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The map label for this gene is ksgA [H]

Identifier: 113474554

GI number: 113474554

Start: 1144783

End: 1145628

Strand: Reverse

Name: ksgA [H]

Synonym: Tery_0708

Alternate gene names: 113474554

Gene position: 1145628-1144783 (Counterclockwise)

Preceding gene: 113474555

Following gene: 113474551

Centisome position: 14.78

GC content: 33.33

Gene sequence:

>846_bases
ATGACTATTCAACCTCGAAAAAGATTTGCTCAACATTGGCTATTGAGTGATAAAGCTCTCAATAAAATTATCCAAGCTGC
TGAATTATCTGAGAGCGATCGCATCCTAGAAATTGGGCCAGGTACAGGGGTCCTCACTCATCGTTTATTGCCTCTAGCAG
CTTCAGTTGTGGCAGTAGAAATTGATAGAGATTTATGTCAAAAGTTAGTCAAAAAATTTGGCAGAGTCAAAAATTTTTTA
TTATTACAAGGAGATATTTTATCCCTAGATTTAGAAACAAATTTAGCACAATTTATAGGTTTCCAAAATCCTCATAAAGT
TGTAGCTAATATACCTTATAATATTACTGGATTAATATTAGAAAAACTATTAGGAACAATTTCCCAACCTCTAACCAATA
CTTATGATTTAATTGTCTTATTATTACAAAAAGAAGTGGCAGATAGAATTTGTGCAAAACCAGATTCAAAAGCTTATAGT
TCCTTATCAGTAAAAATTCAATATTTAGCCAAATGTGAATTTATTTGTGATGTACCTGCTAAAGCATTTTATCCACCACC
CAAAGTAGATTCAGCAGTAATACGACTACGGCCTCAATTAATAGAACCCCAGGCAAATAACCCGAAACAAATGGAAATGT
TAGTTAAATTAGGTTTTGCTAGTAAACGGAAAATGTTGAGAAATAACCTCAAAGCAGTTGTTGAGCGCGATCGCCTTTTC
GAGTTATTAGAAAACTTAAAAGTTAACCCCCAAAGTCGTGCAGAAGATTTAACTGTTCAGGAGTGGGTTACCTTAGCAAA
TAGTTTAGAGCATTTTTTACACTCTCACAATAAACTATTAAAGTAA

Upstream 100 bases:

>100_bases
AATCTGGCTGGTTCTATTTATGACTCTTTTAAGGGTATAAAAAAAAGAAAATATTCTTGCTATTGCTAGGGTAGCTGATA
AATGATAACTGATAACTAAA

Downstream 100 bases:

>100_bases
TTAAGTCGCGCAACCCTGTCTTGGGGAGATGTTTTTACAGGGTTGCTAACTGCCATAATTTTACATAATAATAATATCTT
CTTAAACATTAAAATAAGGA

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MTIQPRKRFAQHWLLSDKALNKIIQAAELSESDRILEIGPGTGVLTHRLLPLAASVVAVEIDRDLCQKLVKKFGRVKNFL
LLQGDILSLDLETNLAQFIGFQNPHKVVANIPYNITGLILEKLLGTISQPLTNTYDLIVLLLQKEVADRICAKPDSKAYS
SLSVKIQYLAKCEFICDVPAKAFYPPPKVDSAVIRLRPQLIEPQANNPKQMEMLVKLGFASKRKMLRNNLKAVVERDRLF
ELLENLKVNPQSRAEDLTVQEWVTLANSLEHFLHSHNKLLK

Sequences:

>Translated_281_residues
MTIQPRKRFAQHWLLSDKALNKIIQAAELSESDRILEIGPGTGVLTHRLLPLAASVVAVEIDRDLCQKLVKKFGRVKNFL
LLQGDILSLDLETNLAQFIGFQNPHKVVANIPYNITGLILEKLLGTISQPLTNTYDLIVLLLQKEVADRICAKPDSKAYS
SLSVKIQYLAKCEFICDVPAKAFYPPPKVDSAVIRLRPQLIEPQANNPKQMEMLVKLGFASKRKMLRNNLKAVVERDRLF
ELLENLKVNPQSRAEDLTVQEWVTLANSLEHFLHSHNKLLK
>Mature_280_residues
TIQPRKRFAQHWLLSDKALNKIIQAAELSESDRILEIGPGTGVLTHRLLPLAASVVAVEIDRDLCQKLVKKFGRVKNFLL
LQGDILSLDLETNLAQFIGFQNPHKVVANIPYNITGLILEKLLGTISQPLTNTYDLIVLLLQKEVADRICAKPDSKAYSS
LSVKIQYLAKCEFICDVPAKAFYPPPKVDSAVIRLRPQLIEPQANNPKQMEMLVKLGFASKRKMLRNNLKAVVERDRLFE
LLENLKVNPQSRAEDLTVQEWVTLANSLEHFLHSHNKLLK

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=270, Percent_Identity=32.5925925925926, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI156415992, Length=284, Percent_Identity=27.8169014084507, Blast_Score=98, Evalue=8e-21,
Organism=Escherichia coli, GI1786236, Length=265, Percent_Identity=32.0754716981132, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI25146882, Length=238, Percent_Identity=36.1344537815126, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI25141369, Length=294, Percent_Identity=24.8299319727891, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324989, Length=232, Percent_Identity=30.6034482758621, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21358017, Length=262, Percent_Identity=33.206106870229, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21357273, Length=286, Percent_Identity=27.6223776223776, Blast_Score=81, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 31789; Mature: 31658

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQPRKRFAQHWLLSDKALNKIIQAAELSESDRILEIGPGTGVLTHRLLPLAASVVAVE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHH
IDRDLCQKLVKKFGRVKNFLLLQGDILSLDLETNLAQFIGFQNPHKVVANIPYNITGLIL
HHHHHHHHHHHHHHHHHHEEEEECCEEEEEHHHHHHHHHCCCCCCCEEEECCCCHHHHHH
EKLLGTISQPLTNTYDLIVLLLQKEVADRICAKPDSKAYSSLSVKIQYLAKCEFICDVPA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
KAFYPPPKVDSAVIRLRPQLIEPQANNPKQMEMLVKLGFASKRKMLRNNLKAVVERDRLF
HHCCCCCCCCHHHHHHCHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ELLENLKVNPQSRAEDLTVQEWVTLANSLEHFLHSHNKLLK
HHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIQPRKRFAQHWLLSDKALNKIIQAAELSESDRILEIGPGTGVLTHRLLPLAASVVAVE
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHH
IDRDLCQKLVKKFGRVKNFLLLQGDILSLDLETNLAQFIGFQNPHKVVANIPYNITGLIL
HHHHHHHHHHHHHHHHHHEEEEECCEEEEEHHHHHHHHHCCCCCCCEEEECCCCHHHHHH
EKLLGTISQPLTNTYDLIVLLLQKEVADRICAKPDSKAYSSLSVKIQYLAKCEFICDVPA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
KAFYPPPKVDSAVIRLRPQLIEPQANNPKQMEMLVKLGFASKRKMLRNNLKAVVERDRLF
HHCCCCCCCCHHHHHHCHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ELLENLKVNPQSRAEDLTVQEWVTLANSLEHFLHSHNKLLK
HHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA