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The map label for this gene is hutH

Identifier: 114797854

GI number: 114797854

Start: 2501226

End: 2502767

Strand: Direct

Name: hutH

Synonym: HNE_2396

Alternate gene names: 114797854

Gene position: 2501226-2502767 (Clockwise)

Preceding gene: 114798638

Following gene: 114800063

Centisome position: 67.51

GC content: 64.01

Gene sequence:

>1542_bases
ATGACCACCATCACGCTGACGCCTGGCTCTGTCCCACTCTCCAGTTGGCGCGCCCTCTGGCAAGGCGCCACGCCCAAGCT
TGATCCGGCCTGCCGCCCCACCATCGCCGGCAGCGCCAGCGCGGTCGCGCGCATCCTCTCCAGAGGAAAACCCGTCTACG
GCATCAATACCGGATTCGGTAAACTCGCTGCCGTGCGTATTCCCGACGATCAGTTGGAAATGCTCCAACGCAACATCGTC
CTCTCACATGCCGCCGGTGTGGGGGAGCCTTCGCCTGCAAACATCGTCCGCCTGATGATGGCCCTCAAGATGACAAATCT
CGGCCGCGGCGCCTCCGGCGTGCGCCTTGAAACCATTGATTTGATGGAAGCGATGCTGGCCGCCGATCTTCTGCCGCTCA
TCCCGGCGCAAGGGTCCGTTGGTGCCTCGGGCGATCTGGCACCCCTCGCCCATATGGCCTGCGCGATGATCGGCGTCGGC
GATGTGTTCCTCAAGGGAGAGCGCCTCAGCGCGGCATCCGCTTTTCGCAAGGCCGGCCTCACGCCCCTCCCCGCACTCGC
GGCCAAGGAAGGCCTCGCCCTCCTCAATGGCACGCAATTTTCTACCGCCTGCGCACTCGCAGGTCTGTTTGAGGCCGAGC
GCATTCTGCAAAGCGCGTTGGTCACCGGCGCCCTCTCCACCGAAGCGGCCAAAGGCTCCGACGCCCCATTCGACCCCCGC
ATTCACGAACTGCGCGGCCATAGGGGGCAGATCGACTGCGCAGATATCCTGCGGGATCTTATGGCGGGGTCTGCAATCCG
CGCCAGCCACCTTGAAAACGATACCCGCGTTCAGGACCCCTACTGCATCCGTTGCCAGCCTCAGGTCGCCGGCGCCGCGC
TCACCCTGCTCCGCCAGGCGGCTGACACACTGCTCACCGAATCCAACGGGGTCTCCGATAACCCTCTGATTTTTCCGGAG
ACGGATGAAGCGCTTTCCGGCGGAAATTTCCACGCCGAACCCGTCGCATTTGCCGCCGACATGATCGCAATGGCGCTGTG
CGAAATTGGCTCCATCTCCGAGCGGAGAATTGCGATGCTGGTCGATCCGGCGCTTTCAGGAATGCCCGCCTTCCTCACGC
CCCAGCCCGGCCTCAACTCCGGCTTCATGATCCCGCAGGTCACGGCGGCCGCCCTGGTCTCCGAGAACAAGCAGATGGCA
TTCCCCGCCAGCGTGGACTCGATCCCCACATCCGCAAATCAGGAAGACCATGTCTCCATGGCCGCCCATGGCGCACGGCG
GCTTCTTACGATGGCAAAGAATGTGGATTATATTCTTGGTATTGAACTTCTCGCTGCGGCGCAGGCTTGCGACTTTCACG
CGCCGCTGCGGTCCAGCGACGCCCTGGAGGCTCTGCGCGCCCGCATTCGCCAGGATGTGCCGCCGCTTGACCATGATCGC
CTGATGCATCCCGATATCGAGGCTGCCACGGGGCTCATTCGCAGCGGCGAAGCCATCCGCGCCGTCAACCGGCCTCTGCC
GGCCCTGGAGGCGGCGCCATGA

Upstream 100 bases:

>100_bases
GAAAGCTCTGCAATCTGAGTATCTGGGACATTGATCGTCCGGCAGAGCTCGTCAACGCCATGGGCCTAAACCCCCTTCAC
ACGCGCGTCTGGAGAGGCCA

Downstream 100 bases:

>100_bases
CCGGCTGGTTGACCGTCAAGGAGGGGCCCCGTCCCCTGATCATTTGCTTTCCGCATACTGGCACCGTTCTGCCGGAAGAT
GTGGCGGACCATTTCGTATC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MTTITLTPGSVPLSSWRALWQGATPKLDPACRPTIAGSASAVARILSRGKPVYGINTGFGKLAAVRIPDDQLEMLQRNIV
LSHAAGVGEPSPANIVRLMMALKMTNLGRGASGVRLETIDLMEAMLAADLLPLIPAQGSVGASGDLAPLAHMACAMIGVG
DVFLKGERLSAASAFRKAGLTPLPALAAKEGLALLNGTQFSTACALAGLFEAERILQSALVTGALSTEAAKGSDAPFDPR
IHELRGHRGQIDCADILRDLMAGSAIRASHLENDTRVQDPYCIRCQPQVAGAALTLLRQAADTLLTESNGVSDNPLIFPE
TDEALSGGNFHAEPVAFAADMIAMALCEIGSISERRIAMLVDPALSGMPAFLTPQPGLNSGFMIPQVTAAALVSENKQMA
FPASVDSIPTSANQEDHVSMAAHGARRLLTMAKNVDYILGIELLAAAQACDFHAPLRSSDALEALRARIRQDVPPLDHDR
LMHPDIEAATGLIRSGEAIRAVNRPLPALEAAP

Sequences:

>Translated_513_residues
MTTITLTPGSVPLSSWRALWQGATPKLDPACRPTIAGSASAVARILSRGKPVYGINTGFGKLAAVRIPDDQLEMLQRNIV
LSHAAGVGEPSPANIVRLMMALKMTNLGRGASGVRLETIDLMEAMLAADLLPLIPAQGSVGASGDLAPLAHMACAMIGVG
DVFLKGERLSAASAFRKAGLTPLPALAAKEGLALLNGTQFSTACALAGLFEAERILQSALVTGALSTEAAKGSDAPFDPR
IHELRGHRGQIDCADILRDLMAGSAIRASHLENDTRVQDPYCIRCQPQVAGAALTLLRQAADTLLTESNGVSDNPLIFPE
TDEALSGGNFHAEPVAFAADMIAMALCEIGSISERRIAMLVDPALSGMPAFLTPQPGLNSGFMIPQVTAAALVSENKQMA
FPASVDSIPTSANQEDHVSMAAHGARRLLTMAKNVDYILGIELLAAAQACDFHAPLRSSDALEALRARIRQDVPPLDHDR
LMHPDIEAATGLIRSGEAIRAVNRPLPALEAAP
>Mature_512_residues
TTITLTPGSVPLSSWRALWQGATPKLDPACRPTIAGSASAVARILSRGKPVYGINTGFGKLAAVRIPDDQLEMLQRNIVL
SHAAGVGEPSPANIVRLMMALKMTNLGRGASGVRLETIDLMEAMLAADLLPLIPAQGSVGASGDLAPLAHMACAMIGVGD
VFLKGERLSAASAFRKAGLTPLPALAAKEGLALLNGTQFSTACALAGLFEAERILQSALVTGALSTEAAKGSDAPFDPRI
HELRGHRGQIDCADILRDLMAGSAIRASHLENDTRVQDPYCIRCQPQVAGAALTLLRQAADTLLTESNGVSDNPLIFPET
DEALSGGNFHAEPVAFAADMIAMALCEIGSISERRIAMLVDPALSGMPAFLTPQPGLNSGFMIPQVTAAALVSENKQMAF
PASVDSIPTSANQEDHVSMAAHGARRLLTMAKNVDYILGIELLAAAQACDFHAPLRSSDALEALRARIRQDVPPLDHDRL
MHPDIEAATGLIRSGEAIRAVNRPLPALEAAP

