Click here to switch to the map view.

The map label for this gene is hisC [H]

Identifier: 114797469

GI number: 114797469

Start: 2457587

End: 2458741

Strand: Direct

Name: hisC [H]

Synonym: HNE_2357

Alternate gene names: 114797469

Gene position: 2457587-2458741 (Clockwise)

Preceding gene: 114797241

Following gene: 114799330

Centisome position: 66.33

GC content: 59.22

Gene sequence:

>1155_bases
TTGACACGCCGCGGGCTGTTTTCAGCCGGCGCTGGCGTTGCCGCAGTTGGCCTCGCCGGCTGTACAACGACAACATCGGC
TACCGCTGCAGCCGCCGAGGCGACCGGCGCATTTCCGGCCGAAGCATCCGGCCCTGCGCTGTTCGGACCGGAAGCCGGGC
TGGCTCTGCTCTCGCGCAACGAAAACCCTTATGGCCCGGCGCCATCAGCCCTCAAGATGATCAGCAAAGCGGCTGAAAAG
GGCGCCTATTACACTAACCAGGAAGCCATCGTTACGCTCAACAAGCTCATTGCTGACCGTCACGGGGTCTCACCCGAACA
GATCGTCATCACCACCGGCTCGGGCGAAGCGCTCAGCGCGCTGGCCCTGATCTATGGCCCCAAAGGACCCATCGTCGCGC
CGCGCCTCTTCTGGGATACCACCGCGCTCTATGCAGCCAAGCTGGGCATGGCAGAAATCATCCGTGTTCCACTGACCGAA
GACATGGATATGGACCTGGCCGCCATCGACGCGGCCATCACGCCGGAAACCGGCATGGTACAGCTTTGCAATCCGAACAA
TCCCACCGGCATCGCCATGCCCGGCTCCGTCATCCGGGCTGCCGTCTCGAAGATGGCCGCGAAAACTACCGTGGTTGTGG
ATGAAGCCTATATCGAACTTGTTGATGATGAAGCCTCGATGACCTGCGTGCCCCTTATCAAAGAAGGCAAGGATGTCATC
GTCACGCGCACTTTCTCGAAAATCTACGGTATGGCGGGCATCCGCGTCGGCTACACGATCTCGTCGGCAGAAACCGCCGA
GAAGATCCGCTACACGCAGATGTCCTGGACGCCGTGCACCTCCATCGCCGCCGCCATCGGCTGTTATGATGACACCGCCT
TCCTTGACTATTCCAAGTCAAAGATCGTCGAAGCCCGCGAGATGATCACCACGACACTGGACGCGCTCGATCTCAAATAC
CTGAAATCACAGACCAACTTCGTTTACTTCCAGAGCGGCATGCCCGCTAACGATCTGGCCAAAGCCATGGCTGCGGAGAA
AATCTCAATCCGTGGACAGTACATGGATTACGTGCCGTGGAGCCGCGTTTCGACCGGCAAGATCCAAGATGTCGAGCGTT
TCTGCAAAGCGTTGCCCCGGCTTGTAAACGCATGA

Upstream 100 bases:

>100_bases
TCACGCACTGCGCCGCTTCTGGCCGATCCCGTGCCCGCGGTAACCACCATCAATGCCGACATTTCACTTTCCAATCAGGA
GGAAGATCATGGGATATAGA

Downstream 100 bases:

>100_bases
CAGACGGCCACTCCGGAAACGCCTTAATAGTCTGCCTGCAGAACTTAAAGAATACGCATCCGGAAAAGTGAGGTTTATGC
CCGGATCGGTGAAATTTTAT

Product: classes I and II aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MTRRGLFSAGAGVAAVGLAGCTTTTSATAAAAEATGAFPAEASGPALFGPEAGLALLSRNENPYGPAPSALKMISKAAEK
GAYYTNQEAIVTLNKLIADRHGVSPEQIVITTGSGEALSALALIYGPKGPIVAPRLFWDTTALYAAKLGMAEIIRVPLTE
DMDMDLAAIDAAITPETGMVQLCNPNNPTGIAMPGSVIRAAVSKMAAKTTVVVDEAYIELVDDEASMTCVPLIKEGKDVI
VTRTFSKIYGMAGIRVGYTISSAETAEKIRYTQMSWTPCTSIAAAIGCYDDTAFLDYSKSKIVEAREMITTTLDALDLKY
LKSQTNFVYFQSGMPANDLAKAMAAEKISIRGQYMDYVPWSRVSTGKIQDVERFCKALPRLVNA

Sequences:

>Translated_384_residues
MTRRGLFSAGAGVAAVGLAGCTTTTSATAAAAEATGAFPAEASGPALFGPEAGLALLSRNENPYGPAPSALKMISKAAEK
GAYYTNQEAIVTLNKLIADRHGVSPEQIVITTGSGEALSALALIYGPKGPIVAPRLFWDTTALYAAKLGMAEIIRVPLTE
DMDMDLAAIDAAITPETGMVQLCNPNNPTGIAMPGSVIRAAVSKMAAKTTVVVDEAYIELVDDEASMTCVPLIKEGKDVI
VTRTFSKIYGMAGIRVGYTISSAETAEKIRYTQMSWTPCTSIAAAIGCYDDTAFLDYSKSKIVEAREMITTTLDALDLKY
LKSQTNFVYFQSGMPANDLAKAMAAEKISIRGQYMDYVPWSRVSTGKIQDVERFCKALPRLVNA
>Mature_383_residues
TRRGLFSAGAGVAAVGLAGCTTTTSATAAAAEATGAFPAEASGPALFGPEAGLALLSRNENPYGPAPSALKMISKAAEKG
AYYTNQEAIVTLNKLIADRHGVSPEQIVITTGSGEALSALALIYGPKGPIVAPRLFWDTTALYAAKLGMAEIIRVPLTED
MDMDLAAIDAAITPETGMVQLCNPNNPTGIAMPGSVIRAAVSKMAAKTTVVVDEAYIELVDDEASMTCVPLIKEGKDVIV
TRTFSKIYGMAGIRVGYTISSAETAEKIRYTQMSWTPCTSIAAAIGCYDDTAFLDYSKSKIVEAREMITTTLDALDLKYL
KSQTNFVYFQSGMPANDLAKAMAAEKISIRGQYMDYVPWSRVSTGKIQDVERFCKALPRLVNA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=235, Percent_Identity=25.9574468085106, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=365, Percent_Identity=24.1095890410959, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40691; Mature: 40560

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRGLFSAGAGVAAVGLAGCTTTTSATAAAAEATGAFPAEASGPALFGPEAGLALLSRN
CCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCEEECCCCCEEEEECC
ENPYGPAPSALKMISKAAEKGAYYTNQEAIVTLNKLIADRHGVSPEQIVITTGSGEALSA
CCCCCCCHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHE
LALIYGPKGPIVAPRLFWDTTALYAAKLGMAEIIRVPLTEDMDMDLAAIDAAITPETGMV
EEEEECCCCCEECCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHCEEECCCCCEE
QLCNPNNPTGIAMPGSVIRAAVSKMAAKTTVVVDEAYIELVDDEASMTCVPLIKEGKDVI
EEECCCCCCCCCCCHHHHHHHHHHHHHHEEEEEEEEEEEEECCCCCEEEEEEECCCCEEE
VTRTFSKIYGMAGIRVGYTISSAETAEKIRYTQMSWTPCTSIAAAIGCYDDTAFLDYSKS
EEEEHHHHHCCCCEEEEEEECCHHHHHHHEEEECCCCCHHHHHHHHHCCCCCCEEECCHH
KIVEAREMITTTLDALDLKYLKSQTNFVYFQSGMPANDLAKAMAAEKISIRGQYMDYVPW
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHEECCCEECCCCC
SRVSTGKIQDVERFCKALPRLVNA
CCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TRRGLFSAGAGVAAVGLAGCTTTTSATAAAAEATGAFPAEASGPALFGPEAGLALLSRN
CCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCEEECCCCCEEEEECC
ENPYGPAPSALKMISKAAEKGAYYTNQEAIVTLNKLIADRHGVSPEQIVITTGSGEALSA
CCCCCCCHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHE
LALIYGPKGPIVAPRLFWDTTALYAAKLGMAEIIRVPLTEDMDMDLAAIDAAITPETGMV
EEEEECCCCCEECCHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHCEEECCCCCEE
QLCNPNNPTGIAMPGSVIRAAVSKMAAKTTVVVDEAYIELVDDEASMTCVPLIKEGKDVI
EEECCCCCCCCCCCHHHHHHHHHHHHHHEEEEEEEEEEEEECCCCCEEEEEEECCCCEEE
VTRTFSKIYGMAGIRVGYTISSAETAEKIRYTQMSWTPCTSIAAAIGCYDDTAFLDYSKS
EEEEHHHHHCCCCEEEEEEECCHHHHHHHEEEECCCCCHHHHHHHHHCCCCCCEEECCHH
KIVEAREMITTTLDALDLKYLKSQTNFVYFQSGMPANDLAKAMAAEKISIRGQYMDYVPW
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHEECCCEECCCCC
SRVSTGKIQDVERFCKALPRLVNA
CCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA