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The map label for this gene is 113474356

Identifier: 113474356

GI number: 113474356

Start: 781534

End: 783267

Strand: Direct

Name: 113474356

Synonym: Tery_0488

Alternate gene names: NA

Gene position: 781534-783267 (Clockwise)

Preceding gene: 113474355

Following gene: 113474357

Centisome position: 10.08

GC content: 35.29

Gene sequence:

>1734_bases
ATGTTAATTCTGAAAAAAATGAATGATGAAAAAACTGTGATTGGTTCTAACTATTCTGGTATTTCTTATCTATTGGATAA
TAATCATAATCAATTTACTGTACCTGTAAATTTACTAATTCCATATTCAGCAGGTCTACAAGCTTTAGATGGAAATGATA
CAATAATAGGCTCATTAAGCCCTGAATTGATTAATGGTAATCAAGGTAACGATAATATTTTTGGTGGAAGTGGTTCTGAT
ACTTTACGAGGTGGTAGAGGTAATGATTTTATTGAAGCTGACCAAGGTAACGATCAAGTTTTTGGAGATTTAGGTAAGGA
TACAGTTTATGGAGAAATCGGAAATGATCAAATTTATGGAGGGAAAGGAGAGGATATTTTATTCGGAGGCAATGGTAATG
ATACAATTTATGGGGATTTAGGAAAAGATACATTAATTGGAGAAGCAGGCAATGATATATTTGTTTTGCGAGATTCACCA
AATAATAACAATTTAGATACTGCAGATATTATTTATGATTTTAATCCTAATTTTGACAGTATTCAAATGCCAGCAAACTT
AACAGAAAGTGACATTCTATTAAGAGAAGATTTTTATTATGGAGGTACATTAATTCAAGTTCAGGCAAATGGTTCCATAT
TAGCAATAGTTAAAGACATATCTAATACAAACGTTAAAAGTGAGTTAATTTTTGGAGATACCGCAAATACTAATGAACTT
TTACAAACGAATAGTTCTGTAAGACCAACCTTTAATAATATTTTTGGATATGGTTTAGTCGATGCCTCAGCAGCAGTAGC
CAGTGCTATTGGTAGTACTTCCTTTCCAGAAGTTCCTGATTTAGGAGGAAATCAGTGGGGACTAGACTTGGTTAAAGCAC
CCGAAGTTTGGAATCAAGGCTTTCTGGGAGATGGTATTGTAGTAGCCGTTATTGATAGTGGTGTAGACTATACCCATCCA
GAATTAACAGGCCAAATTTGGAAGAATAGCCGTGAAATTCCTAACAATAATATTGATGATGATGCTAATGGCTATGTGGA
TGATTTTCAGGGTTGGGATTTTATCAATGATGATAATGACTCAAGAGATGAAAAAGGTCATGGAACTCATATTGCAGGCA
CTATAGCTGCCAAGAGAGATGGGATAGGGACAACTGGTATAGCTCCAAATGTCCAAATTATGCCTCTCAGGATACTTAAT
GATCAAGGAACAGGTAAAGTTAGCGATGGTATAGAGGCTATTCGTTATGCTGTTGATAATGGAGCAGATGTGATTAACTT
TAGCTCTGGTGATAGAAATTTAGTTAGTGGGGAAATTGAAGCTATTCGTTATGCTGCTGAACGAGGTGTTGTATTTGTTT
CTGCTGCAGGTAATGGTAGTTTAAGTAGTCCTGATTATCCAGCAAAGTTAGCTGATAAACAGGGAATTGCGGTTGGGTCA
GTAGAGAAAAATGGGAAATTTTCTTCTTTTTCCAATGAAGCTGGAAACCAACCTTTAGATTATGTCGTTGCTCCAGGGGG
GGATGGTTTTCCTGAAGATGCAGGAGATATCTATGCCCCTGTACCTCTTTCTATAAAAGGTAATTTATATAGTTTCTTGA
CAGGTACTTCAATGGCTACACCTTATGTTACAGGTATAGTAGCTTTAATTAAACAAGCTAATCCAAGTTTGTCTGTTGAG
GCCATTGAAAATATAATTACTTATACTACTAACTCAGCAGATGTGATTGTCTAA

Upstream 100 bases:

>100_bases
TTATAAATCAACTTCAAGTTTTTCAATTAAATATGTTCTCAAACTTTTTATAAAAAGGCTAGCGTAAATGCTAAGATATG
CGCCATTAGTTTTTGTTTAG

Downstream 100 bases:

>100_bases
TTTAGACTACTGAAGAAAATATGAATGGGAAAGGGACTGGGAATATCCTGGACAGATTTTTATAAAATCCCTGTATACTG
GGCGCAAAAATACTTAAGTC

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MLILKKMNDEKTVIGSNYSGISYLLDNNHNQFTVPVNLLIPYSAGLQALDGNDTIIGSLSPELINGNQGNDNIFGGSGSD
TLRGGRGNDFIEADQGNDQVFGDLGKDTVYGEIGNDQIYGGKGEDILFGGNGNDTIYGDLGKDTLIGEAGNDIFVLRDSP
NNNNLDTADIIYDFNPNFDSIQMPANLTESDILLREDFYYGGTLIQVQANGSILAIVKDISNTNVKSELIFGDTANTNEL
LQTNSSVRPTFNNIFGYGLVDASAAVASAIGSTSFPEVPDLGGNQWGLDLVKAPEVWNQGFLGDGIVVAVIDSGVDYTHP
ELTGQIWKNSREIPNNNIDDDANGYVDDFQGWDFINDDNDSRDEKGHGTHIAGTIAAKRDGIGTTGIAPNVQIMPLRILN
DQGTGKVSDGIEAIRYAVDNGADVINFSSGDRNLVSGEIEAIRYAAERGVVFVSAAGNGSLSSPDYPAKLADKQGIAVGS
VEKNGKFSSFSNEAGNQPLDYVVAPGGDGFPEDAGDIYAPVPLSIKGNLYSFLTGTSMATPYVTGIVALIKQANPSLSVE
AIENIITYTTNSADVIV

Sequences:

>Translated_577_residues
MLILKKMNDEKTVIGSNYSGISYLLDNNHNQFTVPVNLLIPYSAGLQALDGNDTIIGSLSPELINGNQGNDNIFGGSGSD
TLRGGRGNDFIEADQGNDQVFGDLGKDTVYGEIGNDQIYGGKGEDILFGGNGNDTIYGDLGKDTLIGEAGNDIFVLRDSP
NNNNLDTADIIYDFNPNFDSIQMPANLTESDILLREDFYYGGTLIQVQANGSILAIVKDISNTNVKSELIFGDTANTNEL
LQTNSSVRPTFNNIFGYGLVDASAAVASAIGSTSFPEVPDLGGNQWGLDLVKAPEVWNQGFLGDGIVVAVIDSGVDYTHP
ELTGQIWKNSREIPNNNIDDDANGYVDDFQGWDFINDDNDSRDEKGHGTHIAGTIAAKRDGIGTTGIAPNVQIMPLRILN
DQGTGKVSDGIEAIRYAVDNGADVINFSSGDRNLVSGEIEAIRYAAERGVVFVSAAGNGSLSSPDYPAKLADKQGIAVGS
VEKNGKFSSFSNEAGNQPLDYVVAPGGDGFPEDAGDIYAPVPLSIKGNLYSFLTGTSMATPYVTGIVALIKQANPSLSVE
AIENIITYTTNSADVIV
>Mature_577_residues
MLILKKMNDEKTVIGSNYSGISYLLDNNHNQFTVPVNLLIPYSAGLQALDGNDTIIGSLSPELINGNQGNDNIFGGSGSD
TLRGGRGNDFIEADQGNDQVFGDLGKDTVYGEIGNDQIYGGKGEDILFGGNGNDTIYGDLGKDTLIGEAGNDIFVLRDSP
NNNNLDTADIIYDFNPNFDSIQMPANLTESDILLREDFYYGGTLIQVQANGSILAIVKDISNTNVKSELIFGDTANTNEL
LQTNSSVRPTFNNIFGYGLVDASAAVASAIGSTSFPEVPDLGGNQWGLDLVKAPEVWNQGFLGDGIVVAVIDSGVDYTHP
ELTGQIWKNSREIPNNNIDDDANGYVDDFQGWDFINDDNDSRDEKGHGTHIAGTIAAKRDGIGTTGIAPNVQIMPLRILN
DQGTGKVSDGIEAIRYAVDNGADVINFSSGDRNLVSGEIEAIRYAAERGVVFVSAAGNGSLSSPDYPAKLADKQGIAVGS
VEKNGKFSSFSNEAGNQPLDYVVAPGGDGFPEDAGDIYAPVPLSIKGNLYSFLTGTSMATPYVTGIVALIKQANPSLSVE
AIENIITYTTNSADVIV

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI76443679, Length=319, Percent_Identity=26.3322884012539, Blast_Score=71, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25141268, Length=296, Percent_Identity=28.3783783783784, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71983555, Length=296, Percent_Identity=28.3783783783784, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320775, Length=299, Percent_Identity=28.0936454849498, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324576, Length=297, Percent_Identity=28.6195286195286, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319893, Length=284, Percent_Identity=26.7605633802817, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45550681, Length=267, Percent_Identity=25.4681647940075, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 61166; Mature: 61166

Theoretical pI: Translated: 3.89; Mature: 3.89

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER ; PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLILKKMNDEKTVIGSNYSGISYLLDNNHNQFTVPVNLLIPYSAGLQALDGNDTIIGSLS
CEEEEECCCCCEEEECCCCCEEEEEECCCCEEEEEEEEEEECCCCCEEECCCCEEEECCC
PELINGNQGNDNIFGGSGSDTLRGGRGNDFIEADQGNDQVFGDLGKDTVYGEIGNDQIYG
HHHCCCCCCCCCEECCCCCCCCCCCCCCCCEECCCCCCCEECCCCCCEEEEECCCCEEEC
GKGEDILFGGNGNDTIYGDLGKDTLIGEAGNDIFVLRDSPNNNNLDTADIIYDFNPNFDS
CCCCEEEECCCCCCEEEECCCCCEEEECCCCEEEEEECCCCCCCCCEEEEEEECCCCCCC
IQMPANLTESDILLREDFYYGGTLIQVQANGSILAIVKDISNTNVKSELIFGDTANTNEL
EECCCCCCCCCEEEEECEEECCEEEEEECCCCEEEEEECCCCCCCEEEEEECCCCCCHHH
LQTNSSVRPTFNNIFGYGLVDASAAVASAIGSTSFPEVPDLGGNQWGLDLVKAPEVWNQG
HHCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCHHHCCC
FLGDGIVVAVIDSGVDYTHPELTGQIWKNSREIPNNNIDDDANGYVDDFQGWDFINDDND
CCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SRDEKGHGTHIAGTIAAKRDGIGTTGIAPNVQIMPLRILNDQGTGKVSDGIEAIRYAVDN
CCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHCC
GADVINFSSGDRNLVSGEIEAIRYAAERGVVFVSAAGNGSLSSPDYPAKLADKQGIAVGS
CCCEEEECCCCCCEECCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHCCCCCCEEEC
VEKNGKFSSFSNEAGNQPLDYVVAPGGDGFPEDAGDIYAPVPLSIKGNLYSFLTGTSMAT
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEECCCEEECCCEEEEECCCCCCC
PYVTGIVALIKQANPSLSVEAIENIITYTTNSADVIV
HHHHHHHHHHHHCCCCEEHHHHHHHHEEECCCCCEEC
>Mature Secondary Structure
MLILKKMNDEKTVIGSNYSGISYLLDNNHNQFTVPVNLLIPYSAGLQALDGNDTIIGSLS
CEEEEECCCCCEEEECCCCCEEEEEECCCCEEEEEEEEEEECCCCCEEECCCCEEEECCC
PELINGNQGNDNIFGGSGSDTLRGGRGNDFIEADQGNDQVFGDLGKDTVYGEIGNDQIYG
HHHCCCCCCCCCEECCCCCCCCCCCCCCCCEECCCCCCCEECCCCCCEEEEECCCCEEEC
GKGEDILFGGNGNDTIYGDLGKDTLIGEAGNDIFVLRDSPNNNNLDTADIIYDFNPNFDS
CCCCEEEECCCCCCEEEECCCCCEEEECCCCEEEEEECCCCCCCCCEEEEEEECCCCCCC
IQMPANLTESDILLREDFYYGGTLIQVQANGSILAIVKDISNTNVKSELIFGDTANTNEL
EECCCCCCCCCEEEEECEEECCEEEEEECCCCEEEEEECCCCCCCEEEEEECCCCCCHHH
LQTNSSVRPTFNNIFGYGLVDASAAVASAIGSTSFPEVPDLGGNQWGLDLVKAPEVWNQG
HHCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCHHHCCC
FLGDGIVVAVIDSGVDYTHPELTGQIWKNSREIPNNNIDDDANGYVDDFQGWDFINDDND
CCCCCEEEEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SRDEKGHGTHIAGTIAAKRDGIGTTGIAPNVQIMPLRILNDQGTGKVSDGIEAIRYAVDN
CCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHCC
GADVINFSSGDRNLVSGEIEAIRYAAERGVVFVSAAGNGSLSSPDYPAKLADKQGIAVGS
CCCEEEECCCCCCEECCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHCCCCCCEEEC
VEKNGKFSSFSNEAGNQPLDYVVAPGGDGFPEDAGDIYAPVPLSIKGNLYSFLTGTSMAT
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEECCCEEECCCEEEEECCCCCCC
PYVTGIVALIKQANPSLSVEAIENIITYTTNSADVIV
HHHHHHHHHHHHCCCCEEHHHHHHHHEEECCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]