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The map label for this gene is nodT [H]

Identifier: 114797632

GI number: 114797632

Start: 2280613

End: 2282400

Strand: Direct

Name: nodT [H]

Synonym: HNE_2187

Alternate gene names: 114797632

Gene position: 2280613-2282400 (Clockwise)

Preceding gene: 114799793

Following gene: 114800395

Centisome position: 61.55

GC content: 63.65

Gene sequence:

>1788_bases
GTGCGATTATCGCGATCGCCAAGCTGTCGGATTTGTCAGTTTCGAGCCAGCCATGAGACAGCTTGGCGGGCTATGATCGA
TAGTGGCGATGGCAGTTTACGGTTTGATTGGCGACAAATGATGGCAGTTTCACCGGGCAGTACTCCACCTCCGGGCCTCT
CTTCAATCTCCTCTTACCGGTTTCCAGCGCAAGACGCCCCCTCCACCACGGCGTCAAGCCCCGGCTCGCCCGGCGACATT
GAACATGCGCTCCGCGGCCTATGGAAAGTCCCGGCACTCCCGCCGCCCCAGGGCTTTCAAACGGCGACAGCGCTTAATGA
TGCCGATAGCCTTCCTGTCCAGAAACATCACCGGCGCATCTGTTTAGGCGCCCTGATCTGCGCCGGGCTTCTATCGTCCT
GCACAACCGTTGGCCCGGATTATACAGCACCTGATAGCGACAGATATGTCAGCACGGATTTTGCCAAAGCGGCGCCTTAT
GACGATGCCGCGCCCTTATCCGACTGGTGGACGGCGTTCGAAGACCCGGTGCTTGAAAGTCTGATCAAGCGGGGCTTCGA
AGAGAACCGCACGCTCGCCGCCGCGACCGCGAACCTCCGCCTCGCACGCGCCGATCTCGGGCTGGCACAAAGGGCGCGTC
TGCCGGATGACACATTGGAGGCCAGCTATCTGGAAACCCGGCAATCATCAGCCGCCTTCACGGGGATCGCTGACGACGCG
CCCCCGGGTACCGAAACATTCGGCATACCGAGCCTCAGTGTCGCGGCCGGTTGGGAGGTCGATCTCTTCGGACGTGTGGA
CCGCCTCATCGAGGCGGCCGATGCGCGCGCTGGCGCCGCTGAGGCCGCATTGGCGGACATGCAAATTGTCATCGCCACCG
ATATCGCCGCAGCTTATCTTTCAGTACGCGGACTTCGGGACCAGCGGGATGTCGCCCGGCGCAATGTCGAGAACCTTCGT
GAGACCTCTGACCTCGTCCGAGATCTGCGCGATGTCGGACGGGTGAGCGATCTCGAATTGGATCAGGCACACGCCGAACT
GGCGCTGACCGAAGCTTTTCTGCCCGCGCTCAACGCCTCAATCACGGACGCGGAAAATCGACTCGCCGTCCTGATCGGCG
CCACGCCCCAGGAGATCGGTGCCTATCTTGCCGACGACAGCCCGCTGGCTATGATCAAGGCGCCAATCGCAATCGGGGAC
CCTGCAGCGTTGCTGCGCCGACGCCCGGACATTGCTGAACGCGAGCGTCTTCTGGCAGCGGCGACGGCAGGCATCGGGCT
CAACATCGCCGAAGCGTTCCCGCGGATCAGCCTGCTCGGAGAAGCTGGCGTGCGATCGGTGGGCATTGATGATCTCCTCT
CGGAGCGTGCGCTCAATTTCGCAGCCGGTCCCCAGCTTGCCTGGTCCGTCACCGGACTGATCCGTGCGGGCGACCGCGTG
CGCGCCGCGCGCGCCTCGGCCGACGCGGCTTTTGCGATGTATGAGCAGACGGTGCTGCAGGCTCTGGCCGAAACCGAAAC
GGCCCTGGAAAGACAGTCGCAGCTCCAGGCGCGGAGCACGCGCCTTGAGGAAGCCCACGCAGCGGCGACCTCAGCGGCGG
CGCTCGCGACGTTCCGATTTGAAACCGGCACGGCGGATTTTTTGAATGTCCTCGACGCCGAGCGCGTTGAGCTCGATACG
GCCAACCAGCTTGCGGCGGCGCGCAGCGAAGTCGCCCTCGCGCAGGTGGCCGTGTTTCGGGTGCTTCGCGCAGGCGCGCC
ATCACCGGTAGCGCCTTCAGACAGGTGA

Upstream 100 bases:

>100_bases
GACAATCACGCCGTACATTACCCGCAGAGATCGGATTTCCGATTGTCCCCTCAGTATACCTCATCCGTCATGGCGCGTGA
TCAATGTTCGGTGGCCGAGT

Downstream 100 bases:

>100_bases
GGTATACTTGACCCCCAGCCTGCCCTCAGAAGCCTGCGAGGGCGCCGGACATCACGCCCATGAAGATTTTGATTGTTGAA
GATGAGCCGAAAACGATTGC

Product: putative outer membrane efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MRLSRSPSCRICQFRASHETAWRAMIDSGDGSLRFDWRQMMAVSPGSTPPPGLSSISSYRFPAQDAPSTTASSPGSPGDI
EHALRGLWKVPALPPPQGFQTATALNDADSLPVQKHHRRICLGALICAGLLSSCTTVGPDYTAPDSDRYVSTDFAKAAPY
DDAAPLSDWWTAFEDPVLESLIKRGFEENRTLAAATANLRLARADLGLAQRARLPDDTLEASYLETRQSSAAFTGIADDA
PPGTETFGIPSLSVAAGWEVDLFGRVDRLIEAADARAGAAEAALADMQIVIATDIAAAYLSVRGLRDQRDVARRNVENLR
ETSDLVRDLRDVGRVSDLELDQAHAELALTEAFLPALNASITDAENRLAVLIGATPQEIGAYLADDSPLAMIKAPIAIGD
PAALLRRRPDIAERERLLAAATAGIGLNIAEAFPRISLLGEAGVRSVGIDDLLSERALNFAAGPQLAWSVTGLIRAGDRV
RAARASADAAFAMYEQTVLQALAETETALERQSQLQARSTRLEEAHAAATSAAALATFRFETGTADFLNVLDAERVELDT
ANQLAAARSEVALAQVAVFRVLRAGAPSPVAPSDR

Sequences:

>Translated_595_residues
MRLSRSPSCRICQFRASHETAWRAMIDSGDGSLRFDWRQMMAVSPGSTPPPGLSSISSYRFPAQDAPSTTASSPGSPGDI
EHALRGLWKVPALPPPQGFQTATALNDADSLPVQKHHRRICLGALICAGLLSSCTTVGPDYTAPDSDRYVSTDFAKAAPY
DDAAPLSDWWTAFEDPVLESLIKRGFEENRTLAAATANLRLARADLGLAQRARLPDDTLEASYLETRQSSAAFTGIADDA
PPGTETFGIPSLSVAAGWEVDLFGRVDRLIEAADARAGAAEAALADMQIVIATDIAAAYLSVRGLRDQRDVARRNVENLR
ETSDLVRDLRDVGRVSDLELDQAHAELALTEAFLPALNASITDAENRLAVLIGATPQEIGAYLADDSPLAMIKAPIAIGD
PAALLRRRPDIAERERLLAAATAGIGLNIAEAFPRISLLGEAGVRSVGIDDLLSERALNFAAGPQLAWSVTGLIRAGDRV
RAARASADAAFAMYEQTVLQALAETETALERQSQLQARSTRLEEAHAAATSAAALATFRFETGTADFLNVLDAERVELDT
ANQLAAARSEVALAQVAVFRVLRAGAPSPVAPSDR
>Mature_595_residues
MRLSRSPSCRICQFRASHETAWRAMIDSGDGSLRFDWRQMMAVSPGSTPPPGLSSISSYRFPAQDAPSTTASSPGSPGDI
EHALRGLWKVPALPPPQGFQTATALNDADSLPVQKHHRRICLGALICAGLLSSCTTVGPDYTAPDSDRYVSTDFAKAAPY
DDAAPLSDWWTAFEDPVLESLIKRGFEENRTLAAATANLRLARADLGLAQRARLPDDTLEASYLETRQSSAAFTGIADDA
PPGTETFGIPSLSVAAGWEVDLFGRVDRLIEAADARAGAAEAALADMQIVIATDIAAAYLSVRGLRDQRDVARRNVENLR
ETSDLVRDLRDVGRVSDLELDQAHAELALTEAFLPALNASITDAENRLAVLIGATPQEIGAYLADDSPLAMIKAPIAIGD
PAALLRRRPDIAERERLLAAATAGIGLNIAEAFPRISLLGEAGVRSVGIDDLLSERALNFAAGPQLAWSVTGLIRAGDRV
RAARASADAAFAMYEQTVLQALAETETALERQSQLQARSTRLEEAHAAATSAAALATFRFETGTADFLNVLDAERVELDT
ANQLAAARSEVALAQVAVFRVLRAGAPSPVAPSDR

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=440, Percent_Identity=25.9090909090909, Blast_Score=103, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 63341; Mature: 63341

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00037 MYB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSRSPSCRICQFRASHETAWRAMIDSGDGSLRFDWRQMMAVSPGSTPPPGLSSISSYR
CCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCEEEHHHHHHEECCCCCCCCCHHHHHHCC
FPAQDAPSTTASSPGSPGDIEHALRGLWKVPALPPPQGFQTATALNDADSLPVQKHHRRI
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHH
CLGALICAGLLSSCTTVGPDYTAPDSDRYVSTDFAKAAPYDDAAPLSDWWTAFEDPVLES
HHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCHHHCCCCCCCCCCHHHHHHHCCHHHHH
LIKRGFEENRTLAAATANLRLARADLGLAQRARLPDDTLEASYLETRQSSAAFTGIADDA
HHHCCHHCCCEEEEEHHCEEEEHHHCCHHHHCCCCCHHHHHHHHHHHHCCCCEECCCCCC
PPGTETFGIPSLSVAAGWEVDLFGRVDRLIEAADARAGAAEAALADMQIVIATDIAAAYL
CCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCEEEEHHHHHHHHH
SVRGLRDQRDVARRNVENLRETSDLVRDLRDVGRVSDLELDQAHAELALTEAFLPALNAS
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
ITDAENRLAVLIGATPQEIGAYLADDSPLAMIKAPIAIGDPAALLRRRPDIAERERLLAA
CCCCCCCEEEEEECCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHH
ATAGIGLNIAEAFPRISLLGEAGVRSVGIDDLLSERALNFAAGPQLAWSVTGLIRAGDRV
HHCCCCCCHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHH
RAARASADAAFAMYEQTVLQALAETETALERQSQLQARSTRLEEAHAAATSAAALATFRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
ETGTADFLNVLDAERVELDTANQLAAARSEVALAQVAVFRVLRAGAPSPVAPSDR
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRLSRSPSCRICQFRASHETAWRAMIDSGDGSLRFDWRQMMAVSPGSTPPPGLSSISSYR
CCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCEEEHHHHHHEECCCCCCCCCHHHHHHCC
FPAQDAPSTTASSPGSPGDIEHALRGLWKVPALPPPQGFQTATALNDADSLPVQKHHRRI
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHH
CLGALICAGLLSSCTTVGPDYTAPDSDRYVSTDFAKAAPYDDAAPLSDWWTAFEDPVLES
HHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCHHHCCCCCCCCCCHHHHHHHCCHHHHH
LIKRGFEENRTLAAATANLRLARADLGLAQRARLPDDTLEASYLETRQSSAAFTGIADDA
HHHCCHHCCCEEEEEHHCEEEEHHHCCHHHHCCCCCHHHHHHHHHHHHCCCCEECCCCCC
PPGTETFGIPSLSVAAGWEVDLFGRVDRLIEAADARAGAAEAALADMQIVIATDIAAAYL
CCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCEEEEHHHHHHHHH
SVRGLRDQRDVARRNVENLRETSDLVRDLRDVGRVSDLELDQAHAELALTEAFLPALNAS
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCC
ITDAENRLAVLIGATPQEIGAYLADDSPLAMIKAPIAIGDPAALLRRRPDIAERERLLAA
CCCCCCCEEEEEECCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHH
ATAGIGLNIAEAFPRISLLGEAGVRSVGIDDLLSERALNFAAGPQLAWSVTGLIRAGDRV
HHCCCCCCHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHH
RAARASADAAFAMYEQTVLQALAETETALERQSQLQARSTRLEEAHAAATSAAALATFRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
ETGTADFLNVLDAERVELDTANQLAAARSEVALAQVAVFRVLRAGAPSPVAPSDR
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]