEECLLGTTRHAARA
CCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHH
LGLEKATGTLEAGKLCNLSIWDIDRPAELVNAMGLNPLHTRVWRGQ
HCCHHCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCHHHHHHCCCC
>Mature Secondary Structure
MQKKRIWTNARLATMAAGLPGLGIVEDGLIAAEGDRITFAGLASDFPYTEGPSTQGYEVT
CCCCCEECCCHHHHHHCCCCCCCEECCCEEEECCCEEEEEECCCCCCCCCCCCCCCEEEE
DCGGRWILPGLIDCHTHLVWAGSRADEFERRLAGASYEEIARSGGGIRSTVSAVRAASEA
CCCCCCCCCCHHHHHHEEEEECCCHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHH
ELVAESLPRLNALIGEGVTTIEIKSGYGLNIEDELKQLRAARALGEVRPIDVETTLLAAH
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHEEEEE
TLPPEYEGRADAYIDLVCNEIIPAAAQAGLASAVDAFCETIGFTPEQTGRVLSAARHHGL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCE
AVKLHADQLSNLQGGALAARHNALSADHLEYLDEAGIAAMAQAGMVAVMLPGAYYVLRET
EEEEEHHHHCCCCCCCCHHHHCCCCHHHHHHHHHCCHHHHHHCCEEEEEECCEEEEEECC
HPPPLEGLRRAGVSLAISTDCNPGTSPLTSILLAMNMGATLFRMTVEECLLGTTRHAARA
CCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHH
LGLEKATGTLEAGKLCNLSIWDIDRPAELVNAMGLNPLHTRVWRGQ
HCCHHCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA