Click here to switch to the map view.

The map label for this gene is gcvP-1 [H]

Identifier: 110835452

GI number: 110835452

Start: 2930712

End: 2932178

Strand: Reverse

Name: gcvP-1 [H]

Synonym: ABO_2591

Alternate gene names: 110835452

Gene position: 2932178-2930712 (Counterclockwise)

Preceding gene: 110835453

Following gene: 110835451

Centisome position: 93.98

GC content: 60.26

Gene sequence:

>1467_bases
ATGAGCGAGACACAACTGATTTTCCAACTGTCTCATCCAGGTCGTAGCGCCACCTCCCAAGCGCCCAAGGCGCTGGCGGA
AGACAAGCTGTCCGCGATTCCAGCGCACCTGCGTCGCAAGGAAAAGCCGGGCCTGCCGGAAGTGTCCGAAATGCAGGTGG
TACGTCACTACACCAACCTGTCCAGCAAGAACTTCGCCATCGACAAGCAATTCTATCCGCTGGGTTCGTGCACCATGAAG
TACAACCCCCGTGGCGCCAACCGTGCCGCCATGCTACCGGGTTTTTTGAATCGTCACCCGCTGGCACCGGAAAGCCACAG
CCAGGGTTTCCTTAGCTGCATGTTCGAACTGCAGAACTTCCTGAAAGAAGTCACCGGCATGAAAGGGGTGTCCCTGGCGC
CCATGGCCGGCGCTCAGGGTGAGTTTGCCGGCGTCGCCATGATCCGTGCCTACCACGATGCCCGTGGTGATGATCAACGT
ACCGAGATCCTGATCCCGAATGCGGCCCACGGCACCAACCCGGCCACCGCCGTCATGTGTGGCTACAAGGTCCGTGAAGT
TCCTGTTGGCGAAGATGGTGACGTGGACCTGGAAGCACTGAAAGCTGCTTGCGGCCCACAGACCGCTGGCTTGATGATGA
CCAACCCGTCTACTTGTGGCGTGTTCGAACGGCAGGTTGAAGACATCGCCAAAGCCGTGCACGAAGCCGGCGGCTTGCTG
TATTACGATGGCGCAAACCTGAACGCCATCCTCGGCAAGGTGCGCCCCGGAGACATGGGCTTCGACGTTATTCACATGAA
CCTGCACAAAACCTTCGCCACCCCCCACGGTGGTGGTGGCCCCGGTGCCGGCCCGGTCGGTGTCTCCGAACGCTTGTTGC
CTTACCTGCCCACCCCCATGGCCGGCCAGCGCGATGACGGCAGCTATCACTGGGTCGACACCGACTCGCTGGACACCAGC
ATCGGCCACTTGAGTGCCTTTATGGGTAACGCCGGTGTATTGCTGCGCGCTTATTTCTACGCCCGTTCCCTGGGCCGCGA
AGGCATGATCCGCGTGGGCGAGTTTTCCACATTGGCGGCCAACTACCTGCTCAAGCGTCTGGAAGCGGTAGGTTGTACTG
CTGCCTACCCGGATCGTCGTGCCAGCCATGAGTTCATCCTCACCTTCGCAAAAGAAGCGAAGGAGCTGGGCGTCACCGCC
ATGGATATCGCCAAGCGTCTGCTGGACTACAACCAGCACGCGCCCACCACCTACTTCCCGCTGCTGGTGCCGGAGTGCTT
CCTCATCGAGCCCACCGAAACCGAAAGCAAAGAAGCGCTGGACGAGTTCGTGGATGCCATGGCCGCGATCCTGGAAGAAG
CGCGCAACGAACCGGACATGGTGAAAGAAGCGCCCTTCACCCAGCCGGTACGTCGTCTGGATGATGTCAAAGCCGCTCGT
GAGCTGGACTTGGCCTGGAGCGAATAA

Upstream 100 bases:

>100_bases
GCGACTATGACATGAATAATGCGATTCTGGTAAATGCTACCGAAGTCCATTCCGAGCAGGATTTGCAGCTGTTCGAACAA
GCCCTGAAGGAGGTGCTGGC

Downstream 100 bases:

>100_bases
GAGACGCAGCACGCTTCATATAACACGCTTGAAGCGATCAAAACCCGGCGAAAGCCGGGTTTTTTTATGGGTGAAAATAA
GTTGAAACCTCGACATCGCA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MSETQLIFQLSHPGRSATSQAPKALAEDKLSAIPAHLRRKEKPGLPEVSEMQVVRHYTNLSSKNFAIDKQFYPLGSCTMK
YNPRGANRAAMLPGFLNRHPLAPESHSQGFLSCMFELQNFLKEVTGMKGVSLAPMAGAQGEFAGVAMIRAYHDARGDDQR
TEILIPNAAHGTNPATAVMCGYKVREVPVGEDGDVDLEALKAACGPQTAGLMMTNPSTCGVFERQVEDIAKAVHEAGGLL
YYDGANLNAILGKVRPGDMGFDVIHMNLHKTFATPHGGGGPGAGPVGVSERLLPYLPTPMAGQRDDGSYHWVDTDSLDTS
IGHLSAFMGNAGVLLRAYFYARSLGREGMIRVGEFSTLAANYLLKRLEAVGCTAAYPDRRASHEFILTFAKEAKELGVTA
MDIAKRLLDYNQHAPTTYFPLLVPECFLIEPTETESKEALDEFVDAMAAILEEARNEPDMVKEAPFTQPVRRLDDVKAAR
ELDLAWSE

Sequences:

>Translated_488_residues
MSETQLIFQLSHPGRSATSQAPKALAEDKLSAIPAHLRRKEKPGLPEVSEMQVVRHYTNLSSKNFAIDKQFYPLGSCTMK
YNPRGANRAAMLPGFLNRHPLAPESHSQGFLSCMFELQNFLKEVTGMKGVSLAPMAGAQGEFAGVAMIRAYHDARGDDQR
TEILIPNAAHGTNPATAVMCGYKVREVPVGEDGDVDLEALKAACGPQTAGLMMTNPSTCGVFERQVEDIAKAVHEAGGLL
YYDGANLNAILGKVRPGDMGFDVIHMNLHKTFATPHGGGGPGAGPVGVSERLLPYLPTPMAGQRDDGSYHWVDTDSLDTS
IGHLSAFMGNAGVLLRAYFYARSLGREGMIRVGEFSTLAANYLLKRLEAVGCTAAYPDRRASHEFILTFAKEAKELGVTA
MDIAKRLLDYNQHAPTTYFPLLVPECFLIEPTETESKEALDEFVDAMAAILEEARNEPDMVKEAPFTQPVRRLDDVKAAR
ELDLAWSE
>Mature_487_residues
SETQLIFQLSHPGRSATSQAPKALAEDKLSAIPAHLRRKEKPGLPEVSEMQVVRHYTNLSSKNFAIDKQFYPLGSCTMKY
NPRGANRAAMLPGFLNRHPLAPESHSQGFLSCMFELQNFLKEVTGMKGVSLAPMAGAQGEFAGVAMIRAYHDARGDDQRT
EILIPNAAHGTNPATAVMCGYKVREVPVGEDGDVDLEALKAACGPQTAGLMMTNPSTCGVFERQVEDIAKAVHEAGGLLY
YDGANLNAILGKVRPGDMGFDVIHMNLHKTFATPHGGGGPGAGPVGVSERLLPYLPTPMAGQRDDGSYHWVDTDSLDTSI
GHLSAFMGNAGVLLRAYFYARSLGREGMIRVGEFSTLAANYLLKRLEAVGCTAAYPDRRASHEFILTFAKEAKELGVTAM
DIAKRLLDYNQHAPTTYFPLLVPECFLIEPTETESKEALDEFVDAMAAILEEARNEPDMVKEAPFTQPVRRLDDVKAARE
LDLAWSE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=448, Percent_Identity=39.9553571428571, Blast_Score=271, Evalue=9e-73,
Organism=Escherichia coli, GI1789269, Length=454, Percent_Identity=40.0881057268723, Blast_Score=284, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17535605, Length=417, Percent_Identity=41.2470023980815, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI32564013, Length=373, Percent_Identity=41.8230563002681, Blast_Score=241, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6323843, Length=441, Percent_Identity=40.1360544217687, Blast_Score=287, Evalue=3e-78,
Organism=Drosophila melanogaster, GI24645648, Length=416, Percent_Identity=42.3076923076923, Blast_Score=281, Evalue=7e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53145; Mature: 53014

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETQLIFQLSHPGRSATSQAPKALAEDKLSAIPAHLRRKEKPGLPEVSEMQVVRHYTNL
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCC
SSKNFAIDKQFYPLGSCTMKYNPRGANRAAMLPGFLNRHPLAPESHSQGFLSCMFELQNF
CCCCEEECCCCCCCCCEEEEECCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHH
LKEVTGMKGVSLAPMAGAQGEFAGVAMIRAYHDARGDDQRTEILIPNAAHGTNPATAVMC
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHEEEE
GYKVREVPVGEDGDVDLEALKAACGPQTAGLMMTNPSTCGVFERQVEDIAKAVHEAGGLL
CCEEEECCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCEE
YYDGANLNAILGKVRPGDMGFDVIHMNLHKTFATPHGGGGPGAGPVGVSERLLPYLPTPM
EECCCCCHHHEECCCCCCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCC
AGQRDDGSYHWVDTDSLDTSIGHLSAFMGNAGVLLRAYFYARSLGREGMIRVGEFSTLAA
CCCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHH
NYLLKRLEAVGCTAAYPDRRASHEFILTFAKEAKELGVTAMDIAKRLLDYNQHAPTTYFP
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEH
LLVPECFLIEPTETESKEALDEFVDAMAAILEEARNEPDMVKEAPFTQPVRRLDDVKAAR
HHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHH
ELDLAWSE
HHCCCCCC
>Mature Secondary Structure 
SETQLIFQLSHPGRSATSQAPKALAEDKLSAIPAHLRRKEKPGLPEVSEMQVVRHYTNL
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCC
SSKNFAIDKQFYPLGSCTMKYNPRGANRAAMLPGFLNRHPLAPESHSQGFLSCMFELQNF
CCCCEEECCCCCCCCCEEEEECCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHH
LKEVTGMKGVSLAPMAGAQGEFAGVAMIRAYHDARGDDQRTEILIPNAAHGTNPATAVMC
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHEEEE
GYKVREVPVGEDGDVDLEALKAACGPQTAGLMMTNPSTCGVFERQVEDIAKAVHEAGGLL
CCEEEECCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCEE
YYDGANLNAILGKVRPGDMGFDVIHMNLHKTFATPHGGGGPGAGPVGVSERLLPYLPTPM
EECCCCCHHHEECCCCCCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCC
AGQRDDGSYHWVDTDSLDTSIGHLSAFMGNAGVLLRAYFYARSLGREGMIRVGEFSTLAA
CCCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHH
NYLLKRLEAVGCTAAYPDRRASHEFILTFAKEAKELGVTAMDIAKRLLDYNQHAPTTYFP
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEH
LLVPECFLIEPTETESKEALDEFVDAMAAILEEARNEPDMVKEAPFTQPVRRLDDVKAAR
HHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHH
ELDLAWSE
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA