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The map label for this gene is algC [H]

Identifier: 114798536

GI number: 114798536

Start: 3405496

End: 3407013

Strand: Reverse

Name: algC [H]

Synonym: HNE_3238

Alternate gene names: 114798536

Gene position: 3407013-3405496 (Counterclockwise)

Preceding gene: 114799238

Following gene: 114798680

Centisome position: 91.96

GC content: 61.13

Gene sequence:

>1518_bases
ATGTTTCCAAAACCGCTCGCTGACATCGCCCCGAATACGCTTGAATTCGAGGTGCTGCCCCTCGTGAAACCGACCGGCTT
CCGGGAGTATGATGCGCGCTGGTGGTTCAACGGGATCGGGCACGCCAAGCCGGCCGAGCTGAACCTGACGGGCGTTCAGG
CGCTGGGGCTGGGGATGGCGACGCTGTTCCATGAGCTGGGCGTCAAGCCGACCGTGGTGACGGGGCATGACTATCGCTCG
ATCAGCCAGCCGATCAAGAATGCGCTGACCCTGGGGTTGATGGCCGGGGGCTGTGAGGTGCTGGATGTGGGCCTGGCGCT
CTCGCCGATGGTCTATTGGAGCCAGTTTGAGCTCGACGCGGCGTGCTGCGCGATGGTGACCGCCTCGCATAACGAGAATG
GCTGGACGGGCGTGAAGATGGGCGCCGACCGGCCGCTGACCTTCGGGCCGGACGAAATGGGCCGCCTGAAAGAGATTGTC
ATGGGCGGCAAGTTCGTCACCCGTGAGGGCGGCACGCACCGCCGCATCGACGGTATCCGCGAGAAATATATCAAGGCTGT
GGTGGGCGACACGAAGCTGACGCGCAAGCTGAAGGTGGTGGCTGCCTGTGGCAATGGCACGGCAGGCGCCTTTGCGGGCG
ACGTGCTGCGCGCGATTGGCGCGGACGTGATCGAGATGGATTGCAATCTCGATATGACCTTCCCGAAATACAATCCGAAC
CCGGAAGATCAGGAAATGCTGCATGCCATGGCGGTGACCGTCAAGGAAACCGGGGCGGATCTGGCGCTCGGCTTTGACGG
GGACGGGGACCGGTGCGGCGTAGTCGACAATAACGGCGAGGAAATCTACGCCGACAAGATTGGCCTGATGCTGGCACGCG
ACCTGTCGAAGAATTTTGCCAACGCGAAATTTGTGGTCGATGTGAAATCGACCGGCCTCTACAAGACCGACCCGGTGCTG
AAGGCCAACGGCGCGACGGTGGATTATTACAAGACCGGCCACTCCTACATCAAGCGCCGCACAAATGAGCTCGGCGCGCT
GGCGGGGTTTGAAAAGTCCGGCCACTTCTTCTTCCGGCCGCCGATTGGGCTGGGCTATGATGATGGGCTGATTGCGGCCA
AGGCGATCCTCGAAATGCTGGACCGCAACCCCGGCAAGACGATGGCGGACCTGAATGGCGAGCTGGGCGTCGCCTACACC
TCGCTGACCATGGCGGCCCATTGCGGCGACGAGGTGAAATATGATGTCGTTGACAAGATGGTTGCCGAATATCAGGGCCT
CGATGGCACGATGATCCTGGGGCGGAAGGTCGTGGAAGTGAATACGGTCAACGGCGCGCGGGTGACGCTTGAGGATGGCT
CCTGGGTGCTGGTGCGGGCCTCTTCAAACAAGCCCGAACTGGTGGTCGTGGTGGAATCCATGAGCAGCGAAGCCGACATG
AAGGACCTCTTCCATAAGGAAGTGAAACCGCGCCTCGGCAAGCATGCCGAAGTGGGCAAATACAATCAGGAAATCTGA

Upstream 100 bases:

>100_bases
GAATCACGCGCCGTTCCCCTGCGGCGCGAAATCTGCATTGTGTTGCGTCAGACCCAAGGCTCGTGTTCAACACGCGCCAA
ACCGTTTCACGGAGAGACAC

Downstream 100 bases:

>100_bases
AGCCGGGAAATCTGAGCTTTGCGGCCGGTCAAGATCTGACCGGCCCATACTCGGCCGCCGCGGCGTCGTCGAGTTCAACG
GCGCGCAATGCGGCCGGGCG

Product: putative phosphoglucomutase/phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MFPKPLADIAPNTLEFEVLPLVKPTGFREYDARWWFNGIGHAKPAELNLTGVQALGLGMATLFHELGVKPTVVTGHDYRS
ISQPIKNALTLGLMAGGCEVLDVGLALSPMVYWSQFELDAACCAMVTASHNENGWTGVKMGADRPLTFGPDEMGRLKEIV
MGGKFVTREGGTHRRIDGIREKYIKAVVGDTKLTRKLKVVAACGNGTAGAFAGDVLRAIGADVIEMDCNLDMTFPKYNPN
PEDQEMLHAMAVTVKETGADLALGFDGDGDRCGVVDNNGEEIYADKIGLMLARDLSKNFANAKFVVDVKSTGLYKTDPVL
KANGATVDYYKTGHSYIKRRTNELGALAGFEKSGHFFFRPPIGLGYDDGLIAAKAILEMLDRNPGKTMADLNGELGVAYT
SLTMAAHCGDEVKYDVVDKMVAEYQGLDGTMILGRKVVEVNTVNGARVTLEDGSWVLVRASSNKPELVVVVESMSSEADM
KDLFHKEVKPRLGKHAEVGKYNQEI

Sequences:

>Translated_505_residues
MFPKPLADIAPNTLEFEVLPLVKPTGFREYDARWWFNGIGHAKPAELNLTGVQALGLGMATLFHELGVKPTVVTGHDYRS
ISQPIKNALTLGLMAGGCEVLDVGLALSPMVYWSQFELDAACCAMVTASHNENGWTGVKMGADRPLTFGPDEMGRLKEIV
MGGKFVTREGGTHRRIDGIREKYIKAVVGDTKLTRKLKVVAACGNGTAGAFAGDVLRAIGADVIEMDCNLDMTFPKYNPN
PEDQEMLHAMAVTVKETGADLALGFDGDGDRCGVVDNNGEEIYADKIGLMLARDLSKNFANAKFVVDVKSTGLYKTDPVL
KANGATVDYYKTGHSYIKRRTNELGALAGFEKSGHFFFRPPIGLGYDDGLIAAKAILEMLDRNPGKTMADLNGELGVAYT
SLTMAAHCGDEVKYDVVDKMVAEYQGLDGTMILGRKVVEVNTVNGARVTLEDGSWVLVRASSNKPELVVVVESMSSEADM
KDLFHKEVKPRLGKHAEVGKYNQEI
>Mature_505_residues
MFPKPLADIAPNTLEFEVLPLVKPTGFREYDARWWFNGIGHAKPAELNLTGVQALGLGMATLFHELGVKPTVVTGHDYRS
ISQPIKNALTLGLMAGGCEVLDVGLALSPMVYWSQFELDAACCAMVTASHNENGWTGVKMGADRPLTFGPDEMGRLKEIV
MGGKFVTREGGTHRRIDGIREKYIKAVVGDTKLTRKLKVVAACGNGTAGAFAGDVLRAIGADVIEMDCNLDMTFPKYNPN
PEDQEMLHAMAVTVKETGADLALGFDGDGDRCGVVDNNGEEIYADKIGLMLARDLSKNFANAKFVVDVKSTGLYKTDPVL
KANGATVDYYKTGHSYIKRRTNELGALAGFEKSGHFFFRPPIGLGYDDGLIAAKAILEMLDRNPGKTMADLNGELGVAYT
SLTMAAHCGDEVKYDVVDKMVAEYQGLDGTMILGRKVVEVNTVNGARVTLEDGSWVLVRASSNKPELVVVVESMSSEADM
KDLFHKEVKPRLGKHAEVGKYNQEI

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=420, Percent_Identity=28.8095238095238, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789566, Length=390, Percent_Identity=26.9230769230769, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 54767; Mature: 54767

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPKPLADIAPNTLEFEVLPLVKPTGFREYDARWWFNGIGHAKPAELNLTGVQALGLGMA
CCCCCCHHHCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCCCCEEEECHHHHHHHHHH
TLFHELGVKPTVVTGHDYRSISQPIKNALTLGLMAGGCEVLDVGLALSPMVYWSQFELDA
HHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEECCHHCCHHEEEHCCCCH
ACCAMVTASHNENGWTGVKMGADRPLTFGPDEMGRLKEIVMGGKFVTREGGTHRRIDGIR
HHHHHEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCHHHHHHH
EKYIKAVVGDTKLTRKLKVVAACGNGTAGAFAGDVLRAIGADVIEMDCNLDMTFPKYNPN
HHHHHHHHCCHHHHEEEEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCEEEECCCCCCC
PEDQEMLHAMAVTVKETGADLALGFDGDGDRCGVVDNNGEEIYADKIGLMLARDLSKNFA
CCHHHHHHHHHHEEEECCCEEEEEECCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHCCC
NAKFVVDVKSTGLYKTDPVLKANGATVDYYKTGHSYIKRRTNELGALAGFEKSGHFFFRP
CCEEEEEECCCCCEECCCEEECCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCEEEEC
PIGLGYDDGLIAAKAILEMLDRNPGKTMADLNGELGVAYTSLTMAAHCGDEVKYDVVDKM
CCCCCCCCHHHHHHHHHHHHCCCCCCEEHHCCCCCEEEEEHEEHHHHCCCCCHHHHHHHH
VAEYQGLDGTMILGRKVVEVNTVNGARVTLEDGSWVLVRASSNKPELVVVVESMSSEADM
HHHHCCCCCEEEECCEEEEEEECCCCEEEEECCCEEEEEECCCCCCEEEEEECCCCCCHH
KDLFHKEVKPRLGKHAEVGKYNQEI
HHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MFPKPLADIAPNTLEFEVLPLVKPTGFREYDARWWFNGIGHAKPAELNLTGVQALGLGMA
CCCCCCHHHCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCCCCEEEECHHHHHHHHHH
TLFHELGVKPTVVTGHDYRSISQPIKNALTLGLMAGGCEVLDVGLALSPMVYWSQFELDA
HHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEECCHHCCHHEEEHCCCCH
ACCAMVTASHNENGWTGVKMGADRPLTFGPDEMGRLKEIVMGGKFVTREGGTHRRIDGIR
HHHHHEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCHHHHHHH
EKYIKAVVGDTKLTRKLKVVAACGNGTAGAFAGDVLRAIGADVIEMDCNLDMTFPKYNPN
HHHHHHHHCCHHHHEEEEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCEEEECCCCCCC
PEDQEMLHAMAVTVKETGADLALGFDGDGDRCGVVDNNGEEIYADKIGLMLARDLSKNFA
CCHHHHHHHHHHEEEECCCEEEEEECCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHCCC
NAKFVVDVKSTGLYKTDPVLKANGATVDYYKTGHSYIKRRTNELGALAGFEKSGHFFFRP
CCEEEEEECCCCCEECCCEEECCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCEEEEC
PIGLGYDDGLIAAKAILEMLDRNPGKTMADLNGELGVAYTSLTMAAHCGDEVKYDVVDKM
CCCCCCCCHHHHHHHHHHHHCCCCCCEEHHCCCCCEEEEEHEEHHHHCCCCCHHHHHHHH
VAEYQGLDGTMILGRKVVEVNTVNGARVTLEDGSWVLVRASSNKPELVVVVESMSSEADM
HHHHCCCCCEEEECCEEEEEEECCCCEEEEECCCEEEEEECCCCCCEEEEEECCCCCCHH
KDLFHKEVKPRLGKHAEVGKYNQEI
HHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]