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The map label for this gene is thiD [H]

Identifier: 113477226

GI number: 113477226

Start: 5787328

End: 5788164

Strand: Reverse

Name: thiD [H]

Synonym: Tery_3765

Alternate gene names: 113477226

Gene position: 5788164-5787328 (Counterclockwise)

Preceding gene: 113477227

Following gene: 113477223

Centisome position: 74.68

GC content: 39.43

Gene sequence:

>837_bases
ATGGCTGATTTTATGGCATCAAGTATTCCTGTTGCTTTGACTATTGCTGGTTCCGATAGTGGCGGTGGAGCAGGCATTCA
GGCGGACTTGCGTACTTTTGCTTTTCACTGTGTTCATGGTACAAGTGCTTTGACTTGTATTACTGCTCAGAATACTTTGG
GAGTGAATAGGCTTGATGCTTTGTTGCCAGAGGTGGTTAAAGCTCAAATTGAAGCGGTTGTTCAAGATATAGGTGTTCAG
GCGACTAAAACAGGAATGTTACTTAACCAAGATATTATTTTGGTTGTGGCTGAGGTGTTGGAAACTTTAAGTTTAAAACA
ATTGGTGGTAGACCCGGTAATGGTATCCCGTGCAGGTGTTCAGTTGATTGATAATTCTGCTGTGGCTGCTTTACGGGATT
TTTTGCTTCCAAAGGCCAGTATTGTTACTCCTAATATTTATGAGGCCCAGATTTTGGCGGGTTTAGATATTAACAATATT
AATGATATGAAATTGGCGGCTGAGAAAATTCATAAGTTTGGAGTTAATACTGTTCTGGTTAAGGGAGGTGCTCTGAAGCA
TAATTTACGAGGAGTAGATGTTTGGTTTGATGGGGAGTCTTTTGAAACTTTGAAAACTTCTACAGTTGATACTAATAATA
CTCATGGTACTGGTTGTACTCTTTCAGCAGCGATCGCTGCCAATTTAGCTCAAGGACAAGATTTATTTTCCGCAGTTACA
ATGGCTAAGAATTATGTCACAAGTTCTCTACAGTATGCTTTAGAAATTGGTCAAGGTCAAGGCCCTATAGGGCATTTTTT
TCCTTTGCTCTTAAACAATTATATTAAGAGCAGTTGA

Upstream 100 bases:

>100_bases
TCCTGACTTTCTGCAAAGGCGACGAAATCCATCTAATAAGTAAGATTAAAGCAAAGGAAATTTCTTGATATCTAACTCTC
TATAAATTATATTAATTGTT

Downstream 100 bases:

>100_bases
CCTCATTTGGGGGAAGTAGGTGGGGAAATTGGTTAGGATTAGTATTTTGGTCTCCTAGTTCTTAAACATACTAAGAACAA
CAAACCCTGATTAAGTCTCA

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MADFMASSIPVALTIAGSDSGGGAGIQADLRTFAFHCVHGTSALTCITAQNTLGVNRLDALLPEVVKAQIEAVVQDIGVQ
ATKTGMLLNQDIILVVAEVLETLSLKQLVVDPVMVSRAGVQLIDNSAVAALRDFLLPKASIVTPNIYEAQILAGLDINNI
NDMKLAAEKIHKFGVNTVLVKGGALKHNLRGVDVWFDGESFETLKTSTVDTNNTHGTGCTLSAAIAANLAQGQDLFSAVT
MAKNYVTSSLQYALEIGQGQGPIGHFFPLLLNNYIKSS

Sequences:

>Translated_278_residues
MADFMASSIPVALTIAGSDSGGGAGIQADLRTFAFHCVHGTSALTCITAQNTLGVNRLDALLPEVVKAQIEAVVQDIGVQ
ATKTGMLLNQDIILVVAEVLETLSLKQLVVDPVMVSRAGVQLIDNSAVAALRDFLLPKASIVTPNIYEAQILAGLDINNI
NDMKLAAEKIHKFGVNTVLVKGGALKHNLRGVDVWFDGESFETLKTSTVDTNNTHGTGCTLSAAIAANLAQGQDLFSAVT
MAKNYVTSSLQYALEIGQGQGPIGHFFPLLLNNYIKSS
>Mature_277_residues
ADFMASSIPVALTIAGSDSGGGAGIQADLRTFAFHCVHGTSALTCITAQNTLGVNRLDALLPEVVKAQIEAVVQDIGVQA
TKTGMLLNQDIILVVAEVLETLSLKQLVVDPVMVSRAGVQLIDNSAVAALRDFLLPKASIVTPNIYEAQILAGLDINNIN
DMKLAAEKIHKFGVNTVLVKGGALKHNLRGVDVWFDGESFETLKTSTVDTNNTHGTGCTLSAAIAANLAQGQDLFSAVTM
AKNYVTSSLQYALEIGQGQGPIGHFFPLLLNNYIKSS

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=258, Percent_Identity=41.0852713178295, Blast_Score=182, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6325378, Length=278, Percent_Identity=32.0143884892086, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6324997, Length=275, Percent_Identity=33.4545454545455, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6324517, Length=275, Percent_Identity=33.4545454545455, Blast_Score=112, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 29306; Mature: 29175

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADFMASSIPVALTIAGSDSGGGAGIQADLRTFAFHCVHGTSALTCITAQNTLGVNRLDA
CCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHH
LLPEVVKAQIEAVVQDIGVQATKTGMLLNQDIILVVAEVLETLSLKQLVVDPVMVSRAGV
HHHHHHHHHHHHHHHHHCCCEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QLIDNSAVAALRDFLLPKASIVTPNIYEAQILAGLDINNINDMKLAAEKIHKFGVNTVLV
EEECCHHHHHHHHHHCCCCCCCCCCCCHHHEEECCCCCCCCHHHHHHHHHHHCCCCEEEE
KGGALKHNLRGVDVWFDGESFETLKTSTVDTNNTHGTGCTLSAAIAANLAQGQDLFSAVT
ECCCEECCCCEEEEEECCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHH
MAKNYVTSSLQYALEIGQGQGPIGHFFPLLLNNYIKSS
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADFMASSIPVALTIAGSDSGGGAGIQADLRTFAFHCVHGTSALTCITAQNTLGVNRLDA
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHH
LLPEVVKAQIEAVVQDIGVQATKTGMLLNQDIILVVAEVLETLSLKQLVVDPVMVSRAGV
HHHHHHHHHHHHHHHHHCCCEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QLIDNSAVAALRDFLLPKASIVTPNIYEAQILAGLDINNINDMKLAAEKIHKFGVNTVLV
EEECCHHHHHHHHHHCCCCCCCCCCCCHHHEEECCCCCCCCHHHHHHHHHHHCCCCEEEE
KGGALKHNLRGVDVWFDGESFETLKTSTVDTNNTHGTGCTLSAAIAANLAQGQDLFSAVT
ECCCEECCCCEEEEEECCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHH
MAKNYVTSSLQYALEIGQGQGPIGHFFPLLLNNYIKSS
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA