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The map label for this gene is gudP [H]

Identifier: 114799861

GI number: 114799861

Start: 2494358

End: 2495767

Strand: Direct

Name: gudP [H]

Synonym: HNE_2390

Alternate gene names: 114799861

Gene position: 2494358-2495767 (Clockwise)

Preceding gene: 114797743

Following gene: 114798638

Centisome position: 67.32

GC content: 62.91

Gene sequence:

>1410_bases
GTGACCGCAAGTTCATTTCTGAACATAAGACCTGCATATTGTTTCAACAGAAACGATCTCAAGAGTGGAAGTTTCATGTC
CCCGACACTCCTGCCACCCGGCACTGCCGCCGATCCGCAACAGCGCGTTCGGGTCACCCTCTGGCTCCTGCTGATCGTCA
ATGCGTTCAACTTTGTAGACCGTCAGATCGTCAACATCCTGGCTGAGCCGATCAAGAATGATCTCGGCCTCAACGACACA
CAGATCGGCCTGATGACCGGCCTCGCCTTTGCGGTCGTCTACACCTCGCTCGGCATTCCGATTGCGCGCTGGGCCGATAA
TCCCAAGTCAAACCGCGTCGGCATCATCGCCGGCTCGCTCGCCATCTGGTCGGGCATGACGGCGATCTGCGGTGTCGCCC
AGAATTTCTGGCAGATGTTGCTCGCCCGCATCGGCGTGGGCATTGGCGAAGCAGGCTGCACGCCGGCCTCCCACTCACTG
ATCGGGGATACCGTACCGCCTGAAAAACGGGGCTCGGCCATCGCCTTTTTCGGCCTTGGCATTCCGATCGGTTCGCTTTT
CGGCATGGTCATCGGCGGGGTTCTGGCAGACGCTGTCGGCTGGCGCATTGCGTTCATGGCCGTCGGCGTTCCGGGCGTCA
TCCTCGCCCTGCTCCTCTGGTTCCTCGTCAAGGAGCCCCGCAAGGACGGCACCCTCGCCGAAGCCGCCGCACGCCTCAAG
CAAAGCCAGGCCGCGCCCCGCGCCTCGATCCGCGAAACCATCGCCGAAGTGCTCAGCTCCAAGGTCTTCATTTACGCCAC
TCTCGGCGCGTCCTTCGTCGCCTTCCTGGGCTATGGCAAAGGCGTCTGGAACGGCATCTTCCTCATTCGCACGCATGGCC
TCTCGCTTACCGAAGTCGGTCTGCTCTACGGCGTCAGCGCAGGTCTCGGCGGCGTGGCAGGCACATGGCTGGGCGGTTGG
ACGTCGGACAAGTTCGGCATCCGCAAGCCGGTCCACTATATGCTCGCCCCGGCCGTCGCCATGCTGCTTACCGTGCCGAT
CCTACTGATCGGCTATGCCGGTCCCGTCTGGGTCGCCATCCCGATGCTCTGCCTCTCGGCGGCGCTGTCGGGCGTCTATT
ACGCGCCCACCTTCGGCTGTGTTCAGCTCCTCATCAGCCCGGCCTCGCGCGCCGTGGCGGTCTCTCTGATGCTGTTCACG
CTGAACCTGATCGGCCTCGGCCTCGGCCCGCTCCTGTTCGGCATCCTGTCAGATCTTCTGGCGCCGATGGCGGGCAGCGA
AAGCGTGCGCTGGTCGCTGTATGTGGCCGGGTGTATGGGCGTCATTCCCGCCGTGCTCTACTGGCTCGCCAGCAAGAATA
TCGGCCGCGAACTCAATGAGAAGGCCGCCCGCGACACCGCTCTTTCGTAA

Upstream 100 bases:

>100_bases
AGCGCGCCGCGCACATTCGGGGTCACCCTGCGCGGATCATTCTGATCAGGCTGACGTTACGTAACCTGCTGCGACTTGCG
GTCATCCCTTCCAAAATGGG

Downstream 100 bases:

>100_bases
GGCAGAGCGCCCCAAACAAAAACGGGATCGGGCCACCGCCTGATCCCGTTTTCCATTTCCGGTGTGCCTCAAGGCCCGGT
GAAGCGAATGTTCCCGGCTT

Product: major facilitator transporter

Products: NA

Alternate protein names: D-glucarate permease [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTASSFLNIRPAYCFNRNDLKSGSFMSPTLLPPGTAADPQQRVRVTLWLLLIVNAFNFVDRQIVNILAEPIKNDLGLNDT
QIGLMTGLAFAVVYTSLGIPIARWADNPKSNRVGIIAGSLAIWSGMTAICGVAQNFWQMLLARIGVGIGEAGCTPASHSL
IGDTVPPEKRGSAIAFFGLGIPIGSLFGMVIGGVLADAVGWRIAFMAVGVPGVILALLLWFLVKEPRKDGTLAEAAARLK
QSQAAPRASIRETIAEVLSSKVFIYATLGASFVAFLGYGKGVWNGIFLIRTHGLSLTEVGLLYGVSAGLGGVAGTWLGGW
TSDKFGIRKPVHYMLAPAVAMLLTVPILLIGYAGPVWVAIPMLCLSAALSGVYYAPTFGCVQLLISPASRAVAVSLMLFT
LNLIGLGLGPLLFGILSDLLAPMAGSESVRWSLYVAGCMGVIPAVLYWLASKNIGRELNEKAARDTALS

Sequences:

>Translated_469_residues
MTASSFLNIRPAYCFNRNDLKSGSFMSPTLLPPGTAADPQQRVRVTLWLLLIVNAFNFVDRQIVNILAEPIKNDLGLNDT
QIGLMTGLAFAVVYTSLGIPIARWADNPKSNRVGIIAGSLAIWSGMTAICGVAQNFWQMLLARIGVGIGEAGCTPASHSL
IGDTVPPEKRGSAIAFFGLGIPIGSLFGMVIGGVLADAVGWRIAFMAVGVPGVILALLLWFLVKEPRKDGTLAEAAARLK
QSQAAPRASIRETIAEVLSSKVFIYATLGASFVAFLGYGKGVWNGIFLIRTHGLSLTEVGLLYGVSAGLGGVAGTWLGGW
TSDKFGIRKPVHYMLAPAVAMLLTVPILLIGYAGPVWVAIPMLCLSAALSGVYYAPTFGCVQLLISPASRAVAVSLMLFT
LNLIGLGLGPLLFGILSDLLAPMAGSESVRWSLYVAGCMGVIPAVLYWLASKNIGRELNEKAARDTALS
>Mature_468_residues
TASSFLNIRPAYCFNRNDLKSGSFMSPTLLPPGTAADPQQRVRVTLWLLLIVNAFNFVDRQIVNILAEPIKNDLGLNDTQ
IGLMTGLAFAVVYTSLGIPIARWADNPKSNRVGIIAGSLAIWSGMTAICGVAQNFWQMLLARIGVGIGEAGCTPASHSLI
GDTVPPEKRGSAIAFFGLGIPIGSLFGMVIGGVLADAVGWRIAFMAVGVPGVILALLLWFLVKEPRKDGTLAEAAARLKQ
SQAAPRASIRETIAEVLSSKVFIYATLGASFVAFLGYGKGVWNGIFLIRTHGLSLTEVGLLYGVSAGLGGVAGTWLGGWT
SDKFGIRKPVHYMLAPAVAMLLTVPILLIGYAGPVWVAIPMLCLSAALSGVYYAPTFGCVQLLISPASRAVAVSLMLFTL
NLIGLGLGPLLFGILSDLLAPMAGSESVRWSLYVAGCMGVIPAVLYWLASKNIGRELNEKAARDTALS

Specific function: Uptake of D-glucarate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI185136021, Length=384, Percent_Identity=25.2604166666667, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI215490096, Length=392, Percent_Identity=25.765306122449, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI14042968, Length=392, Percent_Identity=25.765306122449, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI215490100, Length=382, Percent_Identity=25.6544502617801, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI2367379, Length=420, Percent_Identity=25.7142857142857, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789152, Length=357, Percent_Identity=24.6498599439776, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789515, Length=455, Percent_Identity=25.4945054945055, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082320, Length=306, Percent_Identity=24.8366013071895, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI87082404, Length=295, Percent_Identity=25.0847457627119, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193209775, Length=486, Percent_Identity=23.2510288065844, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17539092, Length=454, Percent_Identity=24.2290748898678, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17557872, Length=429, Percent_Identity=24.4755244755245, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71992409, Length=480, Percent_Identity=22.9166666666667, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17864456, Length=311, Percent_Identity=24.7588424437299, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24654039, Length=311, Percent_Identity=24.7588424437299, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24654037, Length=393, Percent_Identity=22.64631043257, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24654041, Length=393, Percent_Identity=22.64631043257, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640209, Length=414, Percent_Identity=25.1207729468599, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24654044, Length=244, Percent_Identity=25.4098360655738, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49495; Mature: 49364

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASSFLNIRPAYCFNRNDLKSGSFMSPTLLPPGTAADPQQRVRVTLWLLLIVNAFNFVD
CCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RQIVNILAEPIKNDLGLNDTQIGLMTGLAFAVVYTSLGIPIARWADNPKSNRVGIIAGSL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEECHH
AIWSGMTAICGVAQNFWQMLLARIGVGIGEAGCTPASHSLIGDTVPPEKRGSAIAFFGLG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECC
IPIGSLFGMVIGGVLADAVGWRIAFMAVGVPGVILALLLWFLVKEPRKDGTLAEAAARLK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
QSQAAPRASIRETIAEVLSSKVFIYATLGASFVAFLGYGKGVWNGIFLIRTHGLSLTEVG
HHHCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHCCCHHHCCEEEEEECCCCHHHHH
LLYGVSAGLGGVAGTWLGGWTSDKFGIRKPVHYMLAPAVAMLLTVPILLIGYAGPVWVAI
HHHHHHCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
PMLCLSAALSGVYYAPTFGCVQLLISPASRAVAVSLMLFTLNLIGLGLGPLLFGILSDLL
HHHHHHHHHCCCEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APMAGSESVRWSLYVAGCMGVIPAVLYWLASKNIGRELNEKAARDTALS
HCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TASSFLNIRPAYCFNRNDLKSGSFMSPTLLPPGTAADPQQRVRVTLWLLLIVNAFNFVD
CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RQIVNILAEPIKNDLGLNDTQIGLMTGLAFAVVYTSLGIPIARWADNPKSNRVGIIAGSL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEECHH
AIWSGMTAICGVAQNFWQMLLARIGVGIGEAGCTPASHSLIGDTVPPEKRGSAIAFFGLG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECC
IPIGSLFGMVIGGVLADAVGWRIAFMAVGVPGVILALLLWFLVKEPRKDGTLAEAAARLK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
QSQAAPRASIRETIAEVLSSKVFIYATLGASFVAFLGYGKGVWNGIFLIRTHGLSLTEVG
HHHCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHCCCHHHCCEEEEEECCCCHHHHH
LLYGVSAGLGGVAGTWLGGWTSDKFGIRKPVHYMLAPAVAMLLTVPILLIGYAGPVWVAI
HHHHHHCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
PMLCLSAALSGVYYAPTFGCVQLLISPASRAVAVSLMLFTLNLIGLGLGPLLFGILSDLL
HHHHHHHHHCCCEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APMAGSESVRWSLYVAGCMGVIPAVLYWLASKNIGRELNEKAARDTALS
HCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7704254; 9384377 [H]