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The map label for this gene is menE [H]

Identifier: 113477490

GI number: 113477490

Start: 6279994

End: 6281409

Strand: Reverse

Name: menE [H]

Synonym: Tery_4067

Alternate gene names: 113477490

Gene position: 6281409-6279994 (Counterclockwise)

Preceding gene: 113477491

Following gene: 113477485

Centisome position: 81.05

GC content: 30.86

Gene sequence:

>1416_bases
ATGAACCTAATCTTTAACTACCTAAAAAAATACCAAGTCAAAAGAAGTAAAACTTTTTTGAGCTCTAGCGAATTTTCTTA
TCTTACGAACAAAAAAATTAAAAACTTAATCAAAATTGCAAATCCAAGAACTCCTAGCAAAGTATTAATATCAGAATCAA
ATCCAACAGAATTTATTTCTAGTTTTCTTGCTGCTGTTGGTGCTAATTGTCAAGTATTTTTATGTAATCCAAAATGGGGA
CAACTAGAATGGGAAAAAGTTTTAAAATTAGTAGAACCAGACATGATTTTGGGAAATATTCTTAACCATAAATCTCTCGA
AAAGTCTTTAGAAAAAATATCTAGTTTGTCTAGAGATAACCCCTGTAAAAAAACTCTGACTACTGAGGAAAATTTGATTA
TGATTCCTACTGGTGGCTCATCTGGCAAAATTAAATTTGCTATTCATACATGGGAAACTTTAATGTCATCTGTAAGAGGT
TTCCAAGGATATTTCCAAGTACAAGAAATTAATTCATTTTGTGTTTTACCCCTATATCATGTCAGTGGTTTAATGCAGTT
TATACGCTCCTTTACTACTGGGGGAAATTTAATAATTTTGCCATCCTATAAAGATATTTTAGAACAAAAAGAATGGAATA
TTAACCCCAATGAATTTTTCATTTCCCTAGTACCAACTCAGTTACACCATTTGTTACAAAAGGCAGAAACAGCTAACTGG
TTATCTAATTTTAAAATAGTGCTTTTAGGTGGTTCCGCAGCTTGGGAAGAATTATTTGATGCTGCAAGAAAATATCAAAT
TAAATTAGCTCCAACTTATGGAATGACAGAAACTGCTTCTCAAGTTGCGACTCTTAAACCACAAGATTTTTTGGCAGGAA
ATAATAGTAACGGTCAAGTATTACCTCACGCTAAAATTATTGTGAAAAATGAAAGTGGGAAAATATTATATCAAAATCAA
ATTGGTAATATTAGCATTAAAGCTAATTCTTTGGCGTTAGGGTATTATCCTGATATATTTAATAATTATGAAAGTCTAGT
AACAGATGATTTAGGATTTTTTGATCATCAAGGTTACTTAAAAATAGTAGGTCGTAGTAGTCAAAAAATTATTACTGGTG
GGGAAAATGTTTTTCCGGCAGAAGTTGAAGCTGCTATTTTGACAACTGGTTTAGTTGATGATATTTGTGTAATTGGCTTA
GCAGATAAATATTGGGGTGAAGTTGTAACTGCTGTTTATGTGGGTAATTATTTTGAAGTTTCTAAGGAAAAGTTGTTAGC
TGCTATTGATAAAAAATTGAGCAAATTTAAGCAGCCTAAATATTGGCTAAGAGTAGAAAGTTTACCTCGTAATTCTCAAG
GAAAAATTAATCGAGAGTTTTTAAAAGAAATTGCTATTCAAAGAATAGGAGAATAG

Upstream 100 bases:

>100_bases
TTTCAGTCTTTATTTGCAGGAGGTAGTCAAACTTTATAGTCTTTTTTACAATAAAATTAATCATAAACTATCAGCAAAAT
ACTAATACTATAACTAATTT

Downstream 100 bases:

>100_bases
GTCTAACTATTACAGCACTTTTAAAATACATAAACCACATTATCAAAACCAAAAATATGTGCAGATAAATATTTGGCATC
AGGTTGTAAATTCTCATAAA

Product: O-succinylbenzoic acid--CoA ligase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MNLIFNYLKKYQVKRSKTFLSSSEFSYLTNKKIKNLIKIANPRTPSKVLISESNPTEFISSFLAAVGANCQVFLCNPKWG
QLEWEKVLKLVEPDMILGNILNHKSLEKSLEKISSLSRDNPCKKTLTTEENLIMIPTGGSSGKIKFAIHTWETLMSSVRG
FQGYFQVQEINSFCVLPLYHVSGLMQFIRSFTTGGNLIILPSYKDILEQKEWNINPNEFFISLVPTQLHHLLQKAETANW
LSNFKIVLLGGSAAWEELFDAARKYQIKLAPTYGMTETASQVATLKPQDFLAGNNSNGQVLPHAKIIVKNESGKILYQNQ
IGNISIKANSLALGYYPDIFNNYESLVTDDLGFFDHQGYLKIVGRSSQKIITGGENVFPAEVEAAILTTGLVDDICVIGL
ADKYWGEVVTAVYVGNYFEVSKEKLLAAIDKKLSKFKQPKYWLRVESLPRNSQGKINREFLKEIAIQRIGE

Sequences:

>Translated_471_residues
MNLIFNYLKKYQVKRSKTFLSSSEFSYLTNKKIKNLIKIANPRTPSKVLISESNPTEFISSFLAAVGANCQVFLCNPKWG
QLEWEKVLKLVEPDMILGNILNHKSLEKSLEKISSLSRDNPCKKTLTTEENLIMIPTGGSSGKIKFAIHTWETLMSSVRG
FQGYFQVQEINSFCVLPLYHVSGLMQFIRSFTTGGNLIILPSYKDILEQKEWNINPNEFFISLVPTQLHHLLQKAETANW
LSNFKIVLLGGSAAWEELFDAARKYQIKLAPTYGMTETASQVATLKPQDFLAGNNSNGQVLPHAKIIVKNESGKILYQNQ
IGNISIKANSLALGYYPDIFNNYESLVTDDLGFFDHQGYLKIVGRSSQKIITGGENVFPAEVEAAILTTGLVDDICVIGL
ADKYWGEVVTAVYVGNYFEVSKEKLLAAIDKKLSKFKQPKYWLRVESLPRNSQGKINREFLKEIAIQRIGE
>Mature_471_residues
MNLIFNYLKKYQVKRSKTFLSSSEFSYLTNKKIKNLIKIANPRTPSKVLISESNPTEFISSFLAAVGANCQVFLCNPKWG
QLEWEKVLKLVEPDMILGNILNHKSLEKSLEKISSLSRDNPCKKTLTTEENLIMIPTGGSSGKIKFAIHTWETLMSSVRG
FQGYFQVQEINSFCVLPLYHVSGLMQFIRSFTTGGNLIILPSYKDILEQKEWNINPNEFFISLVPTQLHHLLQKAETANW
LSNFKIVLLGGSAAWEELFDAARKYQIKLAPTYGMTETASQVATLKPQDFLAGNNSNGQVLPHAKIIVKNESGKILYQNQ
IGNISIKANSLALGYYPDIFNNYESLVTDDLGFFDHQGYLKIVGRSSQKIITGGENVFPAEVEAAILTTGLVDDICVIGL
ADKYWGEVVTAVYVGNYFEVSKEKLLAAIDKKLSKFKQPKYWLRVESLPRNSQGKINREFLKEIAIQRIGE

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=300, Percent_Identity=29.3333333333333, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI122937307, Length=256, Percent_Identity=27.34375, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI115511026, Length=400, Percent_Identity=25.5, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI157311624, Length=368, Percent_Identity=22.8260869565217, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI157311622, Length=368, Percent_Identity=22.8260869565217, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI58082049, Length=382, Percent_Identity=23.2984293193717, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1788595, Length=342, Percent_Identity=32.7485380116959, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI145693145, Length=379, Percent_Identity=25.065963060686, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788107, Length=364, Percent_Identity=25.2747252747253, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI221142682, Length=252, Percent_Identity=27.3809523809524, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1786810, Length=353, Percent_Identity=23.5127478753541, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32563687, Length=474, Percent_Identity=26.1603375527426, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17558820, Length=344, Percent_Identity=30.2325581395349, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17531443, Length=303, Percent_Identity=26.4026402640264, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17538037, Length=313, Percent_Identity=26.517571884984, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17557194, Length=306, Percent_Identity=26.797385620915, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560308, Length=327, Percent_Identity=24.7706422018349, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994690, Length=357, Percent_Identity=23.249299719888, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994703, Length=357, Percent_Identity=23.249299719888, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994694, Length=357, Percent_Identity=23.249299719888, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17559526, Length=312, Percent_Identity=26.6025641025641, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71985884, Length=363, Percent_Identity=24.5179063360882, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=307, Percent_Identity=26.3843648208469, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6319264, Length=391, Percent_Identity=22.7621483375959, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24581924, Length=343, Percent_Identity=27.9883381924198, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355181, Length=316, Percent_Identity=26.2658227848101, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24653035, Length=203, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24656500, Length=364, Percent_Identity=21.4285714285714, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161076582, Length=212, Percent_Identity=29.2452830188679, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21356947, Length=214, Percent_Identity=27.5700934579439, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24648255, Length=229, Percent_Identity=27.9475982532751, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20130357, Length=263, Percent_Identity=25.4752851711027, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 53049; Mature: 53049

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIFNYLKKYQVKRSKTFLSSSEFSYLTNKKIKNLIKIANPRTPSKVLISESNPTEFIS
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHH
SFLAAVGANCQVFLCNPKWGQLEWEKVLKLVEPDMILGNILNHKSLEKSLEKISSLSRDN
HHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PCKKTLTTEENLIMIPTGGSSGKIKFAIHTWETLMSSVRGFQGYFQVQEINSFCVLPLYH
CCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHHHHHHHHHHHHEEEEEECCCEEEHHHHH
VSGLMQFIRSFTTGGNLIILPSYKDILEQKEWNINPNEFFISLVPTQLHHLLQKAETANW
HHHHHHHHHHHCCCCCEEEECCHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHH
LSNFKIVLLGGSAAWEELFDAARKYQIKLAPTYGMTETASQVATLKPQDFLAGNNSNGQV
HCCCEEEEEECCHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHCCCCHHHCCCCCCCCEE
LPHAKIIVKNESGKILYQNQIGNISIKANSLALGYYPDIFNNYESLVTDDLGFFDHQGYL
ECCEEEEEECCCCCEEEEECCCEEEEEECCEEEECCCHHHCCHHHHHHHCCCCCCCCCEE
KIVGRSSQKIITGGENVFPAEVEAAILTTGLVDDICVIGLADKYWGEVVTAVYVGNYFEV
EEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHCCCHHHH
SKEKLLAAIDKKLSKFKQPKYWLRVESLPRNSQGKINREFLKEIAIQRIGE
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLIFNYLKKYQVKRSKTFLSSSEFSYLTNKKIKNLIKIANPRTPSKVLISESNPTEFIS
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHH
SFLAAVGANCQVFLCNPKWGQLEWEKVLKLVEPDMILGNILNHKSLEKSLEKISSLSRDN
HHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PCKKTLTTEENLIMIPTGGSSGKIKFAIHTWETLMSSVRGFQGYFQVQEINSFCVLPLYH
CCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHHHHHHHHHHHHEEEEEECCCEEEHHHHH
VSGLMQFIRSFTTGGNLIILPSYKDILEQKEWNINPNEFFISLVPTQLHHLLQKAETANW
HHHHHHHHHHHCCCCCEEEECCHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHH
LSNFKIVLLGGSAAWEELFDAARKYQIKLAPTYGMTETASQVATLKPQDFLAGNNSNGQV
HCCCEEEEEECCHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHCCCCHHHCCCCCCCCEE
LPHAKIIVKNESGKILYQNQIGNISIKANSLALGYYPDIFNNYESLVTDDLGFFDHQGYL
ECCEEEEEECCCCCEEEEECCCEEEEEECCEEEECCCHHHCCHHHHHHHCCCCCCCCCEE
KIVGRSSQKIITGGENVFPAEVEAAILTTGLVDDICVIGLADKYWGEVVTAVYVGNYFEV
EEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHCCCHHHH
SKEKLLAAIDKKLSKFKQPKYWLRVESLPRNSQGKINREFLKEIAIQRIGE
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA