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The map label for this gene is dhlA [H]

Identifier: 114798230

GI number: 114798230

Start: 1000907

End: 1001905

Strand: Reverse

Name: dhlA [H]

Synonym: HNE_0985

Alternate gene names: 114798230

Gene position: 1001905-1000907 (Counterclockwise)

Preceding gene: 114797492

Following gene: 114797538

Centisome position: 27.04

GC content: 64.06

Gene sequence:

>999_bases
ATGAAGGTCATGCGGACACCGGACGCACGGTTTGAAAACCTGCCGGATTACCCCTTCGCCCCGCATTATCACAACGTGAC
AGCCCCAGACGGCACACCCCTGCGGATGCATTATCTCGACGAAGGCCCGCGTGACGGCGAGATCCTCCTCTGCCTCCACG
GCCAGCCCTCCTGGAGCTATCTTTACCGCAAGATGATCCCCCTGCTGACGGCCGCCGGATACCGCGTCCTGGCGCCAGAC
CTCATCGGCTTCGGCAAATCCGACAAGCCAGGGGCCATCGAGGACTATTCCTATTCCGGCCATGCCGCCTGGCTGGAAGA
GTGGATGCTGGCCCTGGACCTCACCGGTCTCACCCTCGTCTGTCAGGACTGGGGCGGCCTCCTCGGCCTGCGCCTGGCGG
GTATGCACCCGGATCGCTTCAAACGCCTCGTCGTGGCCAATACCGGCCTGCCCGATTCCAGACAACTCGCCCCGCAGATG
TCGGAAATGCTCGGCATGCTCTATCCGCAGGTGCCCGTGCCCAGCGCCAGCGATGTGGGCGATGCCTTCCGCTCTGGCGC
GCCCGGCGCTTTTCTCTTCTGGGTCAAATACGCCGCCGAGGCACCGGACTTTGCCGTCCGCGATGTCTTTGGTCTTCTGT
CGGACATTTCCGACGACGCCGTTCTGAATGGTTATGAGGCTCCGTTCCCGGACGAAACCTATCTCGCCGGCGCCCGCCGT
TTTCCCTCCCTCGTACCCCTCCTGCCCAATGGCGCGGAGGAGCGCGCCAAGAACGACGCCGCCTGGGCCGTTCTGGAAAA
GTTCGAGAAGCCTGTCCTCACCGCCTTCGCTGATGACGATCCCGTCACCAAGGGCGGCGAAGCGGCTTTCCAGACCCGTA
TCCCCGGCGCCAAGGGCCAGAACCACGTCACCATCTCTGGCGGCGGCCACTTCCTGCAAGAACACCGCCCCGAAGCCTTC
AGCCAGGCCATCATCACCTTCATGCGCGCCAACCCCTGA

Upstream 100 bases:

>100_bases
GCTCAGGAGCCTCAAAAAAAATCCTGTTGCCCCCCGCCTGAAGAAGTGGCACGAATAATGCCAATACCTGAAATGCCAAG
GCTGGGGGCAAGAGAAAAAA

Downstream 100 bases:

>100_bases
AGCCCTCTCAGATTTAGTACACACCCCCGCCGCCCCTTCCCCTGCGTCGGGGCTCCCAAGACGGCTTACCGCACGTTAAA
CGAAGCGCAGACCTGTTTAA

Product: haloalkane dehalogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKVMRTPDARFENLPDYPFAPHYHNVTAPDGTPLRMHYLDEGPRDGEILLCLHGQPSWSYLYRKMIPLLTAAGYRVLAPD
LIGFGKSDKPGAIEDYSYSGHAAWLEEWMLALDLTGLTLVCQDWGGLLGLRLAGMHPDRFKRLVVANTGLPDSRQLAPQM
SEMLGMLYPQVPVPSASDVGDAFRSGAPGAFLFWVKYAAEAPDFAVRDVFGLLSDISDDAVLNGYEAPFPDETYLAGARR
FPSLVPLLPNGAEERAKNDAAWAVLEKFEKPVLTAFADDDPVTKGGEAAFQTRIPGAKGQNHVTISGGGHFLQEHRPEAF
SQAIITFMRANP

Sequences:

>Translated_332_residues
MKVMRTPDARFENLPDYPFAPHYHNVTAPDGTPLRMHYLDEGPRDGEILLCLHGQPSWSYLYRKMIPLLTAAGYRVLAPD
LIGFGKSDKPGAIEDYSYSGHAAWLEEWMLALDLTGLTLVCQDWGGLLGLRLAGMHPDRFKRLVVANTGLPDSRQLAPQM
SEMLGMLYPQVPVPSASDVGDAFRSGAPGAFLFWVKYAAEAPDFAVRDVFGLLSDISDDAVLNGYEAPFPDETYLAGARR
FPSLVPLLPNGAEERAKNDAAWAVLEKFEKPVLTAFADDDPVTKGGEAAFQTRIPGAKGQNHVTISGGGHFLQEHRPEAF
SQAIITFMRANP
>Mature_332_residues
MKVMRTPDARFENLPDYPFAPHYHNVTAPDGTPLRMHYLDEGPRDGEILLCLHGQPSWSYLYRKMIPLLTAAGYRVLAPD
LIGFGKSDKPGAIEDYSYSGHAAWLEEWMLALDLTGLTLVCQDWGGLLGLRLAGMHPDRFKRLVVANTGLPDSRQLAPQM
SEMLGMLYPQVPVPSASDVGDAFRSGAPGAFLFWVKYAAEAPDFAVRDVFGLLSDISDDAVLNGYEAPFPDETYLAGARR
FPSLVPLLPNGAEERAKNDAAWAVLEKFEKPVLTAFADDDPVTKGGEAAFQTRIPGAKGQNHVTISGGGHFLQEHRPEAF
SQAIITFMRANP

Specific function: Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the haloalkane dehalogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI27597073, Length=115, Percent_Identity=33.9130434782609, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562298, Length=311, Percent_Identity=25.7234726688103, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17554012, Length=121, Percent_Identity=29.7520661157025, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.8.1.5 [H]

Molecular weight: Translated: 36432; Mature: 36432

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVMRTPDARFENLPDYPFAPHYHNVTAPDGTPLRMHYLDEGPRDGEILLCLHGQPSWSY
CCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCHHH
LYRKMIPLLTAAGYRVLAPDLIGFGKSDKPGAIEDYSYSGHAAWLEEWMLALDLTGLTLV
HHHHHHHHHHHCCCEEECHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
CQDWGGLLGLRLAGMHPDRFKRLVVANTGLPDSRQLAPQMSEMLGMLYPQVPVPSASDVG
EHHHCCHHHHHCCCCCHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHH
DAFRSGAPGAFLFWVKYAAEAPDFAVRDVFGLLSDISDDAVLNGYEAPFPDETYLAGARR
HHHHCCCCCCEEHEEHHHCCCCCHHHHHHHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHH
FPSLVPLLPNGAEERAKNDAAWAVLEKFEKPVLTAFADDDPVTKGGEAAFQTRIPGAKGQ
CCCCCCCCCCCHHHHHCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHEEECCCCCCCC
NHVTISGGGHFLQEHRPEAFSQAIITFMRANP
CEEEECCCCHHHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVMRTPDARFENLPDYPFAPHYHNVTAPDGTPLRMHYLDEGPRDGEILLCLHGQPSWSY
CCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCHHH
LYRKMIPLLTAAGYRVLAPDLIGFGKSDKPGAIEDYSYSGHAAWLEEWMLALDLTGLTLV
HHHHHHHHHHHCCCEEECHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEE
CQDWGGLLGLRLAGMHPDRFKRLVVANTGLPDSRQLAPQMSEMLGMLYPQVPVPSASDVG
EHHHCCHHHHHCCCCCHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHH
DAFRSGAPGAFLFWVKYAAEAPDFAVRDVFGLLSDISDDAVLNGYEAPFPDETYLAGARR
HHHHCCCCCCEEHEEHHHCCCCCHHHHHHHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHH
FPSLVPLLPNGAEERAKNDAAWAVLEKFEKPVLTAFADDDPVTKGGEAAFQTRIPGAKGQ
CCCCCCCCCCCHHHHHCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHEEECCCCCCCC
NHVTISGGGHFLQEHRPEAFSQAIITFMRANP
CEEEECCCCHHHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA