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The map label for this gene is mco [H]

Identifier: 113474240

GI number: 113474240

Start: 551971

End: 553365

Strand: Direct

Name: mco [H]

Synonym: Tery_0359

Alternate gene names: 113474240

Gene position: 551971-553365 (Clockwise)

Preceding gene: 113474237

Following gene: 113474241

Centisome position: 7.12

GC content: 37.13

Gene sequence:

>1395_bases
ATGGCAACTTTAATCACTCAATGTAATATAAATAATACTCAAAAAAATCAACAACTTATATCATCATACCCTCAAATACA
TCAGAGCCAAGATGGAATTCTAGAAATTGATTTGACAGCTAATATTAGTCAAATAAATCTGGGAAATAAACAAGCTTATG
TATTAAATTATAACGGACAAATTCCCGGACCAAGATTAGAAGTAAAACCAAGAGATACAATTAGGATTAATTTCACTAAC
AATTTACCCCAACCTACAAATATTCATTATCACGGACTACATATTCCCATGACTGGAAATGCTGATAACGTATTTCTGAA
TATTTCTCCAGGCGATCGCTTGACATATCAGTTTCAAATTCCTGAAAATCACCATGCTGGAATGTTTTGGTATCATCCAC
ATCTCCATGGTTTAGTAGCAGAACAAATTTTTGGGGGGTTAGCTGGATTATTTATTGTCCGTGGAGAGCTCGATGAAATT
CCCGAAGTAAAAGCTGCTTCAGAACAATTTTTAGTGTTGCAGGATTTTGCCCTAGACCAAAAAGGAAATATACTCCCATC
TCATGAGCTTTCAATAATGACAGGAAGGCAAGGAAATTTGATCACTGCTAACGGTCAGTCTAACCCTAAATTAACCATTC
CCCCTCAAAATTTATTAAGAATTCGTATTCTTAATGCTTCAAGTTCCAGATTTTATCGGTTATCTTTAGAAGAACACCCA
TTTTATTTAATAGCTACTGATGGAGGAGCATTAGCTGAACCTGTAGAAATGTCAGAACTATTATTGACTCCTGGAGAACG
TGCAGATGTATTAGTCCAAGGTAACCGAGAGCCAGGAAAATATCGCTTGTTGAATTTACCTTATGAACGAGTGGGTATTG
GTATGATGGGGAGAAATGTATCTGAAAGTCAACCACAAGTTTTAGCAACAGTGAGTTATGACCAACAGTCCACTGCTGTG
CCACTGCCAACCAAACTCATCCCTGTCCCAGCATTGCCCGAACCTCAAAAAGTACGTCGTTTTCAGATGAACCATGGCAT
GATACCTGGTCAAGGGATGGCATTTTTGTTTAATGGTCAGCCATATCAACCAGAAAGAATTGATACTCAAGTTCAGCTCA
ATACCGTTGAAGACTGGGAATTAATTAACACAGGCATAATGGATCATCCCTTTCATATTCATAGCAATGCTTTTCAAGTT
TTGAGTCGGAATGGCAAACCAGAACCCTATCGTGCCTGGAAAGATGTAGTCTTAGTCAGACAGGGAGAAACAGTTTTAAT
TCGGATGCCATTACAAGATTTTGCTGGAAAAACTGTTTATCATTGTCATATTCTTGACCACGAAGATTTAGGAATGATAG
GAAATTTGGAAATTAAAGCAAGACTTTCTATTTAA

Upstream 100 bases:

>100_bases
ATTGGCTAAAATAAAATGTTAAATCAAATATAAAATTCCCAAAATATTAATTGTGAAAAAAATTAATCGAAGAAAATTTT
TCATCCTAAGTTCCAGTGCG

Downstream 100 bases:

>100_bases
CCAGAAAATTTATCATTACAATAGAGTACTATAGATTATTTAAGGTAATAATTATGAAAAAAGTTTTCTCTAATTGGATA
AAGTCTTTAATTGCTGGTGT

Product: multicopper oxidase, type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MATLITQCNINNTQKNQQLISSYPQIHQSQDGILEIDLTANISQINLGNKQAYVLNYNGQIPGPRLEVKPRDTIRINFTN
NLPQPTNIHYHGLHIPMTGNADNVFLNISPGDRLTYQFQIPENHHAGMFWYHPHLHGLVAEQIFGGLAGLFIVRGELDEI
PEVKAASEQFLVLQDFALDQKGNILPSHELSIMTGRQGNLITANGQSNPKLTIPPQNLLRIRILNASSSRFYRLSLEEHP
FYLIATDGGALAEPVEMSELLLTPGERADVLVQGNREPGKYRLLNLPYERVGIGMMGRNVSESQPQVLATVSYDQQSTAV
PLPTKLIPVPALPEPQKVRRFQMNHGMIPGQGMAFLFNGQPYQPERIDTQVQLNTVEDWELINTGIMDHPFHIHSNAFQV
LSRNGKPEPYRAWKDVVLVRQGETVLIRMPLQDFAGKTVYHCHILDHEDLGMIGNLEIKARLSI

Sequences:

>Translated_464_residues
MATLITQCNINNTQKNQQLISSYPQIHQSQDGILEIDLTANISQINLGNKQAYVLNYNGQIPGPRLEVKPRDTIRINFTN
NLPQPTNIHYHGLHIPMTGNADNVFLNISPGDRLTYQFQIPENHHAGMFWYHPHLHGLVAEQIFGGLAGLFIVRGELDEI
PEVKAASEQFLVLQDFALDQKGNILPSHELSIMTGRQGNLITANGQSNPKLTIPPQNLLRIRILNASSSRFYRLSLEEHP
FYLIATDGGALAEPVEMSELLLTPGERADVLVQGNREPGKYRLLNLPYERVGIGMMGRNVSESQPQVLATVSYDQQSTAV
PLPTKLIPVPALPEPQKVRRFQMNHGMIPGQGMAFLFNGQPYQPERIDTQVQLNTVEDWELINTGIMDHPFHIHSNAFQV
LSRNGKPEPYRAWKDVVLVRQGETVLIRMPLQDFAGKTVYHCHILDHEDLGMIGNLEIKARLSI
>Mature_463_residues
ATLITQCNINNTQKNQQLISSYPQIHQSQDGILEIDLTANISQINLGNKQAYVLNYNGQIPGPRLEVKPRDTIRINFTNN
LPQPTNIHYHGLHIPMTGNADNVFLNISPGDRLTYQFQIPENHHAGMFWYHPHLHGLVAEQIFGGLAGLFIVRGELDEIP
EVKAASEQFLVLQDFALDQKGNILPSHELSIMTGRQGNLITANGQSNPKLTIPPQNLLRIRILNASSSRFYRLSLEEHPF
YLIATDGGALAEPVEMSELLLTPGERADVLVQGNREPGKYRLLNLPYERVGIGMMGRNVSESQPQVLATVSYDQQSTAVP
LPTKLIPVPALPEPQKVRRFQMNHGMIPGQGMAFLFNGQPYQPERIDTQVQLNTVEDWELINTGIMDHPFHIHSNAFQVL
SRNGKPEPYRAWKDVVLVRQGETVLIRMPLQDFAGKTVYHCHILDHEDLGMIGNLEIKARLSI

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=486, Percent_Identity=29.6296296296296, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1789394, Length=425, Percent_Identity=28.7058823529412, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323703, Length=471, Percent_Identity=25.6900212314225, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24650186, Length=256, Percent_Identity=28.515625, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI18859919, Length=265, Percent_Identity=28.6792452830189, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 52141; Mature: 52010

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLITQCNINNTQKNQQLISSYPQIHQSQDGILEIDLTANISQINLGNKQAYVLNYNGQ
CCEEEEEECCCCCHHHHHHHHHCHHHHCCCCCEEEEEEECCEEEEECCCCEEEEEEECCC
IPGPRLEVKPRDTIRINFTNNLPQPTNIHYHGLHIPMTGNADNVFLNISPGDRLTYQFQI
CCCCEEEECCCCEEEEEECCCCCCCCCEEEEEEEEEEECCCCEEEEEECCCCEEEEEEEC
PENHHAGMFWYHPHLHGLVAEQIFGGLAGLFIVRGELDEIPEVKAASEQFLVLQDFALDQ
CCCCCCCEEEECCCHHHHHHHHHHHCCEEEEEEECCHHCCCCCCCCCCEEEEEEEECCCC
KGNILPSHELSIMTGRQGNLITANGQSNPKLTIPPQNLLRIRILNASSSRFYRLSLEEHP
CCCCCCCCCEEEEECCCCCEEEECCCCCCEEEECCCCEEEEEEEECCCCEEEEEEECCCC
FYLIATDGGALAEPVEMSELLLTPGERADVLVQGNREPGKYRLLNLPYERVGIGMMGRNV
EEEEEECCCCCCCCCCCHHEEECCCCCCEEEEECCCCCCCEEEEECCHHHHCEEEECCCC
SESQPQVLATVSYDQQSTAVPLPTKLIPVPALPEPQKVRRFQMNHGMIPGQGMAFLFNGQ
CCCCCCEEEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEECCC
PYQPERIDTQVQLNTVEDWELINTGIMDHPFHIHSNAFQVLSRNGKPEPYRAWKDVVLVR
CCCCCCCCCEEEEEECCCCEEHHCCCCCCCEEECCCHHHHHHCCCCCCHHHHCCEEEEEE
QGETVLIRMPLQDFAGKTVYHCHILDHEDLGMIGNLEIKARLSI
CCCEEEEEECHHHHCCCEEEEEEEECCCCCCEEECEEEEEEECC
>Mature Secondary Structure 
ATLITQCNINNTQKNQQLISSYPQIHQSQDGILEIDLTANISQINLGNKQAYVLNYNGQ
CEEEEEECCCCCHHHHHHHHHCHHHHCCCCCEEEEEEECCEEEEECCCCEEEEEEECCC
IPGPRLEVKPRDTIRINFTNNLPQPTNIHYHGLHIPMTGNADNVFLNISPGDRLTYQFQI
CCCCEEEECCCCEEEEEECCCCCCCCCEEEEEEEEEEECCCCEEEEEECCCCEEEEEEEC
PENHHAGMFWYHPHLHGLVAEQIFGGLAGLFIVRGELDEIPEVKAASEQFLVLQDFALDQ
CCCCCCCEEEECCCHHHHHHHHHHHCCEEEEEEECCHHCCCCCCCCCCEEEEEEEECCCC
KGNILPSHELSIMTGRQGNLITANGQSNPKLTIPPQNLLRIRILNASSSRFYRLSLEEHP
CCCCCCCCCEEEEECCCCCEEEECCCCCCEEEECCCCEEEEEEEECCCCEEEEEEECCCC
FYLIATDGGALAEPVEMSELLLTPGERADVLVQGNREPGKYRLLNLPYERVGIGMMGRNV
EEEEEECCCCCCCCCCCHHEEECCCCCCEEEEECCCCCCCEEEEECCHHHHCEEEECCCC
SESQPQVLATVSYDQQSTAVPLPTKLIPVPALPEPQKVRRFQMNHGMIPGQGMAFLFNGQ
CCCCCCEEEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEECCC
PYQPERIDTQVQLNTVEDWELINTGIMDHPFHIHSNAFQVLSRNGKPEPYRAWKDVVLVR
CCCCCCCCCEEEEEECCCCEEHHCCCCCCCEEECCCHHHHHHCCCCCCHHHHCCEEEEEE
QGETVLIRMPLQDFAGKTVYHCHILDHEDLGMIGNLEIKARLSI
CCCEEEEEECHHHHCCCEEEEEEEECCCCCCEEECEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]