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=473, Percent_Identity=44.1860465116279, Blast_Score=370, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17567831, Length=482, Percent_Identity=44.3983402489627, Blast_Score=357, Evalue=8e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_HYPNA (Q0BZK2)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_761091.1
- ProteinModelPortal:   Q0BZK2
- SMR:   Q0BZK2
- STRING:   Q0BZK2
- GeneID:   4287124
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_2396
- NMPDR:   fig|228405.5.peg.2310
- TIGR:   HNE_2396
- eggNOG:   COG2986
- HOGENOM:   HBG510887
- OMA:   CKPDDTI
- ProtClustDB:   PRK09367
- BioCyc:   HNEP81032:HNE_2396-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 53769; Mature: 53637

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTITLTPGSVPLSSWRALWQGATPKLDPACRPTIAGSASAVARILSRGKPVYGINTGFG
CCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCC
KLAAVRIPDDQLEMLQRNIVLSHAAGVGEPSPANIVRLMMALKMTNLGRGASGVRLETID
CEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEHHHH
LMEAMLAADLLPLIPAQGSVGASGDLAPLAHMACAMIGVGDVFLKGERLSAASAFRKAGL
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHEEECCHHHHHHHHHHCCC
TPLPALAAKEGLALLNGTQFSTACALAGLFEAERILQSALVTGALSTEAAKGSDAPFDPR
CCCHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
IHELRGHRGQIDCADILRDLMAGSAIRASHLENDTRVQDPYCIRCQPQVAGAALTLLRQA
HHHHCCCCCCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHH
ADTLLTESNGVSDNPLIFPETDEALSGGNFHAEPVAFAADMIAMALCEIGSISERRIAML
HHHHHHCCCCCCCCCEECCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEE
VDPALSGMPAFLTPQPGLNSGFMIPQVTAAALVSENKQMAFPASVDSIPTSANQEDHVSM
ECHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHH
AAHGARRLLTMAKNVDYILGIELLAAAQACDFHAPLRSSDALEALRARIRQDVPPLDHDR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
LMHPDIEAATGLIRSGEAIRAVNRPLPALEAAP
CCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TTITLTPGSVPLSSWRALWQGATPKLDPACRPTIAGSASAVARILSRGKPVYGINTGFG
CEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCC
KLAAVRIPDDQLEMLQRNIVLSHAAGVGEPSPANIVRLMMALKMTNLGRGASGVRLETID
CEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEHHHH
LMEAMLAADLLPLIPAQGSVGASGDLAPLAHMACAMIGVGDVFLKGERLSAASAFRKAGL
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHEEECCHHHHHHHHHHCCC
TPLPALAAKEGLALLNGTQFSTACALAGLFEAERILQSALVTGALSTEAAKGSDAPFDPR
CCCHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
IHELRGHRGQIDCADILRDLMAGSAIRASHLENDTRVQDPYCIRCQPQVAGAALTLLRQA
HHHHCCCCCCCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHHH
ADTLLTESNGVSDNPLIFPETDEALSGGNFHAEPVAFAADMIAMALCEIGSISERRIAML
HHHHHHCCCCCCCCCEECCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEE
VDPALSGMPAFLTPQPGLNSGFMIPQVTAAALVSENKQMAFPASVDSIPTSANQEDHVSM
ECHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHH
AAHGARRLLTMAKNVDYILGIELLAAAQACDFHAPLRSSDALEALRARIRQDVPPLDHDR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
LMHPDIEAATGLIRSGEAIRAVNRPLPALEAAP
CCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA