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The map label for this gene is czcR [H]

Identifier: 114800395

GI number: 114800395

Start: 2282460

End: 2283143

Strand: Direct

Name: czcR [H]

Synonym: HNE_2188

Alternate gene names: 114800395

Gene position: 2282460-2283143 (Clockwise)

Preceding gene: 114797632

Following gene: 114798801

Centisome position: 61.6

GC content: 58.33

Gene sequence:

>684_bases
ATGAAGATTTTGATTGTTGAAGATGAGCCGAAAACGATTGCGTATCTGCAGCGCGGCCTCACTGAGCAGGGCTATGCCGT
TGATACCGCCGCGAACGGTGAAGACGGGCTGCATCTTGCGCTGACCGGCGAATATGACGCCATCGTGATGGACGTCATGA
TGCCAGGACTTGACGGGGTCTTGGTGCTTCAATCGTTGCGCATATCGAAAGATACACCTGTTATCTTCCTGACCGCCAGA
GACAAGGTCGATGACCGCCTGCGCGGACTGGGCGCGGGAGCTGACGACTATCTGGTGAAACCCTTCTCTTTTCTGGAGCT
GGTTGCACGGATTCAGGCAATCACGCGCCGCGGCCGGACCCGGGAGACCACCCTAATCCAGGTTGCCGATCTGCATATCG
ATCTGGTGTCGCGACGCGCCATCCGCGGCGCCCGGAGGCTCAACCTGACGGCGCGCGAGTTCTCCCTGCTGGCAGCCCTC
GCCCGCCGCCGCTCTCAGATCGTTTCCAAGACCGCTATTGCCGAACTCGTCTGGGATATCAATTTCGACACGAATACAAA
TGTGGTCGAAGTGGCCATCAAACGCCTGCGGAGCAAACTCGAAGAGCCAGGCGAAATCAGGCTCCTCCATACGGTGAGGG
GTATGGGATATGTGCTGGAGCTACGCGAGGAAGGCGGGCTATGA

Upstream 100 bases:

>100_bases
GCGCAGGCGCGCCATCACCGGTAGCGCCTTCAGACAGGTGAGGTATACTTGACCCCCAGCCTGCCCTCAGAAGCCTGCGA
GGGCGCCGGACATCACGCCC

Downstream 100 bases:

>100_bases
AAGGACGCTCGATCGCGCTCCACCTTGCCGTGATGTTTGGTCTCTCGGTCGCCATCGTCTCTTCGGTCGCTGGCGTTGCG
ATCAATATCTTTCAAGCCGA

Product: DNA-binding heavy metal response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MKILIVEDEPKTIAYLQRGLTEQGYAVDTAANGEDGLHLALTGEYDAIVMDVMMPGLDGVLVLQSLRISKDTPVIFLTAR
DKVDDRLRGLGAGADDYLVKPFSFLELVARIQAITRRGRTRETTLIQVADLHIDLVSRRAIRGARRLNLTAREFSLLAAL
ARRRSQIVSKTAIAELVWDINFDTNTNVVEVAIKRLRSKLEEPGEIRLLHTVRGMGYVLELREEGGL

Sequences:

>Translated_227_residues
MKILIVEDEPKTIAYLQRGLTEQGYAVDTAANGEDGLHLALTGEYDAIVMDVMMPGLDGVLVLQSLRISKDTPVIFLTAR
DKVDDRLRGLGAGADDYLVKPFSFLELVARIQAITRRGRTRETTLIQVADLHIDLVSRRAIRGARRLNLTAREFSLLAAL
ARRRSQIVSKTAIAELVWDINFDTNTNVVEVAIKRLRSKLEEPGEIRLLHTVRGMGYVLELREEGGL
>Mature_227_residues
MKILIVEDEPKTIAYLQRGLTEQGYAVDTAANGEDGLHLALTGEYDAIVMDVMMPGLDGVLVLQSLRISKDTPVIFLTAR
DKVDDRLRGLGAGADDYLVKPFSFLELVARIQAITRRGRTRETTLIQVADLHIDLVSRRAIRGARRLNLTAREFSLLAAL
ARRRSQIVSKTAIAELVWDINFDTNTNVVEVAIKRLRSKLEEPGEIRLLHTVRGMGYVLELREEGGL

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=50.2304147465438, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=48.8789237668161, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=34.0909090909091, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=36.7256637168142, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=35.1111111111111, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=35.6828193832599, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=35.1598173515982, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=34.6846846846847, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=30.3571428571429, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=36.1233480176211, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=33.9366515837104, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=30.8370044052863, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=29.9559471365639, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=38.3177570093458, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790299, Length=136, Percent_Identity=28.6764705882353, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788713, Length=105, Percent_Identity=35.2380952380952, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25321; Mature: 25321

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIVEDEPKTIAYLQRGLTEQGYAVDTAANGEDGLHLALTGEYDAIVMDVMMPGLDGV
CEEEEEECCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCHHEEEEHHHCCCCHH
LVLQSLRISKDTPVIFLTARDKVDDRLRGLGAGADDYLVKPFSFLELVARIQAITRRGRT
HHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHCCCC
RETTLIQVADLHIDLVSRRAIRGARRLNLTAREFSLLAALARRRSQIVSKTAIAELVWDI
CCCEEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
NFDTNTNVVEVAIKRLRSKLEEPGEIRLLHTVRGMGYVLELREEGGL
CCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCC
>Mature Secondary Structure
MKILIVEDEPKTIAYLQRGLTEQGYAVDTAANGEDGLHLALTGEYDAIVMDVMMPGLDGV
CEEEEEECCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCHHEEEEHHHCCCCHH
LVLQSLRISKDTPVIFLTARDKVDDRLRGLGAGADDYLVKPFSFLELVARIQAITRRGRT
HHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHCCCC
RETTLIQVADLHIDLVSRRAIRGARRLNLTAREFSLLAALARRRSQIVSKTAIAELVWDI
CCCEEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
NFDTNTNVVEVAIKRLRSKLEEPGEIRLLHTVRGMGYVLELREEGGL
CCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]