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The map label for this gene is maeB [C]

Identifier: 113477420

GI number: 113477420

Start: 6159015

End: 6160403

Strand: Reverse

Name: maeB [C]

Synonym: Tery_3983

Alternate gene names: 113477420

Gene position: 6160403-6159015 (Counterclockwise)

Preceding gene: 113477421

Following gene: 113477419

Centisome position: 79.49

GC content: 40.03

Gene sequence:

>1389_bases
ATGGTAAAACTAACACCAAATCCCTCATTTAGTTTAACAATTAGCCTCGAAACTCCTAACCGTACTGGAATGTTGGCCAA
GGTTACCCAAGCCATCGCATCAGAAGGAGGCAATATAGGTAACGTTGACCTAATAAAACAAAGTCGCCAAATCATAATTA
GAGAAATTACAGTCGATGCCTACAGTACAGAGCATATTGAAAAAATTGTTCAAGCTGTCAAAACCCTGCCAGAAATAAAA
CTCGTCAATGTGTATGACCGAACCTTCGATATACATAAAGGTGGTAAAATCACAGTTCAAGGCAAAATACCTCTCAAATC
CCAAGCCGATCTATCAATGGCTTATACTCCAGGAGTAGGAAGAATTTCTAAAGCAATTGCAGAAGACCCTCAACAAATCT
ATAATTTCACCATCAAAAAAAATACAGTTGCTATTGTGACAGATGGCAGTGCAGTTTTAGGACTAGGAAATCTTGGCCCC
GGAGGAGCTTTACCAGTAATGGAAGGTAAGGCTATGTTATTTAAAGAATTTGCTGGAATCGACGCTTTCCCTATTTGTCT
GGCTACTCAAGATACTGATGCTATTGTCGAGACAGTTAAAAATATTGCTCCTGTTTTTGGTGGAGTTAACTTAGAAGATA
TTGCTGCTCCTCGTTGTTTTGAAATAGAAGTCAAGCTAAGAGAGATATTAGATATTCCAGTATTTCACGATGACCAGCAT
GGCACAGCAATAGTTAGTTTAGCTGCGTTAATCAATGCTTTAAAATTGGTCAAAAAATCTATAGAAGATATTCGGATCGT
TATTAATGGTGCTGGTGCTGCTGGAATAGCTATCACTCGTCTATTACAAAAAGCAGGAGCTAATCAAATTTGCTTATGTG
ACTCTAAAGGTATAGTCTCCAAAAGTCGTACTGGTCTTAACTCAGAAAAACAAGCATTTGCCGTTGAGTCTTCAGGAACC
CTCGCAGATGCTTTAATGGGAGCTGATGTATTTTTAGGTGTTAGTGTCCCGGGAGTTCTTACTCCAGAAATGGTCCGTTC
TATGGCCAAAGACCCTATAGTCTTTGCAATGGCTAATCCTATTCCGGAAATACAGCCAGAATTAGTTGCAGAAGAAGTAG
CAGTGATGGCCACAGGTCGGAGTGATTATCCGAATCAAATTAATAATGTTTTGGCATTTCCAGGCATATTTAGGGGCGCT
CTAGATTGTCGGGCTACTACTCTCACCTCTACAATGTATTTAGAAGCTGCTAGAGCGATCGCTTCATTAGTCAAAACTTC
AGACCTTGACCAAGAACATATTATTCCTTCAGTATTTGACACTAGGGTAGCTACTGCGGTTGCAGGTGCAGTAGCTTCAG
CAGCTCGTACTGAAGGTGTAACTGTTTAA

Upstream 100 bases:

>100_bases
AATTCCTAGCTAAACCCAAGAAATGTTCACTCACAACTTAAGATGGACTACTATGTCACTAAATAAAATTTAGGACTTAA
AACCTAAAACCAAATTTAAC

Downstream 100 bases:

>100_bases
GCAGGATTTTTTATATCATTTCACTGAACTCAGAAGTCAGAAGACACGATTTACCTTTTGATCGACTAAAAACTTTGAAA
AGGCAATAGTTTCAGGTAAT

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MVKLTPNPSFSLTISLETPNRTGMLAKVTQAIASEGGNIGNVDLIKQSRQIIIREITVDAYSTEHIEKIVQAVKTLPEIK
LVNVYDRTFDIHKGGKITVQGKIPLKSQADLSMAYTPGVGRISKAIAEDPQQIYNFTIKKNTVAIVTDGSAVLGLGNLGP
GGALPVMEGKAMLFKEFAGIDAFPICLATQDTDAIVETVKNIAPVFGGVNLEDIAAPRCFEIEVKLREILDIPVFHDDQH
GTAIVSLAALINALKLVKKSIEDIRIVINGAGAAGIAITRLLQKAGANQICLCDSKGIVSKSRTGLNSEKQAFAVESSGT
LADALMGADVFLGVSVPGVLTPEMVRSMAKDPIVFAMANPIPEIQPELVAEEVAVMATGRSDYPNQINNVLAFPGIFRGA
LDCRATTLTSTMYLEAARAIASLVKTSDLDQEHIIPSVFDTRVATAVAGAVASAARTEGVTV

Sequences:

>Translated_462_residues
MVKLTPNPSFSLTISLETPNRTGMLAKVTQAIASEGGNIGNVDLIKQSRQIIIREITVDAYSTEHIEKIVQAVKTLPEIK
LVNVYDRTFDIHKGGKITVQGKIPLKSQADLSMAYTPGVGRISKAIAEDPQQIYNFTIKKNTVAIVTDGSAVLGLGNLGP
GGALPVMEGKAMLFKEFAGIDAFPICLATQDTDAIVETVKNIAPVFGGVNLEDIAAPRCFEIEVKLREILDIPVFHDDQH
GTAIVSLAALINALKLVKKSIEDIRIVINGAGAAGIAITRLLQKAGANQICLCDSKGIVSKSRTGLNSEKQAFAVESSGT
LADALMGADVFLGVSVPGVLTPEMVRSMAKDPIVFAMANPIPEIQPELVAEEVAVMATGRSDYPNQINNVLAFPGIFRGA
LDCRATTLTSTMYLEAARAIASLVKTSDLDQEHIIPSVFDTRVATAVAGAVASAARTEGVTV
>Mature_462_residues
MVKLTPNPSFSLTISLETPNRTGMLAKVTQAIASEGGNIGNVDLIKQSRQIIIREITVDAYSTEHIEKIVQAVKTLPEIK
LVNVYDRTFDIHKGGKITVQGKIPLKSQADLSMAYTPGVGRISKAIAEDPQQIYNFTIKKNTVAIVTDGSAVLGLGNLGP
GGALPVMEGKAMLFKEFAGIDAFPICLATQDTDAIVETVKNIAPVFGGVNLEDIAAPRCFEIEVKLREILDIPVFHDDQH
GTAIVSLAALINALKLVKKSIEDIRIVINGAGAAGIAITRLLQKAGANQICLCDSKGIVSKSRTGLNSEKQAFAVESSGT
LADALMGADVFLGVSVPGVLTPEMVRSMAKDPIVFAMANPIPEIQPELVAEEVAVMATGRSDYPNQINNVLAFPGIFRGA
LDCRATTLTSTMYLEAARAIASLVKTSDLDQEHIIPSVFDTRVATAVAGAVASAARTEGVTV

Specific function: In addition to the NAD-dependent oxidative decarboxylation of L-malate, the enzyme catalyzes the decarboxylation of oxaloacetate [H]

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=382, Percent_Identity=27.2251308900524, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4505145, Length=364, Percent_Identity=28.021978021978, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI62420882, Length=365, Percent_Identity=27.9452054794521, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI62420880, Length=365, Percent_Identity=27.9452054794521, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI239049447, Length=365, Percent_Identity=27.9452054794521, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI270265879, Length=321, Percent_Identity=28.6604361370716, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1788806, Length=397, Percent_Identity=50.6297229219144, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI87081919, Length=411, Percent_Identity=23.8442822384428, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17537199, Length=527, Percent_Identity=23.1499051233397, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322823, Length=373, Percent_Identity=26.2734584450402, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI78707242, Length=414, Percent_Identity=26.0869565217391, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI78707238, Length=414, Percent_Identity=26.0869565217391, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI78707240, Length=414, Percent_Identity=26.0869565217391, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281362674, Length=436, Percent_Identity=27.5229357798165, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281362672, Length=436, Percent_Identity=27.5229357798165, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356279, Length=436, Percent_Identity=27.5229357798165, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646388, Length=411, Percent_Identity=27.9805352798054, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24646386, Length=411, Percent_Identity=27.9805352798054, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI281363503, Length=418, Percent_Identity=23.444976076555, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI78707232, Length=416, Percent_Identity=23.5576923076923, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281363505, Length=416, Percent_Identity=23.5576923076923, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI78707236, Length=416, Percent_Identity=23.5576923076923, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 48916; Mature: 48916

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLTPNPSFSLTISLETPNRTGMLAKVTQAIASEGGNIGNVDLIKQSRQIIIREITVDA
CEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEEEEECC
YSTEHIEKIVQAVKTLPEIKLVNVYDRTFDIHKGGKITVQGKIPLKSQADLSMAYTPGVG
CCHHHHHHHHHHHHCCCCEEEEEEECCEEEECCCCEEEEEECCCCCCCCCCEEEECCCHH
RISKAIAEDPQQIYNFTIKKNTVAIVTDGSAVLGLGNLGPGGALPVMEGKAMLFKEFAGI
HHHHHHHCCHHHHHEEEEECCEEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCC
DAFPICLATQDTDAIVETVKNIAPVFGGVNLEDIAAPRCFEIEVKLREILDIPVFHDDQH
CCEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEEHHHHHCCCCEECCCC
GTAIVSLAALINALKLVKKSIEDIRIVINGAGAAGIAITRLLQKAGANQICLCDSKGIVS
CHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCC
KSRTGLNSEKQAFAVESSGTLADALMGADVFLGVSVPGVLTPEMVRSMAKDPIVFAMANP
CCCCCCCCCCCEEEEECCCCHHHHHHCCCEEEEECCCCCCCHHHHHHHCCCCEEEEECCC
IPEIQPELVAEEVAVMATGRSDYPNQINNVLAFPGIFRGALDCRATTLTSTMYLEAARAI
CCCCCHHHHHHHHHHEECCCCCCCHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
ASLVKTSDLDQEHIIPSVFDTRVATAVAGAVASAARTEGVTV
HHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVKLTPNPSFSLTISLETPNRTGMLAKVTQAIASEGGNIGNVDLIKQSRQIIIREITVDA
CEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEEEEECC
YSTEHIEKIVQAVKTLPEIKLVNVYDRTFDIHKGGKITVQGKIPLKSQADLSMAYTPGVG
CCHHHHHHHHHHHHCCCCEEEEEEECCEEEECCCCEEEEEECCCCCCCCCCEEEECCCHH
RISKAIAEDPQQIYNFTIKKNTVAIVTDGSAVLGLGNLGPGGALPVMEGKAMLFKEFAGI
HHHHHHHCCHHHHHEEEEECCEEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCC
DAFPICLATQDTDAIVETVKNIAPVFGGVNLEDIAAPRCFEIEVKLREILDIPVFHDDQH
CCEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEEHHHHHCCCCEECCCC
GTAIVSLAALINALKLVKKSIEDIRIVINGAGAAGIAITRLLQKAGANQICLCDSKGIVS
CHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCC
KSRTGLNSEKQAFAVESSGTLADALMGADVFLGVSVPGVLTPEMVRSMAKDPIVFAMANP
CCCCCCCCCCCEEEEECCCCHHHHHHCCCEEEEECCCCCCCHHHHHHHCCCCEEEEECCC
IPEIQPELVAEEVAVMATGRSDYPNQINNVLAFPGIFRGALDCRATTLTSTMYLEAARAI
CCCCCHHHHHHHHHHEECCCCCCCHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
ASLVKTSDLDQEHIIPSVFDTRVATAVAGAVASAARTEGVTV
HHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2644282 [H